Vassilis Gorgoulis - Selected Publications#

Google scholar H-index 76 (26,408 citations, i10-index 239)

1. Zampetidis CP, Galanos P, Angelopoulou A, Zhu Y, Polyzou A, Karamitros T, Kotsinas A, Lagopati N, Mourkioti I, Mirzazadeh R, Polyzos A, Garnerone S, Mizi A, Gusmao EG, Sofiadis K, Gál Z, Larsen DH, Pefani DE, Demaria M, Tsirigos A, Crosetto N, Maya-Mendoza A, Papaspyropoulos A, Evangelou K, Bartek J, Papantonis A, Gorgoulis VG. A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization. Mol Cell. 2021 Nov 12: S1097-2765(21)00909-6. (IF: 17,970)
Important study addressing the unanswered question of how “escape from oncogene-induced senescence” occurs, upgrading the previously proposed “oncogene-induced DNA damage model for cancer development” (see ref 8: Halazonetis et al, Science 2008).

2. Gorgoulis V*, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M*. Cellular Senescence: Defining a Path Forward. Cell. 2019 Oct 31;179(4): 813-827. (*co-correspendance) (IF: 41,582; 544 citations)
Landmark article that provides, among others, for the first time guidelines for senescence detection, implementing also our newly developed chemical compound GL13 (trademark name SenTraGor - licensed by Biotechne and Cayman).

3. Harvati K*, Röding C, Bosman AM, Karakostis FA, Grün R, Stringer C, Karkanas P, Thompson NC, Koutoulidis V, Moulopoulos LA, Gorgoulis VG*, Kouloukoussa M. Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia. Nature. 2019 Jul;571(7766): 500-504. (*co-correspendance) (IF: 49,962; 141 citations)
Landmark study on human evolution and development, featured 77th among the 100 top most influential studies of 2019 (https://www.altmetric.com/top100/2019/; https://www.altmetric.com/top100/2019/?subject=Studies+in+Human+Society&details=69411337).

4. Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, Sfikakis P, Bartek J, Fitzgerald RC, Thanos D, Mills Shaw KR, Petty R, Tsirigos A, Gorgoulis VG. A Deep Learning Framework for Predicting Response to Therapy in Cancer. Cell Rep. 2019 Dec 10;29(11):3367-3373.e4. (IF: 9,423; 59 citations)
One of the first studies demonstrating machine learning approaches to predict drug responses and survival of cancer patients based on molecular signatures.

5. Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018 Mar 16;19(1): 37. (IF: 13,583; 40 citations)
Key study that presents how error-prone mechanisms prevail in DNA repair and fuel genomic instability during neoplastic transformation, thus expanding the concept that genomic instability is the driving force for cancer development within the context of the previously proposed “oncogene-induced DNA damage model for cancer development” (see ref 8: Halazonetis et al, Science 2008).

6. Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG. Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol. 2016 Jul;18(7): 777-89. (IF: 28,824; 196 citations)
Key study that uncovers for the first time the concept of “escape from oncogene-induced senescence”.
Featured on cover page of same journal issue and accompanied by commentaries in: Nat Cell Biol 2016, Nat Rev Cancer 2016, Nat Rev Mol Cell Biol. 2016.

7. Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, Kletsas D, Papafotiou G, Klinakis A, Volarevic S, Gu W, Bartek J, Halazonetis TD, Gorgoulis VG. Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol. 2013 Aug;15(8): 967-77. (IF: 28,824; 115 citations)
Key study unraveling the functional interplay between the DNA Damage Response network and ARF-INK4A as antitumor checkpoint responses, previously considered to function independently, thus expanding the formerly proposed “oncogene-induced DNA damage model for cancer development” (see ref 8: Halazonetis et al, Science 2008).
Accompanied by commentary in: Cell Death Differ 2013.

8. Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science. 2008 Mar 7;319(5868): 1352-5. (IF: 47,728; 1797 citations)
Landmark review article describing for the first time the “oncogene-induced DNA damage model for cancer development” (based particularly on references 9 and 10, as well as on Karakaidos et al, Am J Pathol 2004; Tsantoulis et al, Oncogene 2008; Liontos et al, Cancer Res 2007).

9. Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7. (IF: 49,962; 1986 citations)
Landmark study demonstrating that oncogene-induced senescence is a DNA damage stress response acting as a barrier to cancer development. Pivotal article for the formulation of the “oncogene-induced DNA damage model for cancer development” (Halazonetis T, Gorgoulis V, Bartek J; Science 2008).
Accompanied by commentary in: Nature 2006.
“All time article recommendation” by the F1000 Faculty Prime

10. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005 Apr 14;434(7035): 907-13. (IF: 49,962; 2226 citations)-
Landmark study demonstrating that the DNA damage response network is an early barrier to cancer development. Pivotal article for the formulation of the “oncogene-induced DNA damage model for cancer development” (Halazonetis T, Gorgoulis V, Bartek J; Science 2008).
Featured on cover page of same journal issue and accompanied by commentary in: Nature 2005.
“All time article recommendation” by the F1000 Faculty Prime.