1: Wittmann T, Lohse MJ, Schmitt JP. Phospholamban pentamers attenuate
PKA-dependent phosphorylation of monomers. J Mol Cell Cardiol. 2015 Jan
3;80C:90-97. doi: 10.1016/j.yjmcc.2014.12.020. [Epub ahead of print] PubMed PMID:
25562800.


2: Holthoff HP, Göbel S, Li Z, Faßbender J, Reimann A, Zeibig S, Lohse MJ, Münch 
G, Ungerer M. Prolonged TSH receptor A subunit immunization of female mice leads 
to a long-term model of Graves´ disease, tachycardia and cardiac hypertrophy.
Endocrinology. 2015 Jan 6:en20141813. [Epub ahead of print] PubMed PMID:
25562617.


3: Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, 
Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ. PKA catalytic
subunit mutations in adrenocortical Cushing's adenoma impair association with the
regulatory subunit. Nat Commun. 2014 Dec 5;5:5680. doi: 10.1038/ncomms6680.
PubMed PMID: 25477193.


4: Bock A, Kostenis E, Tränkle C, Lohse MJ, Mohr K. Pilot the pulse: controlling 
the multiplicity of receptor dynamics. Trends Pharmacol Sci. 2014
Dec;35(12):630-8. doi: 10.1016/j.tips.2014.10.002. Epub 2014 Oct 31. PubMed PMID:
25455830.


5: Calebiro D, Godbole A, Lyga S, Lohse MJ. Trafficking and function of GPCRs in 
the endosomal compartment. Methods Mol Biol. 2015;1234:197-211. doi:
10.1007/978-1-4939-1755-6_16. PubMed PMID: 25304358.


6: Sungkaworn T, Rieken F, Lohse MJ, Calebiro D. High-resolution spatiotemporal
analysis of receptor dynamics by single-molecule fluorescence microscopy. J Vis
Exp. 2014 Jul 25;(89):e51784. doi: 10.3791/51784. PubMed PMID: 25145374.


7: Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman CE, Lohse
MJ, Schmitt JP. β-Myosin heavy chain variant Val606Met causes very mild
hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice
carrying other HCM mutations. Circ Res. 2014 Jul 7;115(2):227-37. doi:
10.1161/CIRCRESAHA.115.303178. Epub 2014 May 14. PubMed PMID: 24829265; PubMed
Central PMCID: PMC4086907.


8: Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE,
Harvey RD. Role of membrane microdomains in compartmentation of cAMP signaling.
PLoS One. 2014 Apr 21;9(4):e95835. doi: 10.1371/journal.pone.0095835. eCollection
2014. PubMed PMID: 24752595; PubMed Central PMCID: PMC3994114.


9: Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A,
Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T,
Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro
A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J,
Strom TM, Allolio B. Constitutive activation of PKA catalytic subunit in adrenal 
Cushing's syndrome. N Engl J Med. 2014 Mar 13;370(11):1019-28. doi:
10.1056/NEJMoa1310359. Epub 2014 Feb 26. PubMed PMID: 24571724.


10: Lohse MJ, Maiellaro I, Calebiro D. Kinetics and mechanism of G
protein-coupled receptor activation. Curr Opin Cell Biol. 2014 Apr;27:87-93. doi:
10.1016/j.ceb.2013.11.009. Epub 2013 Dec 17. Review. PubMed PMID: 24530699.


11: Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin 
JP, Guitart X. G protein-coupled receptor oligomerization revisited: functional
and pharmacological perspectives. Pharmacol Rev. 2014 Feb 10;66(2):413-34. doi:
10.1124/pr.113.008052. Print 2014. Review. PubMed PMID: 24515647; PubMed Central 
PMCID: PMC3973609.


12: Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, 
Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G,
Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ,
Garbi N, Kastenmüller W, Knolle PA, Kurts C, Engel DR. Crosstalk between sentinel
and helper macrophages permits neutrophil migration into infected uroepithelium. 
Cell. 2014 Jan 30;156(3):456-68. doi: 10.1016/j.cell.2014.01.006. PubMed PMID:
24485454; PubMed Central PMCID: PMC4258064.


13: Lohse MJ, Hoffmann C. Arrestin interactions with G protein-coupled receptors.
Handb Exp Pharmacol. 2014;219:15-56. doi: 10.1007/978-3-642-41199-1_2. PubMed
PMID: 24292823.


14: Volff JN, Selz Y, Hoffmann C, Froschauer A, Schultheis C, Schmidt C, Zhou Q, 
Bernhardt W, Hanel R, Böhne A, Brunet F, Ségurens B, Couloux A, Bernard-Samain S,
Barbe V, Ozouf-Costaz C, Galiana D, Lohse MJ, Schartl M. Gene amplification and
functional diversification of melanocortin 4 receptor at an extremely polymorphic
locus controlling sexual maturation in the platyfish. Genetics. 2013
Dec;195(4):1337-52. doi: 10.1534/genetics.113.155952. Epub 2013 Sep 27. PubMed
PMID: 24077304; PubMed Central PMCID: PMC3832277.


15: Emami-Nemini A, Roux T, Leblay M, Bourrier E, Lamarque L, Trinquet E, Lohse
MJ. Time-resolved fluorescence ligand binding for G protein-coupled receptors.
Nat Protoc. 2013;8(7):1307-20. doi: 10.1038/nprot.2013.073. Epub 2013 Jun 13.
PubMed PMID: 23764938.


16: Ruppert C, Deiss K, Herrmann S, Vidal M, Oezkur M, Gorski A, Weidemann F,
Lohse MJ, Lorenz K. Interference with ERK(Thr188) phosphorylation impairs
pathological but not physiological cardiac hypertrophy. Proc Natl Acad Sci U S A.
2013 Apr 30;110(18):7440-5. doi: 10.1073/pnas.1221999110. Epub 2013 Apr 15.
PubMed PMID: 23589880; PubMed Central PMCID: PMC3645583.


17: Lohse MJ, Calebiro D. Cell biology: Receptor signals come in waves. Nature.
2013 Mar 28;495(7442):457-8. doi: 10.1038/nature12086. Epub 2013 Mar 20. PubMed
PMID: 23515157.


18: Calebiro D, Rieken F, Wagner J, Sungkaworn T, Zabel U, Borzi A, Cocucci E,
Zürn A, Lohse MJ. Single-molecule analysis of fluorescently labeled
G-protein-coupled receptors reveals complexes with distinct dynamics and
organization. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):743-8. doi:
10.1073/pnas.1205798110. Epub 2012 Dec 24. PubMed PMID: 23267088; PubMed Central 
PMCID: PMC3545784.


19: Boivin-Jahns V, Schlipp A, Hartmann S, Panjwani P, Klingel K, Lohse MJ, Ertl 
G, Jahns R. Antibodies to cardiac receptors. Herz. 2012 Dec;37(8):843-8. doi:
10.1007/s00059-012-3699-5. PubMed PMID: 23183584.


20: Münch G, Boivin-Jahns V, Holthoff HP, Adler K, Lappo M, Truöl S, Degen H,
Steiger N, Lohse MJ, Jahns R, Ungerer M. Administration of the cyclic peptide
COR-1 in humans (phase I study): ex vivo measurements of anti-β1-adrenergic
receptor antibody neutralization and of immune parameters. Eur J Heart Fail. 2012
Nov;14(11):1230-9. doi: 10.1093/eurjhf/hfs118. Epub 2012 Sep 11. Erratum in: Eur 
J Heart Fail. 2013 Apr;15(4):478. Dosage error in article text. PubMed PMID:
22968742.


21: Hlavackova V, Zabel U, Frankova D, Bätz J, Hoffmann C, Prezeau L, Pin JP,
Blahos J, Lohse MJ. Sequential inter- and intrasubunit rearrangements during
activation of dimeric metabotropic glutamate receptor 1. Sci Signal. 2012 Aug
14;5(237):ra59. doi: 10.1126/scisignal.2002720. PubMed PMID: 22894836.


22: Vidal M, Wieland T, Lohse MJ, Lorenz K. β-Adrenergic receptor stimulation
causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway. Cardiovasc Res. 2012 
Nov 1;96(2):255-64. doi: 10.1093/cvr/cvs249. Epub 2012 Jul 27. PubMed PMID:
22843704.


23: Holthoff HP, Zeibig S, Jahns-Boivin V, Bauer J, Lohse MJ, Kääb S, Clauss S,
Jahns R, Schlipp A, Münch G, Ungerer M. Detection of anti-β1-AR autoantibodies in
heart failure by a cell-based competition ELISA. Circ Res. 2012 Aug
31;111(6):675-84. doi: 10.1161/CIRCRESAHA.112.272682. Epub 2012 Jul 18. PubMed
PMID: 22811559.


24: Deiss K, Kisker C, Lohse MJ, Lorenz K. Raf kinase inhibitor protein (RKIP)
dimer formation controls its target switch from Raf1 to G protein-coupled
receptor kinase (GRK) 2. J Biol Chem. 2012 Jul 6;287(28):23407-17. doi:
10.1074/jbc.M112.363812. Epub 2012 May 17. PubMed PMID: 22610096; PubMed Central 
PMCID: PMC3390617.


25: Hoffmann C, Nuber S, Zabel U, Ziegler N, Winkler C, Hein P, Berlot CH,
Bünemann M, Lohse MJ. Comparison of the activation kinetics of the M3
acetylcholine receptor and a constitutively active mutant receptor in living
cells. Mol Pharmacol. 2012 Aug;82(2):236-45. doi: 10.1124/mol.112.077578. Epub
2012 May 7. PubMed PMID: 22564786.


26: Emami-Nemini A, Gohla A, Urlaub H, Lohse MJ, Klenk C. The guanine nucleotide 
exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq
signaling. Mol Pharmacol. 2012 Aug;82(2):217-25. doi: 10.1124/mol.112.078824.
Epub 2012 May 3. PubMed PMID: 22554804.


27: Lohse MJ, Nuber S, Hoffmann C. Fluorescence/bioluminescence resonance energy 
transfer techniques to study G-protein-coupled receptor activation and signaling.
Pharmacol Rev. 2012 Apr;64(2):299-336. doi: 10.1124/pr.110.004309. Epub 2012 Mar 
8. Review. PubMed PMID: 22407612.


28: Ambrosio M, Lohse MJ. Nonequilibrium activation of a G-protein-coupled
receptor. Mol Pharmacol. 2012 Jun;81(6):770-7. doi: 10.1124/mol.112.077693. Epub 
2012 Feb 29. PubMed PMID: 22379120.


29: Werthmann RC, Volpe S, Lohse MJ, Calebiro D. Persistent cAMP signaling by
internalized TSH receptors occurs in thyroid but not in HEK293 cells. FASEB J.
2012 May;26(5):2043-8. doi: 10.1096/fj.11-195248. Epub 2012 Jan 30. PubMed PMID: 
22291442.


