Tamas Bartfai - List of publications 1972-2009#

Full papers and reviews:

1. Bartfai, T., Mannervik, B. A procedure based on statistical criteria for discrimination between steady state kinetic models. FEBS Letters 26:252-256, 1972.

2. Bartfai, T., Mannervik, B. An attempt to discriminate between mathematical models in enzyme steady state kinetics. In: Analysis and Stimlation of iochemical Systems (H.C. Hemker and B Hess, eds.) North Holland, Amsterdam 197-209, 1972.

3. Mannervik, B., Lindström, L., Bartfai, T. Partial purification and characterization of glyoxalase I from porcine erythrocytes. Eur. J. Biochem. 29:276-281, 1972.

4. Bartfai, T. Ekwall, K., Mannervik, B. Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I. Biochemistry 12:387-391, 1973.

5. Bartfai, T., Mannervik, B. Application of weight factors in the discrimination between mathematical models of enzyme kinetics. FEBS Letters 32:179-183, 1973.

6. Mannervik, B., Bartfai, T. Discrimination between mathematical models of biological systems exemplified by enzyme steady state kinetics. Acta Biol. Med. Germanica. 31:203-215, 1973.

7. Mannervik, B., Gorna-Hall, B., Bartfai, T. The steady-state kinetics of glyoxalase I from porcine erythrocytes. Evidence for random-pathway mechanism involving one-and two-substrate branches. Eur. J. Biochem. 37:270-281, 1973.

8. Augustinsson, K.-B., Bartfai, T., Mannervik, B. A steady-state kinetic model of butyrylcholinesterase from horse plasma. Biochem. J. 141:825-834, 1974.

9. Bartfai, T., Anner, J., Schultzberg, M., Montelius, J. Partial purification and characterization of a muscarinic acetylcholine receptor from rat cerebral cortex. Biochem. Biophys. Res. Commun. 59:725-733, 1974.

10. Mannervik, B., Bartfai, T., Gorna-Hall, B. Random pathway mechanism involving parallel one- and two-substrate branches for glyoxalase I from yeast. J. Bio. Chem. 249:901-903, 1974.

11. Hollander, P.M., Bartfai, T., Gatt, S. Studies of the reaction mechanism of DT-diaphorase. Intermediary plateau and through regions in the initial velocity visavi substrate concentration curves. Arch. Biochem. Biophys. 169:568-576, 1975.

12. Alberts, P., Bartfai, T. Muscarinic acetylcholine receptor from rat brain. Partial purification and characterization. J. Biol. Chem. 251:1543-1547, 1976.

13. Gatt, S., Bartfai, T. Proceedings: Rate equations and simulation curves for enzymatic reaction utilizing lipids as substrates. Isr. J. Med. Sci. 11:1172, 1975.

14. Bartfai, T., Berg, P., Schultzberg, M., Heilbronn, E. Isolation of a synaptic membrane fraction enriched in cholinergic receptors by controlled phospholipase A2 hydrolysis of synaptic membranes. Biochim. Biophys. Acta. 426:186-197, 1976.

15. Hall, C.L., Heijkenskjöld, L., Bartfai, T., Ernster, L., Kamin, H. Acyl Coenzyme A dehydrogenases and electron-transferring flavoprotein from beef heart mitochondria. Arch. Biochem. Biophys. 177:402-414, 1976.

16. Rase, B., Bartfai, T., Ernster, L. Purification of DT-diaphorase by affinity hromatography. Arch. Biochem. Biophys. 172:380-386, 1976.

17. Bartfai, T., Study, R.E., Greengard, P. Muscarinic stimulation and cGMP synthesis in the nervous system. In: Cholinergic Mechanisms and Psychopharmacology (D.E. Jenden, ed.) Plenum Press 285-295, 1977.

18. Gatt, S., Bartfai, T. Rate equations and stimulation curves for enzymatic reactions which utilize lipids as substrates. I. Interaction of enzymes with the monomers and micelles of soluble amphiphilic lipids. Biochem. Biophys. Acta. 488:1-12, 1977.

19. Gatt, S., Bartfai, T. Rate equations and stimulation curves for enzymatic reactions which utilize lipids as substrates. II. Effect of adsorption of the substrate or enzyme on the steady-state kinetics. Biochim. Biophy. Acta. 488:13-24, 1977.

20. Bartfai, T. Cyclic nucleotides in the central nervous system. Trends in Biochem. Sci. 3:121-124, 1978.

21. Bartfai, T., Breakefield, X.O. Muscarinic stimulation of cGMP synthesis in N1E-115 neuroblastoma cells. In: Molecular Biology and Pharmacology of Cyclic Nucleotides. (G. Folco and R. Paoletti, eds.) Elsevier, Amsterdam 57-67, 1978.

22. Bartfai, T., Breakefield, X.O., Greengard, P. Regulation of synthesis of guanosine 3’:5’-cyclic monophosphate in neuroblastoma cells. Biochem. J. 176:119-127, 1978.

23. Heilbronn, E., Bartfai, T. Muscarinic acetylcholine receptor. Progress in Neurobiology 11:171-188, 1978.

24. Elfman, L., Heilbronn, E., Bartfai, T. Immunological and binding studies on chloroform-methanol extracts from electroplax of Torpedo marmorata and from rat brain cortex. Comparison of the material solubilized by organic solvents with the receptor proteins solubilized by detergents. Acta Chem. Scand. B-32:370-374, 1978.

25. Stjärne, L., Alberts, P., Bartfai, T. Models of regulation of norepinephrine secretion by prejunctional receptors and by facilitation: Role of calcium and cyclic nucleotides. In: Catecholamines: Basic and Clinical Fontiers (E. Usdin, I.P. Kopin and J. Barchas, eds.) Pergamon Press 292-297, 1978.

26. Study, R.E., Breakefield, X.O., Bartfai, T., Greengard, P. Voltage-sensitive calcium channels regulate guanosine 3’5’-cyclic monophosphate levels in neuroblastoma cells. Proc. Nalt. Acad. Sci. USA 75:6295-6299, 1978.

27. Askelöf, P., Bartfai, T. Effect of whooping-cough vaccine on cyclic-GMP levels in the brain. FEMS Microbiology Letters 6:223-225, 1979.

28. Bartfai, T. Preparation of metal-chelate complexes and the design of steady-state kinetic experiments involving metal nucleotide complexes. In: Advances in Cyclic Nucleotides Res. (G. Brooker, P. Greengard, G.A. Robinson, eds.) Raven Press, N.Y. 10:219-242, 1979.

29. Hedlund, B., Bartfai, T. The importance of thiol- and disulfide groups in agonist and antagonist binding to the muscarinic receptor. Mol. Pharmacol. 15:531-544, 1979.

30. Hedlund, B., Gamarra, M., Bartfai, T. Inhibition of striatal muscarinic receptors in vivo by cadmium. Brain Res. 168:216-218, 1979.

31. Järv, J., Hedlund, B., Bartfai, T. Isomerization of the muscarinic receptor-antagonist complex. J. Biol. Chem. 254:5595-5598, 1979.

32. Stjärne, L., Bartfai, T., Alberts, P. The influence of 8-Br 3’5’-cyclic nucleotide analogues and of inhibitors of 3’5’-cyclic nucleotide phosphodiesterase on noradrenaline secretion and neuromuscular transmission in guinea-pig vas deferens. Naunyn-Schmiedeberg’s Arch. Pharmacol. 308:99-105, 1979.

33. Tjörnhammar, M.-L., Schwarcz, R., Bartfai, T., Fuxe K. Guanylate cyclase activity increases after kainic acid lesion of rat striatum. Brain Res. 171:567-572, 1979.

34. Bartfai, T. Cyclic nucleotides in the central nervous system. In: Current Topics in Cellular Regulation (B.L. Horecker and E.R. Stadtman, eds.) Academic Press, Inc. 16:225-269, 1980.

35. Bartfai, T., Hedlund, B., Järv, J., Nordström Ö. Muscarinic acetylcholine receptor. In: Natural Toxins (D. Baker and T. Wadström, eds.) Pergamon Press, Oxford and New York 531-536, 1980.

36. Bartfai, T., Nordström, Ö., Tjörnhammar, M.-L. Cyclic guanosine 3’5’-monophosphate in the nervous system: Pre-, post- and transsynaptic effects. Progress in Pharmacol. 4:151-157 1980.

37. Danielsson, E., Nordström, Ö., Bartfai, T. Azide reversibly raises cyclic GMP levels in hepatic slices and activates guanylate cyclase. Acta Chem. Scand. B-34:219-220, 1980.

38. Grimm, V.E., Bartfai, T., Palmskog, G., Sedvall, G. Possible correlation between noradrenergic innervation in the cerebellum and jumping behaviour in mice. Neuroscience 5:373-378, 1980.

39. Hedlund, B., Undén, A., Grynfarb, M., Bartfai, T. Agonist-antagonist-muscarinic receptor ternary complex. Acta Chem. Scand. B-34:767-769, 1980.

40. Järv, J., Hedlund, B., Bartfai, T. Kinetic studies on muscarinic antagonist-agonist competition. J. Biol. Chem. 255:2649-2651, 1980.

41. Lindqvist, L., Bartfai, T., Berg, J.-O., Blomlöf, L. In vivo and in vitro studies of inhibitory effects of restorative dental materials on salivary esterases. Scand. J. Dent. Res. 88:229-235, 1980.

42. Nordström, Ö., Bartfai, T. Muscarinic autoreceptor regulates acetylcholine release in rat hippocampus: in vitro evidence. Acta Physiol. Scand. 108:347-353, 1980.

43. Alberts, P., Bartfai, T., Stjärne, L. Site(s) and ionic basis of -autoinhibition and facilitation of 3H noradrenaline secretion in guinea-pig vas deferens. J. Physiol. 312:297-334, 1981.

44. Bartfai, T., Nordström, Ö., Hedlund, B., Undén, A., Westlind, A., Grynfarb, M. Pre- and postsynaptic muscarinic receptors. In: Chemical Neurotransmission 75 years (L. Stjärne, P. Hedquist, H. Lagercrantz and Å. Wennmalm, eds.) Academic Press, New York, London 399-410, 1981.

