Antonino Cattaneo - Selected Publications#

List of selected publication out of more than 220 papers.

Cattaneo A, Maffei L, Morrone C (1981) Patterns in the discharge of simple and complex visual cortical cells. Proc R Soc Lond B Biol Sci 212:279-297.

Cattaneo A, Maffei L, Morrone C (1981) Two firing patterns in the discharge of complex cells encoding different attributes of the visual stimulus. Exp Brain Res 43:115-118.

Cattaneo A, Biocca S, Nasi S, Calissano P (1983) Hidden receptors for nerve growth factor in PC12 cells. Eur J Biochem 135:285-290

Cattaneo A, Neuberger MS (1987) Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain. Embo J 6:2753-2758.

Cattaneo A, Rapposelli B, Calissano P (1988) Three distinct types of monoclonal antibodies after long-term immunization of rats with mouse nerve growth factor. J Neurochem 50:1003-1010.

Biocca S, Neuberger MS, Cattaneo A (1990) Expression and targeting of intracellular antibodies in mammalian cells. Embo J 9:101-108.

Piccioli P, Ruberti F, Biocca S, Di Luzio A, Werge TM, Bradbury A, Cattaneo A (1991) Neuroantibodies: molecular cloning of a monoclonal antibody against substance P for expression in the central nervous system. Proc Natl Acad Sci U S A 88:5611-5615.

Bradbury A, Persic L, Werge T, Cattaneo A (1993) Use of living columns to select specific phage antibodies. Nature Biotechnology (N Y) 11:1565-1569.

Tavladoraki P, Benvenuto E, Trinca S, De Martinis D, Cattaneo A, Galeffi P (1993) Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack. Nature 366:469-472.

Berardi N, Cellerino A, Domenici L, Fagiolini M, Pizzorusso T, Cattaneo A, Maffei L (1994) Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system. Proc Natl Acad Sci U S A 91:684-688.

Biocca S, Pierandrei-Amaldi P, Campioni N and Cattaneo A (1994) Intracellular immunization with cytosolic recombinant antibodies. Nature Biotechnology (N Y) 12:396-399.

Biocca S, Cattaneo A (1995) Intracellular immunization: antibody targeting to subcellular compartments. Trends Cell Biol 5:248-252.

Biocca S, Ruberti F, Tafani M, Pierandrei-Amaldi P and Cattaneo A (1995) Redox state of single chain Fv fragments targeted to the endoplasmic reticulum, cytosol and mitochondria. Nature Biotechnology (N Y) 13:1110-1115.

Bradbury A, Cattaneo A (1995) The use of phage display in neurobiology. Trends Neurosci 18:243-249.

Piccioli P, Di Luzio A, Amann R, Schuligoi R, Surani MA, Donnerer J, Cattaneo A (1995) Neuroantibodies: ectopic expression of a recombinant anti-substance P antibody in the central nervous system of transgenic mice. Neuron 15:373-384.

Tongiorgi E, Righi M, Cattaneo A (1997) Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J Neurosci 17:9492-9505.

Cattaneo A, Biocca S (1999) The selection of intracellular antibodies. Trends Biotechnol 17:115-121.

Cattaneo A, Capsoni S, Margotti E, Righi M, Kontsekova E, Pavlik P, Filipcik P, Novak M (1999) Functional blockade of tyrosine kinase A in the rat basal forebrain by a novel antagonistic anti-receptor monoclonal antibody. J Neurosci 19:9687-9697.

Visintin M, Tse E, Axelson H, Rabbitts TH, Cattaneo A (1999) Selection of antibodies for intracellular function using a two-hybrid in vivo system. Proc Natl Acad Sci U S A 96:11723-11728.

Fasulo L, Ugolini G, Visintin M, Bradbury A, Brancolini C, Verzillo V, Novak M, Cattaneo A (2000) The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis. J Neurochem 75:624-633.

Capsoni S, Ugolini G, Comparini A, Ruberti F, Berardi N, Cattaneo A (2000) Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc Natl Acad Sci U S A 97:6826-6831.

Pesavento E, Margotti E, Righi M, Cattaneo A, Domenici L (2000) Blocking the NGF-TrkA interaction rescues the developmental loss of LTP in the rat visual cortex: role of the cholinergic system. Neuron 25:165-175.

