!!Hans Clevers - Publications\\
__Key Publications out of ~ 550 peer-reviewed papers, yielding ~ 80,000 citations; h-index of ~143.__
\\ \\
1) van de Wetering, M., Oosterwegel, M., Dooijes, D., and Clevers, H.C. Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box.\\
__ EMBO J.__, 10:123-132 (1991) 

2) Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. and Clevers, H.C. An HMG box containing T-cell factor required for thymocyte differentiation.\\ 
__Nature__ 374: 70-74 (1995) 

3) Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H .Sox-4 gene is required for cardiac outflow tract formation and pro-B lymphocyte expansion.\\
__Nature__, 380: 711-714 (1996) 

4) Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O. And Clevers, H. Xtcf-3 Transcription factor mediates beta-catenin-induced axis formation in xenopus embryos.\\
__Cell__, 86, 391-399 (1996) 

5) Korinek, V, Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. Constitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC -/- Colon Carcinoma.\\
__Science__, 275: 1784-1787 (1997) 

6) Morin, P.J., Sparks, A., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.\\ 
__Science__ 275: 1787-1790 (1997) 

7) Van de Wetering, M., Cavallo, R., Dooijes, D., Van Beest, M., Van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF. \\
__Cell__, 88, 789-799 (1997) 

8) Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. and Clevers, H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.\\ 
__Nat Genet__ 19(4): 379-383 (1998) 

9) Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.\\ 
Nature 395(6702): 608-612 (1998) 

10) Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1.\\ 
__Science__ 285: 1923-1926 (1999) 

11) Korswagen, R., Herman, M. and Clevers, H. Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans.\\
__Nature__ 406: 527-532 (2000) 

12) Bienz, M., and Clevers, H. Linking colorectal cancer to Wnt signaling. ''Review''.\\
__Cell__ 103: 311-320 (2000) 

13) Van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., Van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A-P., Tjon-Pon-Fong, M., Moerer, P., Van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., Clevers, H. The beta-catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.\\
__Cell__ 111: 241-250 (2002) 

14) Battle, E., Henderson, J.T., Beghtel, H., van den Born, M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., Clevers, H. Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.\\
__Cell__ 111: 251-263 (2002) 

15) Hurlstone A.F., Haramis A.P., Wienholds E., Begthel H., Korving J., Van Eeden F., Cuppen E., Zivkovic D., Plasterk R.H., Clevers H. , The Wnt/beta-catenin pathway regulates cardiac valve formation.\\ 
__Nature__ 425:633-7 (2003) 

16) Baas A.F., Kuipers J., van der Wel N.N., Batlle E., Koerten H.K., Peters P.J., Clevers H.C. , Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.\\
__Cell__ 116:457-66 (2004) 

17) Haramis A.P., Begthel H., van den Born M., van Es J., Jonkheer S., Offerhaus G.J., Clevers H. , De novo crypt formation and Juvenile Polyposis upon BMP inhibition.\\
Science. 303:1684-6 (2004) 

18) Radtke, F and Clevers, H., Self-renewal and cancer of the gut: Two sides of a coin. ''Review''.\\
__Science__. 307:1904-1909 (2005) 

19) Reya T., Clevers H., Wnt signalling in stem cells and cancer. ''Review''.\\
__Nature__ 434:843-850 (2005)

20) Van Es J.H., Van Gijn M.E., Riccio O., Van den Born M., Vooijs M., Begthel H., Cozijnsen M., Robine S., Winton D.J., Radtke F., Clevers H. Notch pathway/gamma-secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells.\\ 
__Nature__ 435:959-963 (2005) 

21) Batlle E., Bacani J., Begthel H., Jonkheer S., Gregorieff A., Van de Born M., Malats N., Sancho E., Boon E., Pawson T., Gallinger S., Pals S., Clevers H., EphB activity suppresses colorectal cancer progression.\\
__Nature__ 435:1126-1130 (2005)

22) Clevers, H. Wnt/ß-catenin signaling in development and disease.\\
__Cell__ 127: 469-480 (2006) 

23) Barker, N, van Es, J.H., Kuipers, J., Kujala P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., and Clevers, H. Identification of Stem Cells in Small Intestine and Colon by a Marker Gene LGR5.\\ 
__Nature__, 449:1003-1007 (2007)

24) Jaks V., Barker N., Kasper M., van Es J.H., Snippert H.J., Clevers H., Toftgård R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells.\\
__Nat Genet__. 40 : 1291-1299 (2008) 

25) Barker N., Ridgway R.A., van Es J.H.,van de Wetering M., Begthel H., van den Born M., Danenberg E., Clarke A.R., Sansom O.J., Clevers H. Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer.\\
__Nature__ 457:608-611(2009) 

26) van der Flier, L.G., van Gijn, M.E., .., and Clevers H. Transcription factor Achaete scute-like 2 (Ascl2) controls intestinal stem cell fate.\\
__Cell__ 136: 903-12 (2009)

27) Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche 459(7244):262-5.\\
__Nature__ 459 :262-5 (2009) 

28) Barker, N, Huch, M., ..., and Hans Clevers.  Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.\\
__Cell Stem Cell__, 6: 25-36 (2010)

29) Snippert, H.J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J.H., Barker, N., van de Wetering,
M., van den Born, M., Begthel, H., Vries, R.G., Stange, D.E., Toftgård, R., Clevers H.  Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.\\
__Science__ 327: 1385-1389 (2010)

30) Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.\\
__Nature__ 469: 415-418 (2010)