45. Hedlund, B., Bartfai, T. Binding of 3H-pilocarpine to membranes from rat cerebral cortex. Naunyn-Schmiedeberg’s Arch. Pharmacol. 317:126-130, 1981.

46. Nordström, O., Bartfai, T. 8-Br-cyclic GMP mimics activation of muscarinic autoreceptor and inhibits acetylcholine release from rat hippocampal slices. Brain Res. 213:467-471, 1981.

47. Nordström, Ö., Westlind, A., Hedlund, B., Undén, A., Bartfai, T. On the ionic mechanism of presynaptic muscarinic receptor action in rat hippocampus. In: Cholinergic Mechanisms: Phylogenietic Aspects, Central and Peripheral Synapses and Clinical Significance (G. Pepeu and H. Ladinsky, eds.) Plenum Press, New York 579-586, 1981.

48. Sokolovsky, M., Bartfai, T. Biochemical studies on muscarinic receptors. Trends in Biochem. Sci. 6:303-305, 1981.

49. Taylor, P., Bartfai, T. Modulation and transduction of receptor-mediated signals: Chairmen’s overview. In: Chemical Neurotransmission 75 years. (L. Stjärne, P. Hedqvist, H. Lagercrantz and Å. Wennmalm, eds.) Academic Press, New York, London 425-427, 1981.

50. Westlind, A., Grynfarb, M., Hedlund, B., Bartfai, T., Fuxe, K. Muscarinic supersensitivity induced by septal lesion or chronic atropine treatment. Brain Res. 225:131-141, 1981.

51. Bartfai, T. Cyclic nucleotides and the nervous system. Trends in Pharmacol. Sci. 3:338-340, 1982.

52. Nordström, Ö., Westlind, A., Undén, A., Meyerson, B., Sachs, C., Bartfai, T. Pre- and postsynaptic muscarinic receptors in surgical samples from human cerebral cortex. Brain Res. 234:287-297, 1982.

53. Alberts, P., Bartfai, T., Stjärne, L. The effects of atropine on 3H acetylcholine secretion from guinea-pig myenteric plexus evoked electrically or by high potassium. J. Physiol. 329:93-112, 1982.

54. Hedlund, B., Grynfarb, M., Bartfai, T. Two ligands may bind simultaneously to the muscarinic receptor. Naunyn-Schmiedeberg’s Arch. Pharmacol. 320:3-13, 1982.

55. Hedlund, B., Norin, H., Christakopoulos, A., Alberts, P., Bartfai, T. Acetylarsenocholine: A cholinergic agonist. J. Neurochem. 39:871-873, 1982.

56. Järv, J., Bartfai, T. The importance of hydrophobic interactions in the antagonist binding to the muscarinic acetylcholine receptor. Acta Chem. Scand. B-36:487-490, 1982.

57. Lundberg, J.M., Hedlund, B., Bartfai, T. Vasoactive intestinal polypeptide enhances muscarinic ligand binding in cat submandibular salivary gland. Nature 295:147-149, 1982.

58. Nordström, Ö., Bartfai, T. Mechanism of action of the muscarinic autoreceptor in the rat hippocampus. In: Proceedings of Fourth European Society for Neurochemistry, Cantania 189-196, 1982.

59. Danielsson, E., Undén, A., Bartfai T. Orthovanadate induces loss of muscarinic cholinergic binding sites. Biochem. Biophys. Res. Commun. 110:67-52, 1983.

60. Hedlund, B., Abens, J., Bartfai, T. Vasoactive intestinal polypeptide and muscarinic receptors: Supersensitivity induced by long-term atropine treatment. Science 220:519-521, 1983.

61. Lundberg, J.M., Hedlund, B., Änggård, A., Fahrenkrug, J., Hökfelt, T., Tatemoto, K., Bartfai, T. Costorage of peptides and classical transmitters in neurons. In: Systemic Role of Regulatory Peptides (S.R. Bloom, J.M. Polak and E. Lindenlaub, eds.) F.K. Schattauer Verlag, Stuttgart, New York 93-119, 1983.

62. Nordström, Ö., Alberts, P., Westlind, A., Undén, A., Bartfai, T. Presynaptic antagonist-postsynaptic agonist at muscarinic cholinergic synapses: N-Methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. Molec. Pharmacol. 24:1-5, 1983.

63. Peterson, L.-L., Bartfai, T. In vitro and in vivo inhibition of 3H imipramine binding by cadmium. Eur. J. Pharmacol. 90:289-292, 1983.

64. Undén, A., Meyerson, B., Winblad, B., Sachs, C., Bartfai, T. Postmortem changes in binding to the muscarinic receptor from human cerebral cortex. J. Neurochem. 41:102-106, 1983.

65. Tjörnhammar, M.-L., Lazaridis, G., Bartfai, T. Cyclic GMP efflux from liver slices. J. Biol. Chem. 258:6882-6886, 1983.

66. Abens, J., Westlind, A., Bartfai, T. Chronic atropine treatment causes increase in VIP receptors in rat cerebral cortex. Peptides 5:375-377, 1984.

67. Bartfai, T., Westlind, A., Abens, J., Engström, C., Alberts, P. On acetylcholine-vasoactive intestinal polypeptide coexistence and presynaptic interactions. In: Regulation of Transmitter Function (E.S. Vizi and K. Magyar, eds.) 497-500, 1984.

68. Brodin, E., Peterson, L.-L., Ögren, S.-O., Bartfai, T. Chronic treatment with the serotonin uptake inhibitor zimelidine elevates substance P levels in rat spinal cord. Acta Physiol. Scand. 122:209-211, 1984.

69. Peterson, L.-L., Bartfai, T., Ernster, L., Wickström, G., Roos, B.-E., Wehlin-Åhs, U., Ågren, H. Uncoupler-accelerated efflux of 5-hydroxytryptamine from platelets of healthy subjects and patients with unipolar and bipolar depression. Psych. Res. 13:141-150, 1984.

70. Tjörnhammar, M.-L., Bartfai, T. Interaction of drugs with the cyclic nucleotide generating enzymes in the central nervous system. Med. Res. Rev. 4:513-534, 1984.

71. Undén, A., Bartfai, T. Regulation of neuropeptide Y (NPY) binding by guanine nucleotides in the rat cerebral cortex. FEBS Lett. 177:125-128, 1984.

72. Undén, A., Tatemoto, K., Mutt, V., Bartfai, T. Neuropeptides Y receptor in the rat brain. Eur. J. Biochem. 145:525-530, 1984.

73. Westlind, A., Abens, J., Bartfai, T. Functional aspects of the coexistence of classical neurotransmitters and peptide neurotransmitters. In: Hormones and Cell Regulation (J.E. Dumont and J. Nunez, eds.) Elsevier Science Publishers B.V. 8:195-211, 1984.

74. Ögren, S.O., Nordström, Ö., Danielsson, E., Peterson, L.-L., Bartfai, T. In vivo and in vitro studies on the potentiation of muscarinic receptor stimulation by alaproclate, a selective 5-HT uptake blocker. J. Neural Transmission 61:1-20, 1985.

75. Ögren, S.-O., Carlsson, S., Bartfai, T. Serotonergic potentiation of muscarinic agonist evoked tremor and salivation in rat and mouse. Psychopharmacology 86:258-264, 1985.

76. Danielsson, E., Peterson, L.-L., Grundin, R., Ögren, S.-O., Bartfai, T. Anticholinergic potency of psychoactive drugs in human and rat cerebral cortex and striatum. Life Sciences 36:1451-1457, 1985.

77. Bartfai, T. Presynaptic aspects of the coexistence of classical neuro-transmitters and peptides. Trends in Pharmacol. Sci. 6:331-334, 1985.

78. Undén, A., Peterson, L.-L., Bartfai, T. Somatostatin, substance P, vasoactive intestinal polypeptide, and neuropeptide Y receptors: Critical assessment of biochemical methodology and results. International Review of Neurobiology 27:141-177, 1985.

79. Bartfai, T., Hedlund, B. Phosphorylation of membrane proteins in excitable cells and changes in membrane properties: Experimental paradigms and interpretations, a biochemist’s view. In: Neural Mechanism of conditioning (D.L. Alkon and C.D. Woody, eds.) Plenum Publ. Corp. 373-382, 1985.

80. Brodin, E., Lindefors, N., Theodorsson-Norheim, E., Peterson, L.-L., Bartfai, T., Ögren, S.-O., Rosell, S. Tachykinins in rat central nervous system: distribution, molecular forms, release and effects of chronic treatment with antidepressant drugs. In: Tachykinin Antagonists (R. Håkansson and F. Sundler, eds.) Fernström Foundation Series, Elsevier Science Publishers B.V., Amsterdam 6:15-27, 1985.

81. Sillard, R., Järv, J., Bartfai, T. Kinetic evidence for cooperativity of quinuclidinyl-benzilate interaction with muscarinic receptor from rat brain. Biochimia 2:426-435, 1985.

82. Nordström, Ö., Braesch-Andersen, S., Bartfai, T. Dopamine release is enhanced while acetylcholine release is inhibited by nimodipine(Bay e 9736). Acta Physiol. Scand. 126:115-119, 1986.

83. Woody, C.D., Bartfai, T., Gruen, E., Nairn, A.C. Intracellular injection of cGMP-dependent protein kinase results in increased input resistance in neurons of the mammalian motor cortex. Brain Res. 386:379-385, 1986.

84. Bartfai, T., Iverfeldt, K., Brodin, E., Ögren, S. Functional consequences of coexistence of classical and peptide neurotransmitters. Prog. in Brain Res. 68:321-330, 1986.

85. Bartfai, T., Vizi, E.S. Prevention by nimodipine, a calcium entry blocker, of the effect of -adrenoceptor blocking agents on noradrenaline release: Differential effects of nimodipine, on 3H noradrenaline and 14C acetylcholine release measured concomitantly from the guinea-pig ileum. Arch In Pharmacodyn et de Therapie 284:212-224, 1986.

86. Danielsson, E., Undén, A., Nordström, Ö., Ögren, S.-O., Bartfai, T. Interactions of alaproclate a selective 5HT-uptake blocker, with muscarinic receptors: In vivo and in vitro studies. In Dynamics of Cholinergic Systems (I. Hanin, ed.) B-40:415-422, 1986.

