Martin Humphries- Publications#


  • 2014
    • Guillaume Jacquemet and Martin Humphries. (2014). IQGAP1 is a key node within the small GTPase network. Small GTPases, eScholarID:223587
    • Lennon, R., Byron, A., Humphries, J.D., Randles, M.R., Carisey, A., Murphy, S., Knight, D., Brenchley, P.E., Zent, R. and Humphries, M.J. . (2014). Global analysis reveals the complexity of the human glomerular extracellular matrix. J A S N, eScholarID:236677
    • Mould, P., Craig, S., Byron, S., Humphries, M. & Jowitt, T (2014). Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors. B J, 464(3), 301-313. eScholarID:265872 | DOI:10.1042/BJ20141047
  • 2013
    • Morgan, M., Hamidi, H., Bass, M., Warwood, S., Ballestrem, C. & Humphries, M (2013). Syndecan-4 phosphorylation is a control point for integrin recycling. Dev Cell, 24(5), 472-85. eScholarID:213700 | PMID:23453597 | DOI:10.1016/j.devcel.2013.01.027
    • Byron, A., Humphries, J. & Humphries, M (2013). Defining the extracellular matrix using proteomics. Int J Exp Pathol, eScholarID:188544 | PMID:23419153 | DOI:10.1111/iep.12011
    • Kong, F., Li, Z., Parks, W., Dumbauld, D., García, A., Mould, A., Humphries, M. & Zhu, C (2013). Cyclic Mechanical Reinforcement of Integrin-Ligand Interactions. Mol Cell, eScholarID:188543 | PMID:23416109 | DOI:10.1016/j.molcel.2013.01.015
    • Lin, G., Cohen, D., Desai, R., Breckenridge, M., Gao, L., Humphries, M. & Chen, C (2013). Activation of beta 1 but not beta 3 integrin increases cell traction forces. FEBS Lett, eScholarID:188542 | PMID:23395612 | DOI:10.1016/j.febslet.2013.01.068
  • 2012
    • Le Goff, M., Sutton, M., Slevin, M., Latif, A., Humphries, M. & Bishop, P (2012). Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. J Biol Chem, 287(33), 28027-36. eScholarID:188545 | PMID:22669977 | DOI:10.1074/jbc.M111.331157
    • Rashid, S., Humphries, J., Byron, A., Dhar, A., Askari, J., Selley, J., Knight, D., Goldin, R., Thursz, M. & Humphries, M (2012). Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. J Proteome Res, 11(8), 4052-64. eScholarID:188547 | PMID:22694338 | DOI:10.1021/pr3000927
    • Byron, A., Humphries, J., Craig, S., Knight, D. & Humphries, M (2012). Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Proteomics, 12(13), 2107-14. eScholarID:188548 | PMID:22623428 | DOI:10.1002/pmic.201100487
    • Tonge, D., de Burgh, H., Docherty, R., Humphries, M., Craig, S. & Pizzey, J (2012). Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro. Brain Res, 1453, 8-16. eScholarID:188546 | PMID:22483961 | DOI:10.1016/j.brainres.2012.03.024
  • 2011
    • Bass, M., Williamson, R., Nunan, R., Humphries, J., Byron, A., Morgan, M., Martin, P. & Humphries, M (2011). A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis. Developmental cell, 21(4), 681. eScholarID:134911 | PMID:21982645 | DOI:10.1016/j.devcel.2011.08.007
    • Rantala, J., Pouwels, J., Pellinen, T., Veltel, S., Laasola, P., Mattila, E., Potter, C., Duffy, T., Sundberg, J., Kallioniemi, O., Askari, J., Humphries, M., Parsons, M., Salmi, M. & Ivaska, J (2011). SHARPIN is an endogenous inhibitor of β1-integrin activation. Nat Cell Biol, eScholarID:134912 | PMID:21947080 | DOI:10.1038/ncb2340
    • Tiwari, S., Askari, J., Humphries, M. & Bulleid, N (2011). Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking. J Cell Sci, 124(Pt 10), 1672-80. eScholarID:134913 | PMID:21511727 | DOI:10.1242/jcs.084483
