Leo Sachs - List of publications#

Sachs, L. (1995) The adventures of a biologist: Prenatal diagnosis, hematopoiesis, leukemia, carcinogenesis and tumor suppression. Foundations in Cancer Research. Adv. Cancer Res. 66: 1-40.

Lotem, J., and Sachs, L. (1995) Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone. Cell Growth Differ., 6:647-653.

Peled-Kamar, M., Lotem, J., Okon, E., Sachs, L., and Groner, Y. (1995) Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome. EMBO J., 14:4985-4993.

Lotem, J., and Sachs, L. (1995) A mutant p53 antagonizes the deregulated c-myc mediated enhancement of apoptosis and decrease in leukemogenicity. Proc. Natl. Acad. Sci. USA, 92:9672-9676. PDF Version

Sachs, L. (1996) The control of hematopoiesis and leukemia: From basic biology to the clinic. Proc. Natl. Acad. Sci. USA, 93:4742-4749. PDF Version

Lotem, J., Peled-Kamar, M., Groner, Y., and Sachs, L. (1996) Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds and cytokines. Proc. Natl. Acad. Sci. USA, 93:9166-9171. PDF Version

Kaplinsky, C., Lotem, J. and Sachs, L. (1996) Protection of human myeloid leukemic cells against doxorubicin-induced apoptosis by granulocyte-macrophage colony-stimulating factor and interleukin 3. Leukemia, 10:460-465.

Lotem, J., and Sachs, L. (1997) Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis. Proc. Natl. Acad. Sci. USA, 94:9349-9353. PDF Version

Lotem, J., and Sachs, L. (1998) Different mechanisms for suppression of apoptosis by cytokines and calcium mobilizing compounds. Proc. Natl. Acad. Sci. USA, 95:4601-4606. PDF Version

Lotem, J. and Sachs, L. (1999) Cytokines as suppressors of apoptosis. Apoptosis, 4:187-196. PDF Version

Lotem, J., Kama, R. and Sachs, L. (1999) Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin. Proc. Natl. Acad. Sci. USA, 96:12016-12020. PDF Version

Asher, G., Lotem, J., Cohen, B., Sachs, L. and Shaul, Y. (2001) Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxireductase 1. Proc. Natl. Acad. Sci. USA, 98:1188-1193. PDF Version

Asher, G., Lotem, J., Kama, R., Sachs, L. and Shaul, Y. (2002) NQO1 stabilizes p53 through a distinct pathway. Proc. Natl. Acad. Sci. USA, 99:3099-3104. PDF Version

Yuan, X.-M., Li, W., Dalen H., Lotem, J., Kama, R., Sachs, L. and Brunk, U.T. (2002) Lysosomal destabilization in p53-induced apoptosis. Proc. Natl. Acad. Sci. USA, 99:6286-6291. PDF Version

Lotem, J. and Sachs, L. (2002a) Epigenetics wins over genetics. Induction of differentiation in tumor cells. Sem. Cancer Biol. 12:330-346. PDF Version

Lotem, J. and Sachs, L. (2002) Cytokine control of developmental programs in normal hematopoiesis and leukemia. Oncogene, 21:3284-3294. PDF Version

Asher, G., Lotem, J., Sachs, L., Kahana, C. and Shaul, Y. (2002) Mdm-2 and ubiquitin- independent p53 proteosomal degradation regulated by NQO1. Proc. Natl. Acad. Sci. USA, 99:13125-13130. PDF Version

Lotem, J., Gal, H., Kama, R., Amariglio, N., Rehavi, G., Domany, E., Sachs, L. and Givol, D. (2003) Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes. Proc. Natl. Acad. Sci. USA, 100:6718-6723. PDF Version

Asher, G. Lotem, J., Tsvetkov, P., Reiss, V., Sachs, L. and Shaul, Y. (2003) p53 hot spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H: quinone oxireductase 1. Proc. Natl. Acad. Sci. USA, 100: 15065-15070. PDF Version

Lotem, J., Benjamin, H., Netanely, D., Domany, E., and Sachs, L. (2004) Induction in myeloid leukemic cells of genes that are expressed in different normal tissues, Proc. Natl. Acad. Sci. USA, 101: 16022-16027.

Lotem, J., Netanely, D., Domany, E., and Sachs, L. (2005) Human cancers overexpress genes that are specific to a variety of normal human tissues. Proc. Natl. Acad. Sci. USA, 102: 18556-18561

Tsvetkov, P., Asher, G., Reiss, V., Shaul, Y., Sachs, L., and Lotem, J. (2005) Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin. Proc. Natl. Acad. Sci. USA 103: 5535-5540.

Lotem, J. and Sachs, L. (2006) Epigenetics and the plasticity of differentiation in normal and cancer stem cell. Oncogene 25: 7663-7672.

• Publications: 160
• Citations: 3940
• Fields: Oncology, Genetics & Genealogy, Virology
• Collaborated with 124 co-authors from 1956 to 2010
• Cited by 10071 authors