Thomas Jenuwein - Selected Publications#

Bulut-Karslioglu, A., Perrera, V., Scaranaro, M., de la Rosa-Velazquez, I.A., van de Nobelen, S., Shukeir, N., Popow, J., Gerle, B., Opravil, S., Pagani, M., Meidhof, S., Brabletz, T., Manke, T., Lachner, M. and Jenuwein, T. (2012) A transcription factor-based mechanism for mouse heterochromatin formation. Nat Struct Mol Biol 19, 1023-1030

Pinheiro, I., Margueron, R., Shukeir, N., Eisold, M., Fritzsch, C., Richter, F.M., Mittler, G., Genoud, C., Goyama, S., Kurokawa, M., Son, J., Reinberg, D., Lachner, M. and Jenuwein, T. (2012) Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell 150, 948-960

Fodor, B.D., Shukeir, N., Reuter, G. and Jenuwein T. (2010). Mammalian Su(var) genes in chromatin control. Annu Rev Cell Dev Biol 26, 471-501

Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Celeste, A., Pagani, M., Kauer, M., Opravil, S., Espejo, A., Bedford, M.A., Nussenzweig, A., Busslinger, M. and Jenuwein, T. (2008) A chromatin-wide transition to H4K20 mono-methylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev 22, 2048-2061

Kubicek, S., O'Sullivan, R.J., August, E.M., Hickey, E.R., Zhang, Q., Teodoro, M.L., Rea, S., Mechtler, K., Kowalski, J. R., Hamon, C.A., Kelly, T.A. and Jenuwein, T. (2007) Reversal of H3K9me2 by a small molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25, 473-481

Allis, D., Jenuwein, T. and Reinberg, D., eds., assisted by Caparros, M.L. (2007) Epigenetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York

Fodor B, Kubicek S., Yonezawa M., J. O’Sullivan R., Sengupta R., Perez-Burgos L., Opravil S., Mechtler K., Schotta G. and Jenuwein T. (2006) Jmjd2b antagonizes H3K9 tri-methylation at pericentric heterochromatin in mammalian cells. Genes Dev 20, 1557-1562

Martens, J.H., O'Sullivan, R.J., Braunschweig, U., Opravil, S., Radolf, M., Steinlein, P. and Jenuwein, T. (2005) The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J 24, 800-812

Schotta G., Lachner M., Sarma K., Ebert A., Sengupta R., Reuter G., Reinberg D. and Jenuwein T. (2004) A silencing pathway to induce H3-K9 and H4-K20 tri-methylation at constitutive heterochromatin. Genes & Dev. 18, 1251-1261

Peters A.H., Kubicek S., Mechtler K., O'Sullivan R., Derijck A.A., Perez-Burgos L., Kohlmaier A., Opravil S., Tachibana M., Shinkai Y., Martens J.H. and Jenuwein T. (2003) Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12, 1577-1589

Peters, A.H., Mermoud, J.E., O'Carroll, D., Pagani, M., Schweizer, D., Brockdorff, N. and Jenuwein, T. (2002) Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet 30, 77-80

Peters A.H., O'Caroll D., Scherthan H., Mechtler K., Sauer S., Schöfer C., Weipoltshammer C., Pagani M., Lachner M., Kohlmaier A., Opravil S., Doyle M., Sibilia M. and Jenuwein T. (2001) Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107, 323-337

Lachner M., O'Carroll D., Rea S., Mechtler K. and Jenuwein T. (2001). Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120

Jenuwein T. and Allis C.D. (2001) Translating the histone code. Science 293, 1074-1080

Rea S., Eisenhaber F., O'Carroll D., Strahl B., Sun Z.-W., Schmid M., Opravil S., Mechtler M., Ponting C.P., Allis C.D. and Jenuwein T. (2000) Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-599