Iain Mattaj - Publications#

Book Edited:

"RNA-Protein Interactions" (1994) Eds. K. Nagai and I.W. Mattaj. Oxford University Press.


  1. Wilks, A.F., Cato, A.C.B., Cozens, P.J., Mattaj, I.W. and Jost, J.P. (1981) Isolation and fine-structure organisation of an avian vitellogenin gene coding for the major estrogen-inducible mRNA. Gene 16, 249-259.
  2. Mattaj, I.W., McPherson, M.S. and Wootton, J.C. (1982) Localisation of a strongly conserved section of coding sequence in glutamate dehydrogenase genes. FEBS Letters lll 147, 21-25.
  3. Mattaj, I.W., Mackenzie, A. and Jost, J.-P. (1982). Cloning in a cosmid vector of complete 37 kb and 25 kb ribosomal DNA repeat units from the chicken. Biochim. Biophys. Acta 698, 204-210.
  4. Wilks, A.F., Cozens, P.J., Mattaj, I.W. and Jost, J.-P. (1982). Estrogen includes a demethylation at the 5' end region of the chicken vitellogenin gene. Proc. Natl. Acad. Sci. USA 79, 4252-4255.
  5. Geiser, M., Mattaj, I.W., Wilks, A.F., Seldran, M. and Jost, J.P. (1983). Structure and sequence of the promoter area and of a 5' upstream demethylation site of the estrogen-regulated chicken vitellogenin II gene. J. Biol. Chem. 258, 9024-9030.
  6. Mattaj, I.W., Lienhard, S., Zeller, R. and De Robertis, E.M. (1983). Nuclear exclusion of Transcription Factor IIIA and the 42S particle transfer RNA binding protein in Xenopus oocytes. A possible mechanism for gene control? J. Cell Biol. 97, 1261-1265.
  7. Mattaj, I.W. and Zeller, R. (1983). Xenopus Laevis U2 snRNA genes; tandemly repeated transcription units sharing 5' and 3' flanking homology with other RNA polymerase II transcribed genes. EMBO J. 2, 1883-1891.
  8. De Robertis, E.M., Zeller, R., Carrasco, A. and Mattaj, I.W. (1983). Nucleocytoplasmic transport of macromolecules in frog oocytes and embryos. In Current problems in germ cell differentiation. Eds. A. McLaren and C. Wylie. Cambridge University Press. pp. 377-391.
  9. Mattaj, I.W., Carrasco, A. and Zeller, R. (1983). The snRNA genes of Xenopus Laevis. Experientia 39, 668.
  10. Zeller, R., Carri, M.-T., Mattaj, I.W. and De Robertis, E.M. (1984). Xenopus Laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families. EMBO J. 3, 1075-1081.
  11. Zeller, R., Carri, M.-T. and Mattaj, I.W. (1984). Transcription signals of Xenopus Laevis U snRNA genes. Experientia 40, 642.
  12. Brack, C., Mattaj, I.W., Gautschi, J. and Cammisuli, S. (1984). Cyclosporin A is a differential inhibitor of eukaryotic RNA polymerases. Exp. Cell Res. 151, 314-321.
  13. Mattaj, I.W. (1984). SnRNAs: from gene architecture to RNA processing. Trends in Biochemical Sciences (TIBS) 9, 435-347.
  14. Mattaj, I.W., Zeller, R., Carrasco, A.E., Jamrich, M., Lienhard, S. and De Robertis, E.M. (1985). U snRNA gene families in Xenopus laevis. Oxford Survey on Eukaryotic Genes 2, Ed. Maclean N., Oxford University Press, 121-140.
  15. Mattaj, I.W., Lienhard, S., Jiricny, J. and De Robertis, E.M. (1985). An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes. Nature 316, 163-167.
  16. Mattaj, I.W. and De Robertis, E.M. (1985). Nuclear Segregation of U2 snRNA Requires Binding of Specific snRNP Proteins. Cell 40, 111-118.
  17. De Robertis, E.M., Fritz, A., Goetz, J., Martin, G., Mattaj, I.W., Salo, E., Smith, G.D., Wright, C. and Zeller, R. (1985). The Xenopus homeo boxes. Cold Spring Harb. Symp. Quant. Biol. 50, 271-275.
  18. Mattaj, I.W., Habets, W.J. and van Venrooij, W.J. (1986). Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs. EMBO J. 5, 997-1002.
  19. Mattaj, I.W. (1986). The role of RNA-protein interactions in intracellular targeting. In "Nucleocytoplasmic Transport": Peters, R. and Trendelenburg, M.; Springer Verlag, Berlin Heidelberg, pp. 275-285.
  20. Mattaj, I.W. (1986). Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding. Cell 46, 905-911.
  21. Ciliberto, G., Dathan, N., Frank, R., Philipson, L. and Mattaj, I.W. (1986). Formation of the 3' end on U snRNAs requires at least three sequence elements. EMBO J. 5, 2931-2937.
  22. Tollervey, D. and Mattaj, I.W. (1987). Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U snRNPs. EMBO J. 6, 469-476.
  23. Tebb, G., Kazmaier, M., Parry, H., Dathan, N. and Mattaj, I.W. (1987). Transcription of Xenopus U snRNA genes. Mol. Biol. Rep. 12, 147-149.
