Ole Petersen's Publication List (from 2008 - 2018)#


Peng S, Gerasimenko JV, Tsugorka TM, Gryshchenko O, Samarasinghe S, Petersen OH & Gerasimenko OV (2018) Galactose protects against cell damage in mouse models of acute pancreatitis. J Clin Invest 128, 3769-3778, doi: 10.1172/JCI94714.

Gryshchenko O, Gerasimenko JV, Peng S, Gerasimenko & Petersen OH (2018) Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology. J Physiol 596, 2663-2678, doi: 10.1113/JP275395


Petersen OH, Courjaret R, Machaca K (2017) Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites. J Physiol 595, 2999-3014 (doi: 10.1113/JP272772)

Petersen OH (2017) The effects of Ca2+ buffers on Ca2+ signalling. J Physiol 595, 3107-3108 (doi: 10.1113/JP273852)

Ferdek PE, Jakubowska MA, Nicolau P, Gerasimenko JV, Gerasimenko OV, Petersen OH (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death & Disease 8, e2640 (doi: 10.1038/cddis.2017.41)

Huang W, Cane MC, Mukherjee R, Szatmary P, Zhang X, Elliott V, Ouyang Y, Chvanov M, Latawiec D, Wen L, Booth DM, Haynes AC, Petersen OH, Tepikin AV, Criddle DN, Sutton R (2017) Caffeine protects against experimental pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2 release. Gut 66, 301-313 (doi: 10.1136/gutjnl-2015-309363)


Ferdek PE, Jakubowska MA, Gerasimenko JV, Gerasimenko OV, Petersen OH (2016) Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. J Physiol 594, 6147-6164 (doi: 10.1113/JP272774), *Editor's Choice*, Associated Perspective Article: Hegyi P (2016) Bile as a key aethiological factor of acute but not chronic pancreatitis: a possible theory revealed. J Physiol 594, 6073-6074.

Jakubowska MA, Ferdek PE, Gerasimenko OV, Gerasimenko JV, Petersen OH (2016) Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biology 6, 160149, doi: 10.1098/rsob.160149

Petersen OH, Verkhratsky A (2016) Calcium and adenosine triphosphate control multiple vital functions. Phil Trans R Soc B 371, 20150418, doi: 10.1098/rstb.2015.0418

Peng S, Gerasimenko JV, Tsugorka T, Gryshchenko O, Samarasinghe S, Petersen OH, Gerasimenko OV (2016) Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2. Phil Trans R Soc B 371, 20150423, doi: 10.1098/rstb.2015.0423

Gryshchenko O*, Gerasimenko JV*, Gerasimenko OV, Petersen OH (2016) Ca2+ signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca2+ channel blockade. J Physiol 594.2, 281-293 ('Editors Choice'; see also accompanying Perspective Article: Hegyi P (2016) Blockade of calcium entry provides a therapeutic window in acute pancreatitis. J Physiol 594.2, 257)

Gryshchenko O, Gerasimenko JV, Gerasimenko OV, Petersen OH (2016) Calcium signalling in pancreatic stellate cells: Mechanisms and potential roles. Cell Calcium ' 59, 140-144


Petersen OH (2015) Ca2+ signalling in the endoplasmic reticulum/secretory granule microdomain. Cell Calcium 58, 397-404

Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV (2015) Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Cell Calcium 58, 237-245

Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, Tepikin AV, Petersen OH, Pandol SJ, Gukovsky I, Criddle DN, Gukovskaya AS, Sutton R (2015) Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut DOI: 10.1136/gutjnl-2014-308553


Petersen OH (2014) Calcium signaling and secretory epithelia. Cell Calcium 55, 282-289.

Petersen, O. (2014) Can specific calcium channel blockade be the basis for a drug-based treatment of acute pancreatitis? Expert Rev. Gastroenterology and Hepatology 8, 339-341.

Gerasimenko, J.V., Gerasimenko, O.V. and Petersen, O.H. (2014) The role of Ca2+ in the pathophysiology of pancreatitis. J. Physiol. 592, 269-280.

Huang, W., Booth, D.M., Cane, M.C., Chvanov, M., Javed, M.A., Elliott, V.L., Armstrong, J.A., Dingsdale, H., Cash, N., Li, Y., Greenhalf, W., Mukherjee, R., Kaphalia, B.S., Jaffar, M., Petersen, O.H., Tepikin, A.V., Sutton, R. and Criddle, D.N. (2014) Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis. Gut 63, 1313-1324.


Gerasimenko, J.V., Gryshchenko, O., Ferdek, P.E., Stapleton, E., Hebert, T.O.G., Bychkova, S., Peng, S., Begg, M., Gerasimenko, O.V. and Petersen, OH. (2013) Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proc. Natl. Acad. Sci. USA (PNAS) 110, 13186-13191.

Hegyi, P. and Petersen, O.H. (2013) The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Rev. Physiol. Biochem. Pharmacol. 165, 1-30.


Ferdek, P.E., Gerasimenko, J.V., Peng, S., Tepikin, A.V., Petersen, O.H. and Gerasimenko, O.V. (2012) A novel role for Bcl-2 in regulation of cellular calcium extrusion. Curr. Biol. 22, 1241-1246.

Petersen, O.H. and Spät, A. (Eds) (2012) Cell-specific roles of mitochondrial Ca2+ handling. Pflϋgers Arch. – Eur. J. Physiol. 464, 1 – 131.

Petersen, O.H. (2012) Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells. Pflϋgers Arch. – Eur. J. Physiol. 464, 77-87.

Gerasimenko, O.V., Petersen, O.H. and Gerasimenko, J.V. (2012) Role of intracellular acid Ca2+ stores in pathological pancreatic protease activation. Expert Rev. Gastroenterol. Hepatol. 6, 129-131.

