Wolfgang F. Graier - Peer reviewed publications#


Jain M, Stulic M, P. Rao SP, Kirsch A, Dieter Pullirsch D, Kristin Moreth K, Tanja Klein-Rodewald T, Bekeredjian R, Gailus-Durner V, Fuchs H, Hrab? de Angelis M, Graier WF, Maria Sibilia M, Frank S & Jantsch MF. RNA editing of filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure. EMBO J. 2018 (in press)

Patrikios, I., Yiallouris, A., Elizabeth O, J., Evangelia, S., Dimas, K., De Ford, C., Natalia, F., Sokratous, K., Kyriacou, K., Graier, W.F. & Stephanou, A. Annonacin Promotes Selective Cancer Cell Death via NKA and SERCA Dependent Pathways. Cell Death and Disease 2018 (in press) Fulltext PubMed

Eroglu E, Bischof H, Charoensin S, Waldeck-Weiermaier M, Graier WF, Malli R. Real-Time Imaging of Nitric Oxide Signals in Individual Cells Using geNOps. Methods Mol Biol. 1747:23-34, 2018. (doi: 10.1007/978-1-4939-7695-9_3) Fulltext PubMed

Corina T. Madreiter-Sokolowski, C.T., Sokolowski, A.A., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Targeting mitochondria to counteract age-related cellular dysfunction. Genes Epub ahead of print, 2018 (doi: 10.3390/genes9030165 ) Fulltext PubMed (Review)

Gottschalk, B., Christinae Klec, C., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Intracellular Ca2+ release decelerates mitochondrial cristae dynamics within the junctions to the endoplasmic reticulum. Pflügers Arch - Eur J Physiol Epub ahead of print, 2018 (doi: 10.1007/s00424-018-2133-0) Fulltext PubMed

Eroglu, E., Charoensin, S., Bischof, H., Ramadani, J., Gottschalk, B., Depaoli, M.R., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Genetic Biosensors for Imaging Nitric Oxide in Single Cells. Free Radical Biology and Medicine Epub ahead of print, 2018 (doi: 10.1016/j.freeradbiomed.2018.01.027) Fulltext PubMed (Review)

Duta-Mare, M., Sachdev, V., Leopold, C., Kolb, D., Vujic, N., Korbelius, M., Hofer, D.C., Xia, W., Huber, K., Auer, M., Gottschalk, B., Magnes, C., Graier, W.F., Prokesch, A., Radovic, B., Bogner-Strauss, J.G. & Kratky, D. Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis. BBA - Molecular and Cell Biology of Lipids 1863: 467-478, 2018 (doi: 10.1016/j.bbalip.2018.01.011) Fulltext PubMed

Opelt, M., Wolkart, G., Eroglu, E., Waldeck-Weiermair, M., Malli, R., Graier, W.F., Kollau, A., Fassett, J.T., Schrammel, A., Mayer, B. & Gorren, A.C.F. Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle Without Added Reductants. Implications for the Development of Nitrate Tolerance. Molec. Pharmacol. 93: 335-343, 2018 (doi: 10.1124/mol.117.110783 ) Fulltext PubMed

Bernhart, E., Kogelnik, N., Pratsch, J., Gottschalk, B., Göritzer, M., Deapoli, M.R., Reicher, H., Nusshold, C., Plastira, I., Hammer, A., Fauler, G. Malli, R., Graier, W.F., Malle, E., & Staller, W. Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells. Redox Biology 15: 441-451, 2018 (doi: 10.1016/j.redox.2018.01.003) Fulltext PubMed

Madreiter-Sokolowski, C.T. & Graier, W.F. Manipulation of mitochondrial function by polyphenols as key for new treatment strategies. Polyphenol Book (in press), 2018 (doi:) Fulltext PubMed


Plastira, I., Bernhart, E., Goeritzer, M., DeVaney, T., Reicher, H., Hammer, A., Lohberger, B., Wintersperger, A., Zucol, B., Graier, W.F., Kratky, D., Malle, E. & Sattler, W. Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglia phenotype. J. Neuroinflammation 14:253, 2017 (doi: 10.1186/s12974-017-1024-1) Fulltext PubMed

Rockenfeller,P., Diessl, J., Bashir, M., Muschett, V., Smolnig, M., Schmiedhofer, V., Knittelfelder, O., Ring, J., Franz, J., Foessl, I., Khan, M.J., Rost, R., Graier, W.F., Sepp Kohlwein, S.D., Kroemer, G., Zimmermann, A., Carmona-Gutierrez, D., Eisenberg, T., Büttner, S., Sigrist, S., Kühnlein, R., Gourlay, C. & Frank Madeo, F. Lipotoxicity is executed via a calcium/ calpain dependent necrosis pathway. Cell Death and Differentiation (in press), 2017 (doi: 10.1038/s41418-017-0014-2) Fulltext PubMed

Bischof, H., Rehberg, M., Stryeck, S., Artinger, K., Eroglu, E., Waldeck-Weiermair, M., Gottschalk. B., Rost, R., Deak, A.T., Niedrist, T., Vujic, N., Lindermuth, H., Prassl, P., Pelzmann, B., Groschner, K., Kratky, D., Eller, K., Rosenkranz, A.R., Madl, T., Plesnila, N., Graier, W.F. & Malli, R. Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo. Nat. Commun. 8:1422, 2017 (doi: 10.1038/s41467-017-01615-z) Fulltext PubMed

Madreiter-Sokolwoski, C.T. Sokolowski, A.A. & Graier, W.F. Dosis facit sanitatem - Concentration-dependent effects of resveratrol on mitochondria. Nutrients 9: 1117, 2017 (doi: 10.3390/nu9101117) Fulltext PubMed

Malli, R. & Graier, W.F. The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry. Adv Exp Med Biol. 993: 297-319, 2017 (doi: 10.1007/978-3-319-57732-6_16 ) Fulltext PubMed

Eroglu, E., Hallströmb, S., Bischof, H., Opelt, M., Schmidt, K., Mayer, B., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Real-time visualization of nitric oxide synthase activity in single cells. Nitric Oxide 70: 59-67, 2017, 2017 (doi: 10.1016/j.niox.2017.09.001) Fulltext PubMed

Madreiter-Sokolowski, C.T., Györffy, B., Klec, C., Sokolowski, A.A., Rost, R., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients. Oncotarget 8: 80278-80285, 2017 (doi: 10.18632/oncotarget.20571) Fulltext PubMed

Graier, W.F. & Malli, R. Mitochondrial Calcium: a crucial hub for cancer cell metabolism? Trans Cancer Res. 6 (Suppl.7): S1124-S1127, 2017 (doi: 10.21037/tcr.2017.08.28) Fulltext PubMed

Bärnthaler, T., Maric, J., Platzer, W., Konya, V., Theiler, A., Hasenöhrl, C., Gottschalk, B., Trautmann, S., Schreiber, Y., Graier, W.F., Schicho, R., Marsche, G., Olschewski, A., Thomas, D., Schuligoi, R. & Heinemann, A. The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk. Sci. Rep. 7:7923, 2017 (doi: 10.1038/s41598-017-08228-y) Fulltext PubMed