  24. Tebb, G., Bohmann, D. and Mattaj, I.W. (1987). Only two of the four sites of interaction with nuclear factors within the Xenopus U2 gene promoter are necessary for efficient transcription. Nucl. Acids Res. 15, 6437-6453.
  25. Tebb, G., Mattaj, I.W., Keller, W. and Bohmann, D. (1987). Characterization of an Enhancer-Binding Protein. In "RNA Polymerase and the Control of Transcription": Reznikoff, W.S.; Steenbock Symposium, Vol. 16, 421-426.
  26. Mattaj, I.W., Coppard, N.J., Brown, R.S., Clark, B.F.C. and De Robertis, E.M. (1987). 42S p48 - the most abundant protein in previtellogenic Xenopus oocytes - resembles elongation factor 1 alpha structurally and functionally. EMBO J. 6, 2409-2413.
  27. Konings, D.A.M. and Mattaj, I.W. (1987). Mutant U2 snRNAs of Xenopus Which Can Form an Altered Higher Order RNA Structure Are Unable to Enter the Nucleus. Experimental Cell Research 172, 329-339.
  28. Kazmaier, M., Tebb, G. and Mattaj, I.W. (1987). Functional characterization of X. laevis U5 snRNA genes. EMBO J. 6, 3071-3078.
  29. Hamm, J., Dathan, N., Kazmaier, M. and Mattaj, I.W. (1987). Functional roles of U snRNP components. Mol. Biol. Rep. 12, 174-175.
  30. Hamm, J., Kazmaier, M. and Mattaj, I.W. (1987). In vitro assembly of U1 snRNPs. EMBO J. 6, 3479-3485.
  31. Ciliberto, G., Palla, F., Tebb, G., Mattaj, I.W. and Philipson, L. (1987). Properties of a U1 RNA enhancer-like sequence. Nucl. Acids Res. 15, 2403-2416.
  32. Carbon, P., Murgo, S., Ebel, J.-P., Krol, A., Tebb, G. and Mattaj, I.W. (1987). A Common Octamer Motif Binding Protein Is Involved in the Transcription of U6 snRNA by RNA Polymerase III and U2 snRNA by RNA Polymerase II. Cell 51, 71-79.
  33. Bürglin, T.R., Mattaj, I.W., Newmeyer, D.D., Zeller, R. and De Robertis, E.M. (1987). Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression. Genes & Development 1, 97-107.
  34. Bohmann, D., Keller, W., Dale, T., Schöler, H.R., Tebb, G. and Mattaj, I.W. (1987). A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes. Nature 325, 268-272.
  35. Tebb, G. and Mattaj, I.W. (1988). The Xenopus laevis U2 Gene Distal Sequence Element (Enhancer) Is Composed of Four Subdomains That Can Act Independently and Are Partly Functionally Redundant. Mol. Cell. Biol. 34, 1682-1690.
  36. Mattaj, I.W., Dathan, N.A., Parry, H.D., Carbon, P. and Krol, A. (1988). Changing the RNA polymerase specificity of U snRNA gene promoters. Cell 55, 435-442.
  37. Etzerodt, M., Vignali, R., Ciliberto, G., Scherly, D., Mattaj, I.W. and Philipson, L. (1988). Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K). EMBO J. 7, 4311-4321.
  38. Hamm, J., van Santen, V.L., Spritz, R.A. and Mattaj, I.W. (1988). Loop I of U1 Small Nuclear RNA Is the Only Essential RNA Sequence for Binding of Specific U1 Small Nuclear Ribonucleoprotein Particle Proteins. Mol. Cell. Biol. 36, 4787-4791.
  39. Hamm, J., Scherly, D. and Mattaj, I.W. (1988). Small nuclear RNA-protein complexes. Biochemistry 16, 943-944.
  40. Dreyfuss, G., Philipson, L. and Mattaj, I.W. (1988). Ribonucleoprotein Particles in Cellular Processes. J. Cell. Biol. 106, 1419-1425.
  41. Tebb, G. and Mattaj, I.W. (1988). Positionally exact initiation is required for the formation of a stable RNA polymerase II transcription complex in vivo. EMBO J. 7, 3785-3792.
  42. Pruijn, G.J.M., van der Vliet, P.C., Dathan, N.A., and Mattaj, I.W. (1989). Anti-OTF-1 antibodies inhibit NFIII stimulation of in vitro adenovirus DNA replication. Nucl. Acids Res. 17, 1845-1863.
  43. Mattaj, I.W. and Hamm, J. (1989). Regulated splicing in early development and stage-specific U snRNPs. Development 105, 183-189.
  44. Parry, H.D., Scherly, D. and Mattaj, I.W. (1989). 'Snurpogenesis: The transcription and assembly of U snRNP components. TIBS 14, 15-19.
  45. Mattaj, I.W. (1989). A Binding Consensus: RNA-Protein Interactions in Splicing, snRNPs, and Sex. Cell 57, 1-3.
  46. Parry H.D., Tebb, G. and Mattaj, I.W. (1989). The Xenopus U2 Gene PSE is a Single, Compact, Element Required for Transcription Initiation and 3' End Formation. Nucl Acids Res. 17, 3633-3644.