    • Campbell, I. & Humphries, M (2011). Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol, 3(3), eScholarID:134909 | PMID:21421922 | DOI:10.1101/cshperspect.a004994
    • Byron, A., Humphries, J., Bass, M., Knight, D. & Humphries, M (2011). Proteomic analysis of integrin adhesion complexes. Sci Signal, 4(167), pt2. eScholarID:134910 | PMID:21467297 | DOI:10.1126/scisignal.2001827
  • 2010
    • Askari, J.A., Tynan, C.J., Webb, S.E.D., Martin-Fernandez, M.L., Ballestrem, C., Humphries, M.J. (2010). Focal adhesions are sites of integrin extension. Journal of Cell Biology, 188, 891-903. eScholarID:81444 | DOI:10.1083/jcb.200907174
    • Worth DC, Hodivala-Dilke K, Robinson SD, Morton PE, Gertler FB, Humphries MJ, Parsons M. (2010). αVβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. 189, 369-383. eScholarID:81447
    • Schubert T, Schlegel J, Schmid R, Opolka A, Grässel S, Humphries M, Bosserhoff A-K. (2010). Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP). Experimental Molecular Medicine, 42, 166-174. eScholarID:81449 | DOI:10.3858/emm.2010.42.3.017
  • 2009
    • Mould, A., Koper, E., Byron, A., Zahn, G. & Humphries, M (2009). Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. Biochem J, eScholarID:2578 | PMID:19747169 | DOI:10.1042/BJ20090992
    • Humphries, J., Byron, A., Bass, M., Craig, S., Pinney, J., Knight, D. & Humphries, M (2009). Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal, 2(87), ra51. eScholarID:2579 | PMID:19738201 | DOI:10.1126/scisignal.2000396
    • Faye, C., Moreau, C., Chautard, E., Jetne, R., Fukai, N., Ruggiero, F., Humphries, M., Olsen, B. & Ricard-Blum, S (2009). Molecular interplay between endostatin, integrins, and heparan sulfate. J Biol Chem, 284(33), 22029-40. eScholarID:2582 | PMID:19502598 | DOI:10.1074/jbc.M109.002840
    • Morgan, M., Byron, A., Humphries, M. & Bass, M (2009). Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour. IUBMB Life, 61(7), 731-8. eScholarID:2581 | PMID:19514020 | DOI:10.1002/iub.200
    • Kong, F., García, A., Mould, A., Humphries, M. & Zhu, C (2009). Demonstration of catch bonds between an integrin and its ligand. Journal of cell biology, 185(7), 1275. eScholarID:2580 | PMID:19564406 | DOI:10.1083/jcb.200810002
    • Deakin, N., Bass, M., Warwood, S., Schoelermann, J., Mostafavi-Pour, Z., Knight, D., Ballestrem, C. & Humphries, M (2009). An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. J Cell Sci, 122(Pt 10), 1654-64. eScholarID:2584 | PMID:19401330 | DOI:10.1242/jcs.049130
    • Bass, M., Morgan, M. & Humphries, M (2009). Syndecans shed their reputation as inert molecules. Sci Signal, 2(64), pe18. eScholarID:2585 | PMID:19336838 | DOI:10.1126/scisignal.264pe18
    • Humphries, M (2009). Cell adhesion assays. Methods Mol Biol, 522, 203-10. eScholarID:2586 | PMID:19247616 | DOI:10.1007/978-1-59745-413-1_14
    • Valdembri D, Caswell PT, Anderson KI, Schwarz JP, König I, Astanina E, Caccavari F, Norman JC, Humphries MJ, Bussolino F, Serini G. (2009). Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS biology, 7(1), 115-132. eScholarID:1c8131 | PMID:19175293 | DOI:10.1371/journal.pbio.1000025