Baker, D., Pryce, G., Visintin, C., Sisay, S., Bondarenko, A.I., Ho, W.S.V., Jackson, S.J., Williams, T.E., Al-Izki, S., Sevastou, I., Okuyama, M., Graier, W.F.,Stevenson, L.A., Tanner, C., Ross, R., Pertwee, R.G., Henstridge, C.M., Irving, A.J., Schulman, J., Powell, K., Baker, M.D., Giovannoni, G. & Selwood, D.L. Big conductance calcium-activated potassium channel openers control spasticity without sedation. Br. J. Pharmacol. 174: 2662-2681, 2017 Fulltext PubMed

Eroglu, E., Rost, R., Bischof, H., Blass, S., Schreilechner, A., Gottschalk, B., Deapoli, M.R., Klec, C., Charosin, S., Madreiter-Sokolowski, C.M., Waldeck-Weiermair, Graier, W.F. & Malli, R. Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for real-time imaging of NO• signals in single cells. JoVE 121, 2017 (doi: 10.3791/55486) Fulltext PubMed

Suphachai Charoensin, S., Emrah Eroglu, E., Opelt, M., Bischof, H., Madreiter-Sokolowski, C.T., Kirsch, A., Depaoli, M.R., Frank, S., Schrammel, A., Mayer, B., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS). Free Radical Biol Med 10: 248-259, 2017 (doi: 10.1016/j.freeradbiomed.2016.11.049) Fulltext PubMed

Hofer, D.C., Pessentheiner, A.R., Pelzmann, H.J., Schlager, S., Madreiter-Sokolowski, C.T., Kolb, D., Eichmann, T.O., Rechberger, G., Bilban, M., Graier, W.F., Kratky, D. & Bogner-Strauss, J.G. Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis. BBA - Molecular and Cell Biology of Lipids 1862: 358-368, 2017 (doi: 10.1016/j.bbalip.2016.12.009 ) Fulltext PubMed


Opelt, M., Eroglu, E., Waldeck-Weiermair, M., Russwurm, M., Koesling, D., Malli, R., Graier, W.F., Fassett, J.T., Schrammel, A. & Mayer, M. Formation of nitric oxide by aldehyde dehydrogenase-2 is necessary and sufficient for vascular bioactivation of nitroglycerin. J- Biol. Chem. 291: 24076-24074, 2016 (doi:10.1074/jbc.M116.75207) Fulltext PubMed

Madreiter-Sokolowski, C.T., Klec, C., Parichatikanond, W., , Stryeck, S., Gottschalk, B., Pulido, S., Rost, R., Eroglu, E., Hofmann, N.A., Bondarenko, A.I., Madl, T., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. PRMT1-mediated methylation of MICU1 determines the UCP2/3-dependency of mitochondrial Ca2+ uptake in immortalized cells. Nat. Commun. 7:12897, 2016 (doi:10.1038/ncomms12897) Fulltext Pubmed

Madreiter-Sokolowski, C.T., Gottschalk, B., Parichatikanond, W., Eroglu, E., Klec, C., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Resveratrol specifically kills cancer cells by a devastating increase in the Ca2+ coupling between the greatly tethered endoplasmic reticulum and mitochondria. Cell. Physiol. Biochem. 39: 1404-1420, 2016 (doi:10.1159/000447844) Fulltext PubMed 39: 1404-1420, 2016 (doi:10.1159/000447844)

Malli, R., Eroglu, E., Waldeck-Weiermair, M. & Graier, W.F. Filling a GAP—An Optimized Probe for ER Ca2+ Imaging In Vivo (Preview). Cell Chemical Biology 23: 641-643, 2016 (doi:10.1016/j.chembiol.2016.06.003) Fulltext PubMed

Vinod, M., Patankar, J.V., Sachdev, V., Frank, S., Graier, W.F., Kratky, D. & Kostner, G.M. MiR-206 is Expressed in Pancreatic Islets and Regulates Glucokinase Activity. AJP - Endocrinology and Metabolism 311: E175-E185, 2016 (doi:10.1152/ajpendo.00510.2015) Fulltext PubMed

Radovi, B., Vuji, N., Leopold, C., Schlager, S., Goeritzer, M., Patankar, J.V., Korbelius, M., Kolb, D., Reindl, J., Wegscheider, M., Tomin, T., Birner-Gruenberger, R., Schittmayer, M., Groschner, L., Magnes, C., Diwoky, C., Frank S., Steyrer, E., Du, H., Graier, W.F., Madl, T. & Kratky, D. Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia 59: 1743-1752, 2016 (doi:10.1007/s00125-016-3968-6) Fulltext Pubmed

Prokesch, A., Pelzmann, H.J., Pessentheiner, A.R., Huber, K., Madreiter-Sokolowski, C.T., Drougard, A., Schittmayer, M., Kolb, D., Magnes, C., Trausinger, G., Graier, W.F., Birner-Grünberger, R., Pospisilik, J.A. & Bogner-Strauss, J.G. N-acetylaspartate catabolism determin es cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes. Sci. Rep. 6: 23723, 2016 (doi:10.1038/srep23723) Fulltext Pubmed

Eroglu, E., Gottschalk, B., Charoensin, S., Blass, S., Bischof, H., Rost, R., Madreiter-Sokolowski, C.T., Pelzmann, B., Bernhart, E., Sattler, W., Hallström, S., Malinski, T., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics. Nat. Commun. 7: 10623, 2016 (doi:10.1038/ncomms10623) Fulltext Pubmed

See also: Research Highlights in Nature Methods 13: 288, 2016 Link

Vujic, N., Schlager, S., Eichmann, T.O., Madreiter-Sokolowski, C.T., Goeritzer, M., Rainer, S., Schauer, S., Rosenberger, A., Woelfler, A., Doddapattar, P., Zimmermann, R., Hoefler, G., Lass, A., Graier, W.F., Radovic, B. & Kratky, D. Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. Atherosclerosis 244: 9-21, 2016 (doi:10.1016/j.atherosclerosis.2015.10.109) Fulltext Pubmed


Waldeck-Weiermair, M., Malli, R., Parichatikanond, W., Gottschalk, B., Madreiter-Sokolowski, C.T., Klec, C., Rost, R. & Graier, W.F. Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca2+. Sci. Rep. 5: 15602, 2015 (doi: 10.1038/srep15602)

Bondarenko, A.I., Parichatikanond, W., Madreiter, C.T., Rost, R., Waldeck-Weiermair, M., Malli, R. & Graier, W.F.. UCP2 modulates single channel properties of a MCU-dependent Ca2+ inward current in mitochondria. Pflügers Arch. – Eur. J. Physiol. 467: 2509-25018, 2015 (doi: 10.1007/s00424-015-1727-z)

Goeritzer, M., Vujic, N., Schlager, S., Chandak, P.G., Korbelius, M., Gottschalk, B., Leopold C., Obrowsky, S., Rainer, S.,Doddapattar, P., Aflaki, E., Wegscheider, M., Sachdev, V., Graier, W.F.,Kolb, D., Radovic, B. & Kratky, D. Active autophagy but not lipophagy in macrophages with defective lipolysis. BBA - Molecular and Cell Biology of Lipids 1851: 1304-1316, 2015 (doi: 10.1016/j.bbalip.2015.06.005)

