Marc Delarue - Curriculum Vitae#

  • Habilitation in Biological Sciences, University Louis Pasteur in Strasbourg (1993)
  • Crystallography of Biological Macromolecules (advisor D. Moras), IBMC du CNRS, Univ. L.ouis Pasteur, Strasbourg (1989)
  • These de 3eme cycle in Molecular Biophysics (advisor Cl. Hélène), University of Paris VI (1984)
  • Masters in Physics (Maîtrise) and Chemistry (DEA) University of Paris VI (1981 - 1982)
  • Ecole Normale Supérieure, Physics and Chemistry, Paris (1980-84)

Current Position
  • 2012 - now Head of UMR 3528 du CNRS (Institut Pasteur, Paris), DR1 CNRS
  • 2006 - now Head of Unit (PI) "Dynamique Structurale des Macromolecules", Institut Pasteur, Paris

Scientific activities
  • Articles in peer-reviewed international Journals: 120
  • Cumulative number of citations > 12000 (Google Scholar)
  • 10 Recommended papers by F1000 in the past 10 years
  • International Patents: 3
  • Hirsch h-index: 48 ; i10-index: 94 (Google Scholar)
  • Book chapters: 4 Articles without reviewing: 2
  • Invited Lectures: 45; Published Abstracts from Posters and Talks: 22
  • Organization of Meetings or Workshops: 3
    • France-Stanford Meeting (I.P., Paris, 2010),
    • Normal Modes for Biological Macromolecules (IP, Paris, 2017)
    • CECAM Meeting on Normal Modes with Y.H. Sanejouand and K. Hinsen (IHP, Paris, 2018)

Teaching activities
  • Supervision of 7 PhD students, 10 Masters students, 15 post-doctoral fellows
  • Regular teaching in EMBO workshop courses (Gif/Yvette, then I. Pasteur)
  • Member of PhD defense committees (10). Tutor of external students (7)

Administrative responsibilities and Expertise
  • Expert for the Marie Curie EC international exchange program (2005-2015),
  • Expert for the evaluation of ERC Grants (2017-18)
  • Expert for international grants: Welcome Trust (UK), NWO (NL), FWO (Belgium), AEI (Spain), NSC (Poland), NSF and NIH (USA)
  • International evaluation of Institutes (Severo Ochoa Excellence Program, Spain)
  • Reviewer for scientific journals (≈10 per year): Science, PNAS, Nat. Commun., EMBO Rep., eLife, NAR, Proteins, Bioinformatics
  • Review Editor for Frontiers in Biological Sciences, section Biological Modeling and Simulations
  • DB structures: 171 X-ray structures deposited in the PDB (+5 pending)
  • Reviewer for Beam allocation in LCLS, SLAC, Stanford

Fields of Scholarship
  • Experimental structural biology: crystallography of biological macromolecules; cryo-electron microscopy of large complexes
  • Applied structural biology: structure-inspired drug design, homology modeling, prediction of side-chain conformations
  • Structural bioinformatics: extracting structural and functional information from sequence databases
  • Computational biology: normal mode analysis and exploration of transition paths
  • Synthetic biology: incorporation of non-canonical nucleotides in DNA, both in vitro and in vivo
  • Systems biology: reverse genetics of modified bases incorporation pathway in some phages
  • Statistical physics: application to the study of electrostatic properties of macromolecules
  • DNA polymerases: functional studies and engineering for biotechnological applications
  • Ligand-gated ion channels: structural basis for gating and allosteric control

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