Michael Thomas Heneka - Selected publications#

Current H Factor 44 (ISI); total citations > 5200


1. Heneka MT, Klockgether T, Feinstein DL. Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J Neurosci 2000;20:6862-6867.

2. Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O´Banion MK, Klockgether T , Feinstein DL. Noradrenergic depletion potentiates b-amyloid induced cortical inflammation: Implications for Alzheimer’s disease. J Neurosci 2002;22:2434-2442.

3. Heneka MT, Dewachter I, Sastre M, Dumitrescu-Ozimek L, Cuiperi K, Landreth GE, Klockgether, Van. Leuven F. Acute treatment with the PPAR agonist pioglitazone and ibuprofen reduces inflammation and A1-42 levels in APP V717I transgenic mice. Brain 2005;128:1442-1453.

4. Schütz B, Reimann J, Dumitrescu-Ozimek L, Kappes-Horn K, Landreth GE, Schürmann B, Zimmer A, Heneka MT. The oral antidiabetic pioglitazone protects from neurodegeneration and ALS-like symptoms in SOD1-G93A transgenic mice. J Neurosci 2005;25:7805-7812.

5. Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghraef P, Evert BO, Dumitrescu-Ozimek D, Thal DR, Landreth GE, Walter J, Klockgether T, Van Leuven F, Heneka MT (2006) NSAIDs suppress BACE1 gene expression by the activation of PPAR. Proc Natl Acad Sci USA 2006;103:443-448.

6. Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Debeir T, Sastre M, Bilkei-Gorzo A, Zimmer A, Galldiks N, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M. Locus ceruleus degeneration promotes Alzheimer pathogenesis in APP transgenic mice. J. Neurosci 2006;26:1343-1354.

7. Weberpals M, Hermes M, Hermann M, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT (2009) NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits, J Neurosci, 29:14177-84.

8. Heneka MT, Nadrigny F, Regen T, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch U, Kummer MP (2010) Locus ceruleus controls Alzheimer disease pathology by modulating microglial functions through norepinephrine. Proc. Natl. Acad. Sci. U.S.A., 107:6058-63.

9. Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König, S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT (2011) Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation. Neuron 71:833-44.

10. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Jan 31;493(7434):674-8.