Lars Andreas Akslen - Publications#

Major research papers:

1. Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Pollack JR, Rees CA, Ross DT, Johnsen H, Akslen LA, Haugen DRF, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, Børresen-Dale AL, Brown PO, Botstein D. Molecular Characterization and Classification of Human Breast Tumors using cDNA Microarrays. Nature 2000;406:747-752. (IF=49.9)

2. Stefansson IM, Salvesen H, Akslen LA. Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer. J Clin Oncol 2004; 22(7):1242-52. (IF=44.5)

3. Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA, Salvesen HB, Otte AP, Akslen LA. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate and breast. J Clin Oncol 2006;24(2):268-73. (IF=44.5)

4. Stefansson IM, Salvesen HB, Akslen LA. Vascular proliferation is important for clinical progress of endometrial cancer. Cancer Res 2006; 66(6):3303-9. (IF=13.3)

5. Gravdal K, Halvorsen OJ, Haukaas SA, Akslen LA. A switch to N-cadherin expression is of strong prognostic importance in prostate cancer. Clinical Cancer Res 2007;13(23):7003-11. (IF=13.8)

6. Salvesen, HB, Carter SL, Mannelqvist M, Getz G, Stefansson IM, Engelsen IB, Dutt A, Trovik J, Greulich H, Bø TH, Jonassen I, Thomas R, Garraway LA, Øyan AM, Sellers WR, Kalland KH, Meyerson M, Akslen LA, Beroukhim R. Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. PNAS. 2009; 106(12):4834-9. (shared last author) (IF=12.7)

7. Straume O, Shimamura T, Lampa MJG, Carretero J, Oyan AM, Borgman CL, Downing SR, Short S, Kang S-Y, Watnick R, Chen L, Collett K, Bachmann IM, Wong K-K, Shapiro GI, Kalland KH, Folkman J, Akslen LA, Naumov GN. Suppression of Heat Shock Protein 27 induces long-term dormancy in human breast cancer. PNAS 2012;109(22):8699-704. (shared last author) (IF=12.7)

8. Catena R, Bhattacharya N, El Rayes T, Wang S, Choi H, Gao D, Ryu S, Joshi N, Bielenberg D, Lee SB, Haukaas SA, Gravdal K, Halvorsen OJ, Akslen LA, Watnick RS, Mittal V. Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1. Cancer Discov. 2013;3(5):578-89. (IF=39.3)

9. Hofvind S, Holen Å, Houssami N, Aase HS, Sebuødegård S, Moger TA, Haldorsen IS, Akslen LA. Screening performance measures for two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening program - a randomized controlled trial. Lancet Oncol 2019;20(6):795-805. (IF=54.4)

10. Sui L, Wang S, Ganguly D, El Rayes TP, Askeland C, Børretzen A, Sim D, Halvorsen OJ, Knutsvik G, Arnes J, Aziz S, Haukaas S, Foulkes WD, Bielenberg DR, Ziemys A, Mittal V, Brekken RA, Akslen LA, Watnick RS. PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nat Commun 2022;13:7959 (published online Dec 27, 2022) (IF=17.6)

11. Kjølle S, Finne K, Birkeland E, Ardawatia V, Winge I, Aziz S, Knutsvik G, Wik E, Paulo JA, Vethe H, Kleftogiannis D, Akslen LA. Hypoxia induced responses are reflected in the stromal proteome of breast cancer. Nat Commun. 2023;14(1):3724 (published online June 22, 2023) (IF=17.6).

Other major publications:

Lars A. Akslen & Randolph S. Watnick (Eds.) Biomarkers of the Tumor Microenvironment. Springer 2022 (textbook, second edition)