    • Askari JA, Buckley PA, Mould AP, Humphries MJ. (2009). Linking integrin conformation to function. Journal of cell science, 122(Pt 2), 165-70. eScholarID:1c8129 | PMID:19118208 | DOI:10.1242/jcs.018556
    • Mahoney CM, Morgan MR, Harrison A, Humphries MJ, Bass MD. (2009). Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate Rac1. The Journal of biological chemistry, eScholarID:1c8130 | PMID:19147498 | DOI:10.1074/jbc.M804281200
    • Byron, A., Humphries, J.D., Askari, J.A., Craig, S.E., Mould, A.P., Humphries, M.J. (2009). Anti-integrin monoclonal antibodies. Journal of Cell Science, 122, 4009-4011. eScholarID:81442 | DOI:10.1242/jcs.056770
  • 2008
    • Valdramidou D, Humphries MJ, Mould AP. (2008). Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1. The Journal of biological chemistry, 283(47), 32704-14. eScholarID:1c8128 | PMID:18820259 | DOI:10.1074/jbc.M802066200
    • Telci D, Wang Z, Li X, Verderio EA, Humphries MJ, Baccarini M, Basaga H, Griffin M. (2008). Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. The Journal of biological chemistry, 283(30), 20937-47. eScholarID:1c8126 | PMID:18499669 | DOI:10.1074/jbc.M801763200
    • Bass MD, Morgan MR, Roach KA, Settleman J, Goryachev AB, Humphries MJ. (2008). p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4. The Journal of cell biology, 181(6), 1013-26. eScholarID:1c8127 | PMID:18541700 | DOI:10.1083/jcb.200711129
    • Kloepper JE, Hendrix S, Bodó E, Tiede S, Humphries MJ, Philpott MP, Fässler R, Paus R. (2008). Functional role of beta 1 integrin-mediated signalling in the human hair follicle. Experimental cell research, 314(3), 498-508. eScholarID:1c8123 | PMID:18155697 | DOI:10.1016/j.yexcr.2007.10.030
    • Parsons M, Messent AJ, Humphries JD, Deakin NO, Humphries MJ. (2008). Quantification of integrin receptor agonism by fluorescence lifetime imaging. Journal of cell science, 121(Pt 3), 265-71. eScholarID:1c8124 | PMID:18216331 | DOI:10.1242/jcs.018440
  • 2007
    • Morgan MR, Humphries MJ, Bass MD. (2007). Synergistic control of cell adhesion by integrins and syndecans. Nature reviews. Molecular cell biology, 8(12), 957-69. eScholarID:1c8121 | PMID:17971838 | DOI:10.1038/nrm2289
    • Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC. (2007). Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Developmental cell, 13(4), 496-510. eScholarID:1c8122 | PMID:17925226 | DOI:10.1016/j.devcel.2007.08.012
    • Bass MD, Roach KA, Morgan MR, Mostafavi-Pour Z, Schoen T, Muramatsu T, Mayer U, Ballestrem C, Spatz JP, Humphries MJ. (2007). Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. The Journal of cell biology, 177(3), 527-38. eScholarID:1c6840 | PMID:17485492 | DOI:10.1083/jcb.200610076
    • Bax DV, Mahalingam Y, Cain S, Mellody K, Freeman L, Younger K, Shuttleworth CA, Humphries MJ, Couchman JR, Kielty CM. (2007). Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation. Journal of cell science, 120(Pt 8), 1383-1392. eScholarID:1c6519 | PMID:17374638 | DOI:10.1242/jcs.003954
    • Askari JA, Thornton DJ, Humphries JD, Buckley PA, Humphries MJ. (2007). The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module. Matrix Biology, 26, 485-93. eScholarID:1c6590 | PMID:17490871 | DOI:10.1016/j.matbio.2007.04.001
    • Humphries JD, Humphries MJ. (2007). CD14 is a ligand for the integrin alpha4beta1. FEBS letters, 581(4), 757-63. eScholarID:1c6842 | PMID:17274987 | DOI:10.1016/j.febslet.2007.01.038
