Nigel Hooper - Selected Publications#

Total number of publications = 243
H-index = 55
Total number of citations = 11,466

Tipnis, S.R., Hooper, N.M., Hyde, R., Karran, E.H., Christie, G. & Turner, A.J. (2000) J. Biol. Chem. 275, 33238-33243. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. (721 citations).

Perera, W.S.S. & Hooper, N.M. (2001) Current Biology 11, 519-523. Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region. (183 citations)

Cordy, J.M., Hussain, I., Dingwall, C., Hooper, N.M. & Turner, A.J. (2003) Proc. Natl. Acad. Sci. USA 100, 11735-11740. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. (258 citations)

Parkin, E.T., Watt, N.T., Hussain, I., Eckman, E.A., Eckman, C.B., Manson, J.C., Baybutt, H.N., Turner, A.J. & Hooper, N.M. (2007) Proc. Natl. Acad. Sci. USA 104, 11062-11067. Cellular prion protein regulates beta-secretase cleavage of the Alzheimer’s amyloid precursor protein. (154 citations)

Taylor, D.R., Parkin, E.T., Cocklin, S.L., Ault, J.R., Ashcroft, A.E., Turner, A.J. & Hooper, N.M. (2009) J. Biol. Chem. 284, 22590-22600. Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. (65 citations)

Belyaev, N.D., Kellett, K.A.B., Beckett, C., Makova, N.Z., Revett, T.J., Nalivaeva, N.N., Hooper, N.M. & Turner, A.J. (2010) J. Biol. Chem. 285, 41443-41454. The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a beta-secretase dependent pathway. (JBC Paper of the week) (78 citations)

Griffiths, H.H., Whitehouse, I.J., Baybutt, H., Brown, D., Kellett, K.A.B., Jackson, C.D., Turner, A.J., Piccardo, P., Manson, J.C. & Hooper, N.M. (2011) J. Biol. Chem. 286, 33489-33500. Prion protein interacts with BACE1 protein and differentially regulates its activity towards wild type and Swedish mutant amyloid precursor protein. (35 citations)

Watt, N.T., Taylor, D.R., Kerrigan, T.L., Griffiths, H.H., Rushworth, J.V., Whitehouse, I.J. & Hooper, N.M. (2012) Nature Communications, 3, doi:10.1038/ncomms2135. Prion protein facilitates uptake of zinc into neuronal cells. (39 citations)

Rushworth, J.V., Griffiths, H.H., Watt, N.T. & Hooper, N.M. (2013) J. Biol. Chem. 288, 8935-8951. Prion protein-mediated neurotoxicity of amyloid-beta oligomers requires lipid rafts and the transmembrane LRP1. (51 citations) (JBC’s best Neurobiology article of 2013).

Xu, J., Begley, P., Church, S.J., McHarg, S., Kureishy, N., Hollywood, K.A., Patassini, S., Waldvogel, H.J., Liu, H., Zhang, S., Lin, W., Herholz, K., Turner, C., Synek, B.J., Curtis, M.A., Rivers-Auty, J., Lawrence, C.B., Kellett, K.A.B., Hooper, N.M., Vardy, E.L.R.C., Wu, D., Unwin, R.D., Faull, R.L.M., Dowsey, A.W. & Cooper, G.J.S. (2016) Sci. Rep. 6, 27524; doi: 10.1038/srep27524. Elevation of brain glucose and polyol-pathway intermediates with accompanying brain- copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia. (3 citations).