87. Danielsson, E., Nordström, Ö., Bartfai, T. N-methyl-N,-nitro-N-nitrosoguanidine and cyclic GMP stimulate phosphorylation of nuclear proteins from rat liver. Acta Chem. Scand. B-40:390-393, 1986.

88. Engström, O., Rodmalm, K., Jörnvall, H., Lundquist, G., Kalman, M., Simoncsits, A., Bartfai, T., Löfdahl, S., Askelöf, A. Characterization of the N-terminal structure of pertussis toxin subunit Sl and hybridization of oligodeoxyribonucleotide probes with a Bordetella pertussis DNA fragment. FEMS Microbiol Lett. 36:219-223, 1986.

89. Hedlund, B., Abens, J., Westlind, A., Bartfai, T. Vasoactive intestinal polypeptide-muscarinic cholinergic interactions. In: Dynamics of Cholinergic Function (I. Hanin, ed.) Plenum Publ. Corp. 30:1019-1025, 1986.

90. Iverfeldt, K., Peterson, L.-L., Brodin, E., Ögren, S.-O., Bartfai, T. Serotonin type-2 receptor mediated regulation of substance P release in the ventral spinal cord and the effects of chronic antidepressant treatment. Naunyn Schmiedeberg’s Arch. Pharm. 333:1-6, 1986.

91. Nordström, Ö., Undén, A., Grimm, V., Frieder, B., Ladinsky, H., Bartfai, T. In vivo and in vitro studies on a muscarinic presynaptic antagonist and postsynaptic agonist: BM-5. In: Dynamics of Cholinergic Function (I. Hanin, ed.) 30:405-413, 1986.

92. Tjörnhammar, M.-L., Lazaridis, G., Bartfai, T. Efflux of cyclic guanosine-3’5’ monophosphate from cerebellar slices stimulated by L-glutamate or high K+ or N-methyl-N’-nitro-N-nitrosoguanidine. Neurosci. Lett. 68:95-99, 1986.

93. Halldén, G., Abens, J., Engström, C., Westlind, A., Mutt, V., Bartfai, T. Iodinated derivatives of the vasoactive intestinal polypeptide (VIP) are agonists at the cat pancreas and the rat submandibular salivary gland. Regulatory Peptides 16:183-188, 1986.

94. Serfözö, T., Bartfai, T., Vizi, E.S. Presynaptic effects of neuropeptide Y on 3H noradrenaline and 3H acetylcholine release. Regulatory Peptides 16:117-123, 1986.

95. Gottfries, C.G., Bartfari, T., Carlsson, A., Eckernas, S., Svennerholm, L. Multiple biochemical deficits in both grat ans white matter of Alzheimer brains. Prog. Neuropsychopharmacol Biol. Psychiatry 10:405-413, 1986.

96. Stjarne, L., Alberts, P., Bartfai, T. Effects of chloride ion substitution on the frequency dependence and alpha-autoinhibition of 3H noradrenaline sereation in guinea-pig vas deferens. Acta Physiol. Scand. 127:327-333, 1986.

97. Solti, M., Bartfai, T. Tachykinin regulation of serotonin release: Enhancement of 3H serotonin release from rat cerebral cortex by neuromedin K and substance P acting at distinct receptor sites. Brain Res. 401:377-380, 1987.

98. Engström, C., Undén, A., Ladinsky, H., Consolo, S., Bartfai, T. BM-5, a centrally active partial muscarinic agonist with low tremorogenic activity. In vivo and in vitro studies. Psychopharmacology 91:161-167, 1987.

99. Nordström, Ö., Melander, T., Hökfelt, T., Bartfai, T., Goldstein, M. Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence. Neurosci. Lett. 73:21-26, 1987.

100. Westlind-Danielsson, S., Undén, A., Abens, J., Andell, S., Bartfai, T. Neuropeptide Y receptors and the inhibition of adenylate cyclase in the human frontal and temporal cortex. Neurosci. Lett. 74:237-242, 1987.

101. Hökfelt, T., Millhorn, P., Seroogy, K., Tsuruo, Y., Ceccatelli, S., Lindh, B., Meister, B., Melander, T., Schalling, M., Bartfai, T., Terenius, L. Coexistence of peptides with classical neurotransmitters. Experientia 43:768-780, 1987.

102. Hedlund, B., Bartfai, T. Determination of thermodynamic constants for agonist binding to muscarinic receptors from rat cerebral cortex. Acta Chem Scand. B-41:225-227, 1987.

103. Nordström, Ö., Eliaz, M., Bartfai, T., Gottfries, C.-G. Increased affinity of choline acetyltransferase for choline in Alzheimer’s disease: a steady-state kinetic study. Brain Res. 420:371-374, 1987.

104. Goobar, L., Bartfai, T. Altered muscarinic regulation of phosphatidylinositol turnover after long term atropin treatment. In: Synaptic Transmitters and Receptors (S. Tucek, ed.) 156-160, 1987.

105. Segura-Aguilar, J.E., Lind, C., Nordström, Ö., Bartfai, T. Regional and subcellular distribution of DT-diaphorase in the rat brain. In: DT-diaphorase (L. Ernster, ed.) Chemica Scripta 27-A:55-57, 1987.

106. Hedlund, B., Ögren, S.-O., Bartfai, T. Biochemical and electrophysiological studies on potentiation of muscarinic responses by alaproclate. In: International Symposium on Muscarinic Cholinergic Mechanisms (S. Cohen and M. Sokolovsky, eds.) Freund Publ. Ltd. 159-170, 1987.

107. Fisone, G., Wu, C., Consolo, S., Nordström, Ö., Brynne, N., Bartfai, T., Melander, T., Hökfelt, T. Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: Histochemical, autoradiographic, in vivo and in vitro studies. Proc. Natl. Acad. Sci. USA 84:7339-7343, 1987.

108. Ögren, S.-O., Altman, H., Bartfai, T. Alaproclate potentiation of muscarinic agonist evoked tremor, salivation and enhanced recall. In: Synaptic Transmitters and Receptors (S. Tucek, ed.) 113-119, 1987.

109. Bartfai, T., Iverfeldt, K., Serfözö, P., Ögren, S.-O. Interactions of coexisting neurotransmitters and effects of chronic drug treatment. In: Receptor-Receptor Interactions: a new intramembrane mechanism. (K. Fuxe and L. Agnati, eds.) MacMillan Press, London 407-417, 1987.

110. Hökfelt, T., Meister, B., Everitt, B., Staines, W., Melander, T., Schalling, M., Mutt, V., Hulting, A.-L., Werner, S., Bartfai, T., Nordström, Ö., Fahrenkrug, J., Goldstein, M. Chemical neuroanatomy of the hypothalamo-pituitary axis: Focus on multimessenger systems. In: Integrative Neuroendocrinology: Molecular, Cellular and Clinical Aspects (S.M. McCann and R.J. Weiner, eds.) Basl. 1-34, 1987.

111. Bartfai, T., Nordström, Ö., Hedlund, B., Grimm, V., Ögren, S.-O. Potentiation of muscarinic responses by the 5HT uptake-blocking antidepressant drug alaproclate: biochemical, pharmacological and behavioural studies. In: Cellular and Molecular Basis of Cholinergic Function (M.J. Dowdall and J.N. Hawthorne, eds.) Ellis Horwood Ltd., Chichester, England and VCH Weinheim, Federal Republic of Germany 828-834, 1987.

112. Schultzberg, M., Svensson, S.B., Undén, A., Bartfai, T. Interleukin-1-like immunoreactivity in peripheral tissues. J. Neurosci. Res. 18:184-189, 1987.

113. Järv, J., Sillard, R., Bartfai, T. Influence of temperature on cooperative binding of N-methylpiperidinyl-benzilate with muscarinic receptor from rat cerebral cortex. Proc. Acad. Sci. Estonian SSR 36:172-179, 1987.

114. Tjörnhammar, M.-L., Bartfai, T. Serotonin mediated increases in cGMP levels and their relation to serotonin uptake in human platelets: An indicator of serotonergic function. In: Perspectives of Psycho-pharmacology (J.D. Barchas and W. Bunney, eds.) A.R. Liss, New York 365-374, 1988.

115. Westlind-Danielsson, A., Andell, S., Abens, J., Bartfai, T. Neuropeptide Y and peptide YY inhibit adenylate cyclase activity in the rat striatum. Acta Physiol. Scand. 132:425-430, 1988.

116. Maslinski, W., Kullberg, M., Nordström, Ö., Bartfai, T. Muscarinic receptors and receptor-mediated actions on rat thymocytes. J. Neuroimmunology 17:265-274, 1988.

117. Maslinski, W., Ryzewski, J., Bartfai, T. Rat thymocytes release a factor which inhibits muscarinic ligand binding. J. Neuroimmunology 17:275-285, 1988.

118. Bartfai, T., Iverfeldt, K., Fisone, G. Regulation of the release of coexisting neurotransmitters. Ann. Rev. Pharmacol. and Toxicol. 28:285-310, 1988.

119. Iverfeldt, K., Ögren, S.-O., Bartfai, T. Substance P receptors in the rat spinal cord: the effect of GTP and of chronic antidepressant treatment. Acta Physiol. Scand. 132:175-179, 1988.

120. Danielsson, E., Eckernäs, S.-Å., Westlind-Danielsson, A., Nordström, Ö., Bartfai, T., Gottfries, C.-G., Wallin, A. VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by Alzheimer’s disease/senile dementia of the Alzheimer type. Neurobiol. of Aging 9:153-162, 1988.

121. Westlind-Danielsson, A., Gillenius, P., Askelöf, P., Bartfai, T. Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. J. Neurochem. 51:38-44, 1988.

122. Goobar, L., Bartfai, T. Long-term atropine treatment lowers the efficacy of carbachol to stimulate phosphatidylinositol breakdown in the cerebral cortex and hippocampus of rats. Biochem. Journal 250:727-734, 1988.

123. Järv, J., Bartfai, T. Muscarinic acetylcholine receptors. In: Handbook of Experimental Pharmacology: Cholinergic Synapse (V.P. Whittaker, ed.) Springer Verlag, Berlin Heidelberg 86:315-345, 1988.