    • Watson PM, Humphries MJ, Relton J, Rothwell NJ, Verkhratsky A, Gibson RM. (2007). Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Molecular and cellular neurosciences, 34(2), 147-54. eScholarID:1c6527 | PMID:17150373 | DOI:10.1016/j.mcn.2006.10.007
    • Bass MD, Morgan MR, Humphries MJ. (2007). Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation. Eur. Physical J. E Soft Matter, 3(3), 372-376. eScholarID:1c6841 | PMID:17372617 | DOI:10.1039/b614610d
    • Humphries JD, Wang P, Streuli CH, Geiger B, Humphries MJ, Ballestrem C. (2007). Vinculin controls focal adhesion formation by direct interactions with talin and actin. Journal of Cell Biology, 179, eScholarID:1c7398 | DOI:10.1083/jcb.200703036
    • Gardiner NJ, Moffatt S, Fernyhough P, Humphries MJ, Streuli CH and Tomlinson DR. (2007). Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal a5 integrin. Molecular and Cellular Neuroscience, 35(2), 249-60. eScholarID:1c6508 | DOI:10.1016/j.mcn.2007.02.020
  • 2006
    • Humphries JD, Byron A, Humphries MJ. (2006). Integrin ligands at a glance. Journal of Cell Science, 119(Pt 19), 3901-3. eScholarID:1c5342 | PMID:16988024 | DOI:10.1242/jcs.03098
    • Wijelath ES, Rahman S, Namekata M, Murray J, Nishimura T, Mostafavi-Pour Z, Patel Y, Suda Y, Humphries MJ, Sobel M. (2006). Heparin-II Domain of Fibronectin Is a Vascular Endothelial Growth Factor-Binding Domain. Enhancement of VEGF Biological Activity by a Singular Growth Factor/Matrix Protein Synergism. eScholarID:1c5341 | PMID:17008606 | DOI:10.1161/01.RES.0000246849.17887.66
    • Sumathipala RN, Xu C, Seago J, Mould AP, Humphries MJ, Craig SE, Patel Y, Wijelath ES, Sobel M, Rahman S. (2006). The "linker" region (aa 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha 5beta 1-dependent cell adhesion on fibronectin. eScholarID:1c5343 | PMID:16982624 | DOI:10.1074/jbc.M603943200
    • Turner NJ, Murphy MO, Kielty CM, Shuttleworth CA, Black RA, Humphries MJ, Walker MG, Canfield AE. (2006). Alpha2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an alpha2beta1 integrin-dependent mechanism: an in vitro and in vivo study. Circulation, 114(8), 820-829. eScholarID:1c5344 | PMID:16908762 | DOI:10.1161/CIRCULATIONAHA.106.635292
    • Bauer R, Humphries M, Fässler R, Winklmeier A, Craig SE, Bosserhoff AK. (2006). Regulation of integrin activity by MIA. The Journal of biological chemistry, 281(17), 11669-77. eScholarID:1c5455 | PMID:16517605 | DOI:10.1074/jbc.M511367200
    • Mould AP, McLeish JA, Huxley-Jones J, Goonesinghe AC, Hurlstone AF, Boot-Handford RP, Humphries MJ. (2006). Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio). BMC cell biology electronic resource, 7, 24. eScholarID:1c5345 | PMID:16787535 | DOI:10.1186/1471-2121-7-24
  • 2005
    • Mould AP, Travis MA, Barton SJ, Hamilton JA, Askari JA, Craig SE, Macdonald PR, Kammerer RA, Buckley PA, Humphries MJ. (2005). Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. The Journal of biological chemistry, 280(6), 4238-46. eScholarID:1c5461 | PMID:15557320 | DOI:10.1074/jbc.M412240200
    • Humphries MJ, Mostafavi-Pour Z, Morgan MR, Deakin NO, Messent AJ, Bass MD. (2005). Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading. Novartis Foundation symposium, 269, 178-88; discussion 188-92, 223-30. eScholarID:1c5456 | PMID:16355540 | DOI:10.1002/047001766X.ch14
