[{Image src='Doka_Eva.jpg' caption='' height='300' class='image_left' alt='Eva Doka'}]
!!Dr. Eva Doka

AFFILIATION: National Institute of Oncology, Budapest, Hungary\\
LINK TO WEBPAGE: [http://www.onkol.hu/en/department-molecular-immunology-and-toxicology-mito]\\
FIELD OF SCHOLARSHIP: Chemistry
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__BIOGRAPHICAL NOTE:__
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Place of studies: University of Debrecen\\
MSc in Chemistry, 2012\\
BSc in Mathematics, 2013\\
PhD in Chemical Sciences, 2016
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__Thesis:__ Experimental and Modelling Studies on the Reactions of the Sulfate Ion Radical\\
Supervisor: Dr. Gábor Lente, Dept. of Inorganic and Analytical Chemistry
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__Current occupation:__ 
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Chemist\\
National Institute of Oncology, Dept. of Molecular Immunology and Toxicology, Budapest, Hungary
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__Foreign studies:__ 
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Karolinska Institutet, Stockholm		1 month
Tohoku University, Sendai, Japan		2 months
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__DETAILS OF RESEARCH:__
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I’ve been trained in the experimental and computational methods of solution phase reaction kinetics, and the studies of the mechanism of complex redox reactions, mainly regarding environmental chemistry.
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I’m currently involved in fundamental biochemical research. Our group has two main lines of interest, the biological actions of hydrogen sulfide, a newly recognized endogenously produced signalling molecule, and the redox regulation of thiol proteins by various posttranslational modifications. A close linker between these subjects are the formation of protein persulfide and polysulfide moieties on cysteine side chains, which was previously shown to regulate enzymatic activities. In our laboratory, we developped a novel experimental method for the detection of protein persulfidation from biological materials such as living cells or tissue samples. Furthermore, we showed that global persulfidation level is tightly regulated by the major disulfide reductase machineries of the cells, the thioredoxin and the glutathione systems. We are currently examining the consequences of this newly recognized functions of the NADPH dependent reductase system on cellular signaling and redox regulation.
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__THREE KEY PUBLICATION REFERENCES:__
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Doka, E., et al. ''Science Advances'', __2016__, 2, e1500968.
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Doka, E., Arnér, E. S. J., Schmidt, E. E., Nagy, P. ''Methods in Molecular Biology'', in press
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Peralta, D., et al. ''Nature Chemical Biology'', __2015__, 11, 156-63.