Fu-Dong Shi - Selected Publications#

1. Li Z, Zhang C, Chang T, Zhang X, Yang H, Gao F, Feng J, Liu H, Chen S, Wang L, Yang C, Li H, Pan Y, Palace J, Shi FD*. A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study. Lancet Regional Heath. 2023, 38:1-9. This study described the creation of a new diagnostic technology and generated the level I evidence for recommending diagnostic methodology for autoimmune diseases though conducting a large-scale clinical trial.

2. Shi K, Li H, Chang T, He W, Kong Y, Qi C, Li R, Huang H, Zhu Z, Zheng P, Ruan Z, Zhou J, Shi FD, Liu Q*. Bone marrow hematopoiesis drives multiple sclerosis progression. Cell. 2022;185: 1-14. This study demonstrated how bone marrow pronounced myelopoiesis drives the progression of multiple sclerosis and opened a new therapeutic avenue for multiple sclerosis.

3. Li Z, Li Y, Han J, Zhu Z, Li M, Liu Q, Wang Y, Shi FD*. Formyl peptide receptor 1 signaling potentiates inflammatory brain injury. Science Translational Medicine. 2021;13(605):eabe9890. This work revealed the mechanism governing brain inflammation following acute stroke and created a small molecule to antagonize formyl peptide receptor 1 for the treatment of acute brain injury caused by stroke.

4. Zhang C, Zhang M, Qiu W, Zhang X, Ma H, Zhu Z, Yang CS, Jia D, Zhang TX, Yuan M, Feng Y, Yang L, Lu W, Yu C, Bennett J, Shi FD*. Tocilizumab versus azathioprine in neuromyelitis optica spectrum disorder (TANGO). Lancet Neurology. 2020;19: 391-401. This clinical trial demonstrated the efficacy of an antibody against an IL-6 receptor in patients with neuromyelitis optica and thus established a new therapy for this disease.

5. Liu Q, Jin WN, Liu Y, Shi K, Sun H, Zhang F, Zhang C, Gonzales R, Sheth KN, La Cava A, Shi FD*. Brain ischemia suppresses immunity in the periphery and brain via different neurogenic innervations. Immunity. 2017;46:474-487. This study revealed the two distinct pathways through which brain controls immune reactions in the periphery as well as within the brain during ischemic stroke.

6. Fu Y, Liu Q, Anrather J, Shi FD*. Immune interventions in stroke. Nature Review Neurology. 2015;11:524-35. This review thoroughly analyzed current understanding of immune mechanisms during stroke and provides perspectives to harness this knowledge in developing immune therapies for stroke patients.

7. Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD*. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nature Neuroscience. 2016; 19:243-52. This work demonstrated intrinsic defects of neural repair during multiple sclerosis which is instrumental in understanding the outcome of many neurological disorders.

8. Gan Y, Liu Q, Wu W, Yin J, Tang Z, Turner G, Chen J, Wang Y, Lanrent J, Yokayama W, Shi FD*. Ischemic neurons recruit NK cells that accelerate brain infarction. Proc Natl Acad Sci USA. 2014;111:2704-

9. This study revealed fundamental immune mechanisms of ischemic stroke. 9. Shi FD*, Ljunggren HG, La Cava A, Van Kaer, L. Organ-specific features of NK cells. Nature Review Immunology. 2011;11;658-671. This review contrasted the cellular and molecular features of immune cells in different organs of autoimmune diseases, analyzed the corresponding mechanisms, and proposed therapeutic implications.

10. Shi FD, Wang H, Li H, Hong S, Tanihuchi M, Link H, Van Kaer L, Ljunggren HG. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nature Immunology. 2000;1:245-251. This study identified an intrinsic link between innate and adaptive immunity during the development of autoimmune diseases.

Total publications: >250 (can be viewed at: https://pubmed.ncbi.nlm.nih.gov/?term=shi+fd). Corresponding authorship is indicated by “*”. Total Citations: 15561; H-index: 71 (Google Scholar)