Waldeck-Weiermair, M., Bischof, H., Blass, S., Deak, A., Klec, C., Graier, T., Roller, C., Rost, R., Eroglu, E., Gottschalk, B., Hofmann, N., Graier, W.F. & Malli, R. Generation of red-shifted cameleons for imaging Ca2+ dynamics of the endoplasmic reticulum. Biosensors 15: 13052-13068, 2015 (doi: 10.3390/s150613052)

Hofmann, N.A., Yang, J., Trauger, S.A., Nakayama, H., Huang, L., Strunk, D., Moses, M.A., Klagsbrun, M., Bischoff, J. & Graier, W.F. The G-protein coupled receptor 55-agonist L-alpha-lysophosphatidylinositol mediates ovarian carcinoma cell induced angiogenesis. Br. J. Pharmacol. 172: 4107-4118, 2015 doi: 10.1111/bph.13196)

Deak, A.T., Jean-Quartier, C., Bondarenko, A.I., Groschner, L.N., Malli, R., Graier, W.F. & Waldeck-Weiermair, M. Assessment of mitochondrial Ca²? uptake. Methods Mol. Biol.1264: 421-439, 2015 (doi: 10.1007/978-1-4939-2257-4_35)


Kozina, A., Opresnik, S., Wong, M.S.K., Hallström, S., Graier, W.F., Malli, R., Schröder, K., Schmidt, K. & Frank, S. Oleoyl-lysophosphatidylcholine limits endothelial nitric oxide bioavailability by induction of reactive oxygen species. PLOSone 9: e113443, 2014 (doi:10.1371/journal.pone.0113443) Goeritzer, M., Schlager, S., Radovic, B., Madreiter, C., Rainer, S., Thomas, G., Lord, C.C., Sacks, J., Brown, A.L., Vujic, N., Obrowsky, S., Sachdev, V., Kolb, D., Chandak, P.G., Graier, W.F., Sattler, W., Brown, J.M. & Kratky, D. J. Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis. Lipid. Res. 55: 2562-2575, 2014 (doi: 10.1194/jlr.M052613 )

Hofmann, N.A., Barth, S., Waldeck-Weiermair, M., Klec, C., Strunk, D., Malli, R. & Graier, W.F. TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation. Biology Open 3: 1164–1172, 2014 (doi:10.1242/bio.20149571)

Rossmann, C., Windpassinger, C., Jud, D., Kovacevic, A., Schweighofer, N., Malli, R., Schuligoi, R., Prokesch, A., Kluve-Beckermann, Graier, W.F., Koyani, C.N., Kratky, D., Sattler, W. & Malle, E. Rat serum amyloid A4 (SAA4): Identification of a novel member of the SAA superfamily. Biochem. Biophys. Res. Commun. 450: 1643-1649, 2014 (doi: 10.1016/j.bbrc.2014.07.054)

Deak, A.T., Jean-Quartier, C., Bondarenko, A.I., Groschner, L.N., Malli, R., Graier, W.F. & Waldeck-Weiermair, M. Assessment of mitochondrial Ca2+ uptake. In: Mitochondrial Medicine: Methods and Protocols; Methods in Molecular Biology, Humana Press/Springer Group (USA) (in press) 2014

Kennedy, B.E., Madreiter, C.T., Vishnu, N., Malli, R.,Graier, W.F. & Karten, B. Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells. J. Biol. Chem. 289: 16278-16289, 2014 (doi:10.1074/jbc.M114.559914 )

Deak, A.T., Blass, S., Khan, M.J., Groschner, L.N., Waldeck-Weiermair, M., Hallström, S., Graier, W.F. & Malli, R. Inositol-1,4,5-trisphosphate (IP3)-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake. J. Cell. Sci. 127: 2944-2955, 2014 (doi: 10.1242/?jcs.149807)

Vinod, M., Chennamsetty, I., Colin, S., De Paoli, F., Belloy, L., Schaider, H., Frank, S., Graier, W.F., Kratky, D., Staels, B., Chinetti-Gbaguidi, G. & Kostner, G.M. MIR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages. BBA - Molecular and Cell Biology of Lipids 1841: 827-833, 2014 (doi: 10.1016/j.bbalip.2014.02.006)

Groschner, L.N., Alam, M.R. & Graier, W.F. Metabolism-secreion coupling and mitochondrial calcium activities in clonal pancreatic beta-cells. Vitam. Horm. 95: 63-86, 2014 (doi: 10.1016/B978-0-12-800174-5.00003-X) Vishnu, N., Khan, M.J., Karsten, F., Groschner, L.N., Waldeck-Weiermair, M., Rost, R., Hallström, S., Imamura, H., Graier, W.F. & Malli, R. ATP Increases within the Lumen of the Endoplasmic Reticulum Upon Intracellular Ca2+-Release. Mol. Biol. Cell. 25: 368-379, 2014 (doi: 10.1091/mbc.E13-07-0433)

Bondarenko, A.I., Jean-Quartier, C., Parichatikanond, W., Alam, M.R., Waldeck-Weiermair, M., Malli, R., & Graier, W.F. Mitochondrial Ca2+ uniporter (MCU) -dependent and -independent Ca2+ channels coexist in the inner mitochondrial membrane. Pflügers Arch. – Eur. J. Physiol. 466: 1411-1420, 2014


Pessentheiner A.R., Pelzmann, H.J., Walenta, E., Schweiger, M., Groschner, L.N., Graier, W.F., Kolb, D., Uno, K., Miyazaki, T., Nitta, A., Rieder, D., Prokesch, A., & Bogner-Strauss, J.G. N-acetyltransferase 8-lik e accelerates lipid turn over and increases energy expenditure in brown adipocytes. J. Biol. Chem. 288. 36040-36051, 2013 (doi: 10.1074/jbc.M113.491324)

Schernthaner, M., Leitinger, G., Wolinski, H., Kohlwein, S.D., Reisinger, B., Barb, R.-A., Graier, W.F., Heitz, J., & Groschner, K. Enhanced Ca2+ entry and tyrosine phosphorylation mediate nanostructure-induced endothelial proliferation. Journal of Nanomaterials Article ID 251063, 2013

Rao, S., Riederer, M., Lechleitner, M., Hermansson, M., Desoye, G., Hallström, S., Graier, W.F. & Frank, S. Acyl chain-dependent effect of lysophosphatidylcholine on endothelium-dependent vasorelaxation PLOSone 8: e65155, 2013 (doi: 10.1371/journal.pone.0065155)

Waldeck-Weiermair, M., Deak, A.T., Groschner, L.N., Alam, M.R., Jean-Quartier, C., Malli, R. & Graier, W.F. Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending on the activity of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). J. Biol. Chem. 288: 15367-15379, 2013 (doi: 10.1074/jbc.M113.462259)