  47. Hamm, J., Dathan, N.A. and Mattaj, I.W. (1989). Functional analysis of mutant Xenopus U2 snRNAs. Cell 59, 159-169.
  48. Scherly, D., Boelens, W., van Venrooij, W.J., Dathan, N.A., Hamm, J. and Mattaj, I.W. (1989). Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO J. 8, 4163-4170.
  49. Tebb, G. and Mattaj, I.W. (1989). The Xenopus laevis U2 gene distal sequence element (enhancer) is composed of four subdomains that can act independently and are partly functionally redundant. Mol. Cell. Biol. 9, 1682-1690.
  50. Hamm, J. and Mattaj, I.W. (1989). An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis. EMBO J. 8, 4179-4187.
  51. Hamm, J., Dathan, N.A., Scherly, D. and Mattaj, I.W. (1990). Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing. EMBO J. 9, 1237-1244.
  52. Mattaj, I.W. (1990). A selective review of RNA-protein interactions in eukaryotes. Mol. Biol. Rep. 14, 151-155.
  53. Vankan, P., Hamm, J., Dathan, N.A. and Mattaj, I.W. (1990). Structure-function in Xenopus snRNPs. Mol. Biol. Rep. 14, 209-210.
  54. Parry, H.D. and Mattaj, I.W. (1990). Positive and negative functional interactions between promoter elements from different classes of RNA polymerase III-transcribed genes. EMBO J. 9, 1097-1104.
  55. Scherly, D., Boelens, W., Dathan, N.A., van Venrooij, W.J. and Mattaj, I.W. (1990). Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B and their cognate RNAs. Nature 345, 502-506.
  56. Boelens, W.C., Scherly, D., Mattaj, I.W. and van Venrooij, W.J. (1990). Analysis of the in vitro binding of A and B snRNP proteins to U1 and U2 snRNAs using mutated A and B proteins. Mol. Biol. Rep. 14, 159.
  57. Scherly, D., Boelens, W., Dathan, N.A., Kambach, C., van Venrooij, W.J. and Mattaj, I.W. (1990). Binding specificity determinants of U1A and U2B proteins. Mol. Biol. Rep. 14, 181-182.
  58. Mattaj, I.W. (1990). Splicing stories and poly(A) tales: An update on RNA processing and transport. Curr. Opinion in Cell Biol. 2,.528-538.
  59. van Venrooij, W.J., Castrop, J., Hageman, B., Mattaj, I.W., van de Putte, L.B. and Hoet, R. (1990). Anti-(U1)snRNA antibodies in anti-snRNP sera from patients with connective tissue diseases. J. Clin. Immunol., 86, 2154-2160.
  60. Hamm, J., Darzynkiewicz, E., Tahara, S.M. and Mattaj, I.W. (1990). The trimethyl-guanosine cap structure of U1 snRNA is a component of a bipartite nuclear targetting signal. Cell 62, 569-577.
  61. Hamm, J. and Mattaj, I.W. (1990). Monomethylated cap structures facilitate RNA export from the nucleus. Cell 63, 109-118.
  62. Hamm, J. and Mattaj, I.W. (1990) Structural analysis of U small nuclear ribonucleoproteins by in vitro assembly. Methods in Enzymol. 181, 273-284.
  63. Boelens, W., Scherly, D., Beijer, R.P., Jansen, E.J.R., Dathan, N.A., Mattaj, I.W. and van Venrooij. W.J. (1991) A weak interaction between the U2A' protein and U2 snRNA helps to stabilize their complex with the U2" protein. Nucl. Acids Res. 19, 455-460.
  64. Boelens, W., Scherly, D., Jansen, E.J.R., Kolen, K., Mattaj, I.W. & van Venrooij, W.J. (1991) Analysis of in vitro binding of U1-A protein mutants to U1 snRNA. Nucl. Acids Res. 19, 4611-4618.
  65. Frankel, A.D., Mattaj, I.W. & Rio, D.C. RNA-Protein interactions. (1991) Cell 647, 1041-1046.
  66. Scherly, D., Kambach, Boelens, W., van Venrooij, W.J. & Mattaj, I.W. (1991) Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding. J. Mol. Biol. 219, 577-584.
  67. Séraphin, B. & Mattaj, I.W. (1991) New pieces in the U5 puzzle. Current Biology 1, 147-149.
  68. Simmen, K.A. & Bernués, J., Parry, H.D., Stunnenberg, H. G., Berkenstam, A., Cavallini, B., Egly, J.-M. & Mattaj, I.W. (1991) TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III. EMBO J. 10, 1853-1862.
  69. Fischer, U., Darzynkiewicz, E., Tahara, S.M., Dathan, N.A., Lührmann, R. & Mattaj, I.W. (1991) Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport. J. Cell Biol. 113, 705-714.
  70. Simmen, K.A., Waldschmidt, R., Bernués, J., Parry, H.D., Seifart, K.H. & Mattaj, I.W. (1992) Proximal sequence element factor binding and species specificity in vertebrate U6 snRNA promoters. J. Mol. Biol. 223, 873-884.
  71. Vankan, P., McGuigan, C. & Mattaj, I.W. (1992) Roles of U4 and U6 snRNAs in the assembly of splicing complexes. EMBO J. 11, 335-343.
  72. Izaurralde, E. & Mattaj, I.W. (1992) Transport of RNA between nucleus and cytoplasm. Seminars in Cell Biol. 3, 279-288.
