Moira Whyte - Selected Publications#
1. McGrath EE, Lawrie A, Marriott HM, Mercer PF, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH, Whyte MKB. 2012. TNF-related apoptosis-inducing ligand (TRAIL) exacerbates lung injury and fibrosis. Thorax 67:796-803
2. Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MKB, Sabroe I. 2012. Pellino-1 selectively regulates epithelial cell responses to rhinovirus. Journal of Virology 86:6595-6604
3. Daigneault M, de Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB, Dockrell DH. 2012. Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathogens 8:e1002814
4. Marriott HM, Daigneault M, Thompson AAR, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MKB, Dockrell DH. 2012. A Decoy Receptor 3 analogue reduces localized defects in phagocyte function in pneumococcal pneumonia. Thorax 67:985-992
5. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffery BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly V, Clish C, Auron PE, Xavier RJ, O’Neill LAJ. 2013. Succinate is a danger signal that induces IL-1β via HIF-1α. Nature 496:238-242
6. Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Simon MC, Johnson RS, Renshaw SA, Whyte MKB and Walmsley SR (Joint senior authors). 2013. Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice and zebrafish. Blood 123:366-376 (with accompanying editorial).
7. Burgon J, Robertson AL, Sadiku P, Wang X, Hooper-Greenhill E, Prince LR, Walker P, Hoggett EE, Ward JR, Farrow SN, Zuercher WJ, Jeffrey P, Savage CO, Ingham PW, Hurlstone AF, Whyte MKB, Renshaw SA. 2014. Serum and Glucocorticoid Regulated Kinase 1 (SGK1) regulates neutrophil clearance during inflammation resolution. Journal of Immunology 192:1796-1805.
8. Walmsley SR and Whyte MKB. 2014. Neutrophil energetics and oxygen sensing (commentary). Blood 123:2753-4.
9. Thompson AA, Walmsley SR, Whyte MK. 2014. A local circadian clock calls time on lung inflammation. Nature Medicine 20:809-11
10. Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger E, Kadirkamanathan V, Whyte MKB, Renshaw SA. 2014. Modulation of reverse migration as an anti-inflammatory mechanism identified by an in vivo zebrafish inflammation screen. Science Translational Medicine 6:225ra29 (with accompanying editorial).
11. Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S, Whyte MKB. 2014. Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease. PLoS One 9(8):e103059
12. Jones R, McDonald KE, Willson JA, Ghesquière B, Sammut D, Daniel E, Harris AJ, Lewis A, Thompson AA, Dickinson RS, Plant T, Murphy F, Sadiku P, Keevil BG, Carmeliet P, Whyte MKB, Newell-Price J, Walmsley SR. 2016. Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression. Blood 127:2641-4 PMID: 27006389
13. Robertson AL, Ogryzko NV, Henry KM, Loynes CA, Foulkes MJ, Meloni MM, Wang X, Ford C, Jackson M, Ingham PW, Wilson HL, Farrow SN, Solari R, Flower RJ, Jones S, Whyte MKB, Renshaw SA. 2016. Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. Disease Models and Mechanisms pii: dmm.024935. PMID: 27079522
14. Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP. 2016. Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD. PLoS One 11:e0163139. PMID 27680884.
15. Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MKB, Walmsley SR. 2017. Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism. Science Immunology 2:pii: eaal2861. PMID 28386604.
16. Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH. 2017. Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages. American Journal of Respiratory and Critical Care Medicine. May 30 PMID: 28557543
17. Prince LR, Dannewitz Prosseda S, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P, Renshaw SA, Whyte MKB and Sabroe I (joint senior authors). 2017. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood. Jun 21. PMID: 28637666