Bondarenko, A.i., Drachuk, K., Panasiuk, O., Sagach, V., Deak, A., Malli, R. & Graier, W.F. N-arachidonoyl glycine suppresses Na+/Ca2+ exchanger-mediated Ca2+ entry into endothelial cells and activates BKCa channels independently of G-protein coupled receptors. Br. J. Pharmacol. 169: 933-948, 2013 (doi: 10.1111/bph.12180)

Bondarenko, A.I., Jean-Quartier, C., Malli, R. & Graier, W.F. Characterization of distinct single channel properties of Ca2+ inward currents in mitochondria. Pflügers Arch. – Eur. J. Physiol. 465: 997-1010, 2013 (doi: 10.1007/s00424-013-1224-1)

Deak, A.T., Groschner, L.N., Alam, M.R., Seles, E., Bondarenko, A.I., Graier, W.F. & Malli, R. The endocannabinoid N-arachidonoyl glycine (NAGly) inhibits store-operated Ca2+ entry by preventing STIM1/Orai1 interaction. J. Cell. Sci.126: 879-888, 2013 (doi: 10.1242/jcs.118075)

2012 Waldeck-Weiermair, M., Alam, M.R., Khan, M.J., Deak, A., Vishnu, N., Karsten, F., Imamura, H., Graier, W.F. & Malli, R. Spatiotemporal correlations between cytosolic and mitochondrial Ca2+ signals using a novel red-shifted mitochondrial targeted cameleon. PLOSone 7(9): e45917, 2012 Fulltext PudMed

Alam, M.R. Groschner, L.N., Parichatikanond, W., Kuo, L., Bondarenko,A.I., Rost, R., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial Ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic ß-cells. J. Biol. Chem. 287: 34445-34454, 2012 Fulltext PudMed

Brkic, L., Riederer, M., Graier, W.F., Malli, R. & Frank, S. Acyl chain-dependent effect of lysophosphatidylcholine on Ca2+-dependent expression of cyclooxygenase (COX)-2 in endothelial cells. Atherosclerosis 224: 348-354, 2012 Fulltext PudMed

Willer, E.A., Malli, R., Bondarenko, A.I., Zahler, S., Vollmar, A.M., Graier, W.F. & Fürst, R. The vascular barrier-protecting hawthorn extract WS® 1442 raises endothelial calcium levels by inhibition of SERCA and activation of the IP3 pathway. Journal of Molecular and Cellular Cardiology 53: 597-577, 2012 Fulltext Pubmed

Khan, M.J., Alam, M.R., Waldeck-Weiermair, M., Karsten, F., Groschner, L., Riederer, M., Hallstroem, S., Rockenfeller, P., Konya, V., Heinemann, A., Madeo, F., Graier, W.F., & Malli, R.. Inhibition of autophagy rescues palmitic acid induced necroptosis of endothelial cells. Journal of Biological Chemistry 287: 21110-21120, 2012 Fulltext Pubmed

Crnkovic, S., Riederer, M., Lechleitner, M., Hallström, S., Malli, R., Graier, W.F., Jörg Lindenmann, J., Popper, H., Olschewski, H., Olschewski, A. & Frank, S. Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest and apoptosis in vascular smooth muscle cells are triggered by Ca2+-dependent induction of oxidative stress. Free Radical Biology & Medicine 52: 1786-1795, 2012 Fulltext Pubmed

Groschner, L.N., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Endothelial mitochondria – less respiration, more integration. Pflügers Arch. – Eur. J. Physiol. 646: 63-76, 2012 Fulltext Pubmed

Aflaki, E., Doddapattar, P., Radovic, B., Vujic, N., Wegscheider, M., Povoden, S., Koefeler, H., Graier, W.F., Malli, R., Kolb, D., Madeo, F., & Kratky, D. C16 ceramide is crucial for apoptosis in adipose triglyceride lipase-deficient macrophages. Cell Death and Disease 3: e280, 2012 Fulltext Pubmed

Book: Store-operated Ca2+ entry (SOCE) pathways. Eds. Klaus Groschner, Wolfgang F. Graier & Christoph Romanin by Springer 2012 Link

Jean-Quartier, J., Bondarenko, A.I., Alam, M.R., Trenker, M., Waldeck-Weiermair, M., Malli, R., & Graier, W.F. Studying mitochondrial Ca2+ uptake - a revisit. Molecular and Cellular Endocrinology 353: 114-127, 2012 Fulltext Pubmed

Malli, R. & Graier, W.F. The contribution of distinct mitochondrial Ca2+ uptake mechanisms, mitochondrial motility and location to store-operated Ca2+ entry. In: Store-operated Ca2+ entry (SOCE) pathways. Eds. Klaus Groschner, Wolfgang F. Graier & Christoph Romanin by Springer, Chapter 15, pg. 211-230, 2012 Link


Waldeck-Weiermair, M., Jean-Quartier, C., Rost, R., Khan, M.J., Vishnu, N., Bondarenko, A.I., Imamura, H., Malli, R. & Graier, W.F. The leucine zipper EF hand-containing transmembrane protein 1 (LETM1) and uncoupling proteins- 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways. J. Biol. Chem. 286: 28444-28455, 2011 Fulltext Pubmed

Bondarenko, A.I., Malli, R. & Graier, W.F. The GPR55 agonist lysophosphatidylinositol directly activates intermediate conductance Ca2+ activated K+ channels. Pflügers Arch. - Eur. J. Physiol. 462: 245–255, 2011 Fulltext Pubmed

Bondarenko, A.I., Malli, R. & Graier, W.F. The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+-activated large-conductance K+ channels in endothelial cells. Pflügers Arch. - Eur. J. Physiol. 461: 177-189, 2011 Fulltext Pubmed

Aflaki, E., Radovic, B., Chandak, P.G., Kolb, D., Eisenberg, T., Ring, J., Fertschai, I., Uellen, A., Wolinski, H., Kohlwein, S.D., Zechner, R., Levak-Frank, S., Sattler, W., Graier, W.F., Malli, R., Madeo, F. & Kratky D. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J.Biol. Chem. 286: 7418-7428, 2011 Fulltext Pubmed


Waldeck-Weiermair, M., Duan, X., Naghdi, S., Khan, M.J., Trenker, M., Malli, R. & Graier, W.F. Uncoupling protein 3 adjusts mitochondrial Ca2+ uptake to high and low Ca2+ signals. Cell Calcium 48: 288-301, 2010 free Fulltext Pubmed doi:10.1016/j.ceca.2010.10.004

Riederer , M., Ojala; P.J., Hrzenjak, A., Graier, W.F., Malli, R., Tritscher, M., Hermansson, M., Watzer, B., Schweer, H., Desoye, G., Heinemann, A. & Frank, S. Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production. J. Lipid. Res. 51: 2957-2966, 2010 Fulltext Pubmed

Naghdi, S., Waldeck-Weiermair, M., Fertschai, I., Poteser, M., Graier, W.F. & Malli, R. Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1/Orai1-dependent store-operated Ca2+ entry. J. Cell Sci. 123: 2553-2564, 2010 Fulltext PubMed