  73. Kambach, C. & Mattaj, I.W. (1992) Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. J. Cell. Biol. 118, 11-21.
  74. Mattaj, I.W. and Séraphin, B. (1992) Picking the needle from the haystack. Current Biol. 2, 363-365.
  75. Izaurralde, E., Stepinski, J., Darzynkiewicz, E. and Mattaj, I.W. (1992) A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs. J. Cell Biol. 118, 1287-1295.
  76. Bernués, J., Gunderson, S.I., Simmen, K.A. and Mattaj, I.W. (1992) Polymerase selectivity and the promoters of U snRNA genes. Nucl. Acids Res. 6, 174-186.
  77. Lescure, A., Tebb, G., Mattaj, I.W., Krol, A. and Carbon, P. (1992) A factor with Sp1 DNA-binding specificity stimulates Xenopus U6 snRNA in vivo transcription by RNA polymerase III. J. Mol. Biol. 228, 387-394.
  78. Simmen, K.A., Bernués, J., Lewis, J.D. and Mattaj, I.W. (1992) Cofractionation of the TATA-binding protein with the RNA polymerase III transcription factor TFIIIB. Nucl. Acids Res. 20, 5889-5898.
  79. Jarmolowski, A. and Mattaj, I.W. (1993) The determinants for Sm protein binding to Xenopus U1 and U5 snRNAs are complex and non-identical. EMBO J. 12, 223-232.
  80. Mattaj, I.W., Tollervey, D. and Séraphin, B. (1993) Small nuclear RNAs in messenger RNA and ribosomal RNA processing. FASEB J. 7, 47-53.
  81. Boelens, W.C., Jansen, E.J.R., van Venrooij, W.J., Stripecke, R., Mattaj, I.W. and Gunderson, S.I. (1993) The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. Cell 72, 881-892.
  82. Mattaj, I.W. (1993) RNA recognition: A family matter? Cell 73, 837-840.
  83. Bernués, J., Simmen, K.A., Lewis, J.D., Gunderson, S.I., Polycarpou-Schwarz, M., Moncollin, V., Egly, J.-M. and Mattaj, I.W. (1993) Common and unique transcription factor requirements of human U1 and U6 snRNA genes. EMBO J. 12, 3573-3585.
  84. Mattaj, I.W., Boelens, W., Izaurralde, E., Jarmolowski, A. and Kambach, C. (1993) Nucleocytoplasmic transport and snRNP assembly. Molec. Biol. Reports 18, 79-83.
  85. van Gelder, C.W.G., Gunderson, S.I., Jansen, E.J.R., Boelens, W.C., Polycarpou-Schwarz, M., Mattaj, I.W. and van Venrooij, W.J. (1993) A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. EMBO J. 12, 5191-5200.
  86. Jones, K.M., McPherson, M.J., Baron, A.J., Mattaj, I.W., Riordan, C.L. and Wootton, J.C. (1993) The gdhA1 point mutation in Escherichia coli K12 CLR207 alters a key lysine residue of glutamate dehydrogenase. Mol. Gen. Genet. 240, 286-28.
  87. Jarmolowski, A., Boelens, W.C., Izaurralde, E. and Mattaj, I.W. (1994) Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol. 124, 627-635.
  88. Gunderson, S.I., Beyer, K., Martin, G., Keller, W., Boelens, W.C. and Mattaj, I.W. (1994) The human U1A snRNP protein regulates polyadenylation via a direct interaction with Poly(A) polymerase. Cell 76, 531-541.
  89. Fabre, E., Boelens, W.C., Wimmer, C., Mattaj, I.W. and Hurt, E.C. (1994) Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell 78, 275-289.
  90. Kambach, C. and Mattaj, I.W. (1994) Nuclear transport of the U2 snRNP-specific U2B protein is mediated by both direct and indirect signalling mechanisms. J. Cell Sci. 107, 1807-1816.
  91. Izaurralde, E., Lewis, J., McGuigan, C., Jankowska, M., Darzynkiewicz, E. and Mattaj, I.W. (1994) A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell 78, 657-668.
  92. Mattaj, I.W. (1994) Splicing in space. Nature 372, 727-728.
  93. Nagai, K. and Mattaj, I.W. (1994) RNA-protein interactions in the splicing snRNPs. In "RNA-Protein Interactions". Eds. K. Nagai and I.W. Mattaj. Oxford University Press, pp. 150-177.
  94. Weis, K., Mattaj, I.W. and Lamond, A.I. (1995) Identification of hSRP1α as a functional receptor for nuclear localization sequences. Science 268, 1049-1052.
  95. Izaurralde, E. and Mattaj, I.W. (1995) RNA export. Cell 81, 153-159.
  96. Boelens, W.C., Dargemont, C. and Mattaj, I.W. (1995) Export of mRNA through the nuclear pore complex. In "Pre-mRNA Processing". Ed. A.I. Lamond. R.G. Landes Company, pp. 173-186.
  97. Boelens, W.C., Palacios, I. and Mattaj, I.W. (1995) Nuclear retention of RNA as a mechanism for localization. RNA 1, 273-283.
  98. Mattaj, I.W. and Nagai, K. (1995) Recruiting proteins to the RNA world. Nature Struct. Biol. 2, 518-522.
  99. Izaurralde, E., Lewis, J., Gamberi, C., Jarmolowski, A., McGuigan, C. and Mattaj, I.W. (1995) A cap-binding protein complex mediating U snRNA export. Nature 376, 709-712.
