!!Filippo Del Bene Biography
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__Summary of the scientific background__\\
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My career has been focused on the study the molecular processes that control the formation and function of neural circuits in the larval zebrafish brain. My approaches combine molecular genetics with functional imaging and behavioural analysis to obtain a multiscale view of the function and development of neuronal circuits.\\
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As a postdoctoral fellow with Herwig Baier at UCSF, and later in my own team, I discovered a number of organizing principles and neuronal components that allow the correct processing of visual information (Del Bene et al. Science 2010; Dunn et al. Neuron 2016; Di Donato et al. Neuron 2018, Vigoroux et al. Science 2021). In this system we have also studied the signalling mechanisms that control the balance of cell proliferation and neuronal differentiation in the developing neuroretina (Del Bene et al. Cell 2008, Albadri et al. Dev Cell 2019.)\\
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We demonstrated that axonal transport plays a central role in the correct development and function of axons and is also involved in neurological disorders (Auer et al. Elife 2015, Bercier et al. Mol Neurodegener 2019). Within this line of research, we have an ongoing collaboration with Carsten Janke to exploit the unique advantages of zebrafish to study tubulin modifications in vivo.\\
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My personal interest in technology development has driven my team to pioneer the application of novel technologies, such as CRISPR/Cas9 based genome editing approaches in zebrafish. This work has firmly established my team as a leading player in the zebrafish community (Auer et al. Genome Res 2014, Auer et al. Nat Protoc 2014, Di Donato et al. Genome Res 2016, Rosello et al. Elife 2021, Rosello et al. Nature Communications 2022). Recently, we contributed to the establishment of Danionella as a novel vertebrate model organism where, thanks to its exceptional small size and tissue transparency, in vivo imaging is possible at adult stages with subcellular resolution (Schulze et al., Nat Methods 2018, Rajan et al, Cell Reports 2023). We are thus is one of the few laboratories in the world with expertise to breed and genetically manipulate Danionella.\\ \\[{ALLOW view All}][{ALLOW edit fdelbene}][{ALLOW upload fdelbene}][{ALLOW comment All}]