30: Alvarez-Curto E, Prihandoko R, Tautermann CS, Zwier JM, Pediani JD, Lohse MJ,
Hoffmann C, Tobin AB, Milligan G. Developing chemical genetic approaches to
explore G protein-coupled receptor function: validation of the use of a receptor 
activated solely by synthetic ligand (RASSL). Mol Pharmacol. 2011
Dec;80(6):1033-46. doi: 10.1124/mol.111.074674. Epub 2011 Aug 31. PubMed PMID:
21880827; PubMed Central PMCID: PMC3228535.


31: Börner S, Schwede F, Schlipp A, Berisha F, Calebiro D, Lohse MJ, Nikolaev VO.
FRET measurements of intracellular cAMP concentrations and cAMP analog
permeability in intact cells. Nat Protoc. 2011 Apr;6(4):427-38. doi:
10.1038/nprot.2010.198. Epub 2011 Mar 10. PubMed PMID: 21412271.


32: Frölich N, Dees C, Paetz C, Ren X, Lohse MJ, Nikolaev VO, Zenk MH. Distinct
pharmacological properties of morphine metabolites at G(i)-protein and β-arrestin
signaling pathways activated by the human μ-opioid receptor. Biochem Pharmacol.
2011 May 15;81(10):1248-54. doi: 10.1016/j.bcp.2011.03.001. Epub 2011 Mar 17.
PubMed PMID: 21396918.


33: Spille JH, Zürn A, Hoffmann C, Lohse MJ, Harms GS. Rotational diffusion of
the α(2a) adrenergic receptor revealed by FlAsH labeling in living cells. Biophys
J. 2011 Feb 16;100(4):1139-48. doi: 10.1016/j.bpj.2010.08.080. PubMed PMID:
21320460; PubMed Central PMCID: PMC3037569.


34: Werthmann RC, Lohse MJ, Bünemann M. Temporally resolved cAMP monitoring in
endothelial cells uncovers a thrombin-induced [cAMP] elevation mediated via the
Ca²+-dependent production of prostacyclin. J Physiol. 2011 Jan 1;589(Pt
1):181-93. doi: 10.1113/jphysiol.2010.200121. Epub 2010 Nov 8. PubMed PMID:
21059757; PubMed Central PMCID: PMC3039268.


35: Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, 
Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. 
Nat Protoc. 2010 Sep;5(10):1666-77. doi: 10.1038/nprot.2010.129. Epub 2010 Sep
23. PubMed PMID: 20885379; PubMed Central PMCID: PMC3086663.


36: Lampert KP, Schmidt C, Fischer P, Volff JN, Hoffmann C, Muck J, Lohse MJ,
Ryan MJ, Schartl M. Determination of onset of sexual maturation and mating
behavior by melanocortin receptor 4 polymorphisms. Curr Biol. 2010 Oct
12;20(19):1729-34. doi: 10.1016/j.cub.2010.08.029. Epub 2010 Sep 30. PubMed PMID:
20869245.


37: Reiner S, Ambrosio M, Hoffmann C, Lohse MJ. Differential signaling of the
endogenous agonists at the beta2-adrenergic receptor. J Biol Chem. 2010 Nov
12;285(46):36188-98. doi: 10.1074/jbc.M110.175604. Epub 2010 Sep 13. PubMed PMID:
20837485; PubMed Central PMCID: PMC2975241.


38: Ambrosio M, Zürn A, Lohse MJ. Sensing G protein-coupled receptor activation. 
Neuropharmacology. 2011 Jan;60(1):45-51. doi: 10.1016/j.neuropharm.2010.08.006.
Epub 2010 Aug 18. Review. PubMed PMID: 20727363.


39: Ziegler N, Bätz J, Zabel U, Lohse MJ, Hoffmann C. FRET-based sensors for the 
human M1-, M3-, and M5-acetylcholine receptors. Bioorg Med Chem. 2011 Feb
1;19(3):1048-54. doi: 10.1016/j.bmc.2010.07.060. Epub 2010 Jul 30. PubMed PMID:
20716489.


40: Klenk C, Vetter T, Zürn A, Vilardaga JP, Friedman PA, Wang B, Lohse MJ.
Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid
hormone receptor. J Biol Chem. 2010 Sep 24;285(39):30355-62. doi:
10.1074/jbc.M110.114900. Epub 2010 Jul 23. PubMed PMID: 20656684; PubMed Central 
PMCID: PMC2943313.


41: Ambrosio M, Lohse MJ. Microscopy: GPCR dimers moving closer. Nat Chem Biol.
2010 Aug;6(8):570-1. doi: 10.1038/nchembio.409. PubMed PMID: 20644543.


42: Jacobs S, Calebiro D, Nikolaev VO, Lohse MJ, Schulz S. Real-time monitoring
of somatostatin receptor-cAMP signaling in live pituitary. Endocrinology. 2010
Sep;151(9):4560-5. doi: 10.1210/en.2010-0341. Epub 2010 Jul 7. PubMed PMID:
20610560.


43: Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B,
Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR,
Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB:
the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 
15;26(14):1804-5. doi: 10.1093/bioinformatics/btq264. Epub 2010 May 25. PubMed
PMID: 20501551; PubMed Central PMCID: PMC2894509.


44: Deubner N, Berliner D, Schlipp A, Gelbrich G, Caforio AL, Felix SB, Fu M,
Katus H, Angermann CE, Lohse MJ, Ertl G, Störk S, Jahns R; Etiology,
Titre-Course, and Survival-Study Group. Cardiac beta1-adrenoceptor autoantibodies
in human heart disease: rationale and design of the Etiology, Titre-Course, and
Survival (ETiCS) Study. Eur J Heart Fail. 2010 Jul;12(7):753-62. doi:
10.1093/eurjhf/hfq072. Epub 2010 May 21. PubMed PMID: 20494925.


45: Zürn A, Klenk C, Zabel U, Reiner S, Lohse MJ, Hoffmann C. Site-specific,
orthogonal labeling of proteins in intact cells with two small biarsenical
fluorophores. Bioconjug Chem. 2010 May 19;21(5):853-9. doi: 10.1021/bc900394j.
PubMed PMID: 20429545.


46: Volpe S, Thelen S, Pertel T, Lohse MJ, Thelen M. Polarization of migrating
monocytic cells is independent of PI 3-kinase activity. PLoS One. 2010 Apr
15;5(4):e10159. doi: 10.1371/journal.pone.0010159. PubMed PMID: 20419163; PubMed 
Central PMCID: PMC2855346.


47: Jahns R, Schlipp A, Boivin V, Lohse MJ. Targeting receptor antibodies in
immune cardiomyopathy. Semin Thromb Hemost. 2010 Mar;36(2):212-8. doi:
10.1055/s-0030-1251506. Epub 2010 Apr 22. Review. PubMed PMID: 20414837.


48: Calebiro D, Nikolaev VO, Lohse MJ. Imaging of persistent cAMP signaling by
internalized G protein-coupled receptors. J Mol Endocrinol. 2010 Jul;45(1):1-8.
doi: 10.1677/JME-10-0014. Epub 2010 Apr 8. Review. PubMed PMID: 20378719.


49: Calebiro D, Nikolaev VO, Persani L, Lohse MJ. Signaling by internalized
G-protein-coupled receptors. Trends Pharmacol Sci. 2010 May;31(5):221-8. doi:
10.1016/j.tips.2010.02.002. Epub 2010 Mar 18. Review. PubMed PMID: 20303186.


50: Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ,
Korchev YE, Harding SE, Gorelik J. Beta2-adrenergic receptor redistribution in
heart failure changes cAMP compartmentation. Science. 2010 Mar
26;327(5973):1653-7. doi: 10.1126/science.1185988. Epub 2010 Feb 25. PubMed PMID:
20185685.


51: Lompré AM, Hajjar RJ, Harding SE, Kranias EG, Lohse MJ, Marks AR. Ca2+
cycling and new therapeutic approaches for heart failure. Circulation. 2010 Feb
16;121(6):822-30. doi: 10.1161/CIRCULATIONAHA.109.890954. Epub 2010 Feb 1. PubMed
PMID: 20124124; PubMed Central PMCID: PMC2834781.


52: Maier-Peuschel M, Frölich N, Dees C, Hommers LG, Hoffmann C, Nikolaev VO,
Lohse MJ. A fluorescence resonance energy transfer-based M2 muscarinic receptor
sensor reveals rapid kinetics of allosteric modulation. J Biol Chem. 2010 Mar
19;285(12):8793-800. doi: 10.1074/jbc.M109.098517. Epub 2010 Jan 18. PubMed PMID:
20083608; PubMed Central PMCID: PMC2838301.


53: Klenk C, Schulz S, Calebiro D, Lohse MJ. Agonist-regulated cleavage of the
extracellular domain of parathyroid hormone receptor type 1. J Biol Chem. 2010
Mar 19;285(12):8665-74. doi: 10.1074/jbc.M109.058685. Epub 2010 Jan 15. PubMed
PMID: 20080964; PubMed Central PMCID: PMC2838289.


54: Wachten S, Masada N, Ayling LJ, Ciruela A, Nikolaev VO, Lohse MJ, Cooper DM. 
Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in
pituitary-derived GH3B6 cells. J Cell Sci. 2010 Jan 1;123(Pt 1):95-106. doi:
10.1242/jcs.058594. PubMed PMID: 20016070; PubMed Central PMCID: PMC2794711.


55: Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J,
Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, 
Tremblay J, Kotchen TA, Kaldunski M, Nüsing R, Szabo B, Jacob HJ, Cowley AW Jr,
Biel M, Stoll M, Lohse MJ, Broeckel U, Hein L. Phosducin influences sympathetic
activity and prevents stress-induced hypertension in humans and mice. J Clin
Invest. 2009 Dec;119(12):3597-3612. doi: 10.1172/JCI38433. Erratum in: J Clin
Invest. 2011 Jan 4;121(1):454. Lorkowski, Stefan [added]. PubMed PMID: 19959875; 
PubMed Central PMCID: PMC2786789.


56: Lohse MJ. Dimerization in GPCR mobility and signaling. Curr Opin Pharmacol.
2010 Feb;10(1):53-8. doi: 10.1016/j.coph.2009.10.007. Epub 2009 Nov 10. Review.
PubMed PMID: 19910252.


57: von Hayn K, Werthmann RC, Nikolaev VO, Hommers LG, Lohse MJ, Bünemann M.
Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle 
cells. Am J Physiol Cell Physiol. 2010 Feb;298(2):C324-32. doi:
10.1152/ajpcell.00197.2009. Epub 2009 Nov 4. PubMed PMID: 19889965.