    • Ewan R, Huxley-Jones J, Mould AP, Humphries MJ, Robertson DL, Boot-Handford RP. (2005). The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family. BMC evolutionary biology electronic resource, 5(1), 31. eScholarID:1c5459 | PMID:15892888 | DOI:10.1186/1471-2148-5-31
    • Bella J, Humphries MJ. (2005). Calpha-H...O=C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions. BioMed Central Structural Biology, 5(1), 4. eScholarID:1c3713 | PMID:15710040 | DOI:10.1186/1472-6807-5-4
    • Gibson RM, Craig SE, Heenan L, Tournier C, Humphries MJ. (2005). Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells. Molecular and cellular neurosciences, 28(3), 588-98. eScholarID:1c4386 | PMID:15737747 | DOI:10.1016/j.mcn.2004.11.004
    • Humphries JD, Schofield NR, Mostafavi-Pour Z, Green LJ, Garratt AN, Mould AP, Humphries MJ. (2005). Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors. Journal of Biological Chemistry, 280(11), 10234-43. eScholarID:1c4387 | PMID:15632175 | DOI:10.1074/jbc.M411102200
    • Clark K, Pankov R, Travis MA, Askari JA, Mould AP, Craig SE, Newham P, Yamada KM, Humphries MJ. (2005). A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. Journal of cell science, 118(Pt 2), 291-300. eScholarID:1c4388 | PMID:15615773 | DOI:10.1242/jcs.01623
    • Gläsner J, Blum H, Wehner V, Stilz HU, Humphries JD, Curley GP, Mould AP, Humphries MJ, Hallmann R, Röllinghoff M, Gessner A. (2005). A small molecule alpha4beta1 antagonist prevents development of murine lyme arthritis without affecting protective immunity. Journal of immunology (Baltimore, Md. : 1950), 175(7), 4724-34. eScholarID:1c4389 | PMID:16177120
    • Meng X, Cheng K, Krohkin O, Mould AP, Humphries MJ, Ens W, Standing K, Wilkins JA. (2005). Evidence for the presence of a low-mass beta1 integrin on the cell surface. Journal of cell science, 118(Pt 17), 4009-16. eScholarID:1c4390 | PMID:16105875 | DOI:10.1242/jcs.02520
    • Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA. (2005). Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. The Journal of cell biology, 168(3), 501-11. eScholarID:1c4391 | PMID:15684035 | DOI:10.1083/jcb.200404112
    • Dallas SL, Sivakumar P, Jones CJ, Chen Q, Peters DM, Mosher DF, Humphries MJ, Kielty CM. (2005). Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. Journal of Biological Chemistry, 280(19), 18871-80. eScholarID:1c4392 | PMID:15677465 | DOI:10.1074/jbc.M410762200
  • 2004
    • Bax DV, Messent AJ, Tart J, Van Hoang M, Kott J, Maciewicz RA, Humphries MJ. (2004). Integrin alpha 5beta 1 and TNFalpha converting enzyme (TACE/ADAM-17) interact in vitro and colocalise in migrating HeLa cells. Journal of Biological Chemistry, 279, 22377-22386. eScholarID:1c2275 | PMID:14970227 | DOI:10.1074/jbc.M400180200
    • Barton SJ, Travis MA, Askari JA, Buckley PA, Craig SE, Humphries MJ, Mould AP. (2004). Novel activating and inactivating mutations in the integrin beta1 subunit A domain. The Biochemical journal, 380, 401-407. eScholarID:1c2276 | PMID:14967067 | DOI:10.1042/BJ20031973
    • Travis MA, Van Der Flier A, Kammerer RA, Paul Mould A, Sonnenberg A, Humphries MJ. (2004). Interaction of filamin A with the integrin beta7 cytoplasmic domain: role of alternative splicing and phosphorylation. FEBS letters, 569(1-3), 185-90. eScholarID:1c2567 | PMID:15225631 | DOI:10.1016/j.febslet.2004.04.099