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130. Schultzberg, M., Andersson, C., Undén, A., Troye-Blomberg, M., Svensson, S.B., Bartfai, T. Interleukin-1 in adrenal chromaffin cells (immunohistochemical and biochemical study). Neuroscience 30:805-810, 1989.

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135. Iverfeldt, K., Serfözö, P., Dias Arnesto, L., Bartfai, T. Differential release of coexisting neurotransmitters: frequency dependence of the efflux of substance P, thyrotropin releasing hormone and 3H serotonin from tissue slices of rat ventral spinal cord. Acta Physiol. Scand. 137:63-71, 1989.

136. Fisone, G., Berthold, M., Bedecs, K., Undén, A., Bartfai, T., Bertorelli, R., Consolo, S., Crawley, J., Martin, B., Nilsson, S., Hökfelt, T. N-terminal galanin-(1-16) fragment is an agonist of the hippocampal galanin receptor. Proc. Natl. Acad. Sci. USA 86:9588-9591, 1989.

137. Hökfelt, T., Millhorn, D., Seroogy, K., Tsuruo, Y., Ceccatelli, S., Lindh, B., Meisterm B., Melander, T., Schalling, M., Bartfai, T. et al.Coexistence of peptides with classical neurotransmitters. Experientia Suppl. 56:154-79, 1989.

138. Iverfeldt, K., Solti, M., Bartfai, T. Substance P and neurokinin A, two coexisting tachykinins stimulating the release of 3H 5-HT from rat cerebral cortical slices. Brain Res. 506:335-338, 1990.

139. Askelöf, P., Rodmalm, K., Wrangsell, G., Larsson, U., Svensson, S.B., Cowell, J.L., Undén, A., Bartfai, T. Proctective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1. Proc. Natl. Acad. Sci. USA 87:1347-1351, 1990.

140. Maslinski, W., Grabczewska, E., Bartfai, T., Ryzewski, J. Muscarinic antagonist binding to intact rat thymocytes. Acta Chem. Scand. 44:147-151, 1990.

141. Bartfai, T., Andersson, C., Bristulf, J., Schultzberg, M., Svensson, S. Interleukin-1 in the noradrenergic chromaffin cells in the rat adrenal medulla. N.Y. Acad. Sci. 89:207-213, 1990.

142. Bartfai, T., Ladinsky, H. Future prospects in muscarinic cholinergic pharmacology. Outstanding problems and promises. Prog. Brain Res. 84:227-229, 1990.

143. Westlind-Danielsson, A., Müller, R.M., Bartfai, T. Atropine treatment induced cholinergic supersensitivity at receptor and second messenger levels in the rat salivary gland. Acta Physiol. Scand. 138:431-441, 1990.

144. Xu, X.J., Wiesenfeld-Hallin, Z., Fisone, G., Bartfai, T., Hökfelt, T. The N-terminal 1-16 but not C-terminal 17-29 galanin fragment affects the flexor reflex in rat. Eur. J. Pharm. 182:137-141, 1990.

145. Crawley, J.N., Austin, M.C., Fiske, S.M., Martin, B., Consolo, S., Berthold, M., Langel, U., Fisone, G., Bartfai, T. Activity of centrally administrated galanin fragments on stimulation of feeding behaviour and on galanin receptor binding in the rat hypothalamus. J. Neurosci. 10:3695-3700, 1990.

146. Consolo, S., Palazzi, E., Bertorelli, R., Fisone, G., Crawley, J., Hökfelt, T., Bartfai, T. Functional aspects of acetylcholine-galanin coexistence in the brain. Prog. Brain Res. 84:279-287, 1990.

147. Palazzi, E., Felinska, S., Zambelli, M., Fisone, G., Bartfai, T., Consolo, S. Galanin reduces carbachol stimulation of phosphoinositide turnover in rat ventral hippocampus by lowering Ca2+ influx through voltage-sensitive Ca2+ channels. J. Neurochem. 56:739-747, 1991.

148. Land, T., Langel, Ü., Fisone, G., Bedecs, K., Bartfai, T. Assay for the galanin receptor. In: Methods in Neurosci. (P.M. Conn, ed.) Academic Press 5:225-234, 1991.

149. Fisone, G., Langel, Ü., Land, T., Berthold, M., Bertorelli, R., Girotti, P., Consolo, S., Crawley, J.N., Hökfelt, T., Bartfai, T. Galanin receptor ligands in the hippocampus: Galanin, N-terminal galanin fragments and analogs. In: Galanin: a new multifunctional peptide in the neuro-endocrine system. Wenner-Gren Center International Symposium Series, (T. Hökfelt, T. Bartfai, D Jacobowitz and D. Ottoson, eds.) MacMillan Press Ltd, London 58:213-220, 1991.

150. Rigler, R., Wennerberg, A., Cooke, R.M., Elofsson, A., Nilsson, L., Vogel, H., Holley, L.H., Carlquist, M., Langel, Ü., Bartfai, T., Campbell, I.D. On the solution structure of galanin. In: Galanin: a new multifunctional pepetide in the neuroendocrine system. Wenner-Gren Center International Symposium Series, (T. Hökfelt, T. Bartfai, D. Jacobowitz and D. Ottoson, eds.) Mac Millan Press Ltd, London 58:17-25, 1991.

151. Consolo, S., Bertorelli, R., La Porta, C., Palazzi, E., Zambelli, M., Fisone, G., Bartfai, T. Galanin regulation of acetylcholine release and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus. In: Galanin: A new multifunctional peptide in the neuroendocrine system. Wenner-Gren Center International Symposium Series, (T. Hökfelt, T. Bartfai, D. Jacobowitz and D. Ottoson, eds.) The MacMillan Press Ltd, London 58:247-258, 1991.

152. Land, T., Langel, Ü., Löw, M., Berthold, M., Undén, A., Bartfai, T. Linear and cyclic N-terminal galanin fragments and analogues as ligands at the hypothalamic galanin receptor. Int. J. Peptides and Prot. Research 38:267-272, 1991.

153. Bristulf, J., Simoncsits, A., Bartfai, T. Characterization of a neuronal interleukin-1 receptor and the corresponding mRNA in the mouse anterior pituitary cell line AtT-20. Neurosci. Lett. 128:173-176, 1991.

154. Magnusson, R., Larsson, U., Bartfai, T., Askelof, P. A sensitive method for measuring neutralizing antibodies to Nordatella pertussis toxin: optimised ADP-ribosylation of transducin. Biologicals 19:9-15, 1991.

155. Land, T., Langel, Ü., Bartfai, T. Hypothalamic degradation of galanin (1-29) and galanin (1-16): identification and characterization of the peptidolytic products. Brain Res. 558:245-250, 1991.

156. Langel, Ü., Land, T., Bartfai, T. Synthetic galanin analogs with biochemical activity. In: Peptides 1990. Proceedings of the Twenty-First European Peptide Symposium September 2-8, 1990, Platja d‘Aro, Spain. (E. Giralt and D. Andreu, eds.) ESCOM Science Publishers B.V., Leiden 727-728, 1991.

157. Consolo, S., Bertorelli, R., Girotti, P., La Porta, C., Bartfai, T., Parenti, M., Zambelli, M. Pertussis toxin-sensitive G-protein mediates galanin’s inhibition of scopol-amine-evoked acetylcholine release in vivo and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus. Neurosci. Lett. 126:29-32, 1991.

158. Askelof, P., Rodmalm, K., Wrangsell, G., Larsson, U., Svenson, S.B., Cowell, J.L., Undén, A., Bartfai, T. Protective immunogenicity of synthetic peptides selected from the amino acid sequence of Bordatella pertussis toxin subunit S2. Dev. Biol. Stand. 73:111-120, 1991.

159. Bartfai, T., Bedecs, K., Land, T., Langel, Ü., Bertorelli, R., Girotti, P., Consolo, S., Xu, X., Wiesenfeld-Hallin, Z., Nilsson, S., Pieribone, V.A., Hökfelt, T. M-15: High affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus and spinal cord. Proc. Natl. Acad. Sci. USA 88:10961-10965, 1991.

160. Fisone, G., Bartfai, T., Nilsson, S., Hökfelt, T. Galanin inhibits the potassium-evoked release of acetylcholine and the muscarinic receptor-mediated stimulation of phosphoinositide turnover in slices of monkey hippocampus. Brain Res. 568:279-284, 1991. 161. Gregersen, S., Hermansen, K., Langel, Ü., Fisone, G., Bartfai, T., Ahrén, B. Galanin-induced inhibition of insulin secretion from rat islets: effects of rat and pig galanin and galanin fragments and analogues. Eur. J. Pharm. 203:111-114, 1991.

162. Alheim, K., Andersson, C., Tingsborg, S., Ziolkowska, M., Schultzberg, M., Bartfai, T. Interleukin 1 expression is inducible by nerve growth factor in PC12 pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 88:9302-9306, 1991.

163. Bedecs, K., Langel, Ü., Bartfai, T., Wiesenfeld-Hallin, Z. Galanin receptors and their second messengers in the lumbar dorsal spinal cord. Acta Physiol. Scand. 144:213-220, 1991.

164. Langel, Ü., Land, T., Bartfai, T. Design of chimeric peptide ligands to galanin receptors and substance P receptors. Int. J. Pept. Prot. Research 39:516-522, 1992.

165. Wiesenfeld-Hallin, Z., Bartfai, T., Hökfelt, T. Galanin in Sensory Neurons in the Spinal Cord. Frontiers in Neuroendocrinology 13:319-343, 1992.

166. Melander, T., Köhler, C., Nilsson, S., Fisone G., Bartfai, T., Hökfelt, T. 125I-galanin binding sites in the rat central nervous system. Handbook of Chemical Neuroanatomy 11:187-221, 1992.

167. Andersson, C., Svensson, S.B., van Deventer, S., Cerami, A., Bartfai, T. Interleukin-1 expression is inducible by cholinergic stimulation in the rat adrenal gland. Neuroscience 47:481-485, 1992.

168. Brenneman, D.E., Schultzberg, M., Bartfai, T., Gozes, I. Cytokine Regulation of Neuronal Survival. J. of Neurochem. 58:454-460, 1992.

169. Wiesenfeld-Hallin, Z., Xu, X.-J., Langel, Ü., Bedecs, K., Hökfelt, T., Bartfai, T. Galanin-mediated control of pain: Enhanced role after nerve injury. Proc. Natl. Acad. Sci. USA 89:3334-3337, 1992.