58: Reiner S, Ziegler N, Leon C, Lorenz K, von Hayn K, Gachet C, Lohse MJ,
Hoffmann C. beta-Arrestin-2 interaction and internalization of the human P2Y1
receptor are dependent on C-terminal phosphorylation sites. Mol Pharmacol. 2009
Dec;76(6):1162-71. doi: 10.1124/mol.109.060467. Epub 2009 Sep 9. PubMed PMID:
19741005.


59: Calebiro D, Nikolaev VO, Gagliani MC, de Filippis T, Dees C, Tacchetti C,
Persani L, Lohse MJ. Persistent cAMP-signals triggered by internalized
G-protein-coupled receptors. PLoS Biol. 2009 Aug;7(8):e1000172. doi:
10.1371/journal.pbio.1000172. Epub 2009 Aug 18. PubMed PMID: 19688034; PubMed
Central PMCID: PMC2718703.


60: Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO,
Lohse MJ, Tominaga M, Mogami H. A technique for monitoring multiple signals with 
a combination of prism-based total internal reflection fluorescence microscopy
and epifluorescence microscopy. Pflugers Arch. 2009 Nov;459(1):227-34. doi:
10.1007/s00424-009-0705-8. Epub 2009 Aug 13. PubMed PMID: 19680684.


61: Lorenz K, Schmitt JP, Vidal M, Lohse MJ. Cardiac hypertrophy: targeting
Raf/MEK/ERK1/2-signaling. Int J Biochem Cell Biol. 2009 Dec;41(12):2351-5. doi:
10.1016/j.biocel.2009.08.002. Epub 2009 Aug 8. Review. PubMed PMID: 19666137.


62: Werthmann RC, von Hayn K, Nikolaev VO, Lohse MJ, Bünemann M. Real-time
monitoring of cAMP levels in living endothelial cells: thrombin transiently
inhibits adenylyl cyclase 6. J Physiol. 2009 Aug 15;587(Pt 16):4091-104. doi:
10.1113/jphysiol.2009.172957. Epub 2009 Jun 22. PubMed PMID: 19546162; PubMed
Central PMCID: PMC2756440.


63: Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ,
Shigemura N, Ninomiya Y, Kojima I. Sweet taste receptor expressed in pancreatic
beta-cells activates the calcium and cyclic AMP signaling systems and stimulates 
insulin secretion. PLoS One. 2009;4(4):e5106. doi: 10.1371/journal.pone.0005106. 
Epub 2009 Apr 8. PubMed PMID: 19352508; PubMed Central PMCID: PMC2663034.


64: Mironov SL, Skorova E, Taschenberger G, Hartelt N, Nikolaev VO, Lohse MJ,
Kügler S. Imaging cytoplasmic cAMP in mouse brainstem neurons. BMC Neurosci. 2009
Mar 27;10:29. doi: 10.1186/1471-2202-10-29. PubMed PMID: 19327133; PubMed Central
PMCID: PMC2674597.


65: Dorsch S, Klotz KN, Engelhardt S, Lohse MJ, Bünemann M. Analysis of receptor 
oligomerization by FRAP microscopy. Nat Methods. 2009 Mar;6(3):225-30. doi:
10.1038/nmeth.1304. Epub 2009 Feb 22. PubMed PMID: 19234451.


66: Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR,
Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND,
Waldhoer M, Woods AS, Franco R. Building a new conceptual framework for receptor 
heteromers. Nat Chem Biol. 2009 Mar;5(3):131-4. doi: 10.1038/nchembio0309-131.
PubMed PMID: 19219011; PubMed Central PMCID: PMC2681085.


67: Vilardaga JP, Bünemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S,
Lohse MJ, Hoffmann C. GPCR and G proteins: drug efficacy and activation in live
cells. Mol Endocrinol. 2009 May;23(5):590-9. doi: 10.1210/me.2008-0204. Epub 2009
Feb 5. Review. PubMed PMID: 19196832.


68: Schmitt JP, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, Maclennan DH,
Seidman CE, Seidman JG, Lohse MJ. Alterations of phospholamban function can
exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum
Ca2+-ATPase inhibition. Circulation. 2009 Jan 27;119(3):436-44. doi:
10.1161/CIRCULATIONAHA.108.783506. Epub 2009 Jan 12. PubMed PMID: 19139388.


69: Zürn A, Zabel U, Vilardaga JP, Schindelin H, Lohse MJ, Hoffmann C.
Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor
activation reveals distinct agonist-specific conformational changes. Mol
Pharmacol. 2009 Mar;75(3):534-41. doi: 10.1124/mol.108.052399. Epub 2008 Dec 23. 
PubMed PMID: 19106230.


70: Lewin G, Matus M, Basu A, Frebel K, Rohsbach SP, Safronenko A, Seidl MD,
Stümpel F, Buchwalow I, König S, Engelhardt S, Lohse MJ, Schmitz W, Müller FU.
Critical role of transcription factor cyclic AMP response element modulator in
beta1-adrenoceptor-mediated cardiac dysfunction. Circulation. 2009 Jan
6;119(1):79-88. doi: 10.1161/CIRCULATIONAHA.108.786533. Epub 2008 Dec 22. PubMed 
PMID: 19103994.


71: Nikolaev VO, Lohse MJ. Novel techniques for real-time monitoring of cGMP in
living cells. Handb Exp Pharmacol. 2009;(191):229-43. doi:
10.1007/978-3-540-68964-5_11. Review. PubMed PMID: 19089332.


72: Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ. A new type of ERK1/2
autophosphorylation causes cardiac hypertrophy. Nat Med. 2009 Jan;15(1):75-83.
doi: 10.1038/nm.1893. Epub 2008 Dec 7. PubMed PMID: 19060905.


73: Krasel C, Zabel U, Lorenz K, Reiner S, Al-Sabah S, Lohse MJ. Dual role of the
beta2-adrenergic receptor C terminus for the binding of beta-arrestin and
receptor internalization. J Biol Chem. 2008 Nov 14;283(46):31840-8. doi:
10.1074/jbc.M806086200. Epub 2008 Sep 18. PubMed PMID: 18801735.


74: Jahns R, Boivin V, Schwarzbach V, Ertl G, Lohse MJ. Pathological
autoantibodies in cardiomyopathy. Autoimmunity. 2008 Sep;41(6):454-61. doi:
10.1080/08916930802031603. Review. PubMed PMID: 18781471.


75: Lohse MJ, Klenk C. Blocking them all: beta-arrestins inhibit cellular
signaling. Mol Cell. 2008 Sep 5;31(5):619-21. doi: 10.1016/j.molcel.2008.08.015. 
PubMed PMID: 18775321.


76: Hoffmann C, Ziegler N, Reiner S, Krasel C, Lohse MJ. Agonist-selective,
receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2.
J Biol Chem. 2008 Nov 7;283(45):30933-41. doi: 10.1074/jbc.M801472200. Epub 2008 
Aug 14. PubMed PMID: 18703513; PubMed Central PMCID: PMC2662168.


77: Iancu RV, Ramamurthy G, Warrier S, Nikolaev VO, Lohse MJ, Jones SW, Harvey
RD. Cytoplasmic cAMP concentrations in intact cardiac myocytes. Am J Physiol Cell
Physiol. 2008 Aug;295(2):C414-22. doi: 10.1152/ajpcell.00038.2008. Epub 2008 Jun 
11. PubMed PMID: 18550706; PubMed Central PMCID: PMC2518413.


78: Schlickum S, Sennefelder H, Friedrich M, Harms G, Lohse MJ, Kilshaw P, Schön 
MP. Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a
ligand-dependent fashion. Blood. 2008 Aug 1;112(3):619-25. doi:
10.1182/blood-2008-01-134833. Epub 2008 May 20. PubMed PMID: 18492951.


79: Herget S, Lohse MJ, Nikolaev VO. Real-time monitoring of phosphodiesterase
inhibition in intact cells. Cell Signal. 2008 Aug;20(8):1423-31. doi:
10.1016/j.cellsig.2008.03.011. Epub 2008 Mar 26. PubMed PMID: 18467075.


80: Shafer OT, Kim DJ, Dunbar-Yaffe R, Nikolaev VO, Lohse MJ, Taghert PH.
Widespread receptivity to neuropeptide PDF throughout the neuronal circadian
clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron.
2008 Apr 24;58(2):223-37. doi: 10.1016/j.neuron.2008.02.018. PubMed PMID:
18439407; PubMed Central PMCID: PMC2586874.


81: Lohse MJ, Nikolaev VO, Hein P, Hoffmann C, Vilardaga JP, Bünemann M. Optical 
techniques to analyze real-time activation and signaling of G-protein-coupled
receptors. Trends Pharmacol Sci. 2008 Mar;29(3):159-65. doi:
10.1016/j.tips.2007.12.002. Epub 2008 Feb 11. Review. PubMed PMID: 18262662.


82: Mayer G, Wulffen B, Huber C, Brockmann J, Flicke B, Neumann L, Hafenbradl D, 
Klebl BM, Lohse MJ, Krasel C, Blind M. An RNA molecule that specifically inhibits
G-protein-coupled receptor kinase 2 in vitro. RNA. 2008 Mar;14(3):524-34. doi:
10.1261/rna.821908. Epub 2008 Jan 29. PubMed PMID: 18230760; PubMed Central
PMCID: PMC2248252.


83: Lohse MJ, Hein P, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetics
of G-protein-coupled receptor signals in intact cells. Br J Pharmacol. 2008
Mar;153 Suppl 1:S125-32. doi: 10.1038/sj.bjp.0707656. Epub 2008 Jan 14. Review.
PubMed PMID: 18193071; PubMed Central PMCID: PMC2268076.


84: Vilardaga JP, Nikolaev VO, Lorenz K, Ferrandon S, Zhuang Z, Lohse MJ.
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors
controls cell signaling. Nat Chem Biol. 2008 Feb;4(2):126-31. doi:
10.1038/nchembio.64. Epub 2008 Jan 13. PubMed PMID: 18193048.


85: Hoffmann C, Zürn A, Bünemann M, Lohse MJ. Conformational changes in
G-protein-coupled receptors-the quest for functionally selective conformations is
open. Br J Pharmacol. 2008 Mar;153 Suppl 1:S358-66. Epub 2007 Dec 3. Review.
PubMed PMID: 18059316; PubMed Central PMCID: PMC2268050.


86: Rohrbach S, Engelhardt S, Lohse MJ, Werdan K, Holtz J, Muller-Werdan U.
Activation of AP-1 contributes to the beta-adrenoceptor-mediated myocardial
induction of interleukin-6. Mol Med. 2007 Nov-Dec;13(11-12):605-14. PubMed PMID: 
17948064; PubMed Central PMCID: PMC2030512.


