Giovanni Gaviraghi - Major publications#

F.Crespi, M,Corsi, A.Reggiani, E.Ratti, G.Gaviraghi
Involvement of cholecystokinin within craving for cocaine: role of cholecystokinin receptor ligands
Expert Opinion & Investigational Drugs, 9, 10, 2249-2258 (2000).

A.Ursini, A.M.Capelli, R.A.E.Carr, P.Cassarà, M.Corsi, O.Curcuroto, G.Curotto, M.Dal Cin, S.Davalli, D.Donati, A.Feriani, H.Finch, G.Finizia, G.Gaviraghi, M.Marien, G.Pentassuglia, S.Polinelli, E.Ratti, A.Reggiani, G.Tarzia, G.Tedesco, M.E. Tranquillini, D.G.Trist, F.T,M. van Amsterdam
Synthesis and SAR of new 5-Phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists
J.Med.Chem., 43, 3596-3613 (2000).

P.Cristofori, A. Lanzoni, M.Quartaroli, A.M.Pastorino, C.Zancanaro, L.Cominacini, G.Gaviraghi, J.Turton
The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse
Journal of Hypertension, 18, 10, 1429-1436 (2000).

S.Bellosta, M.Canavesi, E.Favari, L.Cominacini, G. Gaviraghi, R.Fumagalli, R.Paoletti, F. Benini
Lacidipine modulates the secretion of matrix metalloproteinase-9 by human macrophages
Journal of Pharmacology and Experimental Therapeutics, 296, 3, 736-743 (2001)

Crespi F, Vecchiato E, Lazzarini C, Gaviraghi G.
Electrochemical evidence that lacidipine stimulates release of nitrogen monoxide in rat aorta.
Neuroscience Letters 9, 298, 171-174 (2001)

Sorio C, Bonora A, Orlandini S, Moore PS, Capelii P, Cristofori P, Dal Negro G, Marchiori P, Gaviraghi G, Falconi M, Pederzoli P, Zamboni G, Scarpa A.
Successful xenografting of cryopreserved primaly pancreatic cancers.
Virchows Arch., 438,2,154-158 (2001)

Crespi F, Campagnola M, Neudeck A, McMillan K, Rossetti Z, Pastorino A, Garbin U, Fratta-Pasini A, Reggiani A, Gaviraghi G, Cominacini L.
Can voltammetry measure nitrogen monoxide (NO) and/or nitrites?
J Neurosci Methods, 109,1, 59-70 (2001)

Sorio, Claudio; Bonora, Antonio; Orlandini, Simonetta; Moore, Patrick S.; Capelli, Paola; Cristofori, Patrizia; Dal Negro, Gianni; Marchiori, Piernicola; Gaviraghi,Giovanni; Falconi, Massimo; Pederzoli, Paolo; Zamboni, Giuseppe; Scarpa, Aldo
Successful xenografting of cryopreserved primary pancreatic cancers.
Virchows Archiv, 438, 2,154-158.(2001)

Crespi F, Vecchiato E, Lazzarini C, Andreoli M, Gaviraghi G.
Evidence that lacidipine at nonsustained antihypertensive doses activates nitrogen monoxide system in the endothelium of salt-loaded Dahl-S rats.
J Cardiovasc Pharmacol. 39,4, 471-477.(2002)

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimers brain.
J Neurosci., 24, 26, 6021-7. (2004)

Gaviraghi, G.; Pellicciari, R.
Drug Discovery: Back and forward.
Medicinal Chemistry Research,13,3-4, 216-217 (2004)

Cappuccio I, Calderone A, Busceti CL, Biagioni F, Pontarelli F, Bruno V, Storto M, Terstappen GT, Gaviraghi G, Fornai F, Battaglia G, Melchiorn D, Zukin RS, Nicoletti F, Caricasole A.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.
J Neurosci. , 25, 10, 2647-2657 (2005)

Caricasole A, Bakker A, Copani A, Nicoletti F, Gaviraghi G, Terstappen GC.
Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.
Biosci Rep., 25, 5-6, 309-327 (2005)

Chiamulera, C. Gaviraghi, M.; Fumagalli, G.
Context-dependent action of nicotine on learning: Opposite effecis in the object recognition task in mice.
Behavioural Pharmacology, 16, Supp 1,525-526 (2005)

Terstappen GC, Gaviraghi G, Caricasole A.
The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.
Idrugs, 9, 1, 35-38 (2006)

Caruso A, Motoiese M, Iacovelli L, Caraci F, Copani A, Nicoletti F, Terstappen GC, Gaviraghi G, Caricasole A.
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.
J Neurochem., 98, 2, 364-371 (2006)

Scali C, Caraci F, Gianfricido M, Diodato E, Roncarati R, Pollio G, Gaviraghi G, Copani A, Nicoletti F, Terstappen GC, Caricasole A.
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.
Neurobiol Dis., 24, 2, 254-265 (2006)

Magrini R, Bakker A, G Gaviraghi and G Terstappen
Targeting the P53 tumor suppressor gene function in glioblastomas using small chemical molecules.
Drug Development Research 2006, 67, 790-800

Terstappen GC, Schlupen C, Raggiaschi R, Gaviraghi G
Target deconvolution strategy in drug discovery
Nat Rev Drug Discov,2007, 6, 891-903

Cocconcelli G, Diodato E, Caricasole A, Gaviraghi G, Genesio E, Ghiron C, Magnoni L et al.
Anyl azoles with neuroprotective activity- Parallel synthesis and target identification
Biorganic Med Chem 2008, 16, 2043-52

Heilz, Gaviraghi G et al.
Drug discovery and development for Huntington disease - an orphan indication with high medical need
IDrugs, 2008, 11, 653-660