Dino Moras - Selected Publications#

Reference Papers

ROSSMANN, M. G., MORAS, D. and OLSEN, K.W. (1974) Chemical and Biological evolution of a nucleotide binding protein. Nature, 250, 194-199.

ERIANI , G., DELARUE, M., POCH, O., GANGLOFF, J. and MORAS, D. (1990) Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature, 347, 203-206.

RUFF, M. KRISHNASWAMY, S., BOEGLIN, M., POTERSZMAN, A., MITSCHLER, A., PODJARNY, A., REES, B., THIERRY, J.C., MORAS, D. (1991) Class II aminoacyl tRNA synthetases : crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNAAsp. Science, 252, 1682 - 1689.

BOURGUET, W., RUFF, M., CHAMBON, P., GRONEMEYER, H. and MORAS, D. (1995) Crystal structure of the Ligand Binding Domain of the Human Nuclear Receptor RXRα. Nature, 375,377-382.

RENAUD, J.-P., ROCHEL, N., RUFF, M., VIVAT, V., CHAMBON, P., GRONEMEYER, H. and MORAS, D. (1995) Crystal Structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature 378, 681-689.

Bibliography (Selected Since 2000)

BOURGUET, W., VIVAT, V., WURTZ, J. M., CHAMBON, P., GRONEMEYER, H., and MORAS, D. (2000). Crystal structure of a heterodimeric complex of RAR and RXR ligand- binding domains, Mol Cell 5, 289-98.

EGEA, P. F., MITSCHLER, A., ROCHEL, N., RUFF, M., CHAMBON, P., and MORAS, D. (2000). Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid, EMBO J 19, 2592-601.

ROCHEL, N., WURTZ, J. M., MITSCHLER, A., KLAHOLZ, B., and MORAS, D. (2000). The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand, Mol Cell 5, 173-9.

DOCK-BREGEON, A-C., SANKARANARAYANAN, R., ROMBY, P., CAILLET, J., SPRINGER, M., REES, B., FRANCKLYN, C.S., EHRESMANN, C., MORAS, D. (2000). Transfer RNA-Mediated editing in Threonyl-tRNA synthetase: The class II solution to the double discrimination problem. Cell, 103,1-20.

GRESCHIK, H., WURTZ, J.-M., SANGLIER, S., BOURGUET, W., VAN DORSSELAER A., MORAS, D., RENAUD, J.-P.(2002) Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related- receptor 3. Molecular Cell, 9, 303-313

LECOMPTE, O., RIPP, R., THIERRY, J.-C., MORAS, D. and POCH, O. (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain-scale. Nucleic Acids Research, 30, 1-9.

BILLAS I.S.L., IWEMA T., GARNIER J.-M., MITSCHER A., ROCHEL N. and MORAS D. (2003) Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor. Nature, 426, 91-96.

BRELIVET Y., KAMMERER S., ROCHEL N., POCH O. and MORAS D. (2004) Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level. EMBO Reports, 5, 423-429.

DOCK-BREGEON A.-C. REES B., TORRES-LARIOS A., BEY G., CAILLET J. and MORAS D. (2004) Achieving error-free translation: the mechanism of proofreading of Threonyl-tRNA synthetase at atomic resolution. Molecular Cell, 16, 375-386.

FLAIG R., GRESCHIK H., PELUSO-ILTIS C. and MORAS D. (2005) Structural basis for the Cell-specific activities of the NGFI-B and the Nurr1 Ligand-binding Domain. JBC, 280, 19250-19258.

IWEMA T., BILLAS, I.M.L., BECK Y., BONNETON F., NIERENGARTEN H., CHAUMOT A., RICHARDS G., LAUDET V., MORAS D. (2007) Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor. EMBO J., 26, 3770-3782.

MICHEL F. CRUCIFIX C. GRANGER F. EILER S. MOUSCADET JF KOROLEV S. AGAPKINA J. ZIGANSHIN R. GOTTIKH M. NAZABAL A. EMILIANI S. BENAROUS R. MORAS D. SCHULTZ P. RUFF M. (2009) Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor. EMBO J. 28:980-91.