87: Lohse MJ, Bünemann M, Hoffmann C, Vilardaga JP, Nikolaev VO. Monitoring
receptor signaling by intramolecular FRET. Curr Opin Pharmacol. 2007
Oct;7(5):547-53. Epub 2007 Oct 4. Review. PubMed PMID: 17919975.


88: Lohse MJ, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetic analysis
of G protein-coupled receptor signaling using fluorescence resonance energy
transfer in living cells. Adv Protein Chem. 2007;74:167-88. Review. PubMed PMID: 
17854658.


89: Nikolaev VO, Boivin V, Störk S, Angermann CE, Ertl G, Lohse MJ, Jahns R. A
novel fluorescence method for the rapid detection of functional beta1-adrenergic 
receptor autoantibodies in heart failure. J Am Coll Cardiol. 2007 Jul
31;50(5):423-31. Epub 2007 Jul 13. PubMed PMID: 17662395.


90: Nikolaev VO, Boettcher C, Dees C, Bünemann M, Lohse MJ, Zenk MH. Live cell
monitoring of mu-opioid receptor-mediated G-protein activation reveals strong
biological activity of close morphine biosynthetic precursors. J Biol Chem. 2007 
Sep 14;282(37):27126-32. Epub 2007 Jul 6. PubMed PMID: 17616524.


91: Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G,
Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F,
Filizola M. Requirements and ontology for a G protein-coupled receptor
oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. PubMed
PMID: 17537266; PubMed Central PMCID: PMC1904246.


92: Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ,
Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic 
and Clinical Pharmacology. LXVII. Recommendations for the recognition and
nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev. 2007
Mar;59(1):5-13. Review. PubMed PMID: 17329545.


93: Merkle S, Frantz S, Schön MP, Bauersachs J, Buitrago M, Frost RJ,
Schmitteckert EM, Lohse MJ, Engelhardt S. A role for caspase-1 in heart failure. 
Circ Res. 2007 Mar 16;100(5):645-53. Epub 2007 Feb 15. PubMed PMID: 17303764.


94: Warrier S, Ramamurthy G, Eckert RL, Nikolaev VO, Lohse MJ, Harvey RD. cAMP
microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular
myocytes. J Physiol. 2007 May 1;580(Pt.3):765-76. Epub 2007 Feb 8. PubMed PMID:
17289786; PubMed Central PMCID: PMC2075464.


95: Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. Direct
inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated
pacemaker channels by clonidine. Circulation. 2007 Feb 20;115(7):872-80. Epub
2007 Jan 29. PubMed PMID: 17261653.


96: Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ, Engelhardt S.
Real-time optical recording of beta1-adrenergic receptor activation reveals
supersensitivity of the Arg389 variant to carvedilol. J Clin Invest. 2007
Jan;117(1):229-35. PubMed PMID: 17200720; PubMed Central PMCID: PMC1751291.


97: Seeland U, Selejan S, Engelhardt S, Müller P, Lohse MJ, Böhm M. Interstitial 
remodeling in beta1-adrenergic receptor transgenic mice. Basic Res Cardiol. 2007 
Mar;102(2):183-93. Epub 2006 Nov 24. PubMed PMID: 17122889; PubMed Central PMCID:
PMC2779411.


98: Lohse MJ. G protein-coupled receptors: too many dimers? Nat Methods. 2006
Dec;3(12):972-3. PubMed PMID: 17117152.


99: Nikolaev VO, Bünemann M, Schmitteckert E, Lohse MJ, Engelhardt S. Cyclic AMP 
imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but
locally confined beta2-adrenergic receptor-mediated signaling. Circ Res. 2006 Nov
10;99(10):1084-91. Epub 2006 Oct 12. PubMed PMID: 17038640.


100: Störk S, Boivin V, Horf R, Hein L, Lohse MJ, Angermann CE, Jahns R.
Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor
predict increased mortality in idiopathic cardiomyopathy. Am Heart J. 2006
Oct;152(4):697-704. PubMed PMID: 16996841.


101: Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW. Simultaneous
optical measurements of cytosolic Ca2+ and cAMP in single cells. Sci STKE. 2006
Sep 19;2006(353):pl6. PubMed PMID: 16985238; PubMed Central PMCID: PMC3140640.


102: Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende
U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG. Cardiac myosin missense mutations
cause dilated cardiomyopathy in mouse models and depress molecular motor
function. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14525-30. Epub 2006 Sep
18. PubMed PMID: 16983074; PubMed Central PMCID: PMC1599993.


103: Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot
CH, Lohse MJ, Bünemann M. Gs activation is time-limiting in initiating
receptor-mediated signaling. J Biol Chem. 2006 Nov 3;281(44):33345-51. Epub 2006 
Sep 8. PubMed PMID: 16963443.


104: Jahns R, Boivin V, Lohse MJ. Beta 1-adrenergic receptor-directed
autoimmunity as a cause of dilated cardiomyopathy in rats. Int J Cardiol. 2006
Sep 10;112(1):7-14. Epub 2006 Jul 26. Review. PubMed PMID: 16872696.


105: Nikolaev VO, Hoffmann C, Bünemann M, Lohse MJ, Vilardaga JP. Molecular basis
of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and
Gi-protein heterotrimer. J Biol Chem. 2006 Aug 25;281(34):24506-11. Epub 2006 Jun
20. PubMed PMID: 16787921.


106: Nikolaev VO, Lohse MJ. Monitoring of cAMP synthesis and degradation in
living cells. Physiology (Bethesda). 2006 Apr;21:86-92. Review. PubMed PMID:
16565474.


107: Klenk C, Humrich J, Quitterer U, Lohse MJ. SUMO-1 controls the protein
stability and the biological function of phosducin. J Biol Chem. 2006 Mar
31;281(13):8357-64. Epub 2006 Jan 18. PubMed PMID: 16421094.


108: Vilardaga JP, Steinmeyer R, Harms GS, Lohse MJ. Molecular basis of inverse
agonism in a G protein-coupled receptor. Nat Chem Biol. 2005 Jun;1(1):25-8. Epub 
2005 May 24. PubMed PMID: 16407989.


109: Jahns R, Boivin V, Lohse MJ. beta(1)-Adrenergic receptor function,
autoimmunity, and pathogenesis of dilated cardiomyopathy. Trends Cardiovasc Med. 
2006 Jan;16(1):20-4. Review. PubMed PMID: 16387626.


110: Nikolaev VO, Gambaryan S, Lohse MJ. Fluorescent sensors for rapid monitoring
of intracellular cGMP. Nat Methods. 2006 Jan;3(1):23-5. PubMed PMID: 16369548.


111: Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M. Dynamics of receptor/G
protein coupling in living cells. EMBO J. 2005 Dec 7;24(23):4106-14. Epub 2005
Nov 17. PubMed PMID: 16292347; PubMed Central PMCID: PMC1356310.


112: Castro M, Nikolaev VO, Palm D, Lohse MJ, Vilardaga JP. Turn-on switch in
parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism.
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16084-9. Epub 2005 Oct 18. PubMed
PMID: 16236727; PubMed Central PMCID: PMC1276049.


113: Winstel R, Ihlenfeldt HG, Jung G, Krasel C, Lohse MJ. Peptide inhibitors of 
G protein-coupled receptor kinases. Biochem Pharmacol. 2005 Oct 1;70(7):1001-8.
PubMed PMID: 16102734.


114: Buitrago M, Lorenz K, Maass AH, Oberdorf-Maass S, Keller U, Schmitteckert
EM, Ivashchenko Y, Lohse MJ, Engelhardt S. The transcriptional repressor Nab1 is 
a specific regulator of pathological cardiac hypertrophy. Nat Med. 2005
Aug;11(8):837-44. Epub 2005 Jul 17. PubMed PMID: 16025126.


115: Landa LR Jr, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, 
Nikolaev VO, Lohse MJ, Holz GG, Roe MW. Interplay of Ca2+ and cAMP signaling in
the insulin-secreting MIN6 beta-cell line. J Biol Chem. 2005 Sep
2;280(35):31294-302. Epub 2005 Jun 29. PubMed PMID: 15987680; PubMed Central
PMCID: PMC3508785.


116: Frank M, Thümer L, Lohse MJ, Bünemann M. G Protein activation without
subunit dissociation depends on a G{alpha}(i)-specific region. J Biol Chem. 2005 
Jul 1;280(26):24584-90. Epub 2005 May 2. PubMed PMID: 15866880.


117: Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B,
Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to
determine G protein-coupled receptor activation in living cells. Nat Methods.
2005 Mar;2(3):171-6. Epub 2005 Feb 17. PubMed PMID: 15782185.


118: Humrich J, Bermel C, Bünemann M, Härmark L, Frost R, Quitterer U, Lohse MJ. 
Phosducin-like protein regulates G-protein betagamma folding by interaction with 
tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns 
the switch toward regulation of Gbetagamma folding. J Biol Chem. 2005 May
20;280(20):20042-50. Epub 2005 Mar 2. PubMed PMID: 15745879.


119: Frambach T, Müller T, Freund S, Engelhardt S, Sütterlin M, Lohse MJ, Dietl
J. Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is
mediated through receptor G protein uncoupling. J Clin Endocrinol Metab. 2005
May;90(5):2882-7. Epub 2005 Feb 22. PubMed PMID: 15728216.


120: Krasel C, Bünemann M, Lorenz K, Lohse MJ. Beta-arrestin binding to the
beta2-adrenergic receptor requires both receptor phosphorylation and receptor
activation. J Biol Chem. 2005 Mar 11;280(10):9528-35. Epub 2005 Jan 5. PubMed
PMID: 15634674.


121: Nikolaev VO, Gambaryan S, Engelhardt S, Walter U, Lohse MJ. Real-time
monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis
is faster than hormone-stimulated cAMP synthesis. J Biol Chem. 2005 Jan
21;280(3):1716-9. Epub 2004 Nov 22. PubMed PMID: 15557342.


122: Krasel C, Vilardaga JP, Bünemann M, Lohse MJ. Kinetics of G-protein-coupled 
receptor signalling and desensitization. Biochem Soc Trans. 2004 Dec;32(Pt
6):1029-31. PubMed PMID: 15506955.


123: Schwab KO, Menche U, Schmeisl G, Lohse MJ. Hypoglycemia-dependent
beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia
unawareness in patients with Type-1 diabetes? Horm Res. 2004;62(3):137-41. Epub
2004 Aug 3. PubMed PMID: 15297801.


124: Nikolaev VO, Bünemann M, Hein L, Hannawacker A, Lohse MJ. Novel single chain
cAMP sensors for receptor-induced signal propagation. J Biol Chem. 2004 Sep
3;279(36):37215-8. Epub 2004 Jul 1. PubMed PMID: 15231839.


125: Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E,
Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M. Fluorescence resonance 
energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac
myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ
Res. 2004 Jul 9;95(1):67-75. Epub 2004 Jun 3. PubMed PMID: 15178638.