    • Mould AP, Travis MA, Humphries MJ, Clark K. (2004). Mechanisms of integration of cells and extracellular matrices by integrins. Biochemical Society transactions, 32(Pt 5), 822-5. eScholarID:1c2980 | PMID:15494024
    • Mould AP, Humphries MJ. (2004). Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? Current opinion in cell biology, 16(5), 544-51. eScholarID:1c2981 | PMID:15363805 | DOI:10.1016/j.ceb.2004.07.003
    • Craig SE, Humphries MJ, Kirby H, Zhang X, Moy VT. (2004). Molecular Basis for the Dynamic Strength of the Integrin {alpha}4{beta}1/VCAM-1 Interaction. Biophysical journal, 87(5), 3470-3478. eScholarID:1c2982 | PMID:15347595 | DOI:10.1529/biophysj.104.045690
    • Humphries MJ. (2004). Monoclonal antibodies as probes of integrin priming and activation. Biochemical Society transactions, 32(Pt3), 407-11. eScholarID:1c2983 | PMID:15157148 | DOI:10.1042/BST0320407
  • 2003
    • Mould AP, Symonds EJ, Buckley PA, Grossmann JG, McEwan PA, Barton SJ, Askari JA, Craig SE, Bella J, Humphries MJ. (2003). Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. Journal of Biological Chemistry, 278(41), 39993-9. eScholarID:1c1395 | PMID:12871973 | DOI:10.1074/jbc.M304627200
    • Humphries MJ, McEwan PA, Barton SJ, Buckley PA, Bella J, Paul Mould A. (2003). Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble. Trends in biochemical sciences, 28(6), 313-20. eScholarID:1c1396 | PMID:12826403 | DOI:10.1016/S0968-0004(03)00112-9
    • Bax DV, Bernard SE, Lomas A, Morgan A, Humphries J, Shuttleworth CA, Humphries MJ, Kielty CM. (2003). Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. Journal of Biological Chemistry, 278(36), 34605-34616. eScholarID:1c1915 | PMID:12807887 | DOI:10.1074/jbc.M303159200
    • Mould AP, Barton SJ, Askari JA, Craig SE, Humphries MJ. (2003). Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. Journal of Biological Chemistry, 278(51), 51622-9. eScholarID:1c2029 | PMID:14532288 | DOI:10.1074/jbc.M306655200
    • Humphries MJ, Symonds EJ, Mould AP. (2003). Mapping functional residues onto integrin crystal structures. Current opinion in structural biology, 13(2), 236-43. eScholarID:1c2030 | PMID:12727518 | DOI:10.1016/S0959-440X(03)00035-6
    • Travis MA, Humphries JD, Humphries MJ. (2003). An unraveling tale of how integrins are activated from within. Trends in pharmacological sciences, 24(4), 192-7. eScholarID:1c2031 | PMID:12707006 | DOI:10.1016/S0165-6147(03)00069-5
    • Mostafavi-Pour Z, Askari JA, Parkinson SJ, Parker PJ, Ng TT, Humphries MJ. (2003). Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. The Journal of cell biology, 161(1), 155-67. eScholarID:1c2032 | PMID:12695503 | DOI:10.1083/jcb.200210176
    • Mould AP, Barton SJ, Askari JA, McEwan PA, Buckley PA, Craig SE, Humphries MJ. (2003). Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement. Journal of Biological Chemistry, 278(19), 17028-35. eScholarID:1c2033 | PMID:12615914 | DOI:10.1074/jbc.M213139200
    • D V Bax, SE Bernard, A Lomas, A Morgan, Shuttleworth CC.A, Humphries MM.J, Kielty CM. (2003). Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by a5B1 and avB3 integrins. J. Biol. Chem, 278, 34605-34616. eScholarID:1d25420 | DOI:10.1074/jbc.M303159200
