Christer Betsholtz - Selected publications#


  • Pericytes regulate the blood-brain barrier. Armulik et al. Nature 2010
  • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Tammela et al. Nature 2008
  • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Hellström et al. Nature 2007
  • Endothelial and non-endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. Abramsson et al. J Clin Invest 2003
  • VEGF guides angiogenic sprouting utilizing endothelial tip-cell filopodia. Gerhardt et al. J Cell Biol 2003
  • Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Lindblom et al. Genes Dev 2003
  • Betsholtz, C., Johnsson, A., Heldin, C.-H., Westermark, B., Lind, P., Urdea, M.S., Shows, T.B., Philpott, K., Mellor, A., Knott, T.J. and Scott, J. Complementary DNA sequence and chromosomal localisation of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320,695-699 (1986)
  • Levéen, P., Pekny, P., Gebre-Medhin, S., Swolin, B., Larsson, E. and Betsholtz, C. Mice deficient for PDGF B show renal, cardiovascular and hematological abnormalities. Genes Dev 8, 1875-1887 (1994)
  • Boström, H., Willetts, K., Pekny, M., Levéen, P., Hedstrand, H., Pekna, M., Schalling, M., Nilsson, M., Gebre-Medhin, S., Kurland, S., Törnell, J., Heath, J.K and Betsholtz, C. PDGF-A signaling is a critical event in lung alveolar myofibroblast ontogeny and alveogenesis. Cell 85, 863-873 (1996)
  • Lindahl, P., Johansson, B., Levéen, P., and Betsholtz, C. Pericyte loss and microaneurysm formation in PDGF-B deficient mice. Science, 277, 242-245 (1997)
  • Hellström, M., Kalén, M., Lindahl, P., Abramsson, A. and Betsholtz, C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126:3047-3055 (1999)
  • Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H. and Betsholtz, C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis J. Cell Biol. 153:543-553 (2001)
  • Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D. and Betsholtz, C. VEGF guides angiogenic sprouting utilizing endothelial tip-cell filopodia. J Cell Biol 161:1163-1177 (2003)
  • Lindblom, P., Gerhardt, H., Liebner, S., Abramsson, A., Enge, M., Hellström, M., Bäckström, G., Fredriksson, S., Landegren, U., Nyström, H., Bergström, G., Dejana, E., Östman, A., Lindahl, P. and Betsholtz, C. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev, 17:1835-1840 (2003)
  • Abramsson, A., Lindblom, P., Betsholtz, C. Endothelial and non-endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 112: 1142-1151 (2003)
  • Takemoto, M., He, L., Norlin, J., Asp, J., Patrakka, J., Xiao, Z., Bondjers, C., Mostad, P., Samuelsson, T., Tryggvason, K. and Betsholtz C. Identification of novel kidney glomerulus-specific genes by large scale EST sequencing and microarray analysis. EMBO J, Feb 23; Epub ahead of print (2006)


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