126: Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ. Direct
evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause
of idiopathic dilated cardiomyopathy. J Clin Invest. 2004 May;113(10):1419-29.
PubMed PMID: 15146239; PubMed Central PMCID: PMC406525.


127: Lohse MJ, Vilardaga JP, Bünemann M. Molecular mechanisms of receptor
activation: real-time analysis by fluorescence resonance energy transfer. Auton
Autacoid Pharmacol. 2003 Aug;23(4):231-3. PubMed PMID: 15134067.


128: Lohse MJ. Beta-adrenoceptor polymorphisms and heart failure. Trends Mol Med.
2004 Feb;10(2):55-8. Review. PubMed PMID: 15106619.


129: Foerster K, Kaeferstein T, Groner F, Engelhardt S, Matthes J, Koch WJ, Lohse
MJ, Herzig S. Calcium channel function and regulation in beta 1- and beta
2-adrenoceptor transgenic mice. Naunyn Schmiedebergs Arch Pharmacol. 2004
May;369(5):490-5. Epub 2004 Apr 9. PubMed PMID: 15083268.


130: Kirchhefer U, Jones LR, Begrow F, Boknik P, Hein L, Lohse MJ, Riemann B,
Schmitz W, Stypmann J, Neumann J. Transgenic triadin 1 overexpression alters SR
Ca2+ handling and leads to a blunted contractile response to beta-adrenergic
agonists. Cardiovasc Res. 2004 Apr 1;62(1):122-34. PubMed PMID: 15023559.


131: Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G, Lohse MJ.
Altered calcium handling is critically involved in the cardiotoxic effects of
chronic beta-adrenergic stimulation. Circulation. 2004 Mar 9;109(9):1154-60. Epub
2004 Feb 16. PubMed PMID: 14967726.


132: Hoffmann C, Leitz MR, Oberdorf-Maass S, Lohse MJ, Klotz KN. Comparative
pharmacology of human beta-adrenergic receptor subtypes--characterization of
stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol.
2004 Feb;369(2):151-9. Epub 2004 Jan 17. PubMed PMID: 14730417.


133: Bünemann M, Frank M, Lohse MJ. Gi protein activation in intact cells
involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci U S
A. 2003 Dec 23;100(26):16077-82. Epub 2003 Dec 12. PubMed PMID: 14673086; PubMed 
Central PMCID: PMC307695.


134: Lorenz K, Lohse MJ, Quitterer U. Protein kinase C switches the Raf kinase
inhibitor from Raf-1 to GRK-2. Nature. 2003 Dec 4;426(6966):574-9. PubMed PMID:
14654844.


135: Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, 
Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic
response in different mouse models of beta-adrenergic-induced cardiomyopathy.
Circulation. 2003 Dec 9;108(23):2926-33. Epub 2003 Nov 17. PubMed PMID: 14623810.


136: Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of beta-adrenergic
signaling in heart failure? Circ Res. 2003 Nov 14;93(10):896-906. Review. PubMed 
PMID: 14615493.


137: Lohse MJ, Vilardaga JP, Bünemann M. Direct optical recording of intrinsic
efficacy at a G protein-coupled receptor. Life Sci. 2003 Dec 5;74(2-3):397-404.
PubMed PMID: 14607268.


138: Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan
S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U, Hein L.
Disruption of cardiac Ena-VASP protein localization in intercalated disks causes 
dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2003
Dec;285(6):H2471-81. Epub 2003 Aug 21. PubMed PMID: 12933343.


139: Li Z, Laugwitz KL, Pinkernell K, Pragst I, Baumgartner C, Hoffmann E,
Rosport K, Münch G, Moretti A, Humrich J, Lohse MJ, Ungerer M. Effects of two
Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic
receptor kinase C terminus (betaARKct)--in heart failure. Gene Ther. 2003
Aug;10(16):1354-61. PubMed PMID: 12883532.


140: Maack C, Böhm M, Vlaskin L, Dabew E, Lorenz K, Schäfers HJ, Lohse MJ,
Engelhardt S. Partial agonist activity of bucindolol is dependent on the
activation state of the human beta1-adrenergic receptor. Circulation. 2003 Jul
22;108(3):348-53. Epub 2003 Jul 7. PubMed PMID: 12847069.


141: Vilardaga JP, Bünemann M, Krasel C, Castro M, Lohse MJ. Measurement of the
millisecond activation switch of G protein-coupled receptors in living cells. Nat
Biotechnol. 2003 Jul;21(7):807-12. Epub 2003 Jun 15. PubMed PMID: 12808462.


142: Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L. Differential
control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor 
subtypes. Mol Endocrinol. 2003 Aug;17(8):1640-6. Epub 2003 May 22. PubMed PMID:
12764077.


143: Spindler M, Engelhardt S, Niebler R, Wagner H, Hein L, Lohse MJ, Neubauer S.
Alterations in the myocardial creatine kinase system precede the development of
contractile dysfunction in beta(1)-adrenergic receptor transgenic mice. J Mol
Cell Cardiol. 2003 Apr;35(4):389-97. PubMed PMID: 12689818.


144: Hessling J, Lohse MJ, Klotz KN. Peptide G protein agonists from a phage
display library. Biochem Pharmacol. 2003 Mar 15;65(6):961-7. PubMed PMID:
12623127.


145: Eichmann T, Lorenz K, Hoffmann M, Brockmann J, Krasel C, Lohse MJ, Quitterer
U. The amino-terminal domain of G-protein-coupled receptor kinase 2 is a
regulatory Gbeta gamma binding site. J Biol Chem. 2003 Mar 7;278(10):8052-7. Epub
2002 Dec 16. PubMed PMID: 12486133.


146: Humrich J, Bermel C, Grubel T, Quitterer U, Lohse MJ. Regulation of
phosducin-like protein by casein kinase 2 and N-terminal splicing. J Biol Chem.
2003 Feb 14;278(7):4474-81. Epub 2002 Dec 3. PubMed PMID: 12466282.


147: Hannawacker A, Krasel C, Lohse MJ. Mutation of Asn293 to Asp in
transmembrane helix VI abolishes agonist-induced but not constitutive activity of
the beta(2)-adrenergic receptor. Mol Pharmacol. 2002 Dec;62(6):1431-7. PubMed
PMID: 12435811.


148: Brede M, Wiesmann F, Jahns R, Hadamek K, Arnolt C, Neubauer S, Lohse MJ,
Hein L. Feedback inhibition of catecholamine release by two different
alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation. 
2002 Nov 5;106(19):2491-6. PubMed PMID: 12417548.


149: Hommers LG, Lohse MJ, Bünemann M. Regulation of the inward rectifying
properties of G-protein-activated inwardly rectifying K+ (GIRK) channels by Gbeta
gamma subunits. J Biol Chem. 2003 Jan 10;278(2):1037-43. Epub 2002 Oct 25. PubMed
PMID: 12403784.


150: Castro M, Dicker F, Vilardaga JP, Krasel C, Bernhardt M, Lohse MJ. Dual
regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor
signaling by protein kinase C and beta-arrestins. Endocrinology. 2002
Oct;143(10):3854-65. PubMed PMID: 12239097.


151: Michaelevski I, Chikvashvili D, Tsuk S, Fili O, Lohse MJ, Singer-Lahat D,
Lotan I. Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires
the physical interaction of Gbetagamma with the channel. J Biol Chem. 2002 Sep
20;277(38):34909-17. Epub 2002 Jul 11. PubMed PMID: 12114518.


152: Vetter T, Lohse MJ. Magnesium and the parathyroid. Curr Opin Nephrol
Hypertens. 2002 Jul;11(4):403-10. Review. PubMed PMID: 12105390.


153: Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental
alpha(2)-adrenoceptors control vascular development at the interface between
mother and embryo. Nat Genet. 2002 Jul;31(3):311-5. Epub 2002 Jun 17. PubMed
PMID: 12068299.


154: Engelhardt S, Hein L, Keller U, Klämbt K, Lohse MJ. Inhibition of Na(+)-H(+)
exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic 
receptor transgenic mice. Circ Res. 2002 Apr 19;90(7):814-9. PubMed PMID:
11964375.


155: Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA.
Internalization determinants of the parathyroid hormone receptor differentially
regulate beta-arrestin/receptor association. J Biol Chem. 2002 Mar
8;277(10):8121-9. Epub 2001 Nov 28. PubMed PMID: 11726668.


156: Lohse MJ, Engelhardt S. Protein kinase a transgenes: the many faces of cAMP.
Circ Res. 2001 Nov 23;89(11):938-40. PubMed PMID: 11717148.


157: Brede M, Hadamek K, Meinel L, Wiesmann F, Peters J, Engelhardt S, Simm A,
Haase A, Lohse MJ, Hein L. Vascular hypertrophy and increased P70S6 kinase in
mice lacking the angiotensin II AT(2) receptor. Circulation. 2001 Nov
20;104(21):2602-7. PubMed PMID: 11714657.


158: Scheel AA, Funsch B, Busch M, Gradl G, Pschorr J, Lohse MJ. Receptor-ligand 
interactions studied with homogeneous fluorescence-based assays suitable for
miniaturized screening. J Biomol Screen. 2001 Feb;6(1):11-8. PubMed PMID:
11679161.


159: Chruscinski A, Brede ME, Meinel L, Lohse MJ, Kobilka BK, Hein L.
Differential distribution of beta-adrenergic receptor subtypes in blood vessels
of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Mol Pharmacol.
2001 Nov;60(5):955-62. PubMed PMID: 11641423.


160: Engelhardt S, Boknik P, Keller U, Neumann J, Lohse MJ, Hein L. Early
impairment of calcium handling and altered expression of junctin in hearts of
mice overexpressing the beta1-adrenergic receptor. FASEB J. 2001
Dec;15(14):2718-20. Epub 2001 Oct 15. PubMed PMID: 11606476.


161: Bünemann M, Bücheler MM, Philipp M, Lohse MJ, Hein L. Activation and
deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G
protein-activated inwardly rectifying K+ channel currents. J Biol Chem. 2001 Dec 
14;276(50):47512-7. Epub 2001 Oct 8. PubMed PMID: 11591725.


162: Engelhardt S, Grimmer Y, Fan GH, Lohse MJ. Constitutive activity of the
human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice. Mol
Pharmacol. 2001 Oct;60(4):712-7. PubMed PMID: 11562432.


163: Vilardaga JP, Frank M, Krasel C, Dees C, Nissenson RA, Lohse MJ.
Differential conformational requirements for activation of G proteins and the
regulatory proteins arrestin and G protein-coupled receptor kinase in the G
protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. J
Biol Chem. 2001 Sep 7;276(36):33435-43. Epub 2001 May 31. PubMed PMID: 11387315.


