Rene E. M. Toes - Selected Publications#

Peer reviewed publications (without conference abstracts): 416; 1st author: 18; senior author: 112.
H-factor: 84;
Total number of citations: 29.750; 76 papers cited >100 times; most cited article: 1850 citations (all citations from Web of Science, June 2021).

1. Toes, R. and Raza. K. (2021). The autoimmune response as potential target for tolerance induction before the development of rheumatoid arthritis. Lancet Rheumatol.

2. Kristyanto H, Blomberg NJ, Slot LM, van der Voort EIH, Kerkman PF, Bakker A, Burgers LE, Ten Brinck RM, van der Helm-van Mil AHM, Spits H, Baeten DL, Huizinga TWJ, Toes REM, Scherer HU (2020). Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis. Sci Transl Med. 2020 Nov 18;12(570):eaaz5327.

3. Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC, Kampstra A, Levarht E, Drijfhout JW, Bang H, Bonger KM, Janssen G, van Veelen PA, Huizinga T, Scherer HU, Reth M, Toes R (2020). Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications. K Ann Rheum Dis. 2020 Apr;79(4):472-480. doi: 10.1136/annrheumdis-2019-216499.

4. Toes, R. and D. S. Pisetsky (2019). "Pathogenic effector functions of ACPA: Where do we stand?" Ann Rheum Dis 78(6): 716-721. doi: 10.1136/annrheumdis-2019-215337.

5. Kampstra, A. S. B., J. S. Dekkers, M. Volkov, A. L. Dorjee, L. Hafkenscheid, A. C. Kempers, M. van Delft, T. Kissel, S. Reijm, G. M. C. Janssen, P. A. van Veelen, H. Bang, T. W. J. Huizinga, L. A. Trouw, D. van der Woude and R. E. M. Toes (2019). "Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification." Ann Rheum
Dis 78(7): 908-916. doi: 10.1136/annrheumdis-2018-214950.

6. Scherer, H. U., T. W. Huizinga, G. Kronke, G. Schett and R. E. Toes. (2018). "The B-cell response to citrullinated antigens in the development of rheumatoid arthritis. Nature Rev. Rheumatol. 14(3):157-169. doi: 10.1038/nrrheum.2018.10.

7. Vergroesen, R. D., L. M. Slot, L. Hafkenscheid, M. T. Koning, E. I. H. van der Voort, C. A. Grooff, G. Zervakis, H. Veelken, T. W. J. Huizinga, T. Rispens, H. U. Scherer and R. E. Toes (2018). "B-cell receptor sequencing of ACPA IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation." Ann Rheum Dis 77(6): 956-958.
doi: 10.1136/annrheumdis-2017-212052.

8. Dekkers, J., M. Verheul, J. Stoop, B. Liu, A. Ioan-Facsinay, P. van Veelen, A. de Ru, G. Janssen, M. Hegen, S. Rapecki, T. Huizinga, L. Trouw and R. E. Toes (2017). "Breach of autoreactive B cell tolerance by post-translationally modified proteins." Ann Rheum Dis 76(8): 1449-1457. doi: 10.1136/annrheumdis-2016-210772.

9. Rombouts Y, Willemze A, van Beers J, Shi J, Kerkman P, van Toorn L, Janssen G, Zaldumbide A, Hoeben R, Pruijn G, Deelder A, Wolbink G, Rispens T, van Veelen P, Huizinga T, Wuhrer M, Trouw L, Scherer H, Toes RE (2016). Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis. Ann Rheum Dis. 2016 Mar;75(3):578-85. doi:
10.1136/annrheumdis-2014-206598.

10. van Heemst, J., T. Jansen, S. Polydorides, A. Moustakas, M. Bax, A. Feitsma, D. Bontrop-Elferink, M. Baarse, D. van der Woude, G. Wolbink, T. Rispens, F. Koning, R. de Vries, G. Papadopoulos, G. Archontis, T. Huizinga and R. E. Toes (2015). "Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis." Nat Commun 6: 6681. doi: 10.1038/ncomms7681.