Catharina Svanborg - Publications#


2012
  • Alternatively folded proteins with unexpected beneficial functions
  • Comparison of Asymptomatic Bacteriuria Escherichia coli Isolates from Healthy Individuals versus Those from Hospital Patients Shows that Long-Term Bladder Colonization Selects for Attenuated Virulence Phenotypes
  • Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?
  • HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers
  • HAMLET: functional properties and therapeutic potential.
  • Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: Host-pathogen interaction in urinary tract infections.

2011
  • Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.
  • Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex
  • Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.
  • Genetic control of the variable innate immune response to asymptomatic bacteriuria.
  • Genetics of innate immunity and UTI susceptibility.
  • HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment.
  • MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells

2010
  • HAMLET Interacts with Lipid Membranes and Perturbs Their Structure and Integrity
  • HAMLET Treatment Delays Bladder Cancer Development.
  • HAMLET interacts with lipid membranes and perturbs their structure and integrity.
  • Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients
  • Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.
  • Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.
  • Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.
  • Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection.

2009
  • Changes in proteasome structure and function caused by HAMLET in tumor cells.
  • Characterizing Escherichia coli asymptomatic bacteriuria (ABU) - what drives their successful silent colonization?
  • HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.
  • Therapeutic Effect of Blocking CXCR2 on Neutrophil Recruitment and Dextran Sodium Sulfate-Induced Colitis
  • Virulence properties of asymptomatic bacteriuria Escherichia coli alpha-Lactalbumin, Engineered to be Non-native and **Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A new biological function resulting from partial unfolding.

2008
  • Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
  • Asymptomatic Bacteriuria: An adaptive challenge for Escherichia coli within the urinary tract
  • Can misfolded proteins be beneficial? The HAMLET case.
  • Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection.
  • Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation?
  • Pathogenomics: An updated European Research Agenda
  • Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.
  • Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins
  • TLR- and CXCR1-dependent innate immunity: insights into the genetics of urinary tract infections.

2007
  • A genetic basis of susceptibility to acute pyelonephritis.
  • Bladder cancers respond to intravesical instillation of (HAMLET human alpha-lactalbumin made lethal to tumor cells).
  • Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4.
  • Do type 1 fimbriae promote inflammation in the human urinary tract?
  • Fimbrial lectins influence the chemokine repertoire in the urinary tract mucosa.
  • HAMLET, protein folding, and tumor cell death
  • Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
  • Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection.
  • Reduced Toll-like receptor 4 expression in children with asymptomatic bacteriuria
  • Urinary tract infections revisited.

2006
  • Glycolipid receptor depletion as an approach to specific antimicrobial therapy.
  • HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.
  • Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets via TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome.
  • Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection.
  • Molecular characterization of the Escherichia coli asymptomatic bacteriuria strain 83972: The taming of a pathogen
  • Uropathogenic Escherichia coli as a model of host-parasite interaction.
  • alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.

2005
  • Compact oleic acid in HAMLET.
  • Escherichia coli, fimbriae, bacterial persistence and host response induction in the human urinary tract.
  • Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4.
  • HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy
  • HAMLET; a novel tool to identify apoptotic pathways in tumor cells.
  • Natural history of renal scarring in susceptible mIL-8Rh-/- mice.
  • Neutrophil activation and renal scarring - Reply
  • Stability of HAMLET--A kinetically trapped {alpha}-lactalbumin oleic acid complex.
  • Urinary tract infections and the mucosal Immune system

2004
  • Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin
  • Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis
  • Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
  • PapG-dependent adherence breaks mucosal inertia and triggers the innate host response
  • Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa.
  • Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid
  • Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid.
  • Urinary tract infections as a model for innate mucosal immunity

2003
  • Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays
  • Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract
  • Glycolipid depletion in antimicrobial therapy
  • HAMLET interacts with histones and chromatin in tumor cell nuclei.
  • HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
  • Lipids as cofactors in protein folding: Stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).
  • The host response to urinary tract infection.
  • alpha-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

2002
  • Adhesion, signal transduction and mucosal inflammation
  • Hamlet - A complex from human milk that induces apoptosis in tumor cells but spares healthy cells
  • Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells.
  • Human renal epithelial cells express iNOS in response to cytokines but not bacteria.
  • The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract.

2001
  • A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria
  • Carbohydrate receptor depletion as an antimicrobial strategy for prevention of urinary tract infection
  • Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation
  • Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney
  • Fimbriae, transmembrane signaling, and cell activation
  • Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis
  • Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection
  • The 'innate' host response protects and damages the infected urinary tract
  • The millenium symposium on pyelonephritis and urinary tract infection - Lund, Sweden, 24-26 May 2000 - Introduction
  • Toll-like receptor signaling and chemokine receptor expression influence the severity of urinary tract infection
  • Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells
  • Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo
  • pap genotype and P fimbrial expression in Escherichia coli causing bacteremic and nonbacteremic febrile urinary tract infection

2000
  • Innate defences and resistance to gram negative mucosal infection
  • Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart
  • Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis
  • Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice

1999
  • Cytokine responses during mucosal infections: role in disease pathogenesis and host defence
  • Macrophage inflammatory protein-2 is required for neutrophil passage across the epithelial barrier of the infected urinary tract
  • Neutrophil recruitment and resistance to urinary tract infection

1998
  • Role of fimbriae-mediated adherence for neutrophil migration across Escherichia coli-infected epithelial cell layers

1997
  • Bacterial virulence in urinary tract infection
  • Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration


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