170. Bartfai, T., Fisone, G., Langel, Ü. Galanin and galanin antagonists: molecular and biochemical perspectives. Trends in Pharmacol. Sci. 13:312-318, 1992.

171. Hökfelt, T., Bartfai, T., Ceccatelli, S., Cortés, R., Fisone, G., Hulting, A.-L., Langel, Ü., Meister, B., Melander, T., Pieribone, V., Schalling, M., Verge, V.M.K., Villar, M., Wiesenfeld-Hallin, Z., Xu, X., Xu, Z. Central and Sensory Galanin Neurons and Functional Aspects. The 5th International Symposium on VIP and Related Peptides. Biomedical Research 13:311-317, 1992.

172. Hökfelt, T., Bartfai, T., Wiesenfeld-Hallin, Z. Neuropeptides: Recent Advances with Special Reference to Galanin. Neuroscience Facts 3:77-78, 1992.

173. Hökfelt, T., Åman, K., Arvidsson, U., Bedecs, K., Ceccatelli, S., Hulting, A-L., Langel, Ü., Meister, B., Pieribone, V., Bartfai, T. Galanin message-associated peptide (GAMP)- and galanin-like immunoreactivities: Overlapping and differential distributions in the rat. Neuroscience Lett. 142:139-142, 1992.

174. Lindskog, S., Ahrén, B., Land, T., Langel, Ü., Bartfai, T. The novel high-affinity antagonist galantide blocks the galanin mediated inhibition of glucose-induced insulin secretion. Eur. J. Pharmacol. 210:183-188, 1992.

175. Amoroso, D., Girotti, P., Fisone, G., Bartfai, T., Consolo, S. Mechanism of galanin induced increase in acetylcholine release in vivo from striata of freely moving rats. Brain Res. 589:33-38, 1992.

176. Ögren, S.O., Hökfelt,T., Kask, K., Langel,Ü., Bartfai, T. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience 51:1-5, 1992.

177. Hökfelt, T., Xu, Z., Verge, V., Villar M., Elde, R., Bartfai, T., Xu, X.-J., Wiesenfeld-Hallin, Z. Coexistence and interaction of neuropeptides with substance P in primary sensory neurons, with special reference to galanin. International Symposium on Substance P and Related Peptides - Pain, Inflammation, Visceral and CNS Functions, Shizouka, Japan Nov 3-6, 1992.

178. Hökfelt, T., Arvidsson, U., Bean, A., Castel, M.-N., Ceccatelli, S., Dagerlind, Å., Elde, R.P., Meister, B., Morino, P., Nicholas, A.P., Pelto-Huikko, M., Pieribone, V., Schalling, M., Verge, V., Xu, Z., Bartfai, T., Wiesenfeld-Hallin, Z. Colocalization of neuropeptides and classical neurotransmitters-funtional significance. XVIIIth C.I.N.P. Congress, Nice, Raven Press. June 28-July 2, 1992.

179. Bartfai, T., Hökfelt, T., Langel, Ü. Galanin-a neuroendocrine peptide. Critical Reviews in Neurobiology 7:229-274, 1993.

180. La Porta, C., Bianchi, R., Sozzani, S., Bartfai, T., Consolo, S. Galanin reduces PDBu-induced protein phosphorylation in ventral hippocampus. FEBS Lett. 300:46-48, 1993.

181. Zini, S., Roisin, M.-P., Langel, Ü., Bartfai, T., Ben-Ari, Y. Galanin reduces release of excitatory amino acids but not GABA in the rat hippocampus. Eur. J. Pharmacol. 245:1-7, 1993.

182. Verge, V.M.K., Xu, X.-J., Langel, Ü., Hökfelt, T., Wiesenfeld-Hallin, Z., Bartfai, T. Evidence for endogenous inhibition of autotomy by galanin in the rat after sciatic nerve section: demonstrated by chronic intrathecal infusion of a high affinity galanin receptor antagonist. Neurosci. Lett. 149:193-197, 1993.

183. Crawley, J.N., Robinson, J.K., Langel, Ü., Bartfai, T. Galanin receptor antagonists M40 and C7 block galanin-induced feeding. Brain Res. 600:268-272, 1993.

184. Gregersen, S., Lindskog, S., Land, T., Langel, Ü., Bartfai,T., Ahrén, B. Blockade of galanin-induced inhibition of insulin secretion from isolated mouse islets by the non-methionine containing antagonist M35. Eur. J. Pharmacol. 232:35-39, 1993.

185. Bartfai, T., Schultzberg, M. Cytokines in neuronal cell types. In: Current Aspects in the Neurosciences, Vol. 5, The MacMillan Press, Ltd, London, Neurochem. Int. 22:435-444, 1993.

186. Girotti, P., Bertorelli, R., Fisone, G., Land, T., Langel, Ü., Consolo, S., Bartfai, T. N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo. Brain Res. 612:258-262, 1993.

187. Arvidsson, K., Land, T., Langel, Ü., Bartfai, T., Ehrenberg, A. Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors. Biochemistry 32:7787-7798, 1993.

188. Gatti, S., Bartfai, T. Induction of tumor necrosis factor- mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6. Brain Res. 624:291-294, 1993.

189. Hulting, A.-L., Land, T., Berthold, M., Langel, Ü., Hökfelt. T., Bartfai, T. Galanin receptors from human pituitary tumors assayed with human galanin as ligand. Brain Res. 625:173-176, 1993.

190. Bartfai, T., Langel, Ü., Bedecs, K., Andell, S., Land, T., Gregersen, S., Ahrén, B., Girotti, P., Consolo, S., Corwin, R., Crawley, J., Xu, X.-J., Wiesenfeld-Hallin, Z., Hökfelt, T. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc. Natl. Acad. Sci. USA 90:11287-11291, 1993.

191. Simoncsits, A., Bristulf, J., Tjörnhammar, M-L., Cserzö, M., Pongor, S., Rybakina, E., Gatti, S., Bartfai, T. Deletion mutants of human Interleukin 1 with significantly reduced agonist properties: Search for agonist/antagonist switch in ligands to the Interleukin 1 receptors. Cytokine 6:206-214, 1994.

192. Rodell Lundgren, K., Bergkvist, L., Högman, S., Jöves, H., Eriksson, G., Bartfai, T., van der Laan, J., Rosenberg, E., Shoham, Y. TCF Mill Trial on softwood pulp with Korsnäs thermostable and alkaline stable xylanase T6. FEMS Microbiol. Reviews 13:365-368, 1994.

193. Kahl, U., Langel, Ü., Bartfai, T., Grundemar, L. Functional effects and ligand binding of chimeric galanin-neuropeptide Y (NPY) peptides on NPY and galanin receptor types. Br. J. Pharmacol. 111:1129-1134, 1994.

194. Villar, M.J., Ceccatelli, S., Bedecs, K., Bartfai, T., Bredt, D., Snyder, S.H., Hökfelt, T. Upregulation of nitric oxide synthase and galanin message-associated peptide in hypothalamic magnocellular neurons after hypophysectomy. Immunohistochemical and in situ hybridization studies. Brain Res. 650:219-228, 1994.

195. Bedecs, K., Langel, Ü., Xu, X-J., Wiesenfeld-Hallin, Z., Bartfai, T. Biological activities of two endogenously occurring N-terminally extended forms of galanin in the rat spinal cord. Eur. J. Pharmacol. 259:151-156, 1994.

196. Bristulf, J., Gatti, S., Malinowsky, D., Bjork, L., Sundgren, A.K., Bartfai, T. Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA. Eur. Cytokine Netw. 5:319-330, 1994.

197. Gregersen, S., Langel, Ü., Bartfai, T., Ahrén, B. Galanin message-associated polypeptide (GMAP) does not affect insulin secretion from isolated islets. Eur. J. Pharmacol. 259:79-82, 1994.

198. Elfvin, L.-G., Hökfelt, T., Bartfai, T., Bedecs, K. Immunohistochemical demonstration of galanin-, and galanin message-associated peptide-like immunoreactivities in sympathetic ganglia and adrenal gland of the guinea pig. Microscopy Research and Technique 29:131-142, 1994.

199. Consolo, S., Baldi, G., Russi, G., Civenni, G., Bartfai, T., Vezzani, A. Impulse flow dependency of galanin release in vivo in the rat ventral hippocampus. Proc. Natl. Acad. Sci. USA 91:8047-8051, 1994.

200. Gregersen, S., Langel, Ü., Bartfai, T. Ahren, B. N-terminally elongated fragments of galanin (1-16) inhibit insulin secretion from isolated mouse islets. Regul. Pept. 53:31-7, 1994.

201. Rivera Baeza, C., Kask, K., Langel, Ü, Bartfai, T., Undén, A. Analogs of galanin (1-16) modified in positions 1-3 as ligands to rat hypothalamic galanin receptors. Acta Chemica Scandinavica 48:434-438, 1994.

202. Bartfai, T., Langel, Ü. Galanin receptor ligands as potential therapeutic agents in depression and neurodegeneration. Proceedings of XIIIth International Symposium on Medicinal Chemistry, Paris, Sept. 19-23, 1994.

203. Ji, R.-R., Zhang, Q., Bedecs, K., Arvidsson, J., Zhang, X., Xu, X.-J., Wiesenfeld-Hallin, Z., Bartfai, T., Hökfelt, T. Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy. Proc. Natl. Acad. Sci. USA 91:12540-12543, 1994.

204. Wennerberg, A.B.A., Jackson, M., Öhman, A., Gräslund, A., Langel, Ü., Bartfai, T., Rigler, R., Mantsch, H.H. The structure of the rodent and porcine neuropeptide galanin and antagonists as determined by FT-IR spectroscopy and CD spectroscopy. Can. J. Chem. 72:1495-1499, 1994.

205. Bristulf, J., Bartfai, T. Interleukin-1 and tumor necrosis factor- stimulate the mRNA expression of interleukin-1 receptors in mouse anterior pituitary AtT-20 cells. Neuroscience Lett. 187:53-56, 1995.

