Eugene Vasilevich Grishin - Curriculum Vitae#

Education and employment:

• Deputy Director of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
• Professor of Department Bioorganic Chemistry, M.V.Lomonosov Moscow State University, Biological Faculty

Education:

• M.Sc. in Chemistry, 1969, Moscow State University Chemical Department
• Ph.D. in Chemistry, 1973, Shemyakin Institute of Bioorganic Chemistry
• D.Sc. in Chemistry, 1985, Shemyakin Institute of Bioorganic Chemistry

Professional Experience:

• 1967-1969 M.Sc. thesis, Moscow State University.
• 1969-1976 Junior Scientist, Shemyakin Institute of Bioorganic Chemistry.
• 1976-1987 Senior Scientist, Shemyakin Institute of Bioorganic Chemistry.
• 1987-present Head of the Laboratory for Neuroreceptors and Neuroregulators, Shemyakin Institute of Bioorganic Chemistry
• 1988-present Deputy Director of Shemyakin Institute of Bioorganic Chemistry.
• 1988-present Professor of Biological Department of Moscow State University.
• 1990-present Professor of Shemyakin Institute of Bioorganic Chemistry.
• 1997-present Corresponding Member of Russian Academy of Sciences

Research Activities:

• Protein Chemistry: primary structure of cytoplasmic aspartate aminotransferase from pig heart muscle, structure of latrotoxins, protein modification and crystallization.
• Toxinology: isolation of polypeptide toxins from snake, scorpion , spider and ant venoms; structure of polypeptide toxins; tetrodotoxin modification; structure-function relationships of natural toxins; spatial structure of polypeptide toxins; cloning of cDNA encoding protein toxins; analysis of spider venom EST databases, functional expression and mutagenesis of polypeptide toxins; polyamine spider toxins; neurotoxins as tools for study of receptor components.
• Neuroreceptors: interaction of natural neurotoxins with sodium and potassium channels; isolation of sodium channel components from rat brain; α-latrotoxin receptor from bovine brain; latrophilin; glutamate receptor, hERG channel, TRPV1 and P2X receptors. Electrophysiology of ionic channels, receptor expression in Xenopus oocytes, recombinant DNA technique: site-directed mutagenesis, PCR techniques.

Other Skills and Experience:
Electrophysiology of ionic channels, receptor expression in Xenopus oocytes. Recombinant DNA technique: site-directed mutagenesis, PCR techniques, hybridization and immunological screening of recombinant products; expression systems for genetically engineered proteins.

Current interests:
Toxinology and Molecular Neurobiology in general

Teaching Experience:

• Protein chemistry
• Biochemistry
• Natural toxins
• Membrane transport systems

Affiliations:

• Russian Biochemistry Society
• Russian Society for Neurochemistry
• European Society for Neurochemistry
• International Society for Neurochemistry
• International Society of Toxinology

Honours:

• 1975 State Jr. Scientist Prize
• 1981 State Citizenship Award
• 1985 State Research Prize
• 1994 Ovchinnikov Prize Russian Acad. Sci.
• 2003-present President of Russian Society for Neurochemistry
• 2004 Member of Academia Europaea
• 2004 Doctor Honoris Causa of Universidad Nacional Mayor de San Marcos (Lima, Peru)
• 2004 Doctor Honoris Causa of Universidad Ricardo Palma (Lima, Peru)

Publications:
~320 Papers and Abstracts