!!Nigel Hooper - Selected Publications
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Total number of publications = 243\\
H-index = 55\\
Total number of citations = 11,466\\
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Tipnis, S.R., Hooper, N.M., Hyde, R., Karran, E.H., Christie, G. & Turner, A.J. (2000) J. Biol. Chem. 275, 33238-33243. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. (721 citations).\\
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Perera, W.S.S. & Hooper, N.M. (2001) Current Biology 11, 519-523. Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region. (183 citations)\\
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Cordy, J.M., Hussain, I., Dingwall, C., Hooper, N.M. & Turner, A.J. (2003) Proc. Natl. Acad. Sci. USA 100, 11735-11740. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. (258 citations)\\
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Parkin, E.T., Watt, N.T., Hussain, I., Eckman, E.A., Eckman, C.B., Manson, J.C., Baybutt, H.N., Turner, A.J. & Hooper, N.M. (2007) Proc. Natl. Acad. Sci. USA 104, 11062-11067. Cellular prion protein regulates beta-secretase cleavage of the Alzheimer’s amyloid precursor protein. (154 citations)\\
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Taylor, D.R., Parkin, E.T., Cocklin, S.L., Ault, J.R., Ashcroft, A.E., Turner, A.J. & Hooper, N.M. (2009) J. Biol. Chem. 284, 22590-22600. Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. (65 citations)\\
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Belyaev, N.D., Kellett, K.A.B., Beckett, C., Makova, N.Z., Revett, T.J., Nalivaeva, N.N., Hooper, N.M. & Turner, A.J. (2010) J. Biol. Chem. 285, 41443-41454. The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a beta-secretase dependent pathway. (JBC Paper of the week) (78 citations)\\
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Griffiths, H.H., Whitehouse, I.J., Baybutt, H., Brown, D., Kellett, K.A.B., Jackson, C.D., Turner, A.J., Piccardo, P., Manson, J.C. & Hooper, N.M. (2011) J. Biol. Chem. 286, 33489-33500. Prion protein interacts with BACE1 protein and differentially regulates its activity towards wild type and Swedish mutant amyloid precursor protein. (35 citations)\\
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Watt, N.T., Taylor, D.R., Kerrigan, T.L., Griffiths, H.H., Rushworth, J.V., Whitehouse, I.J. & Hooper, N.M. (2012) Nature Communications, 3, doi:10.1038/ncomms2135. Prion protein facilitates uptake of zinc into neuronal cells. (39 citations)\\
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Rushworth, J.V., Griffiths, H.H., Watt, N.T. & Hooper, N.M. (2013) J. Biol. Chem. 288, 8935-8951. Prion protein-mediated neurotoxicity of amyloid-beta oligomers requires lipid rafts and the transmembrane LRP1. (51 citations) (JBC’s best Neurobiology article of 2013).\\
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Xu, J., Begley, P., Church, S.J., McHarg, S., Kureishy, N., Hollywood, K.A., Patassini, S., Waldvogel, H.J., Liu, H., Zhang, S., Lin, W., Herholz, K., Turner, C., Synek, B.J., Curtis, M.A., Rivers-Auty, J., Lawrence, C.B., Kellett, K.A.B., Hooper, N.M., Vardy, E.L.R.C., Wu, D., Unwin, R.D., Faull, R.L.M., Dowsey, A.W. & Cooper, G.J.S. (2016) Sci. Rep. 6, 27524; doi: 10.1038/srep27524. Elevation of brain glucose and polyol-pathway intermediates with accompanying brain- copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia. (3 citations).