164: Wiesmann F, Ruff J, Engelhardt S, Hein L, Dienesch C, Leupold A, Illinger R,
Frydrychowicz A, Hiller KH, Rommel E, Haase A, Lohse MJ, Neubauer S.
Dobutamine-stress magnetic resonance microimaging in mice : acute changes of
cardiac geometry and function in normal and failing murine hearts. Circ Res. 2001
Mar 30;88(6):563-9. PubMed PMID: 11282889.


165: Lohse MJ. [Drugs--magic or science?]. Krankenpfl J. 2000
Dec;38(11-12):377-88. German. PubMed PMID: 11272986.


166: Boivin V, Jahns R, Gambaryan S, Ness W, Boege F, Lohse MJ. Immunofluorescent
imaging of beta 1- and beta 2-adrenergic receptors in rat kidney. Kidney Int.
2001 Feb;59(2):515-31. PubMed PMID: 11168934.


167: Schröder S, Lohse MJ. Quantification of the tissue levels and function of
the G-protein regulator phosducin-like protein (PhlP). Naunyn Schmiedebergs Arch 
Pharmacol. 2000 Nov;362(4-5):435-9. PubMed PMID: 11111839.


168: Illes P, Klotz KN, Lohse MJ. Signaling by extracellular nucleotides and
nucleosides. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):295-8. PubMed
PMID: 11111824.


169: Quitterer U, Hoffmann M, Freichel M, Lohse MJ. Paradoxical block of
parathormone secretion is mediated by increased activity of G alpha subunits. J
Biol Chem. 2001 Mar 2;276(9):6763-9. Epub 2000 Dec 1. PubMed PMID: 11102444.


170: Hammerschmidt S, Bell M, Büchler N, Wahn H, Remkes H, Lohse MJ, Neubauer S. 
Acute changes of myocardial creatine kinase gene expression under beta-adrenergic
stimulation. Biochim Biophys Acta. 2000 Nov 15;1502(3):471-80. PubMed PMID:
11068189.


171: Krasel C, Dammeier S, Winstel R, Brockmann J, Mischak H, Lohse MJ.
Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by
calmodulin. J Biol Chem. 2001 Jan 19;276(3):1911-5. Epub 2000 Oct 19. PubMed
PMID: 11042191.


172: Jahns R, Boivin V, Krapf T, Wallukat G, Boege F, Lohse MJ. Modulation of
beta1-adrenoceptor activity by domain-specific antibodies and heart
failure-associated autoantibodies. J Am Coll Cardiol. 2000 Oct;36(4):1280-7.
PubMed PMID: 11028484.


173: Ruiz-Gómez A, Humrich J, Murga C, Quitterer U, Lohse MJ, Mayor F Jr.
Phosphorylation of phosducin and phosducin-like protein by G protein-coupled
receptor kinase 2. J Biol Chem. 2000 Sep 22;275(38):29724-30. PubMed PMID:
10884381.


174: Brambilla R, Cattabeni F, Ceruti S, Barbieri D, Franceschi C, Kim YC,
Jacobson KA, Klotz KN, Lohse MJ, Abbracchio MP. Activation of the A3 adenosine
receptor affects cell cycle progression and cell growth. Naunyn Schmiedebergs
Arch Pharmacol. 2000 Mar;361(3):225-34. PubMed PMID: 10731034.


175: Lohse MJ. New directions in pharmacology. Lancet. 1999 Dec;354 Suppl:SIV52. 
PubMed PMID: 10691466.


176: Engelhardt S, Lohse MJ. Determination of adrenergic receptor mRNAs by
quantitative reverse transcriptase-polymerase chain reactions. Methods Mol Biol. 
2000;126:155-68. Review. PubMed PMID: 10685408.


177: Jahns R, Boivin V, Siegmund C, Boege F, Lohse MJ, Inselmann G. Activating
beta-1-adrenoceptor antibodies are not associated with cardiomyopathies secondary
to valvular or hypertensive heart disease. J Am Coll Cardiol. 1999 Nov
1;34(5):1545-51. PubMed PMID: 10551705.


178: Slupsky JR, Quitterer U, Weber CK, Gierschik P, Lohse MJ, Rapp UR. Binding
of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor
signalling. Curr Biol. 1999 Sep 9;9(17):971-4. PubMed PMID: 10508586.


179: Quitterer U, Lohse MJ. Crosstalk between Galpha(i)- and Galpha(q)-coupled
receptors is mediated by Gbetagamma exchange. Proc Natl Acad Sci U S A. 1999 Sep 
14;96(19):10626-31. PubMed PMID: 10485876; PubMed Central PMCID: PMC17933.


180: Lohse MJ. G-Proteins and their regulators. Naunyn Schmiedebergs Arch
Pharmacol. 1999 Jul;360(1):3-4. PubMed PMID: 10463327.


181: Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and
heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci U 
S A. 1999 Jun 8;96(12):7059-64. PubMed PMID: 10359838; PubMed Central PMCID:
PMC22055.


182: Dicker F, Quitterer U, Winstel R, Honold K, Lohse MJ.
Phosphorylation-independent inhibition of parathyroid hormone receptor signaling 
by G protein-coupled receptor kinases. Proc Natl Acad Sci U S A. 1999 May
11;96(10):5476-81. PubMed PMID: 10318908; PubMed Central PMCID: PMC21884.


183: Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F.
Autoantibodies activating human beta1-adrenergic receptors are associated with
reduced cardiac function in chronic heart failure. Circulation. 1999 Feb
9;99(5):649-54. PubMed PMID: 9950662.


184: Danner S, Lohse MJ. Regulation of beta-adrenergic receptor responsiveness
modulation of receptor gene expression. Rev Physiol Biochem Pharmacol.
1999;136:183-223. Review. PubMed PMID: 9932487.


185: Lohse MJ, Förstermann U, Schmidt HH. Pharmacology of NO:cGMP signal
transduction. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jul;358(1):111-2. PubMed 
PMID: 9721011.


186: Lohse MJ. The future of pharmacology. Trends Pharmacol Sci. 1998
Jun;19(6):198-200. PubMed PMID: 9666707.


187: Bauer PH, Lohse MJ. Effects of phosducin on the GTPase cycle of Go. Naunyn
Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):371-7. PubMed PMID: 9606021.


188: Neubauer S, Frank M, Hu K, Remkes H, Laser A, Horn M, Ertl G, Lohse MJ.
Changes of creatine kinase gene expression in rat heart post-myocardial
infarction. J Mol Cell Cardiol. 1998 Apr;30(4):803-10. PubMed PMID: 9602429.


189: Bauer PH, Blüml K, Schröder S, Hegler J, Dees C, Lohse MJ. Interactions of
phosducin with the subunits of G-proteins. Binding to the alpha as well as the
betagamma subunits. J Biol Chem. 1998 Apr 17;273(16):9465-71. PubMed PMID:
9545273.


190: Danner S, Frank M, Lohse MJ. Agonist regulation of human beta2-adrenergic
receptor mRNA stability occurs via a specific AU-rich element. J Biol Chem. 1998 
Feb 6;273(6):3223-9. PubMed PMID: 9452435.


191: Klotz KN, Hessling J, Hegler J, Owman C, Kull B, Fredholm BB, Lohse MJ.
Comparative pharmacology of human adenosine receptor subtypes - characterization 
of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch
Pharmacol. 1998 Jan;357(1):1-9. PubMed PMID: 9459566.


192: Schwab KO, Gerlich M, Broecker M, Söhlemann P, Derwahl M, Lohse MJ.
Constitutively active germline mutation of the thyrotropin receptor gene as a
cause of congenital hyperthyroidism. J Pediatr. 1997 Dec;131(6):899-904. PubMed
PMID: 9427897.


193: Gabilondo AM, Hegler J, Krasel C, Boivin-Jahns V, Hein L, Lohse MJ. A
dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in
receptor internalization. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12285-90. 
PubMed PMID: 9356441; PubMed Central PMCID: PMC24909.


194: Jahns R, Siegmund C, Jahns V, Reiländer H, Maidhof A, Müller-Esterl W, Lohse
MJ, Boege F. Probing human beta1- and beta2 -adrenoceptors with domain-specific
fusion protein antibodies. Eur J Pharmacol. 1997 Sep 3;334(1):115-26. PubMed
PMID: 9346338.


195: Blüml K, Schnepp W, Schröder S, Beyermann M, Macias M, Oschkinat H, Lohse
MJ. A small region in phosducin inhibits G-protein betagamma-subunit function.
EMBO J. 1997 Aug 15;16(16):4908-15. PubMed PMID: 9305633; PubMed Central PMCID:
PMC1170126.


196: Danner S, Lohse MJ. Cell type-specific regulation of beta2-adrenoceptor mRNA
by agonists. Eur J Pharmacol. 1997 Jul 16;331(1):73-8. PubMed PMID: 9274932.


197: Engelhardt S, Zieger W, Kassubek J, Michel MC, Lohse MJ, Brodde OE.
Tocolytic therapy with fenoterol induces selective down-regulation of
beta-adrenergic receptors in human myometrium. J Clin Endocrinol Metab. 1997
Apr;82(4):1235-42. PubMed PMID: 9100601.


198: Boekhoff I, Touhara K, Danner S, Inglese J, Lohse MJ, Breer H, Lefkowitz RJ.
Phosducin, potential role in modulation of olfactory signaling. J Biol Chem. 1997
Feb 14;272(7):4606-12. PubMed PMID: 9020189.


199: Söhlemann P, Soppa J, Oesterhelt D, Lohse MJ. Expression of beta
2-adrenoceptors in halobacteria. Naunyn Schmiedebergs Arch Pharmacol. 1997
Feb;355(2):150-60. PubMed PMID: 9050006.


200: Schröder S, Blüml K, Dees C, Lohse MJ. Identification of a C-terminal
binding site for G-protein betagamma-subunits in phosducin-like protein. FEBS
Lett. 1997 Jan 20;401(2-3):243-6. PubMed PMID: 9013896.


201: Müller S, Straub A, Lohse MJ. Selectivity of beta-adrenergic receptor kinase
2 for G protein betagamma subunits. FEBS Lett. 1997 Jan 13;401(1):25-9. PubMed
PMID: 9003799.


202: Blaukat A, Alla SA, Lohse MJ, Müller-Esterl W. Ligand-induced
phosphorylation/dephosphorylation of the endogenous bradykinin B2 receptor from
human fibroblasts. J Biol Chem. 1996 Dec 13;271(50):32366-74. PubMed PMID:
8943300.


203: Jahns R, Siegmund C, Jahns V, Reiländer H, Maidhof A, Müller-Esterl W, Lohse
MJ, Boege F. Probing human beta 1- and beta 2-adrenoceptors with domain-specific 
fusion protein antibodies. Eur J Pharmacol. 1996 Nov 28;316(1):111-21. PubMed
PMID: 8982658.


