Maarten van Lohuizen - Publications#

10 major publications out off 121 total/10250 citations; overall H index= 55

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression. de Vries NA, Hulsman D, Akhtar W, de Jong J, Miles DC, Blom M, van Tellingen O, Jonkers J, van Lohuizen M. Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01057-2. doi: 10.1016/j.celrep.2014.12.028. [Epub ahead of print]] PMID:25600873

Chromatin position effects assayed by thousands of reporters integrated in parallel.
Akhtar W, de Jong J, Pindyurin AV, Pagie L, Meuleman W, de Ridder J, Berns A, Wessels LF*, van Lohuizen M*, van Steensel B*. Cell. 2013 Aug 15;154(4):914-27. doi: 10.1016/j.cell.2013.07.018. (*co-corresponding authors)

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as keyregulators of neural- and malignant glioma-stem cell homeostasis. Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M. Cancer Cell. 2013 May 13;23(5):660-76. doi: 10.1016/j.ccr.2013.03.030.

Synergy between PI3K/Akt and Bmi1 in mouse prostate carcinogenesis reveals a novel role for Bmi1 phosphorylation in its oncogenic potential, E3 ligase activity and DNA damage repair. Nacerddine K, Beaudry J-B, Ginjala V, Westerman B, Mattiroli F, Song J-Y, van der Poel H, Balague Ponz O, Pritchard C, Cornelissen-Steijger P, Zevenhoven J,Tanger E,Sixma T, Ganesan S, van Lohuizen M. J. Clin Invest 2012 May 1;122(5):1920-32.

Pietersen AM, Evers B, Prasad AA, Tanger E, Cornelissen-Steijger P, Jonkers J, van Lohuizen M. Bmi1 Regulates Stem Cells and Proliferation and Differentiation of Committed Cells in Mammary Epithelium. Curr Biol. 2008 Jul 22;18(14):1094-9

Uren A.G*, Kool J.*, Matentzoglu K., de Ridde J., Mattison J., van Uitert M., Lagcher L., Sie D. Tanger E. Cox T. Reinders M. Hubbard T.J. Rogers J. Jonkers J. #Wessels L., #Adams D.J. #van Lohuizen M. #Berns A. Large scale mutagenesis in p19ARF and p53 deficient mice identifies cancer genes and their collaborative networks.
Cell 2008; 133, 727-741 (*equal contribution; #corresponding authors).

Sophia W.M. Bruggeman, Danielle Hulsman, Ellen Tanger, Tessa Buckle, Marleen Blom, John Zevenhoven, Olaf van Tellingen and Maarten van Lohuizen. Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell 2007, 12, 328-341.

Sparmann A. and van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nature Rev. Cancer 2006, 6, 846-856.

Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A. and van Lohuizen, M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the INK4a locus. Nature 397, 1999, 164-168.

van Lohuizen, M., Verbeek,S., Scheijen, B., Wientjens, E., van der Gulden, H. and Berns, A. Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging. Cell 65, 1991a, 737-752.
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