Ruth Itzhaki - Curriculum Vitae#

DEGREES

BSc (Physics, London), MSc (Biophysics, London), PhD (Biophysics, (London), MA (Cambridge)

POSTS

• Since 2014, Visiting Professorial Fellow, Institute of Population Ageing, University of Oxford, & Emeritus Professorial Fellow, Faculty of Life Sciences, University of Manchester.
  
• 1961 - 1964 Beit Memorial Research Fellow, Dept. Radiotherapeutics, University of Cambridge.
• 1964 - 1966 Wheldale Onslow Memorial Fellow & Praelector, Newnham College, Cambridge
• 1966-1978 Senior Scientist, Paterson Laboratories, Christie Hospital, Manchester, and Honorary Lecturer, Dept. of Biochemistry, University of Manchester
  
• 1979 - 1983 Senior Research Fellow, Department of Virology, South Manchester University Hospital
• 1983 - 2004 Senior Research Fellow & Honorary Reader - then Professorial Fellow - Department of Optometry and Neuroscience, UMIST Also, Honorary Research Fellow, Department of Geriatric Medicine, University of Manchester
• 2004 - 2014 Professorial Fellow, Faculty of Life Sciences, University of Manchester

CURRENT RESEARCH

Aetiology of dementia, especially Alzheimer’s disease and the role of viruses.

INTERESTS

Influence of genetic factors (especially apolipoprotein E) on damage by infectious agents.

Previous interests include chromatin structure (my lab was the first to use nucleases and polylysine to study chromatin structure and its accessibility), and effects of carcinogens on chromatin (my lab was the first to investigate localisation of damage within the genome).

GRANTS

MRC, BBSRC, Leukaemia Research Fund, Sandoz Foundation for Gerontological Res., Wellcome Trust, Mental Health Foundation, Research into Ageing, Fidelity Foundation, Sir Halley Stewart Trust, Alz. Society.

PUBLICATIONS
Sole or senior author of almost all my 155 publications, nearly all in refereed journals. One was listed as a Citation Classic (defined as a ‘highly useful publication as identified by the Science Citation Index’). My 1997 paper in The Lancet was listed (by Lipkin and Hornig, Lancet, 352, end of year review, 1998) as one of the 5 key publications in Neurovirology in 1997-1998.

MISCELLANEOUS

Associate Editor, Journal of Neurovirology (USA), & of Journal of Alzheimer’s Disease. Member: Biochemical Society, Society for General Microbiology, International Society for NeuroVirology. Patent: APOE genotype as a prognostic marker for hepatitis Itzhaki, R.F., Wozniak, M.A. & Irving, W.I. Int. Appl. Nr: PCT/GB2003/000104. Int. Publ. Nr: WO 2003/060158 A3. Inventor, patent filed. WO2014124978) Helicase-primase inhibitors for use in a method for treating Alzheimer's disease.