René J. M. Bindels#

René J. M. Bindels
Email:r.bindels 'at' fysiol.umcn.nl
Membership Number:2322
Membership type:ORDINARY
Main Country of Residence:THE NETHERLANDS
Section:PHYSIOLOGY & NEUROSCIENCE
Username:rbindels
Elected:2005
Homepage: http://www.physiology-nijmegen.nl





Present and Previous Positions
  • 1982-1986 Ph.D. Student, department of Physiology, University of Nijmegen, Prof.Dr. J. Slegers and Dr. C.H. van Os. Subject: “Characterisation of calcium, magnesium and phosphate homeostasis in the spontaneous hypertensive rat”
  • 1986-1987 Post-Doc, Nephrology Research & Training Center, University of Alabama, Birmingham, AL, USA, Prof.Dr. J. Schafer. Subject: “Regulation of sodium transport by aldosterone and vasopressine in A6 cells and primary cultures of rat collecting ducts”
  • 1988-1998 Assistant Professor, department of Cell Physiology, UMC Nijmegen, Subject “Regulation of salt reabsoprtion in the collecting duct of the kidney”
  • 1999-2002 Associate Professor, department of Cell Physiology, UMC Nijmegen, Subject “Regulation of salt reabsorption in the collecting duct of the kidney”
  • 2003-present Full Professor and head of the newly established department of Physiology, Radboud University Nijmegen Medical Centre
  • 2008-present (Elected) Chairmen of the University Council of the Radboud University Nijmegen Medical Centre


Fields of Scholarship
  • regulation of ion transport processes in kidney and small intestine in health and disease
  • molecular mechanisms controlling the calcium and magnesium balance in general and the regulation of the new family of epithelial calcium and magnesium channels (TRPV5, TRPV6, TRPM6 and TRPM7) in particular
  • functional consequences of mutations in the human ROMK2, NKCC2, NCC and TRPM6 transporters identified in Bartter and Gitelman syndrome and inherited hypomagnesemia
  • use of established epithelial cell lines, tissue-specific knockout mice models, and electrophysiological and biochemical analysis of channel activity


Honours and Awards
  • 1986 Fellowship for a post.doc at the Nephrology & Training Center, University of Alabama, Birmingham, AL, USA
  • 1987 “Jacob Hamburger” award, of the Dutch Society of Physiology for the best physiological thesis of 1986
  • 1992 Award for the best oral presentation 1991 of the Dutch Nephrology Society and Dutch Kidney Foundation
  • 1998 2e lustrum award of the Dutch Kidney Foundation for the successful collaboration between the departments of Cell Physiology, Human Genetics and Pediatrics of UMC St Radboud.
  • 2001 Visiting Professor, Departments of Nephrology and Physiology, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, U.S.A.
  • 2002 Visiting Professor (Robert Berliner Professor at Yale), Departments of Physiology and Nephrology, School of Medicine, University of Yale, U.S.A.
  • 2004 Visiting Professor, Division of Nephrology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan
  • 2005 Best teaching course 2004-2005 "Circulation & Respiration I"
  • 2005 Elected as member of the Academia Europaea
  • 2006 Elected as most internationally operating department of the Radboud University Nijmegen Medical Centre
  • 2008 Appointed as ‘Principal Investigator Plus’ by the board of directors of the Radboud University Nijmegen Medical Centre
  • 2009 Quest editor of special issue of Pflügers Archiv – European Journal of Physiology entitled “A molecularly guided tour along the nephron, vol 458, 2009
  • 2009 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section, Experimental Biology 2009 Meeting, New Orleans, U.S.A.
  • 2009 Robert Pitts Lectureship at the XXXVI International Congress of Physiological Sciences, Kyoto, Japan.
  • 2009 Homer Smith Award of the American Society of Nephrology, San Diego, U.S.A.
  • 2010 Radboud Medal of the Radboud University Nijmegen Medical Centre, The Netherlands


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