Petersen, O.H., Gerasimenko, O.V. and Gerasimenko, J.V. (2012) The war within - Unraveling the molecular causes of acute pancreatitis — a potentially deadly disease in which the pancreas essentially digests itself — is yielding clues to how it might be treated. The Scientist February 2012 Open Access: http://the-scientist.com/2012/02/01/the-war-within


Petersen, O.H., Gerasimenko, O.V. and Gerasimenko, J.V. (2011) Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Medicine Reports 3, 15 Open Access: http://f1000.com/reports/m/3/15

Gerasimenko, J.V., Lur, G., Ferdek, P., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Petersen, O.H. and Gerasimenko, O.V. (2011) Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through inositol trisphosphate receptors. Proc. Natl. Acad. Sci. USA (PNAS) 108, 5873-5878.

Petersen, O.H., Gerasimenko, O.V., Tepikin, A.V. and Gerasimenko, J.V. (2011) Aberrant Ca2+ signalling through acidic Ca2+ stores in pancreatic acinar cells. Cell Calcium 50, 193-199.

Lur, G., Sherwood, M.W., Ebisui, E., Haynes, L., Feske, S., Sutton, R., Burgoyne, R.D., Mikoshiba, K., Petersen, O.H. and Tepikin A.V. (2011) IP3 receptors and Orai channels in pancreatic acinar cells: co-localisation and its consequences. Biochem. J. 436, 231-239.

Booth, D.M., Murphy, J.A., Mukherjee, R., Awais, M., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Petersen, O.H., Sutton, R. and Criddle, D.N. (2011) Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140, 2116-2125.


Chvanov, M., Petersen, O.H. & Tepikin, A.V. (2010) Pharmacologically directed cell disposal: labeling damaged cells for phagocytosis as a strategy against pancreatitis. Molecular Interventions 10, 80-85.

Voronina, S.G., Barrow, S.L., Simpson, A.W.M., Gerasimenko, O.V., Da Silva Xavier, G., Rutter, G.A., Petersen, O.H. & Tepikin, A.V. (2010) Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138, 1976-1987.

Walsh, C.M., Chvanov, M., Haynes, L.P., Petersen, O.H., Tepikin, A.V. and Burgoyne, R.D. (2010) Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochem. J. 425, 159-168.


Criddle, D.N, Booth, D.M., Mukherjee, R., McLaughlin, E., Green, G.M., Sutton, R., Petersen, O.H. & Reeve, J.R. (2009) Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. Am. J. Physiol. G. & L Physiology 297, G1085-G1092.

Gerasimenko, J.V., Lur, G., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Gerasimenko, O.V. & Petersen, O.H. (2009) Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc. Natl. Acad. Sci. USA (PNAS) 106, 10758-10763.

Lur, G., Haynes, L.P., Prior, I.A., Gerasimenko, O.V., Feske, S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2009) Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Curr. Biol. 19, 1648-1653.

Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., Ferdek, P., Pozzan, T., Tepikin, A.V., Petersen, O.H., Sutton, R., Watson, A.J.M. & Gerasimenko, O.V. (2009) Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J. Biol. Chem. 284, 20796-20803.

Petersen, O.H., Tepikin, A.V., Gerasimenko, J.V., Gerasimenko, O.V., Sutton, R. & Criddle, D.N. (2009) Fatty acids, alcohol and fatty acid ethyl esters: toxic Ca2+ signal generation and acute pancreatitis. Cell Calcium 45, 634-642.

Petersen, O.H. (2009) Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology. Brazil. J. Med. Biol. Res. 42, 9-16 (Plenary Lecture at IVth Miguel R. Covian Symposium on ‘New Challenges for Physiologists’, University of Sao Paulo).

Walsh, C., Barrow, S., Voronina, S., Chvanov, M., Petersen, O.H. & Tepikin, A (2009) Modulation of calcium signaling by mitochondria. Biochim. Biophys. Acta 1787, 1374-1382.


Petersen, O.H. & Tepikin, A.V. (2008) Polarized calcium signaling in exocrine gland cells. Annu. Rev. Physiol. 70, 273-299.

Mukherjee, R., Criddle, D.N., Gukovaskaya, A., Pandol, S., Petersen, O.H. & Sutton, R. (2008) Mitochondrial injury in pancreatitis. Cell Calcium 44, 14-23.

Chvanov, M., Walsh, C.M., Haynes, L.P., Voronina, S.G., Lur, G., Gerasimenko, O.V., Barraclough, R., Rudland, P.S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2008) ATP depletion induces translocation to puncta and formation of STIM1 - ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflügers Arch. 457, 505-517.

Murphy, J.A., Criddle, D.N., Sherwood, M., Chvanov, M., Mukherjee, R., McLaughlin, E., Booth, D., Gerasimenko, J.V., Raraty, M.G.T., Ghaneh, P., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Green, G.M., Reeve, J.R. Jr., Petersen, O.H. & Sutton, R. (2008) Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135, 632-641. (Editorial: Gastroenterology 135, 357-360, 2008)

Barrow, S.L., Voronina, S.G., Da Silva Xavier, G, Chvanov, M.A., Longbottom, R.E., Gerasimenko, O.V., Petersen, O.H., Rutter, G.A., Tepikin, A.V. (2008) ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Arch. 455, 1025-1029.

Park, M.K., Choi, Y.M., Kang, Y.K. & Petersen, O.H. (2008) The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist 14, 68-77.

Petersen, O.H. (2008) Ca2+-induced pancreatic cell death: roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes. J. Gastroenterol. Hepatol. 23 (suppl. 1), S31-S36.

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