206. Valkna, A., Juréus, A., Karelson, E., Zilmer, M., Bartfai, T., Langel, Ü. Differential regulation of adenylate cyclase activity in rat ventral and dorsal hippocampus by rat galanin. Neuroscience Lett. 187:75-78, 1995.

207. Bartfai, T. Galanin: A neuropeptide with important CNS actions. In: Psychopharmacology: The Fourth Generation of Progress (F.E. Bloom and D.J. Kupfer, eds.) Raven Press, Ltd., New York 563-571, 1995.

208. Xu, X.-J., Andell, S., Zhang, X., Wiesenfeld-Hallin, Z., Langel, Ü., Bedecs, K., Hökfelt, T., Bartfai, T. Peripheral axotomy increases the expression of galanin message-associated peptide (GMAP) in dorsal root ganglion cells and alters the effects of intrathecal GMAP on the flexor reflex in the rat. Neuropeptides 28:299-307, 1995.

209. Bedecs, K., Berthold, M., Bartfai, T. Galanin - 10 Years with a Neuroendocrine Peptide. Int. J. Biochem. Cell Biol. 27:337-349, 1995.

210. Öhman, A., Lycksell, P.-O., Andell, S., Langel, Ü., Bartfai, T., Gräslund, A. Solvent stabilized solution structures of galanin and galanin analogs, studied by circular dichroism spectroscopy. Biochim. Biophys. Acta 1236:259-265, 1995.

211. Bedecs, K., Langel, Ü., Bartfai, T. Metabolism of galanin and galanin (1-16) in isolated cerebrospinal fluid and spinal cord membranes from rat. Neuropeptides 29:137-143, 1995.

212. Xu, X.-J., Andell, S., Hao, J.-X., Wiesenfeld-Hallin, Z., Bartfai, T. The effects of intrathecal galanin message-associated peptide (GMAP) on the flexor reflex in rats. Regulatory Peptides 58:19-24, 1995.

213. Zetterström, M., Trogen, L., Hammarström, L.-G., Juhlin, L., Nilsson, B., Damberg, C., Bartfai, T., Langel, Ü. Synthesis of an N-methyldehydro-alanine-containing fragment of microcystin by combination of solid phase peptide synthesis and -elimination in solution. Acta Chem. Scand. 49:696-700, 1995.

214. Xu, X.-J., Wiesenfeld-Hallin, Z., Langel, Ü., Bedecs, K., Bartfai, T. New high affinity peptide antagonists to the spinal galanin receptor. Br. J. of Pharm. 116:2076-2080, 1995.

215. Kahl, U., Bartfai, T. Galanin receptors. Drug News & Perspectives 8:404-410, 1995.

216. Undén, A., Bartfai, T. Peptides as active probes. In: Interface between Chemistry and Biochemistry. (P. Jollés and H. Jörnvall, Eds.) Birkhäuser Verlag Basel/Switzerland 229-255, 1995.

217. Kask, K., Berthold, M., Bourne, J., Andell, S., Langel, Ü., Bartfai, T. Binding and agonist/antagaonist actions of M35, galanin 1-13)- bradykinin (2-9) amide chimeric peptide, in Rin m 5F insulinoma cells. Regulatory Peptides 59:341-348, 1995.

218. Kask, K., Langel Ü., Bartfai, T. Galanin - a neuropeptide with inhibitory actions. Cell. Molecul. Neurobiol. 15:653-673, 1995.

219. Lundkvist, J., Land, T., Kahl, U., Bedecs, K., Bartfai, T. cDNA sequence, ligand binding, and regulation of galanin/GMAP in mouse brain. Neuroscience Lett. 200:121-124, 1995.

220. Malinowsky, D., Chai, Z., Bristulf, J., Simoncsits, A., Bartfai, T. The type I interleukin-1 receptor mediates fever in the rat as shown by interleukin-1 receptor subtype selective ligands. Neuroscience Lett. 201:33-36, 1995.

221. Schultzberg, M., Tingsborg, S., Nobel, S., Lundkvist, J., Svensson, S., Simoncsits, A., Bartfai, T. Interleukin-1 receptor antagonist protein and mRNA in the rat adrenal gland. J. Interferon and Cytokine Research 15:721-729, 1995.

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248. Eriksson, G., Zetterström, M., Cortés Toro, V., Bartfai, T., Iverfeldt, K. Hypersensitive cytokine response to -amyloid 25-35 in astroglial cells from IL-1 receptor type I-deficient mice. Intl. J. Mol. Med. 1:201-206, 1998.

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280. Khalil, A., Tullus, K., Bartfai T., Bakhiet, M., Jaremko, G., Brauner, A. Renal cytokine responses in acute Escherichia coli pyelonephritis in IL-6-deficient mice. Clin. Exp. Immunol. 122:200-206, 2000.

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283. Blakeman, K.H., Holmberg, K., Hao, J.X., Xu, X.J., Kahl, U., Lendahl, U., Bartfai, T., Wiesenfeld-Hallin, Z., Hökfelt, T. Mice over-expressing galanin have elevated heat nociceptive threshold. Neuroreport 12:423-425, 2001.

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286. Gomez, M., De Castro, E., Guarin, E., Sasakura, H., Kuhara, A., Mori, I., Bartfai, T., Bargmann, C.I., Nef, P. Ca2+ signaling via the neuronal calcium sensor-1 regulated associative learning and memory in C. elegans. Neuron 30:241-248, 2001.

287. Pooga, M., Kut, C., Kihlmark, M., Hällbrink, M., Fernaeus, S., Raid, R., Land, T., Hallberg, E., Bartfai, T., Langel, U. Cellular translocation of proteins by transportan. FASEB Journal 15:1451-1453, 2001.

288. Kehr, J., Yoshitake, T., Wang, W.H., Wynick, D., Holmberg, K., Lendahl, U., Bartfai, T., Yamaguchi, M., Hokfelt, T., Ogren, S.O. Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice. J Neurosci. Methods 109:71-80, 2001.

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291. Elmquist, A., Lindgren, M., Bartfai, T., Langel, U. VE-cadherin-derived cell-penetrating peptide, pVEC with carrier functions. Exp. Cell Res. 269:237-244, 2001.

292. Grundschober, C., Delaunay, F., Puelhofer, A., Triqueneaux, G., Laudet, V., Bartfai, T., Nef, P. Circadian regulation of diverse gene products revealed by mRNA expression profiling of synchronized fibroblasts. J. Biol. Chem. 276:46751-46758, 2001.

293. Kokaia, M., Holmberg, K., Nanobashvili, A., Xu, Z.Q., Kokaia, Z., Lendahl, U., Hilke, S., Theodorsson, E., Kahl, U., Bartfai, T., Lindvall, O., Hokfelt, T. Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin. Proc. Natl. Acad. Sci, USA 98:14006-14011, 2001.

294. Hallbrink, M., Floren, A., Elmquist, A., Pooga, M., Bartfai, T., Langel, U. Cargo delivery kinetics of cell-penetrating peptides. Biochim Biophys Acta 1515:101-109, 2001.

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296. Counts, S.E., Perez, S.E., Kahl, U., Bartfai, T., Bowser, R.P., Deecher, D.C., Mash, D.C., Crawley, J.N., Mufson, E.J. Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer’s disease. CNS Drug Rev., Review 7:445-470, 2001.

297. Gatti, S., Beck, J., Fantuzzi, G., Bartfai, T., Dinarello, C.A. Effect of interleukin-18 on mouse core body temperature. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282:R702-R709, 2002.

298. Toro, V.C., Tehranian, R., Zetterstrom, M., Eriksson, G., Langel, U., Bartfai, T., Iverfeld, K. Increased gene expression of interleukin-1alpha and interleukin-6 in rat primary glial cells induced by beta-amyloid fragment. J. Mol. Neurosci. 17:341-350, 2001.

299. Locati, M., Deuschle, U., Massardi, M.L., Martinez, F.O., Sironi, M., Sozzani, S., Bartfai, T., Mantovani, A. Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J. Immunol. 168:3557-3562, 2002.

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301. Pepys, M.B., Herbert, J., Hutchinson, W.L., Tennent, G.A., Lachmann, H.J., Gallimore, J.R., Lovat, L.B., Bartfai, T., Alanine, A., Hertel, C., Hoffmann, T., Jakob-Roetne, R., Norcross, R.D., Kemp, J.A., Yamamura, K., Suzuki, M., Taylor, G.W., Murray, S., Thompson, D., Purvis, A., Kolstoe, S., Wood, S.P., Hawkins, P.N. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417:254-259, 2002.

302. Gatti, S., Vezzani, A., Bartfai, T. Mechanisms of fever and febrile seizures : Putative role of IL-1/IL-1ra in febrile seizures. In: Febrile Seizures (ed. Baram, T.Z., Shinnar, S.) Academic Press, San Diego, 169-188, 2002.

303. Koob, G.F., Bartfai, T., Roberts, A.J. Molecular Genetic Approaches to the neuropharmacology of corticotrophin-releasing factor. Int. J. of Comparative Psych. 14:90-110, 2002.

304. Baláspiri, L., Langel, U., Mazarati, A.M., Bártfai, T. Galanin receptor ligand and antisense oligonucleotides in the study of hippocampal galanin receptors. Europeon Peptide Symposium, Sorrento, Italy 2002.

305. Bechmann, I., Diano, S., Warden, C.H., Bartfai, T., Nitsch, R., Horvath, T.L. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem. Pharmacol. 64:363-367, 2002.

306. Tehranian, R., Andell-Jonsson, S., Beni, S.M., Yatsiv, I., Shohami, E., Bartfai, T., Kundkvist, J., Iverfeldt, K. Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J. Neurotrauma 19:939-951, 2002.

307. Pooga, M., Soomets, U., Bartfai, T., Langel, U. Synthesis of cell-penetrating peptide-PNA constructs. Methods Mol. Biol. 208:225-236, 2002.

308. Crawley, J.N., Mufson, E.J., Hohmann, J.G., Teklemichael, D., Steiner, R.A., Holmberg, K., Xu, Z.Q., Blakeman, K.H., Xu, X.J., Wiesenfeld-Hallin, Z., Bartfai, T., Hokfelt, T. Galanin overexpressing transgenic mice. Neuropeptides 36:145-156, 2002.