  100. Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W. and Lührmann, R. (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82, 475-483.
  101. Lewis, J.D., Gunderson, S.I. and Mattaj, I.W. (1995) The influence of 5' and 3' end structures on pre-mRNA metabolism. J. Cell Science 19, 13-19.
  102. Izaurralde, E., Mattaj, I.W. and Goldfarb, D.S. (1995) Nuclear transport of uracil-rich small nuclear ribonucleoprotein particles. Membr. Prot. Transport 2, 123-159.
  103. Izaurralde, E., McGuigan, C. and Mattaj I.W. (1995) Nuclear localization of a cap-binding protein complex. Cold Spring Harb. Symp. Quant. Biol. LX, 669-675.
  104. Polycarpou-Schwarz, M., Gunderson, S.I., Kandels-Lewis, S. Séraphin, B. and Mattaj, I.W. (1996) Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B" that are encoded separately in human, potato and yeast. RNA 2, 11-23.
  105. Görlich, D. and Mattaj, I.W. (1996) Nucleocytoplasmic transport. Science 271, 1513-1518.
  106. Palacios, I., Weis, K., Klebe, C., Mattaj, I.W. and Dingwall, C. (1996) RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J. Cell Biol. 133, 485-494.
  107. Visa, N., Izaurralde, E., Ferreira, J., Daneholt, B. and Mattaj, I.W. (1996) A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export. J. Cell Biol. 133, 5-14.
  108. Lewis, J.D., Izaurralde, E., Jarmolowski, A., McGuigan, C. and Mattaj, I.W. (1996) A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. Genes & Dev. 10, 1683-1698.
  109. Lewis, J.D., Görlich, D. and Mattaj, I.W. (1996) A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res. 24, 3332-3336.
  110. Görlich, D., Kraft, R., Kostka, S., Vogel, F., Hartmann, E., Laskey, R.A., Mattaj, I.W. and Izaurralde, E. (1996) Importin provides a link between nuclear protein import and U snRNA export. Cell 87, 21-32.
  111. Stutz, F., Izaurralde, E., Mattaj, I.W. and Rosbash, M. (1996) A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol. Cell. Biol. 16, 7144-7150.
  112. Izaurralde, E., Jarmolowski, A., Beisel, C., Mattaj, I.W., Dreyfuss, G. and Fischer, U. (1997) A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J. Cell Biol. 137, 27-35.
  113. Gamberi, C., Izaurralde, E., Beisel, C. and Mattaj, I.W. (1997) Interaction between the human nuclear cap-binding protein complex and hnRNP F. Mol. Cell. Biol. 17, 2587-2597.
  114. Gunderson, S.I., Vagner, S., Polycarpou-Schwarz, M. and Mattaj, I.W. (1997) Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation. Genes & Dev. 11, 761-773.
  115. Panté, N., Jarmolowski, A., Izaurralde, E., Sauder, U., Baschong, W. and Mattaj, I.W. (1997) Visualizing nuclear export of different classes of RNA by electron microscopy. RNA 3, 498-513.
  116. Fornerod, M., Ohno, M., Yoshida, M. and Mattaj, I.W. (1997) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90, 1051-1060.
  117. Palacios, I., Hetzer, M., Adam, S.A. and Mattaj, I.W. (1997) Nuclear import of U snRNPs requires importin β. EMBO J. 16, 6783-6792.
  118. Arts, G.-J., Englmeier, L. and Mattaj, I.W. (1997) Energy- and temperature-dependent in vitro export of RNA from synthetic nuclei. Biol. Chem. 378, 641-649.
  119. Izaurralde, E., Kutay, U., von Kobbe, C., Mattaj, I.W. and Görlich, D. (1997) The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.EMBO J. 16, 6535-6547.
  120. Flaherty, S.M., Fortes, P., Izaurralde, E., Mattaj, I.W. and Gilmartin, G.M. (1997) Participation of the nuclear cap binding complex in pre-mRNA 3' processing. Proc. Natl. Acad. Sci. USA, 94, 11893-11898.
  121. Kutay, U., Izaurralde, E., Bischoff, F.R., Mattaj, I.W. Görlich D. (1997) Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex. EMBO J. 16, 1153-1163.
  122. Berk, A. and Mattaj, I.W. (1997) Nucleus and gene expression (Editorial for this special issue, for which we were guest editors). Curr. Opin . Cell Biol. 9, 307-309.
  123. Mattaj, I.W. and Englmeier, L. (1998) Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem. 67, 265-306.
  124. Ohno, M., Fornerod, M. and Mattaj, I.W. (1998). Nucleocytoplasmic transport: the last 200 nanometers. Cell, 92, 327-336.
  125. Gunderson, S.I., Polycarpou-Schwarz, M. and Mattaj, I.W. (1998) U1 snRNP regulates pre-mRNA polyadenylation through a direct inhibitory interaction between U1 70K and polyA polymerase. Molecular Cell, 1, 255-264.
  126. . Arts, G.-J., Fornerod, M. and Mattaj, I.W. (1998) Identification of a nuclear export receptor for tRNA. Current Biology, 8, 305-314.
