Yufang Shi - Selected Publications#

1. Shi YF, Sahai BM and Green DR. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. NATURE 1989, 339: 625-626. This publication established "Activation-induced Cell Death (AICD)" in T cells as an important mechanism whereby T cells are dampened after immune responses. Citations=580

2. Shi YF, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP and Green DR. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. SCIENCE 1992, 257: 212-214 (With cover illustration) First description of a key role of c-myc in apoptosis). Citations=821

3. Yin D*, Mufson RA, Wang R and Shi YF*. Fas-mediated cell death promoted by opioids. NATURE 1999, 397:218. This paper revealed that opioid-induced immunosupression is via Fas-mediated apoptosis. (Views in 10+ media including The Scientists - British Journal Medicine). Citations=218

4. Devadas S, Das J, Liu C, Zhang L, Roberts AI, Pan Z, Moore PA, Das G, Shi Y*. Granzyme B is critical for T cell receptor-induced cell death of Type 2 helper T cells. IMMUNITY 2006, 25:237-247. (This demonstrates differential mechanisms of activation-induced cell death in different T cells subsets: Th1 via Fas-FasL & Th2 via granzyme B ). Citations=145

5. Ren GW, Zhang LY, Zhao X, Xu GW, Zhang YY, Roberts AI, Zhao RC, and Shi YF*. Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide. CELL STEM CELLS. 2008, 2:141-150. (This uncovered the fundamental mechanisms of the strong immunosuppression induced by mesenchymal stromal/stem cells, MSC, providing a foundation for the understanding of MSCs in the regulation of tissue microenvironment and regeneration). (Views in Cell, Cell Stem Cell, Nature Reviews Immunology). Citations=1758

6. Ren GW, Su J, Zhang LY, Zhao X, Ling WF, L'huillie A, Zhang JM, Lu Y, Roberts AI, Ji W, Zhang H, Rabson AB, Shi YF*. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. STEM CELLS. 2009, 27:1954-62. (It revealed that MSCs from rodents use iNOS, while MSCs from other mammalian species use IDO to modulate immune responses). Citations=556

7. Ren GW, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan Z, Roberts A, Zhang L, Zheng B, Wen T, Han Y, Rabson A, Tischfield J, Shao C, Shi Y*. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. CELL STEM CELLS. 2012, 11:812-824. (This paper showed a critical role of the interaction between tumor MSCs and macrophages in tumor development). Citations=220

8. Wang Y*, Chen X, Cao W, Shi Y*. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. NATURE IMMUNOLOGY 2014,15: 1009-1016. (Review, primarily based on their own investigations; it systemically surmised how MSCs interact with inflammation and put forward the "plasticity" and "empowerment" theory for MSC-mediated immunomodulation and regeneration). Citations=704

9. Shi Y*, Du L, Lin L, Wang Y*. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. NATURE REVIEWS DRUG DISCOVERY. 2017;16:35-52. (It systemically reviewed population diversity and the functions of MSCs in tumor development and therapy). Citations=160

10. Du L, Lin L, Li Q, Liu K, Huang Y, Wang X, Cao K, Chen X, Cao W, Li F, Shao C, Wang Y*, Shi Y*. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties. CELL METABOLISM. 2019. 29:1363-1375. (This revealed that IGF2, as a stem cell factor, could imprint macrophages an immunosuppressive phenotypes through endowing a oxidative phosphorylation metabolic preference). Citations=19

*Corresponding authorship in 8; first in 2. Total 220 papers with a total citation over 30,200 and an h-index 77 (Google Scholar).

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