309. Hertting, O., Khalil, A., Jaremko, G., Chromek, M., Li, Y.H., Bakhiet, M., Bartfai, T., Tullus, K., Brauner, A. Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice. Clin. Exp. Immunol. 131:225-233, 2003.

310. Bartfai, T., Behrens, M.M., Gaidarova, S., Pemberton, J., Shivanyuk, A., Rebek, J., Jr. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc. Natl. Acad. Sci. USA 100:7971-7976, 2003.

311. Zachariou, V., Brunzell, D.H., Hawes, J., Stedman, D.R., Bartfai, T., Steiner, R.A., Wynick, D., Langel, U., Picciotto, M.R. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc. Natl. Acad. Sci. USA 100:9028-9033, 2003.

312. Hökfelt, T., Bartfai, T., Bloom, F. Neuropeptides opportunities for drug discovery. LANCET Neurology 2:463-472, 2003.

313. Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M.M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C.L., Marinovich, M. Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J. Neurosci. 23:8692-8700, 2003.

314. Hua, X.Y., Hayes, C.S., Hofer, A., Fitzsimmons, B., Kilk, K., Langel, U., Bartfai, T., Yaksh, T.L. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J. Pharmacol. Exp. Ther. 308:574-582, 2003.

315. Wu, W.P., Hao, J.X., Lundstrom, L., Wiesenfeld-Hallin, Z., Langel, U., Bartfai, T., Xu, X.J. Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury. Eur. J. Pharmacol. 15:482(1-3);133-137, 2003.

316. Yoshitake, T., Wang, F.H., Kuteeva, E., Holmberg, K., Yamaguchi, M., Crawley, J.N., Steiner, R., Bartfai, T., Ogren, S.O., Hokfelt, T., Kehr, J. Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test. Proc. Natl. Acad. Sci. USA 101:354-359, 2004.

317. Conti, B., Tabarean, I., Andrei, C., Bartfai, T. Cytokines and Fever. Frontiers in Bioscience 1:1433-1449, 2004.

318. Tabarean, I.V., Behrens, M.M., Bartfai, T., Korn, H. Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition. Proc. Natl. Acad. Sci. USA 101:2590-2595, 2004.

319. Abramov, U., Floren, A., Echevarria, D.J., Brewer, A., Manuzon, H., Robinson, J.K., Bartfai, T., Vasar, E., Langel, U. Regulation of feeding by galnon. Neuropeptides 38:55-61, 2004.

320. Bartfai, T. Pharmacogenomics in drug development: societal and technical aspects. Pharmacogenomics Journal 4:226-232, 2004.

321. Oprica, M., Van Dam, A.M., Lundkvist, J., Iverfeldt, K., Winblad, B., Bartfai, T., Schultzberg, M. Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse. Acta Neuropathol (Berl) 108:69-80, 2004.

322. Wirz, S.A., Morale, M.C., Marchetti, B., Barr, A.M., Sotgiu, S., Rosati, G., Pugliatti, M., Sanna, M.V., Giliberto, O., Bartfai, T., Conti, B. High frequency of TNF alleles-238A and -376A in individuals from northern Sardinia. Cytokine 26:149-154, 2004.

323. Mazarati, A., Lu, X., Kilk, K., Langel, U., Wasterlain, C., Bartfai, T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures: and seizure-induced neurogenesis in the dentate gyrus. Eur. J. Neuroscience 19:3235-3244, 2004.

324. Bartfai, T, Lu, X., Badie-Mahdavi, H., Barr, A.M., Mazarati, A, Hua, X.Y., Yaksh, T., Haberhauer, G., Ceide, S.C., Trembleau, L., Somogyi, L., Krock, L., Rebek J., Jr. Galmic, a nonpeptide galanin receptor agonist, affects behaviours in seizure, pain and forced-swim tests. Proc. Natl. Acad. Sci. USA 101:10470-10475, 2004.

325. Bartfai, T, et al. The State of GPCR Research in 2004: Nature Reviews Drug Discovery 3:577-626, 2004.

326. Mazarati, A., Lu, X., Shinmei, S., Badie-Mahdavi, H., Bartfai, T. Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice. Neuroscience 128:431-441, 2004.

327. Sugama, S., Wirz, S.A., Barr, A.M., Conti, B., Bartfai, T., Shibasaki, T. Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine treatment. Neuroscience 128:451-458, 2004.

328. Kilk, K., Elmquist, A., Saar, K., Pooga, M., Land, T., Bartfai, T., Soomets, U., Langel, U. Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA. Neuropeptides 38:316-324, 2004.

329. Brunkhorst, A., Neuman, T., Hall, A., Arenas, E., Bartfai, T., Hermanson, O., Metsis, M. Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity. Biochem. Biophys.Res. Comm., BBRC 325:574-579, 2004.

330. Ceide, S.C., Trembleau, L., Haberhauer, G., Somogyi, L., Lu, X., Bartfai, T., Rebek, J., Jr. Synthesis of galmic: a nonpeptide galanin receptor agonist. Proc. Natl. Acad. Sci. USA 101:16727-16732, 2004.

331. Dube, C., Vezzani, A., Behrens, M.M., Bartfai, T., Baram, T.Z. Interleukin 1beta contributes to the generation of experimental febrile seizures. Ann. Neurol. 57:152-155, 2004.

332. Lu, X., Barr, A.M., Kinney, J.W., Sanna, P., Conti, B., Behrens, M.M., Bartfai, T. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc. Natl. Acad. Sci. USA 102:874-879, 2005.

333. Quynh, N.T., Islam, S.M., Floren, A., Bartfai, T., Langel, U., Ostenson, CG. Effects on galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem. Biophys.Res. Comm., BBRC 328:213-220, 2005.

334. Sergeyev, V., Fetissov, S., Mathe, A.A., Jimenez, P.A., Bartfai, T., Mortas, P., Gaudet, L., Moreau, J-L., Hokfelt, T. Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacology 178:115-124, 2005.

335. Kilk, K., El-Andaloussi, S., Jarver, P., Meikas, A., Valkna, A., Bartfai, T., Kogerman, P., Metsis, M., Langel, U. Evaluation of transportan 10 in PEI mediated plasmid delivery assay. J. Controlled Release 103:511-523, 2005.

336. Oprica, M., Zhu, S., Goiny, M., Pham, T.M., Mohammed, A.H., Winblad, B., Bartfai, T., Schultzberg, M. Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines. Brain Behav. Immun. 19:223-234, 2005.

337. Conti, B., Sugama, S., Lucero, J., Winsky-Sommerer, R., Wirz, S.A., Maher, P., Andrews, Z., Barr, A.M., Morale, M.C., Paneda, C., Pemberton, J., Gaidarova, S., Behrens, M.M., Beal, F., Sanna, P.P., Horvath, T., Bartfai, T. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. J. Neurochem. 93:493-501, 2005.

338. Badie-Mahdavi, H., Lu, X., Behrens, M.M., Bartfai, T. Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3',5'-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: Studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice. Neuroscience 133:591-604, 2005.

339. Holmberg, K., Kuteeva, E., Brumovsky, P., Kahl, U., Karlstrom, H., Lucas, G.A., Rodriguez, J., Westerblad, H., Hilke, S., Theodorsson, E., Berge, O.G., Lendahl, U., Bartfai, T., Hokfelt, T. Generation and phenotypic characterization of a galanin overexpressing mouse. Neuroscience 133:59-77, 2005.

340. Lu, X., Lundstrom, L., Langel, U., Bartfai, T. Galanin receptor ligands. Neuropeptides 39:143-146, 2005.

341. Lu, X., Mazarati, A., Sanna, P., Shimmei, S., Bartfai, T. Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity. Neuropeptides 39:147-152, 2005.

342. Sollenberg, U., Bartfai, T., Langel, U. Galnon - a low-molecular weight ligand of the galanin receptors. Neuropeptides 39:161-163, 2005.

343. Lu, X., Lundstrom, L., Bartfai, T. Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 39:165-167, 2005.

344. Lundstrom, L., Lu, X., Langel, U., Bartfai, T. Important pharmacophores for binding to galanin receptor 2. Neuropeptides 39:169-171, 2005.

345. Hua, X.Y., Salgado, K.F., Gu, G., Fitzsimmons, B., Kondo, I., Bartfai, T., Yaksh, T.L. Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization? Neuropeptides 39:211-216, 2005.

346. Malkmus, S., Lu., X. Bartfai, T., Yaksh, T.L., Hua, X.Y. Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice. Neuropeptides 39:217-221, 2005.

347. Badie-Mahdavi, H., Behrens, M.M., Rebek, J. Jr., Bartfai, T. Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides 39:247-249, 2005.

348. Zheng, K., Kuteeva, E., Xia, S., Bartfai, T., Hokfelt, T., Xu, Z.Q. Age-related impairments of synaptic plasticity in the lateral perforant path input to the dentate gyrus of galanin overexpressing mice. Neuropeptides 39:257-265, 2005.

349. Pirondi, S., Kuteeva, E., Giardino, L., Ferraro, L., Antonelli, T., Bartfai, T., Ogren, S.O., Hokfelt, T., Calza, L. Behavioral and neurochemical studies on brain aging in galanin overexpressing mice. Neuropeptides 39:303-310, 2005.

350. Lundstrom, L., Elmquist A., Bartfai, T., Langel, U. Galanin and its receptors in neurological disorders. Neuromolecular Med. 7:157-180, 2005.

351. Tabarean, I.V., Conti, B., Behrens, M.M., Korn, H., Bartfai, T. Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture. Neuroscience 135:433-449, 2005.

352. Wirz, S.A., Davis, C.N., Lu, X, Zal, T., Bartfai, T. Homodimerization and internalization of galanin type 1 receptor in living CHO cells. Neuropeptides 39:535-546, 2005.

353. Floren, A., Sollenberg, U., Lundstrom, L., Zorko, M., Stojan, J., Budihna, M., Wheatley, M., Martin, N-P., Kilk, K., Mazarati, A., Bartfai, T., Lindgren, M. Langel, U. Multiple interaction sites of galnon trigger its biological effects. Neuropeptides 39:547-558, 2005.

354. Lu, X., Barr, A.M., Bartfai, T. Galanin receptors as novel drug targets for the treatment of depression and anxiety. Drug Development Research 65:227-236, 2005.