Righi M, Tongiorgi E, Cattaneo A (2000) Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway. J Neurosci 20:3165-3174.

Ruberti F, Capsoni S, Comparini A, Di Daniel E, Franzot J, Gonfloni S, Rossi G, Berardi N, Cattaneo A (2000) Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy. J Neurosci 20:2589-2601.

Capsoni S, Giannotta S, Cattaneo A (2002b) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci U S A 99:12432-12437.

Visintin M, Settanni G, Maritan A, Graziosi S, Marks JD, Cattaneo A (2002) The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies. J Mol Biol 317:73-83.

Tongiorgi E, Armellin M, Giulianini PG, Bregola G, Zucchini S, Paradiso B, Steward O, Cattaneo A, Simonato M (2004) Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J Neurosci 24:6842-6852.

De Rosa R, Garcia AA, Braschi C, Capsoni S, Maffei L, Berardi N, Cattaneo A (2005) Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci U S A 102:3811-3816.

Capsoni S, Cattaneo A (2006) On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer’s disease. Cell Mol Neurobiol. Jul-Aug;25 (4-6):619-33

Melchionna T and Cattaneo A (2007) A protein silencing switch by ligand-induced proteasome targeting intrabodies. J Mol Biol 374:641-54.

Ugolini G, Marinelli S, Covaceuszach S, Cattaneo A, Pavone F (2007) The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain. Proc.Natl Acad Sci USA 104:2985-2990.

Covaceuszach S, Cassetta A., Konarev PV, Gonfloni S, Rudolph R, Svergun D, Lamba D, and Cattaneo A (2008) Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody. J. Mol. Biol., 381: 881-896.

Cattaneo A, Capsoni S and Paoletti F (2008) Towards non invasive Nerve Growth Factor therapies for Alzheimer’s Disease. Journal of Alzheimer’s Disease 15, 255-283.

Meli G, Visintin M, Cannistraci I, Cattaneo A (2009) Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers. J Mol Biol. 2009 Apr 3;387(3):584-606.

Covaceuszach S, Capsoni S, , Marinelli S, Pavone F , Ceci M, Ugolini G, Vignone D, Amato G, Paoletti F, Lamba D and Cattaneo A (2010) In vitro binding properties of a “painless” NGF mutein, linked to Hereditary Sensory Autonomic neuropathy Type V. Biophys. Biochem Res. Comm. (391, 824-829).

Capsoni, S., Tiveron, C., Amato, G., Vignone, D., Cattaneo, A. (2010) Dissecting the involvement of Tropomyosin kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proc Natl Acad Sci USA 107: 12299-12304.

D' Onofrio M, Arisi I, Brandi R, Di Mambro A, Felsani A, Capsoni S, Cattaneo A. (2011) Early inflammation and immune response mRNAs in the brain of AD11 anti−NGF mice. Neurobiol Aging 32, 1007-1022.

Manca A, Capsoni S, Di Luzio A, Vignone D, Malerba F, Paoletti F, Brandi R, Arisi I, Cattaneo A, Levi-Montalcini R (2012) Nerve growth factor regulates axial rotation during early stages of chick embryo development. Proc Natl Acad Sci USA 109: 2009-14.

Cattaneo A, Calissano P (2012) Nerve Growth Factor and Alzheimer's Disease: new facts for an old hypothesis. Mol. Neurobiol. 46:588-604. doi: 10.1007/s12035-012-8310-9.

Tiveron C et al (2013) proNGF/NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice. Cell Death and Differ., 20(8):1017-30. doi: 10.1038/cdd.2013.22.

Cattaneo A (2013) Immunosympathectomy: the first protein silencing with antibodies. Proc. Natl. Acad. Sci. USA 110(13):4877-85. doi: 10.1073/pnas.1217586110. Invited Perspective article

Marchetti L, Callegari A, Luin S, Signore G, Viegi A, Beltram F, Cattaneo A. (2013) Ligand signature in the membrane dynamics of single TrkA receptor molecules. J Cell Sci.126(Pt 19):4445-56. doi: 10.1242/jcs.129916. Epub 2013 Jul 25.