Waldeck-Weiermair, M., Malli, R., Naghdi, S.,Trenker, M., Kahn, M.J. & Graier, W.F. The contribution of UCP2 and UCP3 to mitochondrial Ca2+ uptake is differentially determined by the source of supplied Ca2+. Cell Calcium 47: 433-440, 2010 (doi:10.1016/j.ceca.2010.03.004) Fulltext PubMed

Bondarenko, A., Waldeck-Weiermair, M., Naghdi, S., Poteser, M., Malli, R. & Graier, W.F. G-protein coupled receptor 55-dependent and -independent ion signaling in response to lysophosphatidylinositol in endothelial cells. Br. J. Pharmacol. 161: 308-320, 2010 free Fulltext PubMed -> download PDF

Schmidt, K. Martens-Lobenhoffer, J., Meinitzer, A., Graier, W.F., Torres, C.M., Venema, R.C. & Mayer, B. Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: striking discripancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation. Nitric Oxide 22: 281-289, 2010 Fulltext PubMed

Bentley, M., Nycz, D., Joglekar, A., Fertschai, I., Malli, R., Graier, W.F. & Hay, J.C. Vesicular calcium regulates coat retention, fusogenicity and size of pre-golgi intermediates. Molecular Biology of the Cell 21: 1033-1046, 2010 Fulltext PubMed

Malli, R. & Graier, W.F. Mitochondrial Ca2+ Channels: Great Unknowns with Important Functions. FEBS Lett. 584: 1942-1947, 2010 Fulltext PubMed

Bernhart, E., Kollroser, M., Rechberger, G., Reicher, H., Heinemann, A., Schratl, P., Hallstroem, S., Wintersperger, A., Nusshold, C.. DeVane T., Zorn-Pauly, K., Malli, R., Graier, W., Malle, E., and Sattler, W. Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture. Proteomics 10: 141-158, 2010 Fulltext PubMed


Graier, W.F., Malli, R. and Kostner, G.M. Mitochondrial protein phosphorylation: Instigator or target of lipotoxicity? Trends in Endocrinology and Metabolism 20: 186-193, 2009 (Review) Fulltext PubMed


Trenker, M., Fertschai, I., Malli, R. and Graier, W.F. UCP2/3 – Likely to be fundamental for mitochondrial Ca2+ uniport. Nat. Cell. Biol. 10: 1237-1240, 2008 (Correspondence; doi:10.1038/ncb1108-1237) Fulltext PubMed

Graier, W.F. and Hecker, M. Endothelial H2O2: a bad guy turing good? Arteriosler. Thromb. Vasc. Biol. 28: 1696-1698, 2008 (doi:10.1161/ATVBAHA.108.173963; Editorial) Fulltext PubMed

Malli, R., Shamim Naghdi, S., Romanin, C. and Graier, W.F. Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload. J. Cell. Sci. 121: 3133-3139, 2008 (doi:10.1242/jcs.034496) Fulltext PubMed

Jousset, H., Malli, R., Girardin, N.C., Graier, W.F., Demaurex, N. and M. Frieden, M. Evidence for a receptor-activated Ca2+ entry pathway independent from Ca2+ store depletion in endothelial cells. Cell Calcium 43: 83-94, 2008 Fulltext PubMed

Graier, W.F., Trenker, M. and Malli, R. Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3? Cell Calcium 44: 36-50, 2008 (doi: 10.1016/j.ceca.2008.01.001; Review) Fulltext PubMed

Waldeck-Weiermair, M., Zoratti, C., Osibow, K., Balenga, N., Goessnitzer, E., Waldhoer, M., Malli, R. and Graier, W.F. Integrin-clustering enables endocannabinoid-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor triggered repression. J. Cell. Sci. 121: 1704-1717, 2008 (doi: 10.1242/jcs.020958) Fulltext PubMed

Schweiger, M., Schoiswohl, G., Lass, A., Radner, F.P.W., Haemmerle, G., Malli, R., Graier, W.F., Cornaciu, I., Oberer, M., Salvayre, R., Fischer, J., Zechner, R. and Zimmermann, R. The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J. Biol. Chem. 283: 17211-17220, 2008 (doi:10.1074/jbc.M710566200) Fulltext PubMed


Malli, R., Frieden, M., Hunkova, M., Trenker, M. and Graier, W.F.Ca2+ refilling of the endoplasmic reticulum is largely preserved albeit reduced Ca2+ entry in endothelial cells. Cell Calcium 41: 63-76, 2007 Fulltext PubMed

Trenker, M., Malli, R., Fertschai, I., Levak-Frank, S., and Graier, W.F. Uncoupling-proteins 2 and 3 are elementary for mitochondrial Ca2+ uniport. Nat. Cell. Biol. 9: 445-452, 2007, doi:10.1038/ncb1556 Fulltext PubMed

Graier, W.F., Frieden, M. and Malli, R. Mitochondria and Ca2+ signaling: old guests, new functions. Pflügers Archiv - European Journal of Physiology 455: 375-396, 2007 (Review) Fulltext PubMed

Wiesenberger, G., Steinleitner, K., Malli, R., Graier, W.F., Schweyen, R.J. and Stadler, J.A. Mg2+ deprivation elicits rapid Ca2+ uptake and activates Ca2+/calcineurin signaling in Saccharomyces cerevisiae. Eucarytotic Cell 6: 592-599, 2007, doi:10.1128/EC.00382-06 Fulltext PubMed


Osibow, K., Frank, S., Malli, R., Zechner, R. and Graier, W.F. Mitochondria maintain maturation and secretion of lipoprotein lipase in the endoplasmic reticulum. Biochem. J. 396: 173-182, 2006. Fulltext PubMed

Osibow, K., Malli, R., Kostner, G.M. and Graier, W.F. A new type of non-Ca2+ -buffering apo(a)-based fluorescent indicator for intraluminal Ca2+ in the endoplasmic reticulum. J. Biol. Chem. 281: 5017-5025, 2006 Fulltext PubMed


Kipmen-Korgun, D., Osibow, K., Zoratti, C., Schraml, E., Greilberger, J., Kostner, Juergens, G. and Graier, W.F. T-cadherin mediates low-density lipoprotein-initiated cell proliferation via the Ca2+-tyrosine kinase-Erk1/2 pathway. J. Cardiovasc. Pharmacol. 45: 418-430, 2005 Fulltext PubMed

Malli, R, Frieden, M., Trenker, M. and Graier, W.F. The role of mitochondria for Ca2+ refilling of the ER. J. Biol. Chem. 280: 12114-12122, 2005 Fulltext PubMed

Knot, H.J., Laher, I., Sobie, E.A., Guatimosim, S., Gomez-Viquez, L., Hartmann, H., Song, L.-S., Lederer, W.J.,Graier, W.F., Malli, R., Frieden, M., and Petersen, O.H. Twenty years of calcium imaging: cell physiology to dye for. Molec. Interventions 5: 112-127, 2005 (Review) Fulltext PubMed


Bilban, M., Ghaffari-Tabrizi, N., Hintermann, E., Bauer , S., Molzer, S., Zoratti, C., Malli, R., Sharabi, A., Hiden, U., Graier, W.F., Knöfler, M., Andreae, F., Wagner, O., Quaranta1, V. and Desoye, G. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiologic invasion inhibitor of primary human trophoblasts. J Cell Sci 117:1319-1328, 2004