204: Lohse MJ, Blüml K, Danner S, Krasel C. Regulators of G-protein-mediated
signalling. Biochem Soc Trans. 1996 Nov;24(4):975-80. Review. PubMed PMID:
8968495.


205: Danner S, Lohse MJ. Phosducin is a ubiquitous G-protein regulator. Proc Natl
Acad Sci U S A. 1996 Sep 17;93(19):10145-50. PubMed PMID: 8816766; PubMed Central
PMCID: PMC38351.


206: Schulz K, Danner S, Bauer P, Schröder S, Lohse MJ. Expression of phosducin
in a phosducin-negative cell line reveals functions of a Gbetagamma-binding
protein. J Biol Chem. 1996 Sep 13;271(37):22546-51. PubMed PMID: 8798422.


207: Ungerer M, Kessebohm K, Kronsbein K, Lohse MJ, Richardt G. Activation of
beta-adrenergic receptor kinase during myocardial ischemia. Circ Res. 1996
Sep;79(3):455-60. PubMed PMID: 8781479.


208: Wieland K, Zuurmond HM, Krasel C, Ijzerman AP, Lohse MJ. Involvement of
Asn-293 in stereospecific agonist recognition and in activation of the beta
2-adrenergic receptor. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9276-81.
PubMed PMID: 8799191; PubMed Central PMCID: PMC38632.


209: Gabilondo AM, Krasel C, Lohse MJ. Mutations of Tyr326 in the beta
2-adrenoceptor disrupt multiple receptor functions. Eur J Pharmacol. 1996 Jun
27;307(2):243-50. PubMed PMID: 8832227.


210: Müller S, Straub A, Schröder S, Bauer PH, Lohse MJ. Interactions of
phosducin with defined G protein beta gamma-subunits. J Biol Chem. 1996 May
17;271(20):11781-6. PubMed PMID: 8662655.


211: Lohse MJ, Krasel C, Winstel R, Mayor F Jr. G-protein-coupled receptor
kinases. Kidney Int. 1996 Apr;49(4):1047-52. Review. PubMed PMID: 8691724.


212: Winstel R, Freund S, Krasel C, Hoppe E, Lohse MJ. Protein kinase cross-talk:
membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2105-9. PubMed PMID: 8700892; PubMed
Central PMCID: PMC39917.


213: Schröder S, Lohse MJ. Inhibition of G-protein betagamma-subunit functions by
phosducin-like protein. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2100-4. PubMed
PMID: 8700891; PubMed Central PMCID: PMC39916.


214: Lohse MJ. [Mechanisms of the regulation of adrenergic beta-receptors]. Z
Kardiol. 1996;85 Suppl 7:1-3. Review. German. PubMed PMID: 9082678.


215: Lohse MJ, Engelhardt S, Danner S, Böhm M. Mechanisms of beta-adrenergic
receptor desensitization: from molecular biology to heart failure. Basic Res
Cardiol. 1996;91 Suppl 2:29-34. Review. PubMed PMID: 8957541.


216: Engelhardt S, Böhm M, Erdmann E, Lohse MJ. Analysis of beta-adrenergic
receptor mRNA levels in human ventricular biopsy specimens by quantitative
polymerase chain reactions: progressive reduction of beta 1-adrenergic receptor
mRNA in heart failure. J Am Coll Cardiol. 1996 Jan;27(1):146-54. PubMed PMID:
8522688.


217: Söhlemann P, Hekman M, Puzicha M, Buchen C, Lohse MJ. Binding of purified
recombinant beta-arrestin to guanine-nucleotide-binding-protein-coupled
receptors. Eur J Biochem. 1995 Sep 1;232(2):464-72. PubMed PMID: 7556195.


218: Pippig S, Andexinger S, Lohse MJ. Sequestration and recycling of beta
2-adrenergic receptors permit receptor resensitization. Mol Pharmacol. 1995
Apr;47(4):666-76. PubMed PMID: 7723728.


219: Lohse MJ. G-protein-coupled receptor kinases and the heart. Trends
Cardiovasc Med. 1995 Mar-Apr;5(2):63-8. doi: 10.1016/1050-1738(94)00034-4. PubMed
PMID: 21232239.


220: Müller S, Lohse MJ. The role of G-protein beta gamma subunits in signal
transduction. Biochem Soc Trans. 1995 Feb;23(1):141-8. Review. PubMed PMID:
7758707.


221: Böhm M, Lohse MJ. Quantification of beta-adrenoceptors and beta-adrenoceptor
kinase on protein and mRNA levels in heart failure. Eur Heart J. 1994 Dec;15
Suppl D:30-4. Review. PubMed PMID: 7713110.


222: Freund S, Ungerer M, Lohse MJ. A1 adenosine receptors expressed in CHO-cells
couple to adenylyl cyclase and to phospholipase C. Naunyn Schmiedebergs Arch
Pharmacol. 1994 Jul;350(1):49-56. PubMed PMID: 7935854.


223: Hekman M, Bauer PH, Söhlemann P, Lohse MJ. Phosducin inhibits receptor
phosphorylation by the beta-adrenergic receptor kinase in a PKA-regulated manner.
FEBS Lett. 1994 Apr 25;343(2):120-4. PubMed PMID: 8168616.


224: Ungerer M, Parruti G, Böhm M, Puzicha M, DeBlasi A, Erdmann E, Lohse MJ.
Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing 
human heart. Circ Res. 1994 Feb;74(2):206-13. PubMed PMID: 8293560.


225: Müller S, Hekman M, Lohse MJ. Specific enhancement of beta-adrenergic
receptor kinase activity by defined G-protein beta and gamma subunits. Proc Natl 
Acad Sci U S A. 1993 Nov 15;90(22):10439-43. PubMed PMID: 8248128; PubMed Central
PMCID: PMC47792.


226: Lohse MJ. Molecular mechanisms of membrane receptor desensitization. Biochim
Biophys Acta. 1993 Nov 7;1179(2):171-88. Review. PubMed PMID: 7692969.


227: Söhlemann P, Hekman M, Buchen C, Elce JS, Lohse MJ. Purification and
functional characterization of beta-adrenergic receptor kinase expressed in
insect cells. FEBS Lett. 1993 Jun 7;324(1):59-62. PubMed PMID: 8504860.


228: Pippig S, Andexinger S, Daniel K, Puzicha M, Caron MG, Lefkowitz RJ, Lohse
MJ. Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment
desensitization of beta 2-adrenergic receptors. J Biol Chem. 1993 Feb
15;268(5):3201-8. PubMed PMID: 8381421.


229: Ungerer M, Böhm M, Elce JS, Erdmann E, Lohse MJ. Altered expression of
beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing
human heart. Circulation. 1993 Feb;87(2):454-63. PubMed PMID: 8381058.


230: Ungerer M, Obermaier-Skrobranek B, Lohse MJ. Adenosine A1 receptor gene
structure and regulation in normotensive and spontaneously hypertensive rats. Eur
J Pharmacol. 1992 Aug 3;226(4):381-2. PubMed PMID: 1397063.


231: Bauer PH, Müller S, Puzicha M, Pippig S, Obermaier B, Helmreich EJ, Lohse
MJ. Phosducin is a protein kinase A-regulated G-protein regulator. Nature. 1992
Jul 2;358(6381):73-6. PubMed PMID: 1319556.


232: Cristalli G, Eleuteri A, Vittori S, Volpini R, Lohse MJ, Klotz KN. 2-Alkynyl
derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists 
at A2 adenosine receptors. J Med Chem. 1992 Jun 26;35(13):2363-8. PubMed PMID:
1619615.


233: Lohse MJ, Andexinger S, Pitcher J, Trukawinski S, Codina J, Faure JP, Caron 
MG, Lefkowitz RJ. Receptor-specific desensitization with purified proteins.
Kinase dependence and receptor specificity of beta-arrestin and arrestin in the
beta 2-adrenergic receptor and rhodopsin systems. J Biol Chem. 1992 Apr
25;267(12):8558-64. PubMed PMID: 1349018.


234: Lohse MJ. Stable overexpression of human beta 2-adrenergic receptors in
mammalian cells. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):444-51.
PubMed PMID: 1320210.


235: Pitcher J, Lohse MJ, Codina J, Caron MG, Lefkowitz RJ. Desensitization of
the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase,
cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular
mechanisms. Biochemistry. 1992 Mar 31;31(12):3193-7. PubMed PMID: 1348186.


236: Ott I, Lohse MJ, Klotz KN, Vogt-Moykopf I, Schwabe U. Effects of adenosine
on histamine release from human lung fragments. Int Arch Allergy Immunol.
1992;98(1):50-6. PubMed PMID: 1378041.


237: Roth NS, Campbell PT, Caron MG, Lefkowitz RJ, Lohse MJ. Comparative rates of
desensitization of beta-adrenergic receptors by the beta-adrenergic receptor
kinase and the cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A.
1991 Jul 15;88(14):6201-4. PubMed PMID: 1648731; PubMed Central PMCID: PMC52050.


238: Gross W, Lohse MJ. Mechanism of activation of A2 adenosine receptors. II. A 
restricted collision-coupling model of receptor-effector interaction. Mol
Pharmacol. 1991 Apr;39(4):524-30. PubMed PMID: 2017152.


239: Lohse MJ, Klotz KN, Schwabe U. Mechanism of A2 adenosine receptor
activation. I. Blockade of A2 adenosine receptors by photoaffinity labeling. Mol 
Pharmacol. 1991 Apr;39(4):517-23. PubMed PMID: 2017151.


240: Collins S, Lohse MJ, O'Dowd B, Caron MG, Lefkowitz RJ. Structure and
regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a
model. Vitam Horm. 1991;46:1-39. Review. PubMed PMID: 1660639.


241: Collins S, Bouvier M, Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ.
Mechanisms involved in adrenergic receptor desensitization. Biochem Soc Trans.
1990 Aug;18(4):541-4. Review. PubMed PMID: 2177406.


242: Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a
protein that regulates beta-adrenergic receptor function. Science. 1990 Jun
22;248(4962):1547-50. PubMed PMID: 2163110.


243: Weber RG, Jones CR, Lohse MJ, Palacios JM. Autoradiographic visualization of
A1 adenosine receptors in rat brain with [3H]8-cyclopentyl-1,3-dipropylxanthine. 
J Neurochem. 1990 Apr;54(4):1344-53. PubMed PMID: 2313291.


244: Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Multiple pathways of rapid
beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.
J Biol Chem. 1990 Feb 25;265(6):3202-11. PubMed PMID: 2154473.


