Zhu Chen- Publications#

• Chen Z, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A: Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-locus due to a variant t(11;17) translocation associated with acute promyelocytic leukemia. EMBO J 1993;12:1161-1167.

• Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derre J, Berger R, Waxman S, Chen Z. Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. J Clin Invest 1993;91:2260-2267.

• Zhang T, Hillion J, Tong JH, Cao Q, Chen SJ, Berger R, Chen Z. AML-1 gene rearrangment and AML-1-ETO gene expression as molecular markers of acute myeloblastic leukemia with t(8;21). Leukemia 1994;8:729-734.

• Chen Z, Guidez F, Rousselot P, Agadir A, Chen SJ, Wang ZY, Degos L, Zelent A, Waxman S, Chomienne C. PLZF-RARa fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. Proc Natl Acad Sci USA 1994; 91:1178-1182.*

• Zhu J, Shi XG, Chu HY, Tong JH, Wang ZY, Naoe T, Waxman S, Chen SJ, Chen Z. Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4. Leukmia 1995;9:302-309.

• Huang W, Kuang SQ, Huang QH, Dong S, Zhang T, Gu LJ, Ching LM, Chen SJ, Chan LC, Chen Z: RT/PCR detection of SIL-TAL-1 fusion mRNA in Chinese T-cell acute lymphoblastic leukemia (T-ALL). Cancer Genet Cytogenet 1995;81:76-82.

• Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Yu L, Zhao SY, Waxman S, Labotte M, Wang ZY, Tan JZ, Chen SJ, Chen Z: RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia. Proc Natl Acad Sci USA 1996; 93:5910-5914.

• Kuang SQ, Gu LJ, Dong S, Cao Q, Xu C, Huang W, Su XY, Huang QH, Xie JX, Chen SJ, Chen Z: Long-term follow-up of minimal residual disease in childhood acute lymphoblastic leukemia patients by polymerase chain reaction analysis of multiple clone-specific or malignancy-specific gene markers. Cancer Genet Cytogenet 1996; 88:110-117

• Chen GQ, Zhu J, Shi XG, Ni JH, Zhong HJ, Si GY, Jin XL, Tang W, Li XS, Xong SM, Shen ZX, Sun GL, Ma J, Zhang P, Zhang TD, Gazin C, Naoe T, Chen SJ, Wang ZY, Chen Z. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR/PML proteins. Blood 1996; 88:1052-1061. *

• Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Han ZG, Ni JH, Jia PM, Shen ZX, Li XS, Ma J, Zhang P, Zhang TD, Paul P, Naoe T, Waxman S, Wang Z, deThe H, Chen SJ, Chen Z. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effect on APL cells in vitro and in vivo. Blood 1997;89:3345-3353. *

• Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Tang W, Yang KQ, Qiu QY, Chen Y, Zhou L, Zeng XY, Fang ZW, Wang YT, Zhang P, Zhang TD, Chen SJ, Chen Z, Wang ZY. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in patients at relapse. Blood 1997;89:3354-3360. *

• Zhu J, Koken M, Quignon F, Chelbi-Alix M, Degos L, Wang ZY, Chen Z, deThe H. Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia. Proc Natl Acad Sci USA 1997;94:3978-3983.

• Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z. Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc Natl Acad Sci USA 1998; 95:8175-8180. *

• Hu J, Shen ZX, Sun GL, Chen SJ, Wang Z, Chen Z. Long-term survival and prognostic study in acute promyelocytic leukemia treated with all-trans-retinoic acid, chemotherapy and As2O3: an experience of 120 patients at a single institution. Int J Hematol 1999; 70:248-260

• Han ZG, Zhang QH, Ye M, Kan LX, Gu BW, He KL, Shi SL, Zhou J, Fu G, Mao M, Chen SJ, Yu L, Chen Z. Molecular cloning of six novel Kurppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. JBC 1999; 274: 35741-35748

• Chen Z. Prospects for the Chinese human genome project (HGP) at the beginning of the next century. Progress in Natural Science 2000; 10:172-176(invited review article)