Meli G, Lecci A, Manca A, Krako N, Albertini V, Benussi L, Ghidoni R, Cattaneo A. (2014) Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum. Nature Commun. 2014 May 27;5:3867. doi: 10.1038/ncomms4867.

Scardigli R, Capelli P, Vignone D, Brandi R, Ceci M, La Regina F, Piras E, Cintoli S, Berardi N, Capsoni S, Cattaneo A. (2014) Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone. Stem Cells. 2014 Sep;32(9):2516-28. doi: 10.1002/stem.1744.

Covaceuszach S, Petr V. Konarev , Alberto Cassetta, Francesca Paoletti, Dmitri I. Svergun, Doriano Lamba, Antonino Cattaneo (2015) The conundrum of the “high affinity” NGF binding sites formation unveiled? Biophysical J 108(3):687-97. doi:10.1016/j.bpj.2014.11.3485.

Teresa De Nadai, Laura Marchetti, Carmine Di Rienzo, Mariantonietta Calvello, Giovanni Signore, Pierluigi Di Matteo, Francesco Gobbo, Sabrina Turturro, Sandro Meucci, Alessandro Viegi, Fabio Beltram, Stefano Luin, and Antonino Cattaneo (2016) Precursor and mature NGF live tracking: one versus many at a time in the axons. Scientific Reports; 6:20272. doi: 10.1038/srep20272.

Capsoni S, Malerba F, Carucci N, Rizzi C, Criscuolo C, Origlia N, Calvello MA, Viegi A, Meli G and Cattaneo A (2016) The chemokine CXCL12 mediates the anti-amyloidogenic actions of painless human Nerve Growth Factor. BRAIN, 140 (1): 201-217. doi:https://doi.org/10.1093/brain/aww271.

Chirichella M, Lisi S, Fantini M, Goracci M, Calvello M, Brandi R, Arisi I, D'Onofrio M, Di Primio C, Cattaneo A. (2017) Post-translational selective intracellular silencing of acetylated proteins with de novo selected intrabodies. Nat Methods. 2017 Mar;14(3):279-282. doi: 10.1038/nmeth.4144.

Rizzi C., Tiberi A., Giustizieri M, Marrone MG, Gobbo F, Carucci N, Meli G, Arisi I, D’Onofrio M, Marinelli S, Capsoni S and Cattaneo A (2018) NGF steers microglia towards a neuroprotective phenotype. GLIA (DOI: 10.1002/glia.23312).

Gobbo F, Marchetti L, Jacob A, Pinto B, Binini N, Pecoraro Bisogni F, Alia C, Luin S, Caleo M, Fellin T, Cancedda L and Cattaneo A (2017) Activity-dependent expression of Channelrhodopsin at neuronal synapses. Nature Comm. 8, 1629. DOI: 10.1038/s41467-017-01699-7.

Marchetti L et al (2019) Fast diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands. Proc. Natl Acad. Sci USA 10.1073/ pnas.1902790116. News and Views in PNAS: Chao M (2019) Stoichiometry counts http://www.pnas.org/cgi/doi/10.1073/pnas.1914583116

Testa G, Mainardi M, Morelli C, Olimpico F, Pancrazi L, Petrella C, Severini C, Florio R, Malerba F, Stefanov A, Strettoi E, Brandi R, Arisi I, Heppenstall P, Costa M, Capsoni S and Cattaneo A (2019) The NGFRMutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V. J. Neurosci 39:9702-9715. doi: 10.1523/JNEUROSCI.0688-19.2019

Scopa C, Marrocco F, Latina V, Ruggeri F, Corvaglia V, La Regina F, Ammassari-Teule M, Middei S, Amadoro G, Meli G, Scardigli R and Cattaneo A. (2019) Cell Death Differ. doi: 10.1038/s41418-019-0409-3.

Marco Fantini, Simonetta Lisi, Paolo De Los Rios, Antonino Cattaneo, Annalisa Pastore (2020) Protein Structural Information and Evolutionary Landscape by In Vitro Evolution. Mol Biol Evol. 2020 Apr; 37(4): 1179–1192. Published online 2019 Oct 31. doi: 10.1093/molbev/msz256