John Diffley- Primary research papers#

• Zegerman P;Diffley JFX. Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature 2010; 467 (7314):474-478. DOI: 10.1038/nature09373.
• Sanchez-Pulido L;Diffley JFX;Ponting CP. Homology explains the functional similarities of Treslin/Ticrr and Sld3. Curr Biol 2010; 20 (12):R509-R510. PubMed; DOI: 10.1016/j.cub.2010.05.021.

• Remus D;Diffley JFX. Eukaryotic DNA replication control: Lock and load, then fire. Curr Opin Cell Biol 2009; 21 (6):771-777. PubMed; DOI: 10.1016/j.ceb.2009.08.002.
• Remus D;Beuron F;Tolun G;Griffith JD;Morris EP;Diffley JFX. Concerted Loading of Mcm2-7 Double Hexamers around DNA during DNA Replication Origin Licensing. Cell 2009; 139 (4):719-730. UKPubMed (open access); PubMed; DOI: 10.1016/j.cell.2009.10.015.
• Omberg L;Meyerson JR;Kobayashi K;Drury LS;Diffley JFX;Alter O. Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression. Mol Syst Biol 2009; 5 ():312. UKPubMed (open access); PubMed; DOI: 10.1038/msb.2009.70.
• Zegerman P;Diffley JFX. DNA replication as a target of the DNA damage checkpoint. DNA Repair (Amst) 2009; 8 (9 Spec Iss):1077-1088. PubMed; DOI: 10.1016/j.dnarep.2009.04.023.
• Drury LS;Diffley JFX. Factors Affecting the Diversity of DNA Replication Licensing Control in Eukaryotes. Curr Biol 2009; 19 (6):530-535. PubMed; DOI: 10.1016/j.cub.2009.02.034.

• Segurado M;Diffley JFX. Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev 2008; 22 (13):1816-1827. UKPubMed (open access); PubMed; DOI: 10.1101/gad.477208.
• Zierhut C;Diffley JFX. Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J 2008; 27 (13):1875-1885. UKPubMed (open access); PubMed; DOI: 10.1038/emboj.2008.111.
• Baxter J;Diffley JFX. Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Mol Cell 2008; 30 (6):790-802. PubMed; DOI: 10.1016/j.molcel.2008.04.019.

• Zegerman P;Diffley JFX. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.. Nature 2007; 445 (7125):281-285. DOI: 10.1038/nature05432.

• Mailand N;Diffley JFX. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.. Cell 2005; 122 (6):915-926.

• Mimura S;Seki T;Tanaka S;Diffley JFX. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control.. Nature 2004; 431 (7012):1118-1123.
• Diffley JFX. Regulation of early events in chromosome replication.. Curr Biol 2004; 14 (18):R778-R786.
• Wang XA;Ira G;Tercero JA;Holmes AM;Diffley JFX;Haber JE. Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae.. Mol Cell Biol 2004; 24 (16):6891-6899.
• Merrick CJ;Jackson D;Diffley JFX. Visualization of altered replication dynamics after DNA damage in human cells.. J Biol Chem 2004; 279 (19):20067-20075.
• Early A;Drury LS;Diffley JFX. Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.. Philos Trans R Soc Lond B Biol Sci 2004; 359 (1441):31-38.

• Vernis L;Piskur J;Diffley JFX. Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae.. Nucleic Acids Res 2003; 31 (19):e120. DOI: 10.1093/nar/gng121.
• Zegerman P;Diffley JFX. Lessons in how to hold a fork.. Nat Struct Biol 2003; 10 (10):778-779.
• Tercero JA;Longhese MP;Diffley JFX. A central role for DNA replication forks in checkpoint activation and response. Mol Cell 2003; 11 (5):1323-1336.

• Tanaka S;Diffley JFX. Deregulated G(1)-cyclin expression induces genomic instability by preventing efficient pre-RC formation.. Genes Dev 2002; 16 (20):2639-2649.
• Tanaka S;Diffley JFX. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol 2002; 4 (3):198-207.
• Diffley JFX;Labib K. The chromosome replication cycle.. J Cell Sci 2002; 115 (5):869-872.