Hanns Möhler - Achievements#


In the tradition of Claude Bernard (1813-1878), we are using drugs as tools to investigate the function of the brain. In this endeavour, the target for tranquillizing drugs of the type of Valium was discovered (benzodiazepine receptor). This discovery revealed an inhibitory neuronal break-system (GABA-transmission) which operates ubiquitously in the brain to keep the excitatory stimuli in check. This break system ensures the overall balance of brain activity. A dysfunctional inhibition system can cause anxiety disorders and – in extreme cases – epilepsy. In the meantime, we and others have discovered more than a dozen inhibitory sub-systems in the brain. These more regionally effective break-systems offer the possibility to act as more selective drug targets. Disorders such as dementia, schizophrenia and pain can now be specifically targeted. Novel drugs are also expected to lack the side effects of the classical benzodiazepines.



Any further pages in alphabetic order of their title as created by you.
#

Just click at "Create new page", then type a short title and click OK, then add information on the empty page presented to you (including maybe a picture from your harddisk or a pdf-file by using the "Upload" Button) and finally click at "Save".
...no Data available yet!

Imprint Privacy policy « This page (revision-2) was last updated on Monday, 17. May 2010, 16:16 by System
  • operated by