  127. Mattaj, I. W. (1998) Ribonucleoprotein assembly: Clues from spinal muscular atrophy. Current Biology, 8, 93-95.
  128. Arts, G.-J., Kuersten, S., Romby, P., Ehresmann, B. and Mattaj I.W. (1998) The role of exportin-t in selective nuclear export of mature tRNAs. EMBO J. 17, 7430-7441.
  129. . Fortes, P., Kufel, J., Fornerod, M., Polycarpou-Schwarz, M., Lafontaine, D., Tollervey, D. and Mattaj, I.W. (1999) Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol. Cell. Biol. 19, 6543-6553.
  130. Englmeier, L., Olivo, J.-C. and Mattaj, I.W. (1999) Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Curr. Biol. 9, 30-41.
  131. Wilson, K.F., Fortes, P., Singh, U.S., Ohno, M., Mattaj, I.W. and Cerione, R.A. (1999) The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. J. Biol. Chem. 274, 4166-4173.
  132. Ohno, M. and Mattaj, I.W. (1999) Meiosis: MeiRNA hits the spot. Curr. Biol. 9, 66-69.
  133. Askjaer, P., Bachi, A., Wilm, M., Bischoff, R., Weeks, D.L., Ogniewski, V., Ohno, M., Niehrs, C., Kjems, J., Mattaj, I.W. and Fornerod, M. (1999) RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol. Cell. Biol. 19, 6276-6285.
  134. Fortes, P., Bilbao-Cortés, D., Fornerod, M., Rigaut, G., Raymond W., Séraphin, B. and Mattaj, I.W. (1999) Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Genes Dev. 13, 2425-2438.
  135. Carazo-Salas, R.E., Guarguaglini, G., Gruss, O.J., Segref, A., Karsenti, E. and Mattaj, I.W. (1999) Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400, 178-181.
  136. Mattaj, I.W. and Conti, E. (1999) Snail mail to the nucleus. Nature 399, 208-210.
  137. Ségault, V., Will, C.L., Polycarpou-Schwarz, M., Mattaj, I.W., Branlant, C. and Lührmann, R. (1999) Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts. Mol. Cell. Biol. 19, 2782-2790.
  138. Fortes, P., Inada, T., Preiss, T., Hentze, M.W., Mattaj, I.W. and Sachs, A.B. (2000) The yeast nuclear cap-binding complex can interact with translation factor eIF4G and mediate translation initiation. Mol. Cell. 6, 191-196.
  139. Vagner, S., Vagner, C. and Mattaj, I.W. (2000) The carboxyl terminus of vertebrate Poly (A) polymerase interacts with U2AF 65 to couple 3' end processing and splicing. Genes Dev. 14, 403-413.
  140. Vagner, S., Rüegsegger, U., Gunderson, S.I., Keller, W. and Mattaj, I.W. (2000) Position-dependent inhibition of the cleavage step of pre-mRNA 3' end processing by U1 snRNP. RNA 6, 178-188.
  141. Hetzer, M. and Mattaj, I.W. (2000) An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B U snRNP proteins. J. Cell Biol. 148, 293-303.
  142. Ohno, M., Segref, A., Bachi, A., Wilm, M. and Mattaj, I.W. (2000) PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell 101, 187-198.
  143. . Varani, L., Gunderson, S.I., Mattaj, I.W., Kay, L.E., Neuhaus D. and Varani, G. (2000) The NMR structure of the 38 kDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. Nature Struct. Biol. 7, 329-335.
  144. Hetzer, M., Bilbao-Cortés, D., Walther, T.C., Gruss, O.J. and Mattaj, I.W. (2000) GTP Hydrolysis by Ran is required for nuclear envelope assembly. Mol. Cell 5, 1013-1024.
  145. Gruss, O.J., Carazo-Salas, R.E., Schatz, C.A., Guarguaglini, G., Kast, J., Wilm, M., Le Bot, N., Vernos, I., Karsenti, E. and Mattaj, I.W. (2001) Ran induces spindle assembly by reversing the inhibitory effect of importin α on TPX2 activity. Cell 104, 83-93.
  146. Segref, A., Mattaj, I.W. and Ohno, M. (2001) The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export. RNA 7, 351-360.
  147. Walther, T.C., Fornerod, M., Pickersgill, H., Goldberg, M., Allen, T.D. and Mattaj, I.W. (2001) The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J. 20, 5703-5714.
  148. Hetzer, M., Meyer, H.H., Walther, T.C., Bilbao-Cortes, D., Warren, G. and Mattaj, I.W. (2001) Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nature Cell Biol. 3, 1086-1091.
  149. Englmeier, L., Fornerod, M., Bischoff, F.R., Petosa, C., Mattaj, I.W. and Kutay, U. (2001) RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. EMBO reports 2, 926-932.
  150. Koffa, M.D., Clements, J.B., Izaurralde, E., Wadd, S. Wilson, S.A., Mattaj, I.W. and Kuersten, S. (2001) Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J. 20, 5769-5778.
  151. Carazo-Salas, R.E., Gruss, O.J., Mattaj, I.W. and Karsenti, E. (2001) Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Nature Cell Biol. 3, 228-234.
  152. Kuersten, S., Ohno, M. and Mattaj, I.W. (2001) Nucleocytoplasmic transport: Ran, beta and beyond. Review in: Trends in Cell Biology 11, 497-503.
