!!Julian Downward - Publications
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__Google Scholar profile:__
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H index 124.  300 publications with 71,849total citations (on 17 February 2022) \\
[http://scholar.google.co.uk/citations?user=9bDwgogAAAAJ&hl=en]
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__Past work:__\\
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1. J.Downward, Y.Yarden, E.Mayes, G.Scrace, N.Totty, P.Stockwell, A.Ullrich, J.Schlessinger and M.D.Waterfield (1984) Nature 307, 521-527. "Close similarity of epidermal growth factor receptor and v-erb B oncogene protein sequences." \\
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2. L.Buday and J.Downward (1993) Cell 73, 611-620. "Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein and Sos exchange factor."\\
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3. P.H.Warne, P.Rodriguez Viciana and J.Downward (1993) Nature 364, 352-355. "Direct interaction of Ras with the amino-terminal region of Raf-1 in vitro." \\
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4. P.Rodriguez-Viciana, P.H.Warne, R.Dhand, B.Vanhaesebroeck, I.Gout, M.J.Fry, M.D.Waterfield and J.Downward (1994) Nature 370, 527-532. "Phosphatidylinositol-3-OH kinase as a direct target of Ras." \\
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5. S. Gupta, A.R. Ramjaun, P. Haiko, P.H. Warne, E. Nye, G. Stamp, K. Alitalo and J. Downward (2007) Cell 129, 957-968. “The interaction of Ras with p110α, the catalytic subunit of PI 3-kinase, is required for Ras-driven tumorigenesis and for normal lymphatic development.”\\
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__Recent work:__\\
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1. M.A. Coelho, S. de Carné Trécesson, S. Rana, D. Zecchin, C. Moore, P. East, B. Spencer-Dene, E. Nye, K. Barnouin, A.P. Snijders, W.S. Lai, P.J. Blackshear, J. Downward (2017) Immunity 47, 1083-1099. “Oncogenic RAS signalling promotes tumour immunoresistance by stabilising PD-L1 mRNA”.\\
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2. M.M. Murillo, S. Rana, B. Spencer-Dene, E. Nye, G. Stamp, J. Downward (2018) Cell Reports 25, 3545-3553. “Disruption of the interaction of RAS with PI 3-kinase induces regression of mutant EGFR-driven lung cancer.” \\
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3. D.A. Lionarons, D.C. Hancock, S. Rana, P. East, C. Moore, M.M. Murillo, J. Carvalho, B. Spencer-Dene, E. Herbert, G. Stamp, D. Damry, D.P. Calado, I. Rosewell, R. Fritsch, R.R. Neubig, M. Molina-Arcas, J. Downward (2019) Cancer Cell 36, 68-83. “RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.”\\
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4. M. Molina-Arcas, C. Moore, S. Rana, F. van Maldegem, E. Mugarza, P. Romero-Clavijo, E. Herbert, S. Horswell, L.S. Li, M.R. Janes, D.C. Hancock, J. Downward (2019) Science Translational Medicine 11, eaaw7999. “Development of combination therapies to maximize the impact of G12C KRAS inhibitors in lung cancer”.\\
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5. F. van Maldegem, K. Valand, M. Cole, H. Patel, M. Angelova, S. Rana, E. Colliver, K. Enfield, N. Bah, V.S.K. Tsang, E. Mugarza, C. Moore, P. Hobson, D. Levi, M. Molina-Arcas, C. Swanton, J. Downward (2021) Nature Communications 12, 5906. “Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow”.