Antonius J. Rabelink - Selected Publications#

https://publons.com/researcher/2894488/ton-j-rabelink

Web of Science derived scientific metrics

Publications: >700
Total times cited: >22,000
H-index: 73
I-100: 50 publications
Book chapters: 26

1) Tiemeier GL, Wang G, Dumas SJ, Sol WMPJ, Avramut MC, Karakach T, Orlova VV, van den Berg CW, Mummery CL, Carmeliet P, van den Berg BM, Rabelink TJ. Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation.
Stem Cell Reports. 2019 Nov 12;13(5):803-816. doi: 10.1016/j.stemcr.2019.10.005

Human induced pluripotent stem cell-derived endothelial cells lack functional glycocalyx, fail to align with fluid flow, have reduced mitochondrial function and increased leakage of ROS, which can be improved by inducing maturation with cyclosporin A.

2) van den Berg BM, Wang G, Boels MGS, Avramut MC, Jansen E, Sol WMPJ, Lebrin F, van Zonneveld AJ, de Koning EJP, Vink H, Gröne HJ, Carmeliet P, van der Vlag J, Rabelink TJ. Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium.
J Am Soc Nephrol. 2019 Oct;30(10):1886-1897. doi: 10.1681/ASN.2019020192

Glomerular endothelial hyaluronan was a previously unrecognized extracellular matrix component key to glomerular structure and function, which is lost in diabetic nephropathy.

3) Leuning, DG.; Witjas, FMR.; Maanaoui, M; de Graaf, AMA.; Lievers, E; Geuens, T; Avramut, CM; Wiersma, LE; van den Berg, CW; Sol, WMPJ; de Boer, H; Wang, G; LaPointe, VLS; van der Vlag, J; van Kooten, C; van den Berg, BM; Little, MH; Engelse, MA; Rabelink, TJ. Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium.
Am J Transplant. 2019 May;19(5):1328-1343. doi: 10.1111/ajt.15200.

First steps towards a human bioengineered kidney, by functionally re-endothelializing human decellularized kidney scaffolds using human pluripotent stem cell–derived endothelial cells.

4) van den Berg CW, Ritsma L, Avramut MC, Wiersma LE, van den Berg BM, Leuning DG, Lievers E, Koning M, Vanslambrouck JM, Koster AJ, Howden SE, Takasato M, Little MH, Rabelink TJ. Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo. Stem Cell Reports. 2018 Mar 13;10(3):751-765. doi: 10.1016/j.stemcr.2018.01.041.

First study to show functional human induced pluripotent stem cell-derived vascularisation of complete nephron (functional kidney subunit including tubules and glomerulus), in a mouse transplant model.

5) Rabelink TJ, van den Berg BM, Garsen M, Wang G, Elkin M, van der Vlag J. Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.
Nat Rev Nephrol. 2017 Apr;13(4):201-212. doi: 10.1038/nrneph.2017.6.

Review of the role of heparanase in the development of kidney disease and its potential as a therapeutic target.

6) Leuning DG, Reinders ME, Li J, Peired AJ, Lievers E, de Boer HC, Fibbe WE, Romagnani P, van Kooten C, Little, MH, Engelse MA, Rabelink TJ. Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine.
Stem Cells Transl Med. 2017 Feb;6(2):405-418. doi: 10.5966/sctm.2016-0053

Result of the EU STELLAR consortium, coordinated by nominee, indicating superior therapeutic potential of human kidney‐derived perivascular stromal cells and their secretome in the treatment of kidney diseases.

7) Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, Chaturvedi P, Hol J, Thienpont B, Teuwen LA, Schoors S, Boeckx B, Vriens J, Kuchnio A, Veys K, Cruys B, Finotto L, Treps L, Stav-Noraas TE, Bifari F, Stapor P, Decimo I, Kampen K, De Bock K, Haraldsen G, Schoonjans L, Rabelink T, Eelen G, Ghesquière B, Rehman J, Lambrechts D, Malik AB, Dewerchin M, Carmeliet P. Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.
Cancer Cell. 2016 Dec 12;30(6):968-985. doi: 10.1016/j.ccell.2016.10.006

Showing that stabilisation of tumor vessels as part of anti-cancer treatment can be established by blocking tumor endothelial cell glycolysis and indicating further study as anti-cancer therapy warranted.

8) Boels MG, Avramut MC, Koudijs A, Dane MJ, Lee DH, van der Vlag J, Koster AJ, van Zonneveld AJ, van Faassen E, Gröne HJ, van den Berg BM, Rabelink TJ. Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy.
Diabetes. 2016 Aug;65(8):2429-39. doi:10.2337/db15-1413

First mechanistic explanation of the clinical observation that there is reduced albuminuria after atrasentan in diabetic nephropathy, studied in diabetic apolipoprotein E (apoE)-deficient mice.

9) de Bruin RG, Shiue L, Prins J, de Boer HC, Singh A, Fagg WS, van Gils JM, Duijs JM, Katzman S, Kraaijeveld AO, Böhringer S, Leung WY, Kielbasa SM, Donahue JP, van der Zande PH, Sijbom R, van Alem CM, Bot I, van Kooten C, Jukema JW, Van Esch H, Rabelink TJ, Kazan H, Biessen EA, Ares M Jr, van Zonneveld AJ, van der Veer EP. Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.
Nature Commun. 2016 Mar 31;7:10846. doi: 10.1038/ncomms10846.

Expression levels of the RNA-binding protein Quaking during differentiation shows it plays a central role in posttransciptionally guiding macrophage identity and function.

10) Reinders ME, Dreyer GJ, Bank JR, Roelofs H, Heidt S, Roelen DL, Zandvliet ML, Huurman VA, Fibbe WE, van Kooten C, Claas FH, Rabelink TJ, de Fijter JW. Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study.
J Transl Med. 2015 Nov 4;13:344. doi: 10.1186/s12967-015-0700-0.

Clinical phase Ib, open label, single center study to assess safety of allogeneic bone-marrow derived mesenchymal stromal cell therapy in solid organ transplantation and its effect on biopsy-proven acute rejection and graft loss. Follow-up study on autologous bone-marrow derived mesenchymal stromal cells in allograft rejection after renal transplantation.