  153. Mazza, C., Ohno, M., Segref, A., Mattaj, I.W. and Cusack, S. (2001) Crystal structure of the human nuclear cap binding complex. Mol. Cell 8, 383-396.
  154. Ohno, M., Segref, A., Kuersten, S. and Mattaj, I.W. (2002) Identity elements used in export of mRNAs. Mol. Cell 9, 659-671.
  155. Walther, T.C., Pickersgill, H.S., Cordes, V.C., Goldberg, M.W., Allen, T.D., Mattaj, I.W. and Fornerod, M. (2002) The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. J. Cell Biol. 158, 63-77.
  156. Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P.B. and Mattaj, I.W. (2002) Ran binds to chromatin by two distinct mechanisms. Curr. Biol. 12, 1151-1156.
  157. Kuersten, S., Arts, G.-J., Walther, T.C., Englmeier, L. and Mattaj, I.W. (2002). Steady state nuclear localization of Exportin-t involves RanGTP binding and two distinct Nuclear Pore Complex interaction domains. Mol. Cell. Biol. 22, 5708-5720.
  158. Hetzer, M., Gruss, O.J. and Mattaj, I.W. (2002). The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biol. 4, 177-184.
  159. Massenet, S., Pellizzoni, L., Paushkin, S., Mattaj, I.W. and Dreyfuss, G. (2002) The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway. Mol Cell Biol. 22, 6533-6541.
  160. Mazza, C., Segref, A., Mattaj, I.W. and Cusack, S. (2002) Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering. Acta Crystallogr. 58, 2194-2197.
  161. . Mazza, C., Segref, A., Mattaj, I.W. and Cusack, S. (2002) Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. EMBO J. 21, 5548-5557.
  162. Askjaer, P., Galy, V., Hannak, E. and Mattaj, I.W. (2002). Ran GTPase cycle and Importins α and β are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol. Biol. Cell 13, 4355-4370.
  163. Gruss, O.J., Wittmann, M., Yokoyama, H., Pepperkok, R., Kufer, T., Silljé, H., Karsenti, E., Mattaj, I.W. and Vernos, I. (2002) Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nature Cell Biol. 4, 871-879.
  164. Becskei, A. and Mattaj, I.W. (2003) The strategy for coupling the RanGTP gradient to nuclear protein export. PNAS 100, 1717-1722.
  165. Schatz, C.A., Santarella, R., Hönger, A., Karsenti, E., Mattaj, I.W., Gruss, O.J. and Carazo-Salas, R.E. (2003) Importin α-regulated nucleation of microtubules by TPX2. EMBO J. 22, 2060-2070.
  166. Walther, T.C., Alves, A., Pickersgill, H., Loïodice, I., Hetzer, M., Galy, V., Hülsmann, B.B., Köcher, T., Wilm, M., Allen, T., Mattaj, I.W. and Doye, V. (2003) The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113, 195-206.
  167. Walther, T.C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj, I.W. and Hetzer, M. (2003) RanGTP mediates nuclear pore complex assembly. Nature 424, 689-694.
  168. Galy, V., Mattaj, I.W. and Askjaer, P. (2003) C. elegans nucleoporins Nup93 and Nup205 determine the limit of nulcear pore complex size exclusion in vivo. Mol. Biol. Cell 14, 5104-5115.
  169. Mattaj, I.W. (2004) Sorting out the nuclear envelope from the endoplasmic reticulum. Nature Rev. Mol. Cell Biol. 5, 65-69.
  170. Hachet, V., Köcher, T., Wilm, M. and Mattaj, I.W. (2004) Importin α associates with membranes and participates in Nuclear Envelope Assembly in vitro. EMBO J. 23, 1526-1535.
  171. Yamada, M., Mattaj, I.W. and Yoneda, Y. (2004) An ATP-dependent activity that releases RanGDP from NTF2. J. Biol. Chemistry 279, 36228-36234
  172. Petosa, C., Schoehn, G., Askjaer, P., Bauer, U., Moulin, M., Steuerwald, U., Soler-Lopez, M., Baudin, F., Mattaj, I.W. and Muller, C.W. (2004) Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Mol. Cell 16, 761-775.
  173. Antonin, W. and Mattaj, I.W. (2005) Nuclear pore complexes: Round the bend? Nature Cell Biol. 7, 10-12.
  174. Antonin, W., Franz, C., Haselmann, U., Antony, C. and Mattaj, I.W. (2005) The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation. Mol. Cell 17, 83-92.
  175. Hetzer, M., Walther, T.C. and Mattaj, I.W. (2005). Pushing the Envelope: Structure, Function and dynamics of the nuclear periphery. Annu. Rev. Cell Dev. Biol. 21, 347-380.
  176. Czaplinski, K., Köcher, T., Schelder, M., Segref, A., Wilm, M. and Mattaj, I.W. (2005) Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-β-related mRNA during oogenesis. Dev. Cell 8, 505-515.
  177. Becskei, A. and Mattaj, I.W. (2005) Quantitative models of nuclear transport. Curr. Opin. Cell. Biol. 17, 27-34
  178. Franz, C., Askjaer, P., Antonin, W., López Iglesias, C., Haselmann, U., Schelder, M., Wilm, M., Antony, C. and Mattaj, I.W. (2005) Nup155 is essential for an early step in nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. EMBO J. 24, 3519-3533.