Graziani, A., Bricko, V. Wolfgang F. Graier, W.F. and Klaus Groschner. Cholesterol-and caveolin-rich membrane domains are essential for phospholipase A2-dependent EDHF formation. Cardiovasc Res. 64: 234-242, 2004

Paltauf-Doburzynska, J., Malli,R. and Graier, W.F. Hyperglycemic conditions affect shape and Ca2+ homeostasis of mitochondria in endothelial cells. J. Cardiovasc. Pharmacol. 44: 424-437, 2004

Marsche, G.,, Heller , R., Nuszkowsi , A., Fauler , G., Kovacevic, A., Graier, W.F., Sattler , W. and Malle, E. 2-Chlorohexadecanal, derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis. Arteriosler. Thromb. Vasc. Biol. 24:2302-2306, 2004


Schaeffer, G., Levak-Frank, S., Spitaler, M.M., Fleischhacker, E., Esenabhalu, V.E., Wagner, A.H., Hecker, M. and Graier, W.F. Intercellular signaling within vascular cells under high d-glucose involves free radical-triggered tyrosine kinase activation. Diabetologia 46: 773-783, 2003

Malli, R., Frieden, M., K. Osibow, K. and W.F. Graier, W.F. Mitochondria efficiently buffer subplasmalemmal Ca2+ elevation during agonist stimulation. J. Biol. Chem. 278: 10807-10815, 2003

Esenabhalu, V.E., Schaeffer, G. and Graier, W.F. Free fatty acid overload attenuates Ca2+ signaling and no production in endothelial cells. Antioxidants & Redox Signaling 5: 147-153, 2003

Artwohl, M., Graier, W.F., Roden, M., Bischof, M.,Freudenthaler, Waldhäusl, W.,A. and Baumgartner-Parzer, S.M. Diabetic low-density lipoprotein triggers apoptosis in vascular endothelial cells. Diabetes 52: 1240-1247, 2003

Zoratti, C., Kipmen-Korgun, D., Osibow, K., Malli, R. and Graier, W.F. Anandamide initiates Ca2+ signaling via CB2-receptor linked to phospholipase C in calf pulmonary endothelial cells. Br. J. Pharmacol. 140: 1351-1362, 2003

Malli, R., Frieden, M., Osibow, K., Mayer, M., Demaurex, N. and Graier, W.F. Sustained Ca2+ transfer across mitochondria is essential for mitochondrial Ca2+ buffering, store-operated Ca2+ entry, and Ca2+ store refilling. J. Biol. Chem. 278: 44769-44779, 2003


Bochkov, V.N., Mechtcheriakova, D., Lucerna, M., Huber, J., Malli, R., Graier, W.F., Binder, B.R and Leitinger, N. Oxidized 1-palmitoyl-2-arachidonolyl-sn-glycero-3-phosphorylcholine (OxPAPC) stimulates expression of tissue factor in human endothelial cells through activation of erk/erg-1 and Ca2+/NFAT. Blood 99: 199-206, 2002

Esenabhalu, V.E., Cerimagic, M., Malli, R., Osibow, K., Levak-Frank, S., Frieden, M., Sattler, W., Kostner, G.M. Zechner, R. and Graier, W.F. Tissue specific expression of human lipoprotein lipase in the vacular system affects vascular reactivity in transgenic mice. Br. J. Pharmacol. 135: 143-154, 2002

Frieden, M., Malli, R., Samardzija, M., Demaurex, N. and Graier, W.F. Subplasmalemmal endoplasmic reticulum controls KCa channel activity upon stimulation with moderate histamine concentration in a human umbilical vein endothelial cell line. J. Physiol. 544: 73-84, 2002 (issue’s cover image).

Thyagarajan, B., Malli, R., Schmidt, K., Graier, W.F. and Groschner, K. Evidence for a pivotal role of mitochondria in regulation of capacitive Ca2+entry by nitric oxide. Br. J. Pharmacol. 137: 821-830, 2002

Spitaler, M.M. and Graier, W.F. Vascular targets of redox signalling in diabetes mellitus. Diabetologia 45: 476-494, 2002

Tiran, A., Gruber, H.J., Graier, W.F., Wagner, A.H., Wilders-Truschnig, M. and Tiran, B. Aspirin inhibits Chlamydia pneumoniae-induced NF-kB Activation, cytokine expression and Bacterial development in human endothelial cells. Arteriosler. Thromb. Vasc. Biol. 22:1075-1080, 2002

Spitaler, M., Hammer, A., Malli, R. and Graier, W.F. Functional analysis of histamine receptor subtypes involved in endothelial-mediated relaxation of the human uterine artery. Clin. Exp. Pharmacol. Physiol. 29: 211-216, 2002


Schulter, V., Koolwijk, P., Peters, E., Frank, S., Hrzenjak, A., Graier, W.F., van Hingsbergh, V.W.M. and Kostner, G.M. The impact of apo(a) on in vitro angiogenesis. Arterioscler. Thromb. Vasc. Biol. 21:433-438, 2001

Zimmermann, R., Panzenböck, U., Wintersberger, Levak-Frank, S., Graier, W.F., Glatter, O., Fritz, G., Kostner, G.M. and Zechner, R. Lipoprotein lipase mediates the uptake of glycated low density lipoprotein in fibroblasts, endothelial cells, and macrophages. Diabetes 50: 1643-1653, 2001

Ugdyzhekova, D.S., Bernatskaya, N.A., Stefano, J.B., Graier, V.F., Tam, S.W., Mekhoulam, R. Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of cb1 and cb2 receptors. Bull. Exp. Biol. Med. 131:251-253, 2001

Bowles, D.K., Graier, W.F. and Sturek, M. Hydrogene peroxide activates Na+ dependent Ca2+ influx in coronary endothelial cells. Biochem. Biophys. Res. Commun. 287: 1134-1139, 2001


Fleischhacker, E., Esenabhalu, V.E., Holzmann, S., Skrabal, F., Koidl, B., Kostner, G.M. and Graier, W.F. In human hypercholesterolemia increased reactivity of smooth muscle cells is due to altered subcellular Ca2+ distribution. Atherosclerosis 149: 33-42, 2000

Paltauf-Doburzynska, J., Frieden, M., Spitaler, M. and Graier, W.F.Histamine-induced Ca2+ oscillations in a human endothelial cell line depend on transmembrane ion flux, ryanodine receptor and SERCA. J. Physiol. Lond. 524: 701-713, 2000

Frieden, M. and Graier, W.F. Subplasmalemmal ryanodine-sensitive Ca2+ release contributes to KCa channel activation in a human umbilical vein endothelial cell line. J. Physiol. Lond. 524: 715-724, 2000

Prates, S., Hörl, G., Graier, W.F., Sattler, W., Zechner, R. and Steyrer, E. Intracellular distribution and mobilization of unesterified cholesterol in adipocytes. J. Cell. Sci. 113: 2977-2889, 2000