355. Ostenson, C.G., Gaisano, H., Sheu, L., Tibell, A., Bartfai, T. Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of Type 2 diabetic patients. Diabetes 55:435-440, 2006.

356. Kinney, J.W., Davis, C.N., Tabarean, I., Conti, B., Bartfai, T., Behrens, M.M. A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. J. Neuroscience 26:1604-1615, 2006.

357. Bartfai, T., Lees, G.V. Drug Discovery from beside to wall street: Legal drugs: Big business, your business. Drug Discovery Today, Elsevier, Book 2006.

358. Wirz, S.A., Tobias, P.S., Ulevitch, R.J., Aribibe, L., Bartfai, T. TLR2 is required for the altered transcription of p75NGF receptors in Gram positive infection. Neurochem. Res. 31:297-301, 2006.

359. Sten-Shi, T-J., Hua, X-Y., Lu, X., Malkmus, S., Kinney, J., Holmberg, K., Wirz, S., Ceccatelli, S., Yaksh, T., Bartfai, T., Hokfelt, T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur. J. Neurosci 23:627-636, 2006.

360. Sanchez-Alavez, M., Tabarean, I.V., Behrens, M.M., Bartfai, T. Ceramide mediates the rapid phase of febrile response to Interleukin-1. Proc. Natl. Acad. Sci. USA 1032904-2908, 2006.

361. Davis, C.N., Mann, E., Behrens, M.M., Gaidarova, S., Rebek, M., Rebek, J., Jr., Bartfai, T. MyD88 dependent and independent signaling by IL-1 in neurons probed by bifunctional TIR domain/BB loop mimimetics. Proc. Natl. Acad. Sci. USA 103:2953-2958, 2006.

362. Sollenberg, U.E., Lundstrom, L., Bartfai, T., Langel, U. M871-A novel peptide antagonist selectively recognizing the galanin receptor type 2. Int. J. Pep. Res. Ther. 12:115-119, 2006.

363. Davis, C.N., Tabarean, I.V., Gaidarova, S., Behrens, M.M., Bartfai, T. IL-1 induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. J. Neurochem. 98. 1379-1389. 2006.

364. Barr, A.M., Kinney, J.W., Hill, M.N., Lu, X., Biros, S., Rebek, J. Jr., Bartfai, T.A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neurosci. Lett. 405:111-115, 2006.

365. Robinson, J.K., Bartfai, T., Langel, U. Galanin/GALP receptors and CNS homeostatic processes. CNS Neurol. Disord. Drug Targets 5:327-334, 2006.

366. Bartfai, T. From lab bench to Wall Street. FASEB J. 10:1578-80, 2006

367. Tabarean, I.V., Korn, H., Bartfai, T. Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. Neuroscience 141:1685-1695, 2006.

368. Kovacs, Z., Kekesi, K.A., Szilagyi, N., Abraham, I., Szekacs, D., Kiraly, N., Papp, E., Csaszar, I., Szego, E., Barabas, K., Peterfy, H., Erdei, A., Bartfai, T., Juhasz, G. Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats. Neuroscience 140:731-742, 2006.

369. Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M.C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E.P., de Lecea, L., Bartfai, T. Transgenic mice with a reduced core body temperature have an increased lifespan. Science 314:825-828, 2006.

370. Conti, B., Maier, R., Barr, A. M., Morale, M. C., Lu, X., Sanna, P. P., Bilbe, G., Hoyer, D., and Bartfai, T. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine, Mol. Psychiatry 12:167-189, 2007.

371. Sanchez-Alavez, M., Klein, I., Brownell, S. E., Tabarean, I. V., Davis, C. N., Conti, B., and Bartfai, T. Night eating and obesity in the EP3R-deficient mouse, Proc. Natl. Acad. Sci. USA 104:3009-3014, 2007.

372. Zorrilla, E. P., Brennan, M., Sabino, V., Lu, X., and Bartfai, T. Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge, Physiol. Behav. 91:479-485, 2007.

373. Bartfai, T., Sanchez-Alavez, M., Andell-Jonsson, S., Schultzberg, M., Vezzani, A., Danielsson, E., and Conti, B. Interleukin-1 system in CNS stress: seizures, fever and neurotrauma, Ann. N Y Acad. Sci. 1113:173-177, 2007.

374. Lu, X., Sharkey, L., and Bartfai, T. The brain galanin receptors: targets for novel antidepressant drugs. CNS Neurol. Disord. Drug Targets 6:183-192, 2007.

375. Zorrilla, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., and Conti, B. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency, Proc. Natl. Acad. Sci. USA 104: 11097-11102, 2007.

376. Bartfai, T., Waalen, J., and Buxbaum, J. N. Adipose tissue as a modulator of clinical inflammation: does obesity reduce the prevalence of rheumatoid arthritis? J. Rheumatology 34:488-492, 2007.

377. Sanchez-Alavez, M., and Bartfai, T. It all happens between Toll receptors and caspase 1, Proc. Natl. Acad. Sci. USA 104:7733-7734, 2007.

378. Lundström L, Sollenberg UE, Bartfai T, Langel U. Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions. J. Neurochem. 103:1774-1784, 2007.

379. Bartfai, T., Lees, G. Drug Discovery, text book, Japanese edition, 2008.

380. Bartfai, T., Insel, T., Fishell, G., Rothwell, N. Choices in neuroscience careers. Nat. Rev. Neurosci. 9:401-405, 2008.

381. Spulber, S., Oprica, M., Bartfai, T., Winblad, B., Schultzberg, M. Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse. Eur. J. Neurosci. 27:549-558, 2008.

382. Buxbaum, J.N., Ye, Z., Reixach, N., Friske, L., Levy, C., Das, P., Golde, T., Masliah, E., Roberts, A.R., Bartfai, T. Transthyretin protects Alzheimer's mice from the behavioral and biochemical Effects of Abeta toxicity. Proc. Natl. Acad. Sci. USA 105:2681-2686, 2008.

383. Sharkey, L.M., Madamba, S.G., Siggins, G.R., Bartfai, T. Galanin alters GABAergic neurotransmission in the dorsal raphe nucleus. Neurochem. Res. 33:285-291, 2008.

384. Mitsukawa, K., Lu, X., Bartfai, T. Galanin, galanin receptors and drug targets. Cell. Mol. Life Sci. 65:1796-1805, 2008.

385. Conti, B., Tabarean, I., Sanchez-Alavez, M., Davis, C., Brownell, S., Behrens, M., Bartfai, T. Cytokine receptors in the brain. In: NeuroImmune Biology. Vol. 6: Cytokines and the Brain (C. Phelps and E. Korneva eds.) Amsterdam, The Netherlands 21-38, 2008.

386. Osborn, O., Brownell, S.E., Sanchez-Alavez, M., Salomon, D., Gram, H., Bartfai, T. Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine 44:141-148, 2008.

387. Balosso, S., Maroso, M., Sanchez-Alavez, M., Ravizza, T., Frasca, A., Bartfai, T., Vezzani, A. A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin- 1. Brain 131:3256-3265, 2008.

388. Lu, X., Ross, B., Sanchez-Alavez, M., Zorrilla, E.P., Bartfai, T. Phenotypic analysis of GalR2 knockout mice in anxiety and depression-related behavioral tests. Neuropeptides 42:387–397, 2008.

389. Balosso, S., Maroso, M., Sanchez-Alavez, M., Ravizza, T., Frasca, A., Bartfai, T., Vezzani A. A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. Brain. 2008 Dec;131(Pt 12):3256-65. Epub 2008 Oct 24. PubMed PMID: 18952671; PubMed Central PMCID: PMC2724908.

390. Osborn, O., Gram, H., Zorrilla, E.P., Conti, B., and Bartfai, T. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly. 138:665-73, 2008.

391. Spulber, S., Mateos, L., Oprica, M., Cedazo-Minguez, A., Bartfai, T., Winblad, B., and Schultzberg, M. Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain. J. Neuroimmunol. 2009, 10.1016/j.jneurim.2009.01.010.

392. Lu, X., Bartfai, T. Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice. Arch Pharmacol. 379:417-420, 2009.

393. Mitsukawa, K., Lu, X., Bartfai, T. Bidirectional regulation of stress responses by galanin in mice: involvement of galanin receptor subtype 1. Neuroscience 160:837-846, 2009

394. Spulber, S., Bartfai, T., Schultzberg, M. IL-1/IL-1ra balance in the brain revisited - evidence from transgenic mouse models. Brain Behav. Immun. 23:573-589, 2009.

395. Osborn, O., Sanchez-Alavez, M., Brownell, S.E., Ross, B., Klaus, J., Dubins, J., Beutler, B., Conti, B., Bartfai, T. Metabolic Characterization of a Mouse Deficient in All Known Leptin Receptor Isoforms. Cell. Mol. Neurobiol. 2009 Jul 7. (Epub ahead of print) PubMed PMID: 19582570.

396. Tabarean, I., Morrison, B., Marcondes, M.C., Bartfai, T., Conti, B.. Hypothalamic and dietary control of temperature-mediated longevity. Ageing Res. Rev. 2009 Jul 23. (Epub ahead of print) PubMed PMID: 19631766.

397. Kinney, J.W., Sanchez-Alavez, M., Barr, A.M., Criado, J.R., Crawley, J.N., Behrens, M.M., Henriksen, S.J., Bartfai, T. Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation. Neurobiol. Learn. Mem. 92:429-438, 2009.

398. Sanchez-Alavez, M., Tabarean, I.V., Osborn, O., Mitsukawa, K., Schaefer, J., Dubins, J., Holmberg, K.H., Klein, I., Klaus, J., Gomez, L.F, Kolb, H., Secrest, J., Jochems, J., Myashiro, K., Buckley, P., Hadcock, J.R., Eberwine, J., Conti, B., Bartfai, T. Insulin causes hyperthermia by direct inhibition of warm sensitive neurons. Diabetes. 2009 Oct 21. (Epub ahead of print) PubMed PMID: 19846801.

My department at Hoffman La Roche published over 200 patents, and 198 publications in the area of Psychopharmacology and Neuropharmacology - while I have corrected all these papers / directed all of these activities, I have never put my name as coauthor on any paper as I did not have my own laboratory, at Roche.

The works published 1996-2000 and listed above are from my Stockholm laboratory.

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