!!John van der Oost - Publications
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__Statistics March 2019__
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*papers (peer reviewed): 289 \\
*first authorships: 24\\
*last/corresponding authorships: 100          \\
*H-index: 75 (Google scholar)  \\
*number of citations: 25034 (Google scholar)\\
*papers (popular science): 3\\
* books/monographs: 5\\
*book chapters: 22\\
*patents: 25\\
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__Selected publications (2008-2019)__\\
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Brouns, S.J., Jore, M.M., Lundgren, M., Westra, E.R., Slijkhuis, R.J., Snijders, A.P., Dickman, M.J., Makarova, K.S., Koonin, E.V., Van der Oost*, J. (2008) Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 321, 960-964\\
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Westra, E.R., Van Erp, P.B.G., Wong, S.P., Künne, T., Seegers, C.L.C., Bollen, S., Jore, M.M., De Vos, W.M., Dame, R.T., De Vries, R., Brouns, S.J.J., Van der Oost*, J. (2012) CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3. Molecular Cell 46, 595-605\\
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Swarts, D.C., Jore, M.M., Westra, E.R., Zhu, Y., Janssen, J.H., Snijders, A.P., Wang, Y., Patel, D.J., Berenguer, J., Brouns, S.J.J., Van der Oost*, J. (2014) DNA-guided DNA interference by a prokaryotic Argonaute. Nature 507, 258-261\\
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Staals, R.H.J., Zhu, Y., Taylor, D.W., Kornfeld, J.E., Sharma, K., Barendregt, A., Vlot, M., Varossieau, K., Koehorst, J.J., Sakamoto, K., Suzuki, T., Dohmae, N., Yokoyama, S., Schaap, P.J., Urlaub, H., Heck, A.J.R., Nogales, E., Doudna, J.A., Shinkai, A., Van der Oost*, J. (2014) RNA-targeting by the Type III-A CRISPR-Cas Csm complex of Thermus thermophilus. Molecular Cell 56, 518–530\\
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Swarts, D.C., Hegge, J.W., Hinojo, I., Shiimori, M., Ellis, M.A., Dumrongkulraksa, J., Terns, R.M., Terns, M.P., Van der Oost*, J. (2015) Argonaute of the archaeon Pyrococcus furiosus is a DNA-guided nuclease that targets cognate DNA. Nucleic Acids Research 43, 5120-5129\\
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Mohanraju, P., Makarova, K., Zetsche, B., Zhang, F., Koonin, E., Van der Oost*, J. (2016) Diverse evolutionary roots and mechanistic variations of CRISPR-Cas systems. Science 353, pp. aad5147/1-12\\
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Swarts, D.C., Szczepaniak, M., Sheng, G., Chandradoss, S.D., Zhu, Y., Timmers, E.M., Zhang, Y., Zhao, H., Lou, J., Wang, Y., Joo, C., Van der Oost*, J. (2017) Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute. Molecular Cell 65, 985-998\\
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Zetsche, B., Heidenreich, M., Mohanraju, P., Fedorova, I., Kneppers, J., DeGennaro, E.M., Winblad, N., Choudhury, S.R., Abudayyeh, O.O., Gootenberg, J.S., Wu, W.Y., Scott, D.A., Severinov, K., Van der Oost*, J., Zhang*, F. (2017) Multiplex gene editing by CRISPR-Cpf1 by autonomous processing of a single crRNA array. Nature Biotechnology 35, 31-34.\\
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Mougiakos, I., Mohanraju, P., Bosma, E.F., Finger Bou, M., Vrouwe, V., Nathutodi, M., Gussak, A., Brinkman, R.B., Van Kranenburg, R., Van der Oost*, J. (2017) Hot and sharp: Characterizing a thermo-stable Cas9 for bacterial genome editing and silencing. Nature Communications 8, 1647\\
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Wu, W.Y., Lebbink, J.H.G., Kanaar, R., Geijsen, N., Van der Oost*, J. (2018) Genome editing by natural and engineered CRISPR-associated nucleases. Nature Chemical Biology 14, 642-651