Lintschinger, B., Balzer-Geldsetzer, M., Baskaran, T., Graier, W.F., Romanin, C. Zhu, M.X. and Groschner, K. Coassembly of Trp1 and Trp3 channels generates diacylglycerol and Ca2+ sensitive cation channels. J. Biol Chem. 275:27799-27805, 2000


Posch, K., Schmidt, K. and Graier, W.F. Shear stress selectively stimulates uptake of L-arginine in endothelial cells - A mechanism essential for shearstress-mediated formation of nitric oxide. Life Sci. 64: 663-670, 1999

Schaeffer, G., Wascher, T.C., Kostner, G.M. and Graier, W.F. Alterations in platelet Ca2+ signaling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide production. Diabetologia 42: 167-176, 1999

Fleischhacker, E., Esenabhalu, V.E., Spitaler, M., Holzmann, S., Skrabal, F., Koidl, B., Kostner, G.M. and Graier, W.F. Human diabetes mellitus is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution. Diabetes 48:1323-1330, 1999

Mombouli, J.V., Holzmann, S., Kostner, G.M. and Graier, W.F. Potentiation of endothelial Ca2+ signaling by 11,12-epoxyeicosatrienoic acid. J. Cardiovasc. Pharmacol. 33: 779-784, 1999

Mombouli, J.V., Schaeffer, G., Holzmann, S.,Kostner, G.M. and Graier, W.F. Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. Br. J. Pharmacol. 126: 1593-1600, 1999

Posch, K., Wascher, T.C., Baumgartner-Parzer, S., Kostner, G.M. and Graier, W.F. Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress activated L-arginine uptake in endothelial cells. Diabetes 48:1331-1337, 1999

Paltauf-Doburzynska, J., Frieden, M. and Graier, W.F. Mechanisms of Ca2+ store depletion in single endothelial cells in a Ca2+-free environment. Cell Calcium 25: 345-353, 1999

Graier, W.F., Posch, K., Fleischhacker, E., Wascher, T.C. and Kostner, G.M.Increased superoxide anion formation in endothelial cells during hyperglycemia - An adaptive response or initial step of vascular dysfunction? Diab. Res. Clin. Pract. 45: 153-160, 1999


Graier, W.F., Paltauf-Doburzynska, J., Hill, B., Fleischhacker, E., Hoebel, B.G., Kostner, G.M. and Sturek, S. Submaximal stimulation of porcine endothelial cells causes focal Ca2+ elevation beneath the cell membrane. J. Physiol. Lond. 506: 109-125, 1998

Hoebel, B.G. and Graier, W.F. 11,12-Epoxyeicosatrienoic acid stimulates tyrosine kinase activity in porcine aortic endothelial cells. Eur. J. Pharmacol. 346: 115-117, 1998

Graier, W.F., Hoebel, B.G., Paltauf-Doburzynska, J. and Kostner, G.M. Effects of Superoxide Anions on Endothelial Ca2+ Signaling Pathways. Arteriosler. Thromb. Vasc. Biol. 18: 1470-1479, 1998

Paltauf-Doburzynska, J., Posch, K., Paltauf, G. and Graier, W.F. Stealth ryanodine-sensitive Ca2+ release contributes to activity of capacitative Ca2+ entry and nitric oxide synthase in human and bovine endothelial cells. J. Physiol. Lond. 513: 369-379, 1998

Hoebel, B.G., Steyrer, E. and Graier, W.F. Origin and function of epoxyeicosa-trienoic acids in vascular endothelial cells - More than just endothelium-derived hyperpolarizing factor? Clin. Exp. Pharmacol. Physiol. 25: 826-830, 1998


Paltauf-Doburyzenska, J. and Graier, W.F. Temperature-dependence of agonist-stimulated Ca2+ signaling in cultured endothelial ccells. Cell Calcium 21: 43-51, 1997

Graier, W.F., Simecek, S., Hoebel, B.G., Wascher, T.C., Dittrich, P and Kostner, G. Antioxidants prevent high D-glucose-enhanced endothelial Ca2+/cGMP response by scavanging superoxide anions. Eur. J. Pharmacol. 322: 113-121 1997

Wascher, T.C., Posch, K., Wallner, S., Hermetter, A., Kostner, G.M. and Graier, W.F. Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase? Biochem. Biophys. Res. Commun. 234: 35-38, 1997

Wascher, T.C., Graier, W.F., Dittrich, P., Hussain, M.A., Bahadori, B., Habersack-Wallner, S.and Toplak, H. Effects of low-dose L-arginine on insulin-mediated vasodilation and insulin sensitivity. Eur. J. Clin. Invest. 26: 707-712, 1997

Hoebel, B.G., Kostner, G.M and Graier, W.F. Microsomal cytochrome P450 mono-oxygenase is activated by Ca2+ store depletion and contributes to Ca2+ entry in porcine aortic endothelial cells. Br. J. Pharmacol. 121: 1579-1588, 1997

Graier, W.F., Posch, K., Wascher, T.C., Kukovetz, W.R. and Kostner, G.M. Role of superoxide anions in change of endothelial vasoactive response during acute hyperglycemia. Horm. Met. Res. 29: 622-629, 1997

Graier, W.F. and Kostner, G.M. Glycated LDL and atherosclerosis: The missing link between diabetes mellitus and hypercholesterolemia? Eur. J. Clin. Invest. 27: 457-459, 1997 (Editorial)


He, G.-W., Yang, C.-Q., Graier, W.F. and Yang, J.-A.. Hyperkalemia alters EDHF-mediated hyperpolarization and relaxation in coronary arteries. Am. J. Physiol. 271: H760-H767, 1996

Wascher, T.C., Bachernegg, M., Kickenweiz, A., Stark, G., Stark, U., Toplak, H. and Graier. Involvement of the L-arginine-nitric oxide pathway in hyperglycemia-induced coronary artery dysfunction of ioslated guinea pig hearts. E. J. Clin. Invest. 26: 707-712, 1996

Graier, W.F., Simecek, S., Kukovetz, W.R. and Kostner, G.M. High D-glucose-induced changes in endothelial Ca2+/EDRF signaling is due to generation of superoxide anions. Diabetes 45: 1386-1395, 1996

Graier, W.F., Holzmann, S., Hoebel, B.G., Kukovetz, W.R. and Kostner, G.M. Mechanism of L-NG-nitroarginine/indomethacin-resitant relaxation in bovine and porcine coronary arteries. Br. J. Pharmacol. 119: 1177-1186, 1996


Graier, W.F., Simecek, S., and Sturek, M. Cytochrome P450 mono-oxygenase-regulated signaling of Ca2+ entry in human and bovine endothelial cells. J. Physiol. Lond. 482: 259-274, 1995

Wascher, T.C., Bachernegg, M., Kickenweiz, A., Stark, G., Toplak, H., and Graier, W.F., Krejs, G.J. Elevation of D-glucose impairs coronary artery autoregulation under slight reduction of coronary flow. E. J. Clin. Invest. 25: 590-594, 1995

Graier, W.F., Grubenthal, I., Peter Dittrich, P., Thomas C. Wascher, T.C., Kostner, G.M. Intracellular mechanism of high D-glucose-induced modulation of vascular cell proliferation. Eur. J. Pharmacol. 294: 221-229, 1995

