Jacques Neefjes#


Jacques Neefjes
Email:j.neefjes 'at' nki.nl
Membership Number:3484
Membership type:ORDINARY
Main Country of Residence:THE NETHERLANDS
Section:CELL & DEVELOPMENTAL BIOLOGY
Username:jneefjes
Homepage: http://www.nki.nl/divisions/cell-biology-ii/neefjes-s-group





Present and Previous Positions
  • since 2009 Head Division of Cell Biology II, the Netherlands Cancer Institute, Amsterdam
  • since 1999 Extraordinary professor at the LUMC chair of “Antigen Presentation and Processing”
  • 2007 - 2011 Deputy Scientific Director, the Netherlands Cancer Institute, Amsterdam
  • 2009 - 2011 Visiting professor at the Centre for Immune Regulation of the University of Oslo, Norway
  • 1998 - 2008 Head Division of Tumor Biology, the Netherlands Cancer Institute, Amsterdam
  • 2000 - 2003 Dean Graduate School Oncology Amsterdam (OOA)
  • 1993 - 1997 Staff member, Division of Cellular Biochemistry, the Netherlands Cancer Institute, Amsterdam
  • 1992 - 1993 EMBO long-term fellowship at the Deutsche Krebs Forschungs Zentrum (DKFZ), Heidelberg
  • 1991 - 1992 Visiting scientist at the laboratory of Drs C Benoit and D Mathis at the Institut de Chimie Biologique, Strasbourg Fr

Fields of Scholarship
  • Cell Biology: identified MHC class I and MHC class II cell biology, dynein motor control of vesicles, PI3kinase in MVB biogeneses
  • Immunology: Mechanisms of control of MHC class I and MHC class II expression, bacterial control phagosomes
  • Chemical Biology: developed reciprocal chemical genetics to find host targets controlling bacterial infections and lead structures
  • Cancer: utilizing biophysics showed conformational changes estrogen receptor and deciphered new resistance mechanism
  • Biophysics: Neefjes developed various technologies to measure FRET and FRAP for single cell biochemistry.
  • Chemistry: Neefjes applies chemistry in cell biology. Generated first inhibitors for TAP and for host factor antibiotics
  • Molecular Medicine: Neefjes applied cell biology and next generation sequencing to find new modes of actions of anticancer drug
  • Systems Biology: Neefjes has performed integrated screens to generate new biology that was experimentally validated
  • High throughput screenings: Neefjes performed various genetic and chemical screens to successfully find new targets and leads

Honours and Awards
  • 2011 Recipient ERC Advanced Grant
  • 2010 Elected member European Academy of Cancer Sciences
  • 2006 Elected member EMBO
  • 1996 Recipient NWO Pioneer Grant
  • 1996 Golden Medal of the Royal Dutch Chemical Society KNCV
  • 1992 EMBO long term fellowship
  • 1990 Antoni van Leeuwenhoek Award
  • Honorary Lectures
    • 2012 Ruysch lecture AMC, Amsterdam
    • 2012 Beatty Lecturer, McGill University, Montreal, Canada

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