Hendrik Coenraad Hemker - Curriculum vitae#


Born on July 21, 1934 in Amsterdam, the Netherlands

Main present positions
  • Professor and Senior Councillor Cardiovascular Research Institute Maastricht (CARIM)
  • General director of “Synapse BV, Research, Development and Consultation in Haemostasis and Thrombosis”, a research company.

Career
  • MD University of Amsterdam 1959
  • Ph. D in Biochemistry, Univ. of Amsterdam 1962 (Prof. Dr. E.C. Slater)
  • Head of the research laboratory of the Division of Haemostasis and Thrombosis, Department of Internal Medicine, University of Leyden, 1962-1968.
  • Professor of Internal Medicine, for the biochemistry of heart- and vessel diseases, University of Leyden, 1968-1975 continued on a part time basis until 1996.
  • Professor of Biochemistry, Chairman of the Department, University of Maastricht 1975-1999.
  • Rector Magnificus (Vice Chancellor) University of Maastricht 1982-1985.
  • Professeur Étranger Université René Descartes (Paris V) Hôpital Necker -Enfants Malades and Université. Pierre et Marie Curie (Paris VI), Hôpital Lariboisière 1984-1987.
  • Professeur Étranger Collège de France 1988
  • Affiliate professor of Internal Medicine, Mount Sinai Medical School, New York.1995-2005

Main Distinctions and Awards:
  • Prix Européen Ganassini (Milano) 1967
  • Boerhaave Medal (Leyden) 1974
  • Ernst Jung Price (Hamburg) 1985
  • Commandeur de l'Ordre des Palmes Académiques (France) 1987
  • Member of the Royal Dutch Academy of Arts and Sciences 1987
  • Career Award for contributions to Haemostasis and Thrombosis (ISTH) 1987
  • Medal of Honor Dutch Federation of Thrombosis Services 1989
  • Member of the Academia Europaea 1990
  • Chevalier de la Légion d'Honneur (France) 1990
  • Honorary member of the Royal Flemisch Academy 1991
  • Christiaan Huygens Lecture, Académie des Sciences, Paris 1992
  • Dutch Science Foundation, 8 year program grant 1993
  • Honorary Doctorate Xi’An Medical Faculty 1996
  • Honorary member of the Dutch Society of Thrombosis and Haemostasis 1997
  • Medal of the Medical Faculty Maastricht 1999
  • Knight of the order of "Nederlandse Leeuw" (Royal distinction, The Netherlands) 2000
  • Foreign member of the “Académie Nationale de Médecine” (France) 2001

General:
  • Author of over 400 scientific articles and several books.
  • Supervisor of over 60 Ph.D. theses.
  • Numerous editorial boards; among others1980–2002 Haemostasis (Editor in Chief)

Main Scientific Achievements before 2000
  • Discovery of uncarboxylated clotting factors (PIVKAs) in vitamin K deficiency (Nature, 1963)
  • Discovery of the prothrombin converting enzyme as a complex of factors Xa,Va and phospholipid (Nature 1968)
  • Discovery of the role of the antihaemophilic factors A and B as constituents of the factor X activating enzyme complex (Nature 1968)
  • With J.Rosing: Discovery of the enzyme mechanistic role of factor Va and phospholipid in prothrombinase (JBC 1980)
  • With Chr.Reutelingsberger: Discovery of Annexin V (Vascular AntiCoagulant, Eur J Biochem.1985 )
  • With W.Hermens: Development of ellipsometry as a tool in biochemistry of surface-bound reactions.(JBC, 1992-1999)
  • With S.Béguin: Clarification of the mode of action of heparins in plasma, rationalisation of heparin determinations, development of standard-independent units for heparin activity. (Thrombosis and Haemostasis, 1987 - ongoing).
  • With T.Lindhout and W.Hermens: Thrombin formation at macroscopic surfaces (JBC, 1992-1999)
  • With S.Béguin: Discovery and development of the Endogenous Thrombin Potential (ETP) as a universal laboratory probe for hypercoagulability and the effect of anticoagulant drugs (European and USA Patents. Thrombosis and Haemostasis, 1987 - 1993).
  • With S.Béguin: Development of methods to determine the Thrombin Generation Curve in defibrinated platelet poor plasma automatically by conversion of special chromogenic substrates. (Thrombosis and Haemostasis1993-1998)
  • With S.Béguin: Discovery that fibrin can activate and provokes procoagulant activity in platelets (Thrombosis and Haemostasis1995-ongoing)
  • With S.Béguin: Discovery that von Willebrand factor plays a compulsory role in thrombin generation in platelet rich plasma, together with the receptors GPIIb/IIIa and GPIb (Thrombosis and Haemostasis1997-1999)
  • With J.Rosing: Discovery the biological variable in the clotting system that correlates with pill thrombosis (British Journal of Haematology, 1997-ongoing).
  • With S.Béguin and P.Giesen: Development of Calibrated Automated Thrombinography (CAT) a method to measure thrombin generation in real time in platelet poor or platelet rich plasma. (Thrombosis and Haemostasis 2000-ongoing) ( patents)
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