  • 2002
    • Koch A, Whittard JD, Mould AP, Pertz O, Engel J, Craig SE, Humphries MJ. (2002). E-cadherin is a ligand for integrin alpha2beta1. Matrix biology : journal of the International Society for Matrix Biology, 21(6), 525-32. eScholarID:1c2984 | PMID:12392763 | DOI:10.1016/S0945-053X(02)00037-9
    • Bass MD, Humphries MJ. (2002). Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. The Biochemical journal, 368(Pt 1), 1-15. eScholarID:1c2985 | PMID:12241528 | DOI:10.1042/BJ20021228
    • Parker PJ, Humphries MJ, Gilchrist R, Hart IR, Hughes WE, Keppler MD, Kline A, Messent A, Ng T, Parsons M, Quittau-Prevostel C. (2002). Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and cellular biology, 22(16), 5897-911. eScholarID:1c2986 | PMID:12138200 | DOI:10.1128/MCB.22.16.5897-5911.2002
    • Humphries MJ. (2002). Insights into integrin-ligand binding and activation from the first crystal structure. Arthritis research, 4 Suppl, S69-78. eScholarID:1c2987 | PMID:12110125 | DOI:10.1186/ar563
    • Barton S, Kline AD, Mould AP, McEwan PA, Craig SE, Humphries MJ, Askari JA. (2002). Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. Journal of Biological Chemistry, 277(22), 19800-5. eScholarID:1c2988 | PMID:11893752 | DOI:10.1074/jbc.M201571200
    • Farndale RW, Korda M, Humphries MJ, Tuckwell D, Aquilina A, Bergelson JM. (2002). A novel gain-of-function mutation of the integrin alpha2 VWFA domain. European journal of biochemistry / FEBS, 269(4), 1136-44. eScholarID:1c2989 | PMID:11856343 | DOI:10.1046/j.0014-2956.2001.02740.x
    • Craig SE, Humphries MJ, Halbleib JL, Peters DM, Peterson JA, Santas AJ. (2002). Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading. Journal of Biological Chemistry, 277(16), 13650-8. eScholarID:1c2990 | PMID:11832485 | DOI:10.1074/jbc.M111361200
  • 2001
    • Humphries, M (2001). Cell-substrate adhesion assays. Curr Protoc Cell Biol, Chapter 9, Unit 9.1. eScholarID:2588 | PMID:18228391 | DOI:10.1002/0471143030.cb0901s00
    • Humphries MJ. (2001). Cell-substrate adhesion assays. Current protocols in cell biology / editorial board, Juan S. Bonifacino ... et al., Chapter 9, Unit 9.1. eScholarID:1c8125 | PMID:18228391 | DOI:10.1002/0471143030.cb0901s00
    • Hicks MS, O"Leary V, Wilkin M, Bee SE, Humphries MJ, Baron M. (2001). DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern. Development genes and evolution, 211(5), 263-7. eScholarID:1c1391 | PMID:11455443 | DOI:10.1007/s004270100146
    • Humphries MJ. (2001). Cell adhesion assays. Molecular biotechnology, 18(1), 57-61. eScholarID:1c2991 | PMID:11439699 | DOI:10.1385/MB:18:1:57
    • Kline AD, Robinson MK, Coe AP, Stephens PE, Humphries MJ, Kirby H, Askari JA. (2001). Generation of a minimal alpha5beta1 integrin-Fc fragment. Journal of Biological Chemistry, 276(38), 35854-66. eScholarID:1c2992 | PMID:11389148 | DOI:10.1074/jbc.M103639200
    • Mostafavi-Pour Z, Whittard JD, Humphries MJ, Askari JA. (2001). Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants. Matrix biology : journal of the International Society for Matrix Biology, 20(1), 63-73. eScholarID:1c2993 | PMID:11246004 | DOI:10.1016/S0945-053X(00)00131-1


Imprint Privacy policy « This page (revision-2) was last updated on Wednesday, 8. July 2015, 14:42 by Nowak Aleksandra
  • operated by