Anne Houdusse - Curriculum Vitae#


Research Director 1st class CNRS since 2009

Cursus
  • 1992-1998 Post-doc in Carolyn COHEN’s laboratory, Brandeis University – MA, USA.
  • 1990-1992 PhD in crystallography in Roberto POLJAK’s laboratory, Pasteur Institute – Paris XII
  • 1986-1990 Chemistry studies at Ecole Normale Supérieure - Paris

Professional Experience
  • Oct 06-present member of the Programme Committee for Life Sciences at synchrotron SOLEIL
  • Jul 08-Jun 14 member of the editorial board of the Biophysical Journal
  • Aug 06-Jul 10 member of the CNRS scientific advisory committee for life sciences

  • Octobre, 2009 Directrice de Recherche 1ère Classe – C.N.R.S. France.
  • Octobre, 2004 Directrice de Recherche 2ème Classe – C.N.R.S. France.
  • Oct1999-present Group leader for the Structural Motility team UMR 144 – Institut Curie/CNRS.
  • January, 1999 Chargé de Recherche Première classe - C.N.R.S. France.

Anne Houdusse is an author in 54 publications and has been invited in 53 international conferences.

Major Scientific Contributions

1)-(Cell 1999 - PNAS 2000) Description of three structural states of the conventional myosin head.
2)-(Nature 2003 - EMBO J 2004) Description of the strong affinity state of myosin for actin
3)-(Nature 2005) Structure of the reverse motor Myo6 at the end of the powerstroke –
4)-(Nat Struct Biol 2003 - Mol. Cell 2004 – EMBO J 2006) Caracterisation of the atypical MT binding site of doublecortin at the junction between protofilaments.
5)-(PNAS 2006) Description of the lever arm of an unconventional myosin. First structure of a calmodulin bound to a target in the absence of Ca2+.
6)-(Cell 2007) The structure of Myo6 prior to force generation reveals the cryptic origin of the large amplitude of the powerstroke.
7)-(Mol Cell 2009) Structure of the atypical lever arm of Myo6. Demonstration of the unfolding of a triple helix bundle upon dimerization of the motor to generate a long lever arm.
8)-(Mol Cell 2012) Myo6 uses a kinesin-like mechanism to step, and not a simple swinging lever arm mechanism like Myo5.

Honors
  • 2013 CNRS Silver medal winner
  • 2010 Award winner for one of the three subventions of the Simone and Cino del Duca Foundation
  • 2009 EMBO/FEBS Women in science Award
  • 2005 FEBS Award: FEBS Anniversary Prize for outstanding achievement in the field of Structural Biology.
  • 2004 CNRS Bronze medal winner
  • 1986 Admission to Ecole Normale Supérieure ULM, Paris
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