!!Marc Delarue - Selected Publications
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1. Hu H, Howard RJ, Bastolla U, Lindahl E, and Delarue M. \\
Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. \\
Proc Natl Acad Sci USA.  117 (24) 13437-13446 (2020). First evidence for a role of supra-molecular interactions in this family.\\
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2. Z Fourati, RR Ruza, D Laverty, E Drège, S Delarue-Cochin, D Joseph, P-J Corringer and M Delarue.\\
Barbiturates bind in the GLIC ion channel pore and cause inhibition by stabilizing a closed state.\\
Journal of Biological Chemistry 292 (5), 1550-1558 (2018). Recommended by F1000.\\
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3. Loc'h J, Gerodimos CA, Rosario S, Tekpinar M, Lieber MR, Delarue M.\\
Structural evidence for an in trans base selection mechanism involving Loop1 in polymerase μ at an NHEJ double-strand break junction. J Biol Chem. 2019 294(27):10579-10595 (recommended by F1000).\\
See also Structure 2016 24(9):1452-63 (F1000) and Curr. Op. Struct. Biol. 2018 53, 22-31 (recommended by F1000)\\
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4. Sauguet L, Raia P, Henneke G, Delarue M. \\
Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography. \\
Nat Commun. 2016 7:12227 (recommended by F1000). First evidence that DNA polD have the fold of universal RNA polymerases.\\
[https://insb.cnrs.fr/fr/cnrsinfo/un-seul-et-meme-coeur-catalytique-pour-la-replication-et-la-transcription-chez-les-archees]\\
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5. L Sauguet, A Shahsavar, F Poitevin, C Huon, A Menny, À Nemecz, A Haouz, JP Changeux, PJ Corringer, M. Delarue.\\
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation\\
Proc Natl Acad Sci USA. 2014 111 (3) 966-71. 177 citations. (F1000 recommendation).\\
The first pair of structures in active and resting states of the same ligand-gated ion channel.\\
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6. X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel\\
H Nury, C Van Renterghem, Y Weng, A Tran, M Baaden, V Dufresne, J-P Changeux, JM Sonner, M Delarue, P-J Corringer.
Nature 469, 428-33 (2011). Recommended by F1000. 401 citations.\\
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7. E Lindahl, C Azuara, P Koehl, M Delarue\\
NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis\\
Nucleic acids research 34, W52-W56. (2006). 333 citations. A web-site  recommended by textbooks that also implements:\\
On the use of low-frequency normal modes to enforce collective movements in refining macromolecular structural models, M Delarue, P Dumas. Proceedings of the National Academy of Sciences 101 (18), 6957-6962 (2004). 200 citations.\\
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8. P Koehl, M Delarue. Application of a self-consistent mean field theory to predict protein side-chains conformation and estimate their conformational entropy. Journal of molecular biology 239 (2), 249-275 423 (1994). 423 citations.\\
An extremely rapid algorithm that repacks side-chains on a given backbone, used by many groups in protein design.\\
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9. An attempt to unify the structure of polymerases\\
M Delarue, O Poch, N Tordo, D Moras, P Argos. Protein Engineering, Design and Selection 3 (6), 461-467 (1990). 776 citations.\\
Defines the universally accepted catalytic motifs common to Pol A (Klenow-fold), Pol B and reverse transcriptases (RT). \\
Allowed to model RT from the structure of the Pol I Klenow fragment, at the time when no structure of RT was available.\\
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10. G Eriani, M Delarue, O Poch, J Gangloff, D Moras. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature 347 (6289), 203-206 (1990). 1541 citations.\\
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Defines the two universal classes of aminoacyl-tRNA synthetases and the catalytic motifs of Class II. \\
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Used in M. Delarue. RNA 2007 13, 161-9,  on a possible scenario for the establishment of the genetic code (F1000).