  179. Schetter, A., Askjaer, P.,Piano, F., Mattaj, I. W. and Kemphues, K. J. (2006) Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Dev. Biol. 289, 360-71.
  180. Czaplinski, K. and Mattaj, I.W. (2006) 40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-Localization Element. RNA 12, 213-22.
  181. Ribbeck, K., Groen, A.C., Santarella, R., Bohnsack, M.T., Raemaekers, T., Kocher, T., Gentzel, M., Gorlich, D., Wilm, M., Carmeliet, G., Mitchison, T.J., Ellenberg, J., Hoenger, A., and Mattaj, I.W. (2006) NuSAP, a Mitotic RanGTP Target That Stabilizes and Cross-links Microtubules. Mol Biol Cell. 17, 2646-60
  182. Mansfeld, J., Guttinger S., Hawryluk-Gara L.A., Pante N., Mall M., Galy V., Haselmann U., Muhlhausser P., Wozniak R.W., Mattaj I.W., Kutay U., and Antonin, W. (2006) The Conserved Transmembrane Nucleoporin NDC1 Is Required for Nuclear Pore Complex Assembly in Vertebrate Cells. Mol Cell. 22, 93-103
  183. Koffa, M.D., Casanova, C.M., Santarella, R., Kocher,T., Wilm, M., and Mattaj, I.W. (2006) HURP Is Part of a Ran-Dependent Complex Involved in Spindle Formation. Curr Biol. 16: 743-54.
  184. Ribbeck, K., Raemaekers, T., Carmeliet, G., and Mattaj, I.W. (2007) A role for NuSAP in linking microtubules to mitotic chromosomes. Curr Biol, 17(3), 230-236.
  185. Ulbert, S., Platani, M., Boue, S., and Mattaj, I.W. (2006) Direct membrane protein-DNA interactions required early in nuclear envelope assembly. J. Cell Biol, 173, 469-76.
  186. Galy, V., Askjaer, P., Franz, C., López-Iglesias, C., and Mattaj, I.W. (2006) MEL-28, a novel nuclear envelope and kinetochore protein essential for zygotic nuclear envelope assembly in C. elegans. Curr Biol, 16, 1748-1756.
  187. Gorjánácz, M., Klerkx, E.P.F., Galy, V., Santarella. R., López-Iglesias, C., Askjaer. P., and Mattaj, I.W. (2007) C. elegans BAF-1 and its kinase VRK-1 participate directly in postmitotic nuclear envelope assembly. EMBO J. 26, 132-143.
  188. Ulbert, S., Antonin, W., Platani, M., and Mattaj, I.W. (2006) The inner nuclear membrane protein LEM2 is critical for normal nuclear envelope morphology. FEBS Letters 580, 6435-6441.
  189. Franz, C., Walczak, R., Yavuz, S., Santarella, R., Gentzel, M., and Antonin, W. (2007) MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO Reports, 8, 165-172.
  190. Gorjánácz, M., Jaedicke, A., and Mattaj, I.W. (2007) What can Caenorhabditis elegans tell us about the nuclear envelope? FEBS Letters 581, 2794-801.
  191. Mattaj, I.W., and Tocchini-Valentini, G.W. (2007) Laying solid foundations for Europe. Nature, 447, 377-378.
  192. Fortes, P., Longman, D., McCracken, S., Ip, J.Y., Poot, R., Mattaj, I.W., Caceres, J.F., and Blencowe, B.J. (2007) Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. FEBS Letters 581, 3087-3097.
  193. Arai, K., Cech, T., Chameau, J.L., Horn, P., Mattaj, I.W., Potocnik, J., and Wiley, J. (2007) The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century? EMBO Reports, 9, 804-810.
  194. Kitao, S., Segref, A., Kast, J., Wilm, M., Mattaj, I.W., Ohno, M. (2008) A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus. Mol Cell Biol, 28, 487-97.
  195. Galy, V., Antonin, W., Jaedicke, A., Sachse, M., Santarella, R., Haselmann, U., Mattaj, I.W. (2008) A role for gp210 in mitotic nuclear envelope breakdown. J Cell Sci. 121, 317-28,
  196. Yokoyama, H., Gruss, O.J., Rybina, S., Caudron, M., Schelder, M., Wilm, M., Mattaj, I.W., and Karsenti, E. (2008) CDK11 is a chromosome-dependent microtubule stabilization factor essential for maintenance of spindle assembly rate. J Cell Biol. 180, 867-75.
  197. Hawryluk-Gara, L.A., Platani, M., Santarella, R., Wozniak R.W., Mattaj, I.W. (2008) Nup53 is required for nuclear envelope and nuclear pore complex assembly. Mol Biol Cell 19, 1753-62
  198. Cohen, M., Santarella, R., Wiesel, N., Mattaj, I.W., Gruenbaum, Y. (2008) Electron microscopy of lamin and the nuclear lamina in Caenorhabditis elegans. Methods Cell Biol. 88, 411-29.
  199. Casanova, C.M., Rybina, S., Yokoyama, H., Karsenti, E., Mattaj, I.W. (2008) HURP is required for Chromatin-induced Microtubule Assembly independently of TPX2. Mol Biol Cell 19, p. 4900-4908.
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