David William Ray - Selected Publications#

H Factor 47, citations 6764

1. Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R. (2017) Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 2017 Feb;49(2):274-281. doi: 10.1038/ng.3749
The first paper to find genetic loci associated with sleep, and to further identify links to neuropsychiatric and metabolic traits.

2. Morgan DJ, Poolman TM, Williamson AJ, Wang Z, Clark NR, Ma'ayan A, Whetton AD, Brass A, Matthews LC, Ray DW (2016) Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production. Sci Rep. 2016 May 26;6:26419. doi: 10.1038/srep26419.
The first example of a unique function for the highly conserved gamma isoform of the glucocorticoid receptor.

3. Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R. (2016) Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun 7:10889. doi: 10.1038/ncomms10889.
The first identified genetic loci associated with chrontype, providing evidence for hard-wiring of this important human behavioural trait.

4. Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW. (2015) Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.Proc Natl Acad Sci U S A
112(17):5479-84. doi: 10.1073/pnas.1411356112. Epub 2015 Apr 6.
The first non-genomic action of the glucocorticoid receptor, and also finding evidence that the glucocorticoid receptor is a bone fide tumor suppressor gene.

5.Hand LE, Usan P, Cooper GJ, Xu LY, Ammori B, Cunningham PS, Aghamohammadzadeh R, Soran H, Greenstein A, Loudon AS, Bechtold DA, Ray DW. (2015) Adiponectin Induces A20 Expression in Adipose Tissue To Confer Metabolic Benefit. Diabetes 64(1):128-36.
Identification of a pathway linking adiponectin expression in adipose tissue beds to cause macrophage inflammatory quiesence.

6.Jangani M, Poolman TM, Matthews L, Yang N, Farrow SN, Berry A, Hanley N, Williamson AJ, Whetton AD, Donn R, Ray DW. (2014) The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer. J Biol Chem 289:8931-46. Epub 2014 Jan 31.
Identification of a novel enzyme regulating glucocorticoid receptor function by regulating methylation status in cells.

7. Gibbs J, Ince L, Matthews L, Mei J, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud M, Farrow S, DeMayo F, Hussell T, Worthen GS, Ray DW, Loudon A. (2014) An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action. Nat Med 20:919-26. Epub 2014 Jul 27. Joint corresponding author
Identification of a pathway linking pulmonary epithelial circadian circuits to lung inflammatory response, and anti-microbial defence.

8. Trebble PJ, Woolven JM, Saunders KA, Simpson KD, Farrow SN, Matthews LC, Ray DW. (2013) A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function. J Cell Sci 126:3159-69. Epub 2013 May 17.
Identification of a ligand-receptor interaction that regulates kinetics of glucocorticoid receptor response.

9. Poolman TM, Farrow S, Matthews L, Loudon AS, Ray DW. (2013) Pin1 promotes GR transactivation by enhancing recruitment to target genes. Nucleic Acids Res 41:8515-25. Epub 2013 Jul 25.
The first description of Pin1, an isomerase enzyme, as critical for glucocorticoid receptor transactivation function.

10. Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS. (2012) The nuclear receptor REV-ERB mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A 109:582-7. Joint corresponding author
Discovery of a functional circadian clock in macrophages, and the consequence for immunity.