31) Snippert, .J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. and Clevers, H. Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells.\\
__Cell__ 143:134-44 (2010)

32) de Lau, W., Barker, N., ... and Clevers, H. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling.\\
__Nature__ 476: 293-297 (2011)

33) Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers H. Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex.\\
__Cell__ 149: 1245-1256 (2012)

34) Koo, B-K., Spit, M. Jordens, I., Low, T.Y., Stange, D.E., van de Wetering, M., van Es, J.H., Mohammed, S., Heck, A.J.R., Maurice, M.M. and Hans Clevers. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.\\
__Nature__ 488: 665-669 (2012)

35) Schepers, A.G., Snippert, H.J., Stange, D.E., van den Born, M., van Es, J.H., van de Wetering, M., Clevers, H. Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas.\\
__Science__ 337: 730-735 (2012)

36) van Es, J.H., Sato, T., van de Wetering, M., Lyubimova, A., Yee Nee, A.N., Gregorieff, A., Sasaki, N., Zeinstra, L., van de Born, M., Korving, J., Martens, A.C., Barker, N., van Oudenaarden, A., Clevers, H. DII (+) secretory progenitor cells revert to stem cells upon crypt damage.\\
__Nat Cell Biol__ 14: 1099-1104 (2012)

37) Boj, S,F., van Es, J.H.,Huch. M., Li, V.S., Jose, A., Hatzis, P., Mokry, M., Haegebarth, A., van den Born, M., Chambon, P., Voshol, P., Dor, Y., Cuppenm E., Fillat, C., Clevers, H. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.\\
__Cell__ 151: 1595-1607 (2012)

38) Huch M., Dorell, C., Boj, S.F., van Es, J.H., van de Wetering, M., Li, V.S.W., Hamer, K., Sasaki, N., Finegold, M.J., Haft, A., Grompe, M., Clevers, H. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.\\
__Nature__ 494: 247-250 (2013)

39) Sato, T., Clevers, H., Growing self-organizing mini-guts from a single intestinal stem cells: mechanism and applications. ''Review''.\\
__Science__ 340: 1190-1194 (2013)

40) Clevers, H. The intestinal crypt, a prototype stem cell compartment.\\
__Cell__ 154: 274-284 (2013)

41) Stange, D.E., Koo, B.K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A.,Kujalla, P., Bartfeld, S., Koster, J., Geahlen, J.H., Peters, P.J., van Es, J., van de Wetering, M., Mills, J.C., Clevers, H. Differentiated Troy+ chief cells act as 'reserve' stem cells to generate all lineages of stomach epithelium.\\
__Cell__ 155: 357-368 (2013)

42) Schwank, G., Koo, B.K., Sasselli, V., Dekkers, J.F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C.K., Nieuwenhuis, E.E., Beekman, J.M. and Clevers, H. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.\\
__Cell Stem Cell__ 13: 653-658 (2013)

43) Ritsma, L., Ellenbroek, S.I., Zomer, A., Snippert, H.J., de Sauvage, F.J., Simons, B.D., Clevers, H., van Rheenen, J.. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo imaging.
Nature 507: 362-5 (2014)

44) Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A.., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.\\
__Cell__ 159: 163-75 (2014). 

45) Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M.A., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, S., van de Wetering, M., Sasaki, N., Boers, S.J., Kemperman, H., de Jonge, J., Ijzermans, J.N.M., Niewenhuis, E.E.S., Hoekstra, R., Strom, S., Vries, R.G.J., van der Laan, L.J.W., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human liver.\\
__Cell__ 160: 299-312 (2015)

46) Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M.S., Gracanin, A., Oni, T., Yu, K.H., van Boxtel, R., Huch, M., Rivera, K.D., Wilson, J.P., Feigin, M.E., Öhlund, D., Handly-Santana, A., Ardito-Abraham, C.M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G.N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F.H., Molenaar, I.Q., Borel Rinkes, I.H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I.J., Iacobuzio-Donahue, C., Leach, S.D., Pappin, D.J., Hammell, M., Klimstra, D.S., Basturk, O., Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA. Organoid models of human and mouse ductal pancreatic cancer.\\
__Cell__ 160: 324-338 (2015)

47) van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a 'Living Organoid Biobank' of colorectal cancer patients.\\
__Cell__ (in press)

48) Drost, J, van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells.\\
__Nature__ (in press)

49) Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K.,
Angers, S., Peters, P.J. Maurice, M.M. and Clevers, H. Visualization of the short-range Wnt
gradient in the intestinal stem cell niche.\\
__Nature__ 530: 340-343 (2016)

50) Clevers, H. Modeling development and disease with organoids.\\
__Cell__ 165:1586-1597 (2016)

51) Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S.,
Grolleman, J.E., van Wezel, T., Nik-Zainal, S., Kuiper, R.P., Cuppen, E., and Clevers, H. Use of
CRISPR-modified human stem cell organoids to study the origin of mutational signatures in
__Science__ 358: 234-238 (2017)

52) Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin
A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F,
Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels
L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. A Living Biobank of Breast
Cancer Organoids Captures Disease Heterogeneity.
__Cell__ 2017 Dec 5. pii: S0092-8674(17)31319-3. doi: 10.1016/j.cell.2017.11.010. [[Epub ahead of

53) Roerink, S.F., Sasaki, N., ... , Stratton, MR, and Clevers H. A high-resolution molecular
history of intra-cancer diversification.
__Nature__, 2018. In press