245: Benovic JL, Onorato J, Lohse MJ, Dohlman HG, Staniszewski C, Caron MG,
Lefkowitz RJ. Synthetic peptides of the hamster beta 2-adrenoceptor as substrates
and inhibitors of the beta-adrenoceptor kinase. Br J Clin Pharmacol. 1990;30
Suppl 1:3S-12S. PubMed PMID: 2176526; PubMed Central PMCID: PMC1368092.


246: Hausdorff WP, Lohse MJ, Bouvier M, Liggett SB, Caron MG, Lefkowitz RJ. Two
kinases mediate agonist-dependent phosphorylation and desensitization of the beta
2-adrenergic receptor. Symp Soc Exp Biol. 1990;44:225-40. PubMed PMID: 1983369.


247: Klotz KN, Lohse MJ, Schwabe U, Cristalli G, Vittori S, Grifantini M.
2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist
radioligand for A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989
Dec;340(6):679-83. PubMed PMID: 2615857.


248: Lohse MJ, Maurer K, Klotz KN, Schwabe U. Synergistic effects of
calcium-mobilizing agents and adenosine on histamine release from rat peritoneal 
mast cells. Br J Pharmacol. 1989 Dec;98(4):1392-8. PubMed PMID: 2482106; PubMed
Central PMCID: PMC1854830.


249: Lohse MJ. Calcium-antagonist receptors in cardiomyopathy. N Engl J Med. 1989
Sep 7;321(10):686-7. PubMed PMID: 2549419.


250: von der Leyen H, Schmitz W, Scholz H, Scholz J, Lohse MJ, Schwabe U. Effects
of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine
receptor antagonist, on force of contraction in guinea-pig atrial and ventricular
cardiac preparations. Naunyn Schmiedebergs Arch Pharmacol. 1989 Aug;340(2):204-9.
PubMed PMID: 2554151.


251: Reddington M, Klotz KN, Lohse MJ, Hietel B. Radiation inactivation analysis 
of the A1 adenosine receptor of rat brain. Decrease in radiation inactivation
size in the presence of guanine nucleotide. FEBS Lett. 1989 Jul
31;252(1-2):125-8. PubMed PMID: 2759228.


252: Schuch U, Lohse MJ, Schachner M. Neural cell adhesion molecules influence
second messenger systems. Neuron. 1989 Jul;3(1):13-20. PubMed PMID: 2559759.


253: Raymond JR, Fargin A, Lohse MJ, Regan JW, Senogles SE, Lefkowitz RJ, Caron
MG. Identification of the ligand-binding subunit of the human
5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, 
a high affinity radioiodinated photoaffinity probe. Mol Pharmacol. 1989
Jul;36(1):15-21. PubMed PMID: 2526292.


254: Lohse MJ, Lefkowitz RJ, Caron MG, Benovic JL. Inhibition of beta-adrenergic 
receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic
receptors. Proc Natl Acad Sci U S A. 1989 May;86(9):3011-5. PubMed PMID: 2541428;
PubMed Central PMCID: PMC287054.


255: Richardt G, Waas W, Kranzhöfer R, Cheng B, Lohse MJ, Schömig A. Interaction 
between the release of adenosine and noradrenaline during sympathetic
stimulation: a feed-back mechanism in rat heart. J Mol Cell Cardiol. 1989
Mar;21(3):269-77. PubMed PMID: 2568492.


256: Lohse MJ, Klotz KN, Salzer MJ, Schwabe U. Adenosine regulates the Ca2+
sensitivity of mast cell mediator release. Proc Natl Acad Sci U S A. 1988
Dec;85(23):8875-9. PubMed PMID: 2461558; PubMed Central PMCID: PMC282609.


257: Klotz KN, Lohse MJ, Schwabe U. Chemical modification of A1 adenosine
receptors in rat brain membranes. Evidence for histidine in different domains of 
the ligand binding site. J Biol Chem. 1988 Nov 25;263(33):17522-6. PubMed PMID:
3182861.


258: Lohse MJ, Klotz KN, Diekmann E, Friedrich K, Schwabe U.
2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist
properties at adenosine receptors. Eur J Pharmacol. 1988 Oct 26;156(1):157-60.
PubMed PMID: 3208837.


259: Böhm M, Beuckelmann D, Diet F, Feiler G, Lohse MJ, Erdmann E. Properties of 
cardiac alpha- and beta-adrenoceptors in spontaneously hypertensive rats. Naunyn 
Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):383-91. PubMed PMID: 2854206.


260: Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ. The
genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes
the 5-HT1A receptor. Nature. 1988 Sep 22;335(6188):358-60. PubMed PMID: 3138543.


261: Martens D, Lohse MJ, Schwabe U. [3H]-8-cyclopentyl-1,3-dipropylxanthine
binding to A1 adenosine receptors of intact rat ventricular myocytes. Circ Res.
1988 Sep;63(3):613-20. PubMed PMID: 2842086.


262: Cristalli G, Franchetti P, Grifantini M, Vittori S, Klotz KN, Lohse MJ.
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza
analogues of adenosine derivatives. J Med Chem. 1988 Jun;31(6):1179-83. PubMed
PMID: 3373486.


263: Lohse MJ, Klotz KN, Schwabe U, Cristalli G, Vittori S, Grifantini M.
2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine
receptors. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun;337(6):687-9. PubMed
PMID: 3216901.


264: Weber RG, Jones CR, Palacios JM, Lohse MJ. Autoradiographic visualization of
A1-adenosine receptors in brain and peripheral tissues of rat and guinea pig
using 125I-HPIA. Neurosci Lett. 1988 May 3;87(3):215-20. PubMed PMID: 3380344.


265: Lohse MJ, Elger B, Lindenborn-Fotinos J, Klotz KN, Schwabe U. Separation of 
solubilized A2 adenosine receptors of human platelets from non-receptor [3H]NECA 
binding sites by gel filtration. Naunyn Schmiedebergs Arch Pharmacol. 1988
Jan;337(1):64-8. PubMed PMID: 2835689.


266: Puurunen J, Lohse MJ, Schwabe U. Interactions between intracellular cyclic
AMP and agonist-induced inositol phospholipid breakdown in isolated gastric
mucosal cells of the rat. Naunyn Schmiedebergs Arch Pharmacol. 1987
Nov;336(5):471-7. PubMed PMID: 2830543.


267: Martens D, Lohse MJ, Rauch B, Schwabe U. Pharmacological characterization of
A1 adenosine receptors in isolated rat ventricular myocytes. Naunyn Schmiedebergs
Arch Pharmacol. 1987 Sep;336(3):342-8. PubMed PMID: 2825048.


268: Lohse MJ, Böser S, Klotz KN, Schwabe U. Affinities of barbiturates for the
GABA-receptor complex and A1 adenosine receptors: a possible explanation of their
excitatory effects. Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;336(2):211-7.
PubMed PMID: 2825044.


269: Lohse MJ, Klotz KN, Lindenborn-Fotinos J, Reddington M, Schwabe U, Olsson
RA. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity
antagonist radioligand for A1 adenosine receptors. Naunyn Schmiedebergs Arch
Pharmacol. 1987 Aug;336(2):204-10. PubMed PMID: 2825043.


270: Lohse MJ, Brenner AS, Jackisch R. Pentobarbital antagonizes the A1 adenosine
receptor-mediated inhibition of hippocampal neurotransmitter release. J
Neurochem. 1987 Jul;49(1):189-94. PubMed PMID: 2884276.


271: Lohse MJ, Maurer K, Gensheimer HP, Schwabe U. Dual actions of adenosine on
rat peritoneal mast cells. Naunyn Schmiedebergs Arch Pharmacol. 1987
May;335(5):555-60. PubMed PMID: 2441269.


272: Klotz KN, Lohse MJ. The glycoprotein nature of A1 adenosine receptors.
Biochem Biophys Res Commun. 1986 Oct 15;140(1):406-13. PubMed PMID: 3778456.


273: Lohse MJ, Klotz KN, Schwabe U. Agonist photoaffinity labeling of A1
adenosine receptors: persistent activation reveals spare receptors. Mol
Pharmacol. 1986 Oct;30(4):403-9. PubMed PMID: 3020390.


274: Klotz KN, Lohse MJ, Schwabe U. Characterization of the solubilized A1
adenosine receptor from rat brain membranes. J Neurochem. 1986 May;46(5):1528-34.
PubMed PMID: 3007672.


275: Lohse MJ, Klotz KN, Schwabe U. Effects of temperature and membrane phase
transitions on ligand binding to alpha 2-receptors of human platelets. Mol
Pharmacol. 1986 Mar;29(3):228-34. PubMed PMID: 3005830.


276: Lohse MJ, Klotz KN, Jakobs KH, Schwabe U. Barbiturates are selective
antagonists at A1 adenosine receptors. J Neurochem. 1985 Dec;45(6):1761-70.
Erratum in: J Neurochem 1986 May;46(5):1664. PubMed PMID: 2997396.


277: Klotz KN, Cristalli G, Grifantini M, Vittori S, Lohse MJ. Photoaffinity
labeling of A1-adenosine receptors. J Biol Chem. 1985 Nov 25;260(27):14659-64.
PubMed PMID: 2997218.


278: Schwabe U, Ukena D, Lohse MJ. Xanthine derivatives as antagonists at A1 and 
A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985
Sep;330(3):212-21. PubMed PMID: 2997628.


279: Lohse MJ, Ukena D, Schwabe U. Demonstration of Ri-type adenosine receptors
in bovine myocardium by radioligand binding. Naunyn Schmiedebergs Arch Pharmacol.
1985 Jan;328(3):310-6. PubMed PMID: 2984586.


280: Lohse MJ, Klotz KN, Ukena D, Schwabe U. Characterization of
[3H]phenobarbital binding to rat brain membranes. Neurosci Lett. 1984 Nov
23;52(1-2):97-101. PubMed PMID: 6098882.


281: Lohse MJ, Ukena D, Schwabe U. Adenosine receptors on heart muscle. Lancet.
1984 Aug 11;2(8398):355. PubMed PMID: 6146898.


282: Lohse MJ, Lenschow V, Schwabe U. Two affinity states of Ri adenosine
receptors in brain membranes. Analysis of guanine nucleotide and temperature
effects on radioligand binding. Mol Pharmacol. 1984 Jul;26(1):1-9. PubMed PMID:
6087114.


283: Ukena D, Furler R, Lohse MJ, Engel G, Schwabe U. Labelling of Ri adenosine
receptors in rat fat cell membranes with
(-)-[125iodo]N6-hydroxyphenylisopropyladenosine. Naunyn Schmiedebergs Arch
Pharmacol. 1984 Jun;326(3):233-40. PubMed PMID: 6089004.


284: Lohse MJ, Lenschow V, Schwabe U. Interaction of barbiturates with adenosine 
receptors in rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1984
May;326(1):69-74. PubMed PMID: 6089000.