!!Andrew Loudon - Curriculum vitae

__Education:__ 
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Educated at Abingdon School, England, and then worked as a field
assistant to Dr Louis Leakey, Anthropologist, Nairobi, Kenya (1968-69),
prior to University (Pembroke College, Oxford) where I read zoology (graduated
1972). Following a further year in Africa (Ethiopia), returned to the UK
to study for a PhD at the University of Edinburgh (Territorial and reproductive
behaviour of deer).
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__Early career: __
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This focussed on studies of the neuroendocrine mechanisms
of seasonal timing in mammals. While at the University of Edinburgh, A.
Loudon initiated studies on seasonal timing and neuroendocrine function
(prolactin and gonadotophin secretion). Much of this early work used domesticated
red deer as model organisms and fostered a life-long interest in comparative
physiology. Studies in this period (23 publications from 1983-94) defined
how offspring behaviour and internal timing circuits sculpted neuroendocrine
function, and defined the role of pineal melatonin signalling on gonadotrophin
secretion and growth/metabolic processes. Following a move to the Institute
of Zoology, University College London, A. Loudon was appointed to head
a research unit in Comparative Physiology. During this time, Prof. Loudon
pioneered investigations of seasonal timing in marsupials (neuroendocrine
control of embryonic diapause), and research highlights included discovery
of the mechanisms of prolactin action on ovarian steroid synthesis, and
it s control by melatonin. Prof. Loudon was appointed Head of the MRC/AFRC
joint research council Programme in Reproductive Biology at the Institute
of Zoology (1992-95), and to a visiting Chair, University College, London
(1993-95). During this period, A. Loudon also spent a year working at the
NSF Center for Biological Timing, University of Virginia, USA (1991), (with
Professor Michael Menaker).
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__Subsequent career: __
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Prof. Loudon moved to the Chair in Animal Biology,
University of Manchester in 1995, and for the past 16 years, he has focused
on development and use of novel transgenic mouse models to study circadian
clock function, and on mechanisms of action of melatonin in relation to
neuroendocrine regulation of seasonal physiology. Studies on seasonal timing
mechanisms currently focus on melatonin targets within the pituitary gland
and has recently lead to the elucidation of genomic action of melatonin
in control of hormone release and intra-pituitary signalling pathways (Ivanova
et al 2008, Am J. Physiol; Dupre et al 2008, Endocrinology; Dupre et al
2010 and Dardente et al 2010,Current Biology; Dupre et al Current Biology
2010, 2010; Lu et al Current Biology 2010; Hazlerigg and Loudon, 2008,
Current Biology).
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__Current Collaborative studies with the pharmaceutical industry:__
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Much of the research in the laboratory on circadian timing has developed
as a result of partnerships with UK research funding agencies and major
pharmaceutical companies. This has lead to a joint initiative with GSK
and the formation of a Centre for Nuclear Hormone Receptor Research at
the University of Manchester, which I head jointly with Professor David
Ray. A major current focus of the laboratory now relates to pursuing mechanisms
whereby the core clockwork of the cell drives physiology, much of this
in collaboration with colleagues at Pfizer and GSK. The former link has
involved the laboratory in the use of novel CK1 inhibitors to regulate
cellular timing mechanisms and behaviour (see Meng et al, 2010, PNAS; Meng
et al, 2008, Neuron, Loudon et al 2008, Cold Spring Harbour Symposium;
Walton et al 2009, J Pharmacol Exp Ther; Maywood et al, J.Neuroscience,
2012). These studies continue as we seek to define mechanisms of kinase
regulation of PERIOD protein turnover in the cell, and develop from our
earlier collaborative studies with US colleagues which defined for the
first time post-translational mechanisms underpinning circadian timing
(Lee et al 2002, Cell). Use of CK1 inhibitors have the potential to re-set
aberrant circadian clock and sleep function in man (Meng et al 2010; PNAS).
Collaborations with GSK focus on the orphan nuclear receptor REV-ERBa on
inflammatory pathways in macrophages, and circadian gating control of cytokine
release, initiating from our discovery that a novel ligand of REV-ERB re-sets
the core clockwork mechanism (Meng et al, 2008, J. Cell Sci.).
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__Other services:__ 
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Prof. Loudon has served on many national and international
funding agencies as a panel member and reviewer, on international journal
editorial boards, and has delivered a large number of invited plenary talks
at International meeting, including named lectures. Prof. Loudon has trained
18 PhD students, and supervised 16 post-doctoral research scientists to date.
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__Membership of professional bodies and external responsibilities__
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i) Society for Research on Biological Rhythms, Executive Board member\\
ii)
Endocrine Society (UK)\\
iii) Society for the Study of Fertility\\ 
iv) Endocrine Society (USA) v) British Neuroendocrine Society vi) British Neuroscience
Association.
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''Editorial Board Membership''
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i) Editorial Board, Journal of Endocrinology 1990-1998 ii) Editorial Board,
Neuroendocrinology 2006-present.
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''Membership of non-governmental panels''
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i) Expert Member of the IUCN Species Survival Commission, Deer Specialist
Group\\
ii) Captive Breeding Specialist Group of IUCN/WWF, 1995-present\\
iii) IUCN advisory panel on re-introduction programmes (1990-94)
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''EU panel membership''
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i) 2005: Expert reviewer for Framework 7 Programme in Fundamental Genomic
(Brussels, 1st-4th February)\\
ii) 2004: Expert Reviewer for EU programme
(Mid-Term review of Brain Time, Munich)\\
iii) 2009: Expert reviewer for EU programmes
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''Membership of Research Funding councils and related committee''
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i) 2005-2009 Panel Member Animal Sciences Committee, Biotechnology and
Biological Sciences Research Council (BBSRC), UK\\
ii) Panel Member, Leverhulme Trust Research Board 2005-2009.\\
iii) 2004-2006 Panel Member for MRC Cardiovascular and Reproductive Biology,
Endocrinology and Metabolism Clinical Research Training and Career Development
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''Panel''
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iv) Panel member of BBSRC UK. Animal Welfare Committee (2007-2010)\\
v) Member of BBSRC Veterinary Science and Welfare Panel (2004-6)\\
vi)1997 Member of BBSRC Visiting Group: Babraham Institute, Cambridge\\
vii) 1998 Member of BBSRC Visiting Group, Rosl