Brunner, F., Stessel, H., and Graier, W.F. The effects of intracellular Ca2+ concentration and hyopxia on basal endothelin-1 secretion by cultured bovine aortic endothelial cells. Agents Actions (Suppl.) 45:269-273, 1995

Toplak, H., Graier, W.F., Dittrich, P., Wiesmann, U.N. and Wascher, T.C. Insulin resistance and membrane abnormalties. Lancet 345: 995, 1995 (Letter)


Holzmann, S., Kukovetz, W.R., Windischhofer, W., Paschke, E., and Graier, W.F. Pharmacological differentiation between EDRF- and EDHF-mediated relaxation of coronary arteries. J. Cardiovasc. Pharmacol. 23: 747-756, 1994

Wascher, T.C., Toplak, H., Krejs, G.J., Simecek, S., Kukovetz, W.R., and Graier, W.F. Intracellular mechanisms involved in D-glucose-mediated amplification of agonist-induced Ca2+ response and EDRF formation in vascular endothelial cells. Diabetes 43: 984-991, 1994

Graier, W.F., Simecek, S., Bowles, D.K. and Sturek, M. Heterogeneity of caffeine and bradykinin-sensitive stores in vascular endothelial cells.Biochem. J. 300: 637-641, 1994

Groschner, K., Graier, W.F. and Kukovetz, W.R. Histamine induces K+, Ca2+ and Cl- currents in human vascular endothelial cells - Role of ionic currents in stimulation of nitric oxide biosynthesis. Circ. Res. 75: 304-314, 1994

Graier, W.F., Myers, P.R., Rubin, L.J., Adams, H.R. and Parker, J.L. Escherichia coli endotoxin inhibits agonist-mediated cytosolic calcium mobilization and nitric oxide biosynthesis in cultured endothelial cells. Circ. Res. 75: 659-668, 1994

Brunner, F., Stessel, H., Simecek, S and Graier, W.F., and Kukovetz, W.R. Effect of intracellular Ca2+ concentration on endothelin-1 secretion. Febs Lett. 350: 33-36, 1994

Wascher, T.C., Toplak, H., Bahadori, B., Graier, W.F. and Krejs, G.J. Time course of endothelial dysfunction in diabetes mellitus. Circulation 90: 1109, 1994 (Letter)

Graier, W.F., Sturek, M., and Kukovetz, W.R. Ca2+ regulation and endothelial vascular function. Endothelium 1: 223-236, 1994. 1993

Graier, W.F., Groschner, K., and Kukovetz, W.R. cAMP enhances agonist-induced Ca2+ entry into endothlial cells by activation of potassium channels and membrane hyperpolarization. Biochem. J. 291:263-267, 1993

Graier, W.F., Wascher, T.C., Lackner, L., Toplak, H., Krejs, G.J., and Kukovetz, W.R. Prolonged exposure to elevated glucose concentrations modulates vascular endothelial cell vasodilatatory response. Diabetes 42: 1497-1505, 1993


Graier, W.F., Schmidt, K., and Kukovetz, W.R. Is the bradykinin-induced Ca2+ influx and the formation of endothelium derived relaxing factor mediated by a G protein? European J. Pharmacol. - Molecular Pharmacology Section, 225: 43-49, 1992

Schmidt, K., Klatt, P., Graier, W.F., Kostner, G.M., and Kukovetz, W.R. High-density lipoprotein antagonizes the inhibitory effects of oxidized low-density lipoprotein and lysolecithin on soluble guanylyl cyclase. Biochem. Biophys. Res. Commun. 182: 302-308, 1992

Groschner, K., Graier, W.F., and Kukovetz, W.R. Activation of a small-conductance Ca2+-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells. Biochim. Biophys. Acta 1137: 162-170, 1992

Graier, W.F., Groschner, K., Schmidt, K., and Kukovetz, W.R. SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells. Biochem. Biophys. Res. Commun. 186: 1539-1545, 1992

Graier, W.F., Groschner, K., Schmidt, K., and Kukovetz, W.R. Increases in endothelial cAMP levels amplify agonist-induced formation of endothelium-derived relaxing factor (EDRF). Biochem. J. 288: 345-349, 1992

Kukovetz, W.R., Graier, W.F., and Groschner, K. Contribution of agonist-induced hyperpolarization to Ca2+ influx and formation of EDRF in vascular endothelial cells. Jap. J. Pharmacol. 58 (Suppl.2): 213P-219P, 1992


Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., Böhme, E., and Kukovetz, W.R. Oxidized low-density lipoprotein antagonizes the stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor. Cell. Signal. 3: 361-367, 1991

Graier, W.F., Schmidt, K., and Kukovetz, W.R. Bradykinin-induced Ca2+-influx into cultured endothelial cells is not regulated by inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate. Second Messengers and Phosphoproteins 13: 187-197, 1991

Graier, W.F., Schmidt, K., and Kukovetz, W.R. Activation of G-protein evokes Ca2+ -influx in endothelial cells without correlation to the formation of inositolphosphates. J. Cardiovasc. Pharmacol. 17 (Suppl.3) S71-S78, 1991

Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., Böhme, E., and Kukovetz, W.R. Stimulation of soluble guanylate cyclase by EDRF is antagonized by oxidized low-density lipoprotein. J Cardiovasc Pharmacol 17 (Suppl.3) S83-S86, 1991


Graier, W.F., Schmidt, K., and Kukovetz, W.R. Effect of sodium fluoride on cytosolic free Ca2+-concentration and cGMP-formation in endothelial cells. Cell. Signal. 2: 369-375, 1990

Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., and Kukovetz, W.R. Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein. Biochem. Biophys. Res. Commun. 172: 614-619, 1990

Technical Notes:

Graier, W.F. and Malli, R. Novel live-cell dual excitation/dual emission imaging system for the simultaneous visualization of cytosolic Ca2+ signaltransduction processes and mitochondrial dynamics. International Labmate August 70-71, 2007 PDF


Paltauf-Dobuzynska, J., Kohlwein, S.D. and Graier, W.F. Digital imaging of diabetic endothelial cells. Progress in biomedical optics and imaging 4260: 1-6, 2001

Graier, W.F. and Wascher, T.C. Zelluläre Grundlagen der Gefäßkomplikationen im Diabetes mellitus. Journal für Kardiologie 7: 9-13, 2000

Rubin, L.J., Adams, H.R., Myers, P.R., Graier, W.F. and Parker, J.L. Inhibition of endothelial cell NOS in sepsis and shock. Proceedings of the Third International Shock Congress, Hamamatsu, Japan. In: Excerpta Medica International Congress Series 1102. Elsevier Science, The Netherlands, 1996, pg. 25-36

Graier, W.F. Bedeutung und Rolle des endothelialen Relaxationsfaktors. ÖAZ 46 Jg (23): 457-459, 1992

Schmidt, K., und Graier, W.F. Stereoselektivität bei bioaktiven Substanzen - ein aktuelles Problemgebiet in Chemie und Biologie. ÖAZ 43 Jg. (39): 745-746, 1989

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