!!Shahragim Tajbakhsh - Selected Publications
h-index = 44\\
Five publications from his work are cited by the Faculty of 1000, a classification of the top 2% of published articles in biology and medicine. These were then ranked according to relative interest (Nature, 2004 (FF-8, must read); Nature Cell Biology, 2006 (FF-12, exceptional); Cell, 2007 (FF-8, must read); Development 2010 (FF-9, must read); Cell, 2012 (FF-12, exceptional)). he has also been invited to write about 16 reviews in the last decade (eg. Cell, Nature Reviews Molecular Cell Biology, Nature Reports Stem Cells).\\
Shinin, V., Gayraud-Morel, B., Gomes, D., and Tajbakhsh, S. (2006). Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat Cell Biol 8, 677-82. \\
The first report of asymmetric DNA strand segregation in skeletal muscle from primary stem cells.\\
Citations: 274\\
Sambasivan, R., B. Gayraud-Morel, G. Dumas, C. Cimper, S. Paisant, R. G. Kelly and S. Tajbakhsh (2009). Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Developmental Cell. 16: 810-821.\\
This study demonstrates that skeletal muscle stem cells in distinct anatomical locations have distinct genetic signatures and focuses on cranial muscles as distinct from those that are somite derived.\\
Citations: 111\\
Mourikis, P., R. Sambasivan, D. Castel, P. Rocheteau, V. Bizzarro and S. Tajbakhsh (2012). A critical requirement for Notch signaling in maintenance of the quiescent skeletal muscle stem cell state. Stem Cells, 30: 243-252.\\
This study reports the first regulator of skeletal muscle stem cell quiescence: Notch. Loss of Notch function results in depletion of the stem cell niche, transition from G0 to differentiation with a boycott of S-phase, and failed regeneration following injury.\\
Citations: 88\\
Rocheteau, P., Gayraud-Morel, B., Siegl-Cachedenier, I., Blasco, M. and S. Tajbakhsh (2012). A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division. Cell, 48: 112-125.\\
Here he reports that a subpopulation of quiescent muscle stem cells are in deep quiescence, or dormancy, with low metabolic activity. He also demonstrates for the first time serial transplantations of muscle stem cells. Finally he reports the asymmetric segregation of old and new DNA strands to stem and committed muscle stem cells, respectively.\\
Citations: 110\\
Lathil, M., P. Rocheteau, L. Châtre, S. Sanulli, S. Memet, M. Ricchetti, S. Tajbakhsh#, and F. Chrétien# (2012). Skeletal muscle stem cells adopt a dormant state post mortem and retain regenerative capacity. Nature Communications, June 12; 3: 903     \\
# equal contributing authors\\
Here they show that stem cells can survive for extensive periods post-mortem and identify low temperature and anoxia as critical factors that permit their resistance to this extreme stress.\\
Citations: 22\\
Castel*, D., P. Mourikis*, S. Bartels*, A.B. Brinkman, S. Tajbakhsh#, H.G. Stunnenberg# (2013). Dynamic binding of RBPJ is determined by Notch signalling status. Genes & Development 27(9):1059-71;\\
* equal contribution; #co-corresponding\\
This is the first genome-wide analysis of Rbpj in vertebrates. They show that unlike previously thought, Rbpj does not permanently occupy binding sites, but that a class of inducible genes requires NICD to recruit Rbpj to regulatory sequences.\\
Citations: 35\\
Yennek, S., M. Burute, M. Théry and S. Tajbakhsh (2014). Cell adhesion geometry regulates non-random DNA segregation and asymmetric cell fates in mouse skeletal muscle stem cells. Cell Reports, 7:961-970.\\
Using single cell analysis on micropatterns, they show that the topology of the micropattern and adhesion cues drive asymmetric and symmetric cell fate decisions.\\
Citations: 6\\
Comai*, G., R. Sambasivan*, S. Gopalakrishnan and S. Tajbakhsh (2014). Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations. Developmental Cell, 31:654-67. *equal contribution.\\
They show that lineage reporters that lack sensitivity resulted in reports that muscle cell fate determinants act in independent progenitor cell lineages following cell ablations. They show that only one major progenitor lineage acts during myogenesis, and thus this is not a criterion that impacts on adult stem cell heterogeneity.\\
Citations: 4\\
Gopalakrishnan, S., G. Comai, R. Sambasivan, A. Francou, RG Kelly and S. Tajbakhsh (2015). A cranial mesoderm origin for oesophagus striated muscle. Developmental Cell, 34: 694-704.\\
Oesophagus striated muscles had previously thought to be of somite origin. Here they demonstrated that they are of cranial origin and therefore could be implicated in diseases such as DiGeorge's Syndrome where craniofacial muscles are compromised and swallowing is affected in some patients.\\
Le Roux I., J. Konge, L. Le Cam, P. Flamant, and S. Tajbakhsh (2015). Numb is required to prevent p53-dependent senescence following skeletal muscle injury. Nature Communications, 6:8528.\\
First report of senescence during skeletal muscle regeneration. A transient senescence that is beneficial during regeneration, and a pathological one in absence of Numb.