!!Wolf H. Fridman - Biography
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Professor Wolf H. Fridman is Professor Emeritus of Immunology at the Paris Descartes University Medical School in Paris, France. He received his MD and PhD degrees
from the University of Paris. After 10 years in the laboratory headed by
Jean Dausset, he created his own laboratory at the Cancer Research Centre
in Villejuif in 1976, then moved to Institut Curie in 1983 and is presently
Director of the Cordeliers Research Centre. He is also Head of the Immunology
Laboratory of European Hospital Georges Pompidou in Paris.
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Dr Fridman’s research interests have been focused around the role of the
immune system in controlling human tumors and the biological functions
of receptors for IgG antibodies. He, and his team, identified the protein
references which trigger the biological functions of the receptors for
IgG. In particular, he identified and named the ITIM motif, an inhibitory
motif common to many receptors.
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His main contributions in cancer immunology stand up to 1969 when he published,
with François Kourilsky, the first demonstration of an immune response
of the patient to his own cancer, in acute leukemia. He, then, focused
on the analysis of the tumor microenvironment with the demonstration of
the beneficial effect of a Th1 oriented immune response to control clinical
outcome in cervical cancer. Since 2005, the studies of Jérôme Galon, Franck
Pagès and Wolf H. Fridman have changed the paradigm of host/cancer interactions
by demonstrating that the ‘immune contexture”, taking in account the functionality,
the location and the density of the immune infiltrate in colorectal tumors,
is the major prognostic factor for human cancers. These findings really
open the way for immune-based tools for efficient prognosis and therapy
of cancers. His papers has been cited over 10.000 times and his i. Factor
is 55. He is a world leader in the field of human tumor immunology as assessed
by its recurrent invitations as Symposium Speaker to AACR, Keystone, FASEB
and other top international meetings.
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__Activities and positions:__
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*1982-1986 Member of the CNRS specialized scientific commission (CSS 25)
*1991-1995 President of the INSERM specialized scientific commission (CSS 06)
*1995-1998 President of the Scientific Commission of Institut Curie (Section Médicale et Hospitalière)
*1996-2002 President of the Scientific Council of ARC
*1998-2002 Vice-president of the Scientific Council at University Pierre et Marie Curie – Paris 6
*1998-2002 Member of the Scientific Council of AP/HP
*2000-2002 Member of the Scientific Council of GenHomme Program
*2003-2006 Scientific Director of ARC
*2003- Vice Dean, in charge of Research at the Medical School Paris Descartes
*2005- Member of the Scientific Council of the Medical School Paris Descartes
*2008-2010 : Regular reviewer for the European Research Council (ERC) :
*Evaluator for the FP7-HEALTH-2010-single-stage call for proposals
*Evaluator for CANCER call on “Structuring translational cancer research between cancer research centres”
*Panel member for the ERC Advanced Grant 2010 evaluation