• Gu J, Zhang QH, Huang QH, Ren SX, Wu XY, Ye M, Huang CH, FU G, Zhou J, Niu C, Han ZG, Chen SJ, Chen Z. Gene expression in CD34+ cells from normal bone marrow and leukemic origins. The Hematology Journal 2000; 1: 206-217

• Liu TX, Zhang JW, Tao J, Zhang RB, Zhang QH, Zhao CJ, Tong JH, Lanotte M, Waxman S, Chen SJ, Mao M, Hu GX, Zhu L, Chen Z. Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells. Blood 2000; 96:1496-1504

• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Research 2000; 10: 1088-9051. *

• Shen Y, Shen ZX, Yan H, Chen J, Zeng XY, Li JM, LI XS, Wu W, Xiong SM, Zhao WL, Tang W, Wu F, Liu YF, Niu C, Wang ZY, Chen SJ, Chen Z. Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage. Leukemia 2001; 15: 735-741.

• Fujiyama A, Watanabe H, Toyoda A, Taylor TD, Itoh T, Tsai SF, Park HS, Yaspo ML, Lehrach H, Chen Z, Fu G, Saitou N, Osoegawa K, De Jong PJ, Suto Y, Hattori M, Sakaki Y. Construction and analysis of a human-chimpanzee comparative clone map. Science 2002; 295: 131-134.

• Feng BJ, Huang W, Shugart YY, Lee MK, Xia JC, Wang HY, Feng Z, Huang TB, Jian SW, Huang P, Feng QS, Huang LX, YU XJ, Li D, Chen LZ, Jia WH, Fang Y, Huang HM, Zhu JL, Liu XM, Zhao Y, Liu WQ, Deng MQ, Hu WH, Wu SX, Mo HY, Hong MF, King MC, Chen Z, Zeng YX. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nature genetics, 2002; 31: 395-399.

• Zhu J, Chen Z, Lallemand-Breitenbach V, de Thé H. How acute promyelocytic leukemia revived arsenic. Nature Reviews Cancer 2002; 2:705-713.

• Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou HP, Chen Z, Barhanin J, Huang W. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 2003; 299:251-254. *

• Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, Zhang YX, Xiong H, Lu Gang, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang X, Gu WY, Zhang YQ, Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, Ma W, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Girons I S, Somerville RL, Wen YMei, Shi MH, Chen Z, Xu JG, Zhao GP. Unique physiological and pathogenic features Leptospira interrogans revealed by whole-genome sequencing. Nature 2003; 422: 888-893. *

• Fang J, Chen SJ, Tong JH, Wang ZG, Chen GQ, Chen Z. Treatment of acute promyelocytic leukemia with ATRA and As2O3- a model of molecular target-based cancer therapy. Cancer Biology&Therapy 2003. 1:614-620.

• Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Chen Y, Shen Y, Wu W, Tang W, Waxman S, de Thé H, Wang ZY, Chen SJ, Chen Z. All-trans retinoic acid /As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 2004; 101: 5328-5335. *

• Watanabe H, Fujiyama A, Hattori M, Taylor TD, Toyoda A, Kuroki Y, Noguchi H, BenKahla A, Lehrach H, Sudbrak R, Kube M, Taenzer S, Galgoczy P, Platzer M, Scharfe M, Nordsiek G, Blocker H, Hellmann I, Khaitovich P, Paabo S, Reinhardt R, Zheng HJ, Zhang XL, Zhu GF, Wang BF, Fu G, Ren SX, Zhao GP, Chen Z, Lee YS, Cheong JE, Choi SH, Wu KM, Liu TT, Hsiao KJ, Tsai SF, Kim CG, OOta S, Kitano T, Kohara Y, Saitou N, Park HS, Wang SY, Yaspo ML, Sakaki Y. DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature 2004;429:382-388.

• Yin T, Wu YL, Sun HP, Sun GL, Du YZ, Wang KK, Zhang J, Chen GQ, Chen SJ, Chen Z. Combined Effects of As4S4 and Imatinib on Chronic Myeloid Leukemia Cells and BCR-ABL Oncoprotein. Blood 2004; 104:4219-4225.
• Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z. Hematopoietic Gene Expression Profile in Zebrafish Kidney Marrow. Proc Natl Acad Sci USA 2004. 101:16240-16245