David Lomas - Selected Publications#

Total 330 papers, H-index 64, >£68 million in grant funding over 26 years

1. The mechanism of Z alpha-1-antitrypsin accumulation in the liver. D.A. Lomas, D.L. Evans, J. Finch, R.W. Carrell. Nature 1992; 357:605-607.

2. Dementia caused by polymerisation of a neurone-specific serpin. R.L. Davis, A.E. Shrimpton, P.D. Holohan, C. Bradshaw, D. Feiglin, G.H. Collins, P. Sonderegger, J. Kinter, L.M. Becker, F. Lacbawan, D. Krasnewich, M. Muenke, D.A. Lawrence, M.S Yerby, C.-M. Shaw, B. Gooptu, P.R. Elliott, J.T. Finch, R.W. Carrell, D.A. Lomas. Nature 1999; 401: 376-379.

3. Defining the mechanism of polymerization in the serpinopathies. U.I. Ekeowa, J. Freeke, E. Miranda, B. Gooptu, M.F. Bush, J. Pérez, J. Teckman, C.V. Robinson and D.A. Lomas. Proc. Natl. Acad. Sci. 2010; 107: 17146-17151.

4. Modelling inherited metabolic disorders with patient specific iPSCs. T. Rashid, S. Corbineau, N. Hannan, S.J. Marciniak, E. Miranda, G. Alexander, I. Huang-Doran, L. Ahrlund, R. Semple, A. Webber, D.A. Lomas, L. Vallier. J. Clin. Invest. 2010; 120: 3127-3136.

5. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. K. Yusa*, S.T. Rashid*, H. Strick-Marchand, P.-Q. Liu, D.E. Paschon, E. Miranda, A. Ordóñez, N. Hannan, F. Rohani, G. Alexander, S.J. Marciniak, M.C. Holmes, J.P. Di Santo, D.A. Lomas§, A. Bradley§ and L. Vallier§ (joint first* and senior§ authors). Nature 2011; 478: 391-394.

6. Decline in forced expiratory volume in 1 second in patients with chronic obstructive pulmonary disease: Variability, determinants and biomarkers. J. Vestbo, L.D. Edwards, P.D. Scanlon, J.C. Yates, A. Agusti, P. Bakke, P.M.A. Calverley, B. Celli, H.O. Coxson, C. Crim, D.A. Lomas, W. MacNee, B.E. Miller, E.K. Silverman, R. Tal-Singer, E. Wouters and S.I. Rennard, for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. N. Engl. J. Med. 2011; 365: 1184-1192.

7. A single-chain variable fragment intrabody prevents intracellular polymerisation of Z α1-antitrypsin. A. Ordóñez, J. Pérez, L. Tan, J.A. Dickens, N. Motamedi-Shad, J.A Irving, I. Haq, U. Ekeowa, S.J. Marciniak, E. Miranda*, D.A. Lomas*. (*joint senior authors). FASEB J. 2015; 29: 2667-2678.

8. An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. J.A. Irving, E. Miranda, I. Haq, J. Perez, V.R. Kotov, S.V. Faull, N. Motamedi-Shad, D.A. Lomas. Biochem J. 2015; 468: 99-108.

9. An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour. N. Motamedi-Shad, A.M. Jagger, M. Liedtke, S.V. Faull, A.S. Nanda, E. Salvadori, J.L. Wort, C.W. Kay, N. Heyer-Chauhan, E. Miranda, J. Perez, A. Ordóñez, I. Haq, J.A. Irving, D.A. Lomas. Biochem J. 2016; 473: 3269-90.

10. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. B.D. Hobbs, K. de Jong, M. Lamontagne, Y. Bossé, ....., D.A. Lomas, ....H.M. Boezen, M.H. Cho. Nat Genet. 2017; In press.