Péter Hegyi - Selected Publications#


THREE MAJOR DISCOVERIES WITH HIGH IMPACT IN THE FIELD

Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P. Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology. 2015 Feb;148(2):427-39.e16. (discovery of a new therapeutic target in pancreatitis, the paper was highligted in Nature Reviews HG.)

Pallagi P, Venglovecz V, Rakonczay Z Jr, Borka K, Korompay A, Ozsvári B, Judák L, Sahin-Tóth M, Geisz A, Schnúr A, Maléth J, Takács T, Gray MA, Argent BE, Mayerle J, Lerch MM, Wittmann T, Hegyi P. Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers. Gastroenterology. 2011 Dec;141(6):2228-2239.e6. (discovery of the vicious cycle in pancreatitis)

Venglovecz V, Rakonczay Z Jr, Ozsvári B, Takács T, Lonovics J, Varró A, Gray MA, Argent BE, Hegyi P. Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig. Gut. 2008 Aug;57(8):1102-12. (discovery of the role of pancreatic ducts in the pathomechanism of acute pancreatitis)

SEVEN MAJOR PUBLICATIONS

P Hegyi, J Maléth, J Walters, A Hofmann, and S Keely. Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease. Physiol Rev. 2018 98(4):1983-2023 (comprehensive Review Article on the effects of bile acids on epithelial cells)

Németh BC, Patai ÁV, Sahin-Tóth M, Hegyi P. Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis. Gut. 2017 Sep;66(9):1727-1728. (discovery of a new hereditary pancreatitis)

Maléth J & Hegyi P. Ca2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview. Phil Trans R Soc Lond B 2016 Aug 5;371(1700). (translation of a basic discovery to clinical application)

Hegyi P, Wilschanski M, Muallem S, Lukacs GL, Sahin-Tóth M, Uc A, Gray MA, Rakonczay Z Jr, Maléth J. CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis. Rev Physiol Biochem Pharmacol. 2016;170:37-66. (new insights in the pathomechanism and treatment of pancreatitis)

Hegyi P & Petersen OH. The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Rev Physiol Biochem Pharmacol. 2013;165:1-30. (new concepts in the physiology and pathophysiology of the pancreas)

Maléth J, Venglovecz V, Rázga Z, Tiszlavicz L, Rakonczay Z Jr, Hegyi P. Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells. Gut. 2011 Jan;60(1):136-8. (first discovery of the mitochondrial damage in pancreatic ductal cells)

Farkas K, Yeruva S, Rakonczay Z Jr, Ludolph L, Molnár T, Nagy F, Szepes Z, Schnúr A, Wittmann T, Hubricht J, Riederer B, Venglovecz V, Lázár G, Király M, Zsembery Á, Varga G, Seidler U, Hegyi P. New therapeutic targets in ulcerative colitis: the importance of ion transporters in the human colon. Inflamm Bowel Dis. 2011 Apr;17(4):884-98 